{
    "uniprot_canonical_ac": "A0A5F8MPL8-1",
    "uniprot_ac": "A0A5F8MPL8",
    "uniprot_id": "A0A5F8MPL8_MOUSE",
    "mass": {
        "chemical_mass": 25254.0,
        "monoisotopic_mass": 25254.0
    },
    "refseq": {
        "ac": "NP_783613",
        "name": "BRICHOS domain-containing protein 5",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783613"
    },
    "gene_names": [
        {
            "name": "Bricd5",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A5F8MPL8",
            "id": "A0A5F8MPL8"
        },
        {
            "name": "9930021D14Rik",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783613",
            "id": "NP_783613"
        },
        {
            "name": "9930021D14Rik",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A5F8MPL8",
            "id": "A0A5F8MPL8"
        },
        {
            "name": "Bricd5",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783613",
            "id": "NP_783613"
        }
    ],
    "protein_names": [
        {
            "name": "BRICHOS domain-containing 5",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A5F8MPL8#names_and_taxonomy",
            "id": "A0A5F8MPL8"
        },
        {
            "name": "BRICHOS domain-containing protein 5",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783613",
            "id": "NP_783613"
        }
    ],
    "function": [
        {
            "annotation": "An SFTPC BRICHOS mutant links epithelial ER stress and spontaneous lung fibrosis. Publication Status: Online-Only",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_783613",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783613"
                },
                {
                    "database": "PubMed",
                    "id": "30721158",
                    "url": "https://glygen.org/publication/PubMed/30721158"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A5F8MPL8",
                    "url": "https://www.uniprot.org/uniprot/A0A5F8MPL8"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Bricd5",
            "url": "https://www.uniprot.org/uniprot/A0A5F8MPL8",
            "locus": {
                "chromosome": "17",
                "start_pos": 24473884,
                "end_pos": 24475469,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000045744",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000045744"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000045744",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000045744",
            "database": "Bgee"
        },
        {
            "id": "319259",
            "url": "https://www.ncbi.nlm.nih.gov/gene/319259",
            "database": "GeneID"
        },
        {
            "id": "IPR007084",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR007084",
            "database": "InterPro"
        },
        {
            "id": "mmu:319259",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:319259",
            "database": "KEGG Pathway"
        },
        {
            "id": "2441766",
            "url": "http://www.informatics.jax.org/marker/MGI:2441766",
            "database": "MGI"
        },
        {
            "id": "PQSNRSW",
            "url": "https://omabrowser.org/oma/group/PQSNRSW/",
            "database": "OMA"
        },
        {
            "id": "779909at2759",
            "url": "http://www.orthodb.org/?query=779909at2759",
            "database": "OrthoDB"
        },
        {
            "id": "PF04089",
            "url": "http://pfam.xfam.org/family/PF04089",
            "database": "Pfam"
        },
        {
            "id": "NP_783613",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783613",
            "database": "RefSeq"
        },
        {
            "id": "A0A5F8MPL8",
            "url": "https://www.uniprot.org/uniprot/A0A5F8MPL8",
            "database": "UniProtKB"
        },
        {
            "id": "A0A5F8MPL8-1",
            "url": "https://www.uniprot.org/uniprot/A0A5F8MPL8-1",
            "database": "UniProtKB"
        },
        {
            "id": "Q8BV89",
            "url": "https://www.uniprot.org/uniprot/Q8BV89",
            "database": "UniProtKB"
        },
        {
            "id": "Q8BV89-1",
            "url": "https://www.uniprot.org/uniprot/Q8BV89-1",
            "database": "UniProtKB"
        }
    ],
    "sequence": {
        "sequence": "MKQGRIHTESLRSKPAEVKTKPCHRGWRAAGLLLLLTLLTAGAVAGGLLGFMYSSPKPLLQMLRKTFPSSRVPWPNQTTLVDVAQNMATIVVTPFQSNHSWAVLFDGQNGYICYRPAEHQACFLRLMEAQDWETLQLLLNTSRAQESHVPGRDTHYAQELLAVLGGHTVDPTQVGVSVQHLCADTPIYWTQWAEGPQRQRLIYLCIDICFPSNICVSVCFYYLPD",
        "length": 225,
        "header": "tr|A0A5F8MPL8-1|A0A5F8MPL8_MOUSE Isoform 1 of BRICHOS domain-containing 5  OS=Mus musculus OX=10090 GN=Bricd5 PE=4 SV=1 CANONICAL=A0A5F8MPL8-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A5F8MPL8-1",
            "url": "https://www.uniprot.org/uniprot/A0A5F8MPL8#A0A5F8MPL8-1",
            "sequence": {
                "sequence": "MKQGRIHTESLRSKPAEVKTKPCHRGWRAAGLLLLLTLLTAGAVAGGLLGFMYSSPKPLLQMLRKTFPSSRVPWPNQTTLVDVAQNMATIVVTPFQSNHSWAVLFDGQNGYICYRPAEHQACFLRLMEAQDWETLQLLLNTSRAQESHVPGRDTHYAQELLAVLGGHTVDPTQVGVSVQHLCADTPIYWTQWAEGPQRQRLIYLCIDICFPSNICVSVCFYYLPD",
                "length": 225,
                "header": "tr|A0A5F8MPL8-1|A0A5F8MPL8_MOUSE Isoform 1 of BRICHOS domain-containing 5  OS=Mus musculus OX=10090 GN=Bricd5 PE=4 SV=1 CANONICAL=A0A5F8MPL8-1"
            },
            "locus": {
                "chromosome": "17",
                "start_pos": 24694305,
                "end_pos": 24692911,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000238986.2",
                        "url": "https://www.ensembl.org/id/ENSMUST00000238986.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000159026.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000159026.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q8BV89-1",
            "url": "https://www.uniprot.org/uniprot/A0A5F8MPL8#Q8BV89-1",
            "sequence": {
                "sequence": "MYSSPKPLLQMLRKTFPSSRVPWPNQTTLVDVAQNMATIVVTPFQSNHSWAVLFDGQNGYICYRPAEHQACFLRLMEAQDWETLQLLLNTSRAQESHVPGRDTHYAQELLAVLGGHTVDPTQVGVSVQHLCADTPIYWTQWAEGPQRQRLIYLCIDICFPSNICVSVCFYYLPD",
                "length": 174,
                "header": "tr|Q8BV89-1|A0A5F8MPL8_MOUSE Computationally mapped isoform of BRICHOS domain-containing 5  OS=Mus musculus OX=10090 GN=Bricd5 PE=4 SV=1 CANONICAL=A0A5F8MPL8-1"
            },
            "locus": {
                "chromosome": "17",
                "start_pos": 24694305,
                "end_pos": 24693195,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000054946.10",
                        "url": "https://www.ensembl.org/id/ENSMUST00000054946.10"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000059792.4",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000059792.4"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "An SFTPC BRICHOS mutant links epithelial ER stress and spontaneous lung fibrosis.",
            "journal": "JCI insight",
            "date": "2019",
            "authors": "Katzen J, Wagner BD, Venosa A, Kopp M, Tomer Y, Russo SJ, Headen AC, Basil MC, Stark JM, Mulugeta S, Deterding RR, Beers MF",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_783613",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783613"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "30721158",
                    "url": "https://glygen.org/publication/PubMed/30721158"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:319259",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:319259",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q6PL45-1",
            "protein_name": "BRICHOS domain-containing protein 5",
            "gene_name": "BRICD5",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MEPASCCAERPKPGPTGVKTKPSCGGWRAVSLLLLLLLLVLAAVGVVAGGLLGSAQGPPKPRLQTLRMTLPSPHMPRPNQTILVDVARNAATITVTPPQSNHSWAVLFDGQSGCICYRPEEHQVCFLRLMEDSDRETLRLLVDTSKVQEAWVPSQDTHHTQELLAVQGSLEVDPAQAGALVQRLCMRTPIYWARRAEGESGPLWGKARPSGWFEELGAEPLEIHGTLATGPRRQRLIYLCIDICFPSNICVSVCFYYLPD",
                "length": 260
            },
            "evidence": [
                {
                    "id": "41500221",
                    "url": "http://www.informatics.jax.org/homology/41500221",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 2,
                "go_terms": [
                    {
                        "name": "extracellular space",
                        "id": "GO:0005615",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A5F8MPL8",
                                "url": "https://www.uniprot.org/uniprot/A0A5F8MPL8"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "integral component of membrane",
                        "id": "GO:0016021",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A5F8MPL8",
                                "url": "https://www.uniprot.org/uniprot/A0A5F8MPL8"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 1,
                "go_terms": [
                    {
                        "name": "regulation of cell population proliferation",
                        "id": "GO:0042127",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042127",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A5F8MPL8",
                                "url": "https://www.uniprot.org/uniprot/A0A5F8MPL8"
                            }
                        ],
                        "pmid": "21873635"
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 140,
            "end_pos": 142,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 76,
            "end_pos": 78,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 98,
            "end_pos": 100,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        }
    ]
}