{ "uniprot_canonical_ac": "A0A1Y7VMP7-1", "uniprot_ac": "A0A1Y7VMP7", "uniprot_id": "A0A1Y7VMP7_MOUSE", "mass": { "chemical_mass": 162524.0, "monoisotopic_mass": 162524.0 }, "refseq": { "ac": "XP_006515766", "name": "DNA mismatch repair protein Mlh3 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006515766" }, "gene_names": [ { "name": "Mlh3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A1Y7VMP7", "id": "A0A1Y7VMP7" }, { "name": "AV125803; BB126472", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291404", "id": "NP_001291404" }, { "name": "Mlh3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291404", "id": "NP_001291404" } ], "protein_names": [ { "name": "DNA mismatch repair protein Mlh3 isoform X1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006515766", "id": "XP_006515766" }, { "name": "DNA mismatch repair protein Mlh3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291404", "id": "NP_001291404" }, { "name": "MutL homolog 3", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A1Y7VMP7#names_and_taxonomy", "id": "A0A1Y7VMP7" }, { "name": "mutL 3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291404", "id": "NP_001291404" } ], "function": [ { "annotation": "A point mutation in the nuclease domain of MLH3 eliminates repeat expansions in a mouse stem cell model of the Fragile X-related disorders.", "evidence": [ { "database": "RefSeq", "id": "NP_001291404", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291404" }, { "database": "PubMed", "id": "32619224", "url": "https://glygen.org/publication/PubMed/32619224" } ] }, { "annotation": "Associated with MSH4 in mammalian meiotic cells, supporting the possibility that MLH3 plays a role in meiotic recombination.", "evidence": [ { "database": "RefSeq", "id": "NP_001291404", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291404" }, { "database": "PubMed", "id": "12095912", "url": "https://glygen.org/publication/PubMed/12095912" } ] }, { "annotation": "Double mutant mice homozygous for the Mlh3DN/DN and Mus81-/- mutations show losses in chiasmata close to those observed in Mlh3-/- males, indicating that the MUS81-EME1-regulated crossover pathway can only partially account for the increased residual chiasmata in Mlh3DN/DN spermatocytes Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001291404", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291404" }, { "database": "PubMed", "id": "31170160", "url": "https://glygen.org/publication/PubMed/31170160" } ] }, { "annotation": "Human MLH1/3 variants causing aneuploidy, pregnancy loss, and premature reproductive aging. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001291404", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291404" }, { "database": "PubMed", "id": "34408140", "url": "https://glygen.org/publication/PubMed/34408140" } ] }, { "annotation": "Mlh3 is required for Mlh1 binding to meiotic chromosomes and localizes to chromosomes from the mid pachynema stage of prophase. Mlh3(-/-) spermatocytes reach metaphase before succumbing to apoptosis, oocytes fail to complete meiosis I after fertilization.", "evidence": [ { "database": "RefSeq", "id": "NP_001291404", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291404" }, { "database": "PubMed", "id": "12091911", "url": "https://glygen.org/publication/PubMed/12091911" } ] }, { "annotation": "We identify, de novo, DNA sequence motifs associated with individual components that define temporally varying modes of gene expression control. Analysis of SDA components also led us to identify a rare population of macrophages within the seminiferous tubules of Mlh3(-/-) and Hormad1(-/-) mice, an area typically associated with immune privilege Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001291404", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291404" }, { "database": "PubMed", "id": "31237565", "url": "https://glygen.org/publication/PubMed/31237565" } ] } ], "disease": [ { "disease_id": "DOID:0070276", "recommended_name": { "id": "DOID:0070276", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070276", "name": "hereditary nonpolyposis colorectal cancer type 7", "description": "A Lynch syndrome that has_material_basis_in mutation in the MLH3 gene on chromosome 14q24.3." }, "synonyms": [ { "id": "DOID:0070276", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070276", "name": "HNPCC7", "description": "" }, { "id": "MONDO:0013725", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013725", "name": "colorectal cancer, hereditary nonpolyposis, type 7", "description": "Any hereditary nonpolyposis colon cancer in which the cause of the disease is a mutation in the MLH3 gene." }, { "id": "MONDO:0013725", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013725", "name": "colorectal cancer, hereditary nonpolyposis, type 7", "description": "" }, { "id": "MONDO:0013725", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013725", "name": "MLH3 hereditary nonpolyposis colon cancer", "description": "" }, { "id": "MONDO:0013725", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013725", "name": "HNPCC7", "description": "" }, { "id": "MONDO:0013725", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013725", "name": "hereditary nonpolyposis colon cancer caused by mutation in MLH3", "description": "" }, { "id": "MONDO:0013725", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013725", "name": "colorectal cancer, hereditary nonpolyposis, type 7; HNPCC7", "description": "" }, { "id": "MIM:614385", "resource": "MIM", "url": "https://www.omim.org/entry/614385", "name": "Hereditary non-polyposis colorectal cancer 7", "description": "Hereditary non-polyposis colorectal cancer 7" } ], "evidence": [ { "id": "0070276", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0070276" } ] }, { "disease_id": "DOID:1380", "recommended_name": { "id": "DOID:1380", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1380", "name": "endometrial cancer", "description": "A uterine cancer that is located_in tissues lining the uterus." }, "synonyms": [ { "id": "DOID:1380", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1380", "name": "endometrial Ca", "description": "" }, { "id": "DOID:1380", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1380", "name": "endometrial neoplasm", "description": "" }, { "id": "DOID:1380", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1380", "name": "malignant endometrial neoplasm", "description": "" }, { "id": "DOID:1380", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1380", "name": "malignant neoplasm of endometrium", "description": "" }, { "id": "DOID:1380", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1380", "name": "neoplasm of endometrium", "description": "" }, { "id": "DOID:1380", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1380", "name": "primary malignant neoplasm of endometrium", "description": "" }, { "id": "DOID:1380", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1380", "name": "tumor of Endometrium", "description": "" }, { "id": "MONDO:0011962", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011962", "name": "endometrial cancer", "description": "Primary or metastatic malignant neoplasm involving the endometrium (mucous membrane that lines the endometrial cavity)." }, { "id": "MONDO:0011962", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011962", "name": "endometrial cancer", "description": "" }, { "id": "MONDO:0011962", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011962", "name": "endometrium cancer", "description": "" }, { "id": "MONDO:0011962", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011962", "name": "primary malignant neoplasm of endometrium", "description": "" }, { "id": "MONDO:0011962", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011962", "name": "malignant endometrium neoplasm", "description": "" }, { "id": "MONDO:0011962", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011962", "name": "malignant endometrial neoplasm", "description": "" }, { "id": "MONDO:0011962", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011962", "name": "endometrial Ca", "description": "" }, { "id": "MONDO:0011962", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011962", "name": "cancer of endometrium", "description": "" }, { "id": "MONDO:0011962", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011962", "name": "endometrial neoplasm", "description": "" }, { "id": "MONDO:0011962", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011962", "name": "malignant neoplasm of endometrium", "description": "" }, { "id": "MONDO:0011962", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011962", "name": "tumor of endometrium", "description": "" }, { "id": "MONDO:0011962", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011962", "name": "neoplasm of endometrium", "description": "" }, { "id": "MIM:608089", "resource": "MIM", "url": "https://www.omim.org/entry/608089", "name": "Endometrial cancer", "description": "Endometrial cancer" } ], "evidence": [ { "id": "1380", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1380" } ] }, { "disease_id": "DOID:3883", "recommended_name": { "id": "DOID:3883", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3883", "name": "Lynch syndrome", "description": "A syndrome that is characterized by an increased risk for colon cancer and cancers of the endometrium, ovary, stomach, small intestine, hepatobiliary tract, urinary tract, brain, and skin and has_material_basis_in mutation of mismatch repair genes that increases the risk of many types of cancers." }, "synonyms": [ { "id": "DOID:3883", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3883", "name": "COCA 1", "description": "" }, { "id": "DOID:3883", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3883", "name": "HNPCC - hereditary nonpolyposis colon cancer", "description": "" }, { "id": "DOID:3883", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3883", "name": "Hereditary Defective Mismatch Repair syndrome", "description": "" }, { "id": "DOID:3883", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3883", "name": "hereditary nonpolyposis colorectal cancer", "description": "" }, { "id": "DOID:3883", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3883", "name": "hereditary nonpolyposis colorectal neoplasm", "description": "" }, { "id": "MONDO:0007356", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007356", "name": "Lynch syndrome 1", "description": "A rare genetic neoplastic syndrome with an autosomal dominant pattern of inheritance but incomplete penetrance. It is associated with a greater than 70 % risk of developing colorectal carcinoma. It is caused by a mutation in one of the mismatch repair genes: MSH2, MLH1, MSH6 or PMS2. It usually manifests at age 50 or younger with multiple synchronous or metachronous colorectal carcinomas. Clinical course is rapidly progressive. Prognosis is variable with a high risk for the development of additional colorectal carcinomas. However, survival is significantly better than non-HNPCC carcinomas of equivalent stage." }, { "id": "MONDO:0007356", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007356", "name": "Lynch syndrome type 1", "description": "" }, { "id": "MONDO:0007356", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007356", "name": "COCA1", "description": "" }, { "id": "MONDO:0007356", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007356", "name": "colorectal cancer, hereditary nonpolyposis, type 1", "description": "" }, { "id": "MONDO:0007356", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007356", "name": "LYNCH syndrome I", "description": "" }, { "id": "MONDO:0007356", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007356", "name": "hereditary nonpolyposis colorectal cancer type 1", "description": "" }, { "id": "MONDO:0007356", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007356", "name": "familial non-polyposis colon cancer type 1", "description": "" }, { "id": "MONDO:0007356", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007356", "name": "Lynch 1 syndrome", "description": "" }, { "id": "MONDO:0007356", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007356", "name": "colon cancer, familial nonpolyposis, type 1", "description": "" }, { "id": "MONDO:0007356", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007356", "name": "HNPCC1", "description": "" }, { "id": "MONDO:0007356", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007356", "name": "Lynch syndrome 2", "description": "" }, { "id": "MONDO:0007356", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007356", "name": "Hereditary non-polyposis colon cancer type 1", "description": "" }, { "id": "MIM:120435", "resource": "MIM", "url": "https://www.omim.org/entry/120435", "name": "Hereditary non-polyposis colorectal cancer 1", "description": "Hereditary non-polyposis colorectal cancer 1" } ], "evidence": [ { "id": "3883", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3883" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0023113", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023113", "name": "familial colorectal cancer", "description": "Familial colon cancer is a cluster of colon cancer within a family. Most cases ofcolon cancer occur sporadically in people with little to no family history of the condition. Approximately 3-5% of colon cancer is considered 'hereditary' and is thought to be caused by an inherited predisposition tocolon cancer that is passed down through a family in an autosomal dominant or autosomal recessive manner. In some of these families, the underlying genetic cause is not known; however, many of these cases are caused by changes ( mutations ) in the APC , MYH , MLH1 , MSH2 , MSH6 , PMS2 , EPCAM , PTEN , STK11 , SMAD4 , BMPR1A , NTHL1 , POLE , and POLD1 genes (which are associated with hereditary cancer syndromes). An additional 10-30% of people diagnosed with colon cancer have a significant family history of the condition but have no identifiable mutation in a gene known to cause a hereditary predisposition to colon cancer. These clusters of colon cancer are likely due to a combination of gene(s) and other shared factors such as environment and lifestyle. High-risk cancer screening and other preventative measures such as prophylactic surgeries are typically recommended in people who have an increased risk for colon cancer based on their personal and/or family histories." }, { "id": "MONDO:0023113", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023113", "name": "hereditary colorectal cancer", "description": "" }, { "id": "MONDO:0023113", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023113", "name": "colorectal cancer, familial", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ], "evidence": [ { "id": "9256", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9256" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A0A1Y7VMP7", "url": "https://www.uniprot.org/uniprot/A0A1Y7VMP7" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Mlh3", "url": "https://www.uniprot.org/uniprot/A0A1Y7VMP7", "locus": { "chromosome": "12", "start_pos": 85270599, "end_pos": 85234520, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000021245", "url": "https://www.ensembl.org/id/ENSMUSG00000021245" } ] } } ], "crossref": [ { "id": "ENSMUSG00000021245", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000021245", "database": "Bgee" }, { "id": "217716", "url": "https://www.ncbi.nlm.nih.gov/gene/217716", "database": "GeneID" }, { "id": "IPR013507", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013507", "database": "InterPro" }, { "id": "IPR014721", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014721", "database": "InterPro" }, { "id": "IPR014762", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014762", "database": "InterPro" }, { "id": "IPR014790", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014790", "database": "InterPro" }, { "id": "IPR020568", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020568", "database": "InterPro" }, { "id": "IPR028830", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028830", "database": "InterPro" }, { "id": "IPR036890", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036890", "database": "InterPro" }, { "id": "IPR037198", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037198", "database": "InterPro" }, { "id": "IPR038973", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038973", "database": "InterPro" }, { "id": "IPR042120", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042120", "database": "InterPro" }, { "id": "IPR042121", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042121", "database": "InterPro" }, { "id": "mmu:217716", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:217716", "database": "KEGG Pathway" }, { "id": "1353455", "url": "http://www.informatics.jax.org/marker/MGI:1353455", "database": "MGI" }, { "id": "MMSHFNE", "url": "https://omabrowser.org/oma/group/MMSHFNE/", "database": "OMA" }, { "id": "735423at2759", "url": "http://www.orthodb.org/?query=735423at2759", "database": "OrthoDB" }, { "id": "PTHR10073", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10073", "database": "PANTHER" }, { "id": "PTHR10073:SF47", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10073:SF47", "database": "PANTHER" }, { "id": "PF01119", "url": "http://pfam.xfam.org/family/PF01119", "database": "Pfam" }, { "id": "PF08676", "url": "http://pfam.xfam.org/family/PF08676", "database": "Pfam" }, { "id": "NP_001291404", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291404", "database": "RefSeq" }, { "id": "XP_006515766", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006515766", "database": "RefSeq" }, { "id": "A0A1Y7VJX4", "url": "https://www.uniprot.org/uniprot/A0A1Y7VJX4", "database": "UniProtKB" }, { "id": "A0A1Y7VJX4-1", "url": "https://www.uniprot.org/uniprot/A0A1Y7VJX4-1", "database": "UniProtKB" }, { "id": "A0A1Y7VMP7", "url": "https://www.uniprot.org/uniprot/A0A1Y7VMP7", "database": "UniProtKB" }, { "id": "A0A1Y7VMP7-1", "url": "https://www.uniprot.org/uniprot/A0A1Y7VMP7-1", "database": "UniProtKB" }, { "id": "Q68FG1", "url": "https://www.uniprot.org/uniprot/Q68FG1", "database": "UniProtKB" }, { "id": "Q68FG1-1", "url": "https://www.uniprot.org/uniprot/Q68FG1-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MIRCLSDDVKTKLRSGLAISSLGQCVEELTLNSIDAEATCVAIRVNMETFQVQVIDNGLGMAGDDVEKVGNRYFTSKCHSVRDLENPAFYGFRGEALASIADMAGAVEISSKKNTTLKTFVKMFQNGKALATHEADLTRPSVGTTVTVYNLFYQFPVRRKSMDPRLEFEKVRQRVEALSLMHPSISFSLRNDVSGSMVLQLPKTKDICSRFCQIYGLGKSQKLREIRFKYKEFEFSGYISSEAHYNKNMQFLFVNRRLVLRTKLHKLIDFLLRKESIICRPKNGSASRQMNSSPRHRSASELHGIYVINVQCPFCEYDVCIEPAKTLIEFQSWDTVLICIQEGVKRFLKQEKLFVELSGEDIKEFNEDNGFSLFGTTLQTHVSTHEKCDQSSFREACNKILDSYEMFNLQSKAVKRIATLENKTRQNPGDSETIRKKTVGSLYTDASDGPCYSKSVESVLQDSNNSAYLEPRVSEEEVAKTSHSGENEKWKKSFLENKTSGRIHETSPKMFSSPIQMHHLLEEREADLEMQTISSTVNVMAANIPQNNDIPSQLEKWKDAPEVGCQPLPFETTLLRVRGTQRKKERRKKEPSSRGRVNVFSYGQVKLCSTGFITHVVQSEHAKSTETEHSFKNYARPGPVSAQETFGKRTHHAIETPDSSDLTSTLSKESSQPPNKRFCRTNTGYGTENKPVATDDNLALFQESCKESHTDRLLPDASSFPWCRYVSDGCRKIDKRGSFKQVVRRKLSLRSQVGSLEKFKRQYGKVSSSLDTEKDNNTEVRTHLDPQNEPDVLLKDKSHLDMSDGCEITTVEHSETCQPLSPILYPEKILFSKEDRLEQMPHLRESPITLEELSHCNRKADVEKSAASLASKLSKLKDSEKEMQTVGMTGHTSELPDSNPSWKDNSQCTRLDLDFCELLKNKLEKIESDMLPMADSATEDGPINKNSELHPNNTTDDTEKPETPLLFPCNDSKISRDSDVLIRTSEQPTGNPDSVGKVIMSQVEDGIGSQGGVCPQGDESKARSCSKNEPNAHCMDWQQHFDVTLGRMVYINRMTGLSTFVAPTDDLHTACTKDLTTVAVDVLLGNGAQYRCHPFRSDLVLPFLPRAQEERTMLRHNSNAVDAAAAAVSEPLQSLFSEWSNPVFARYPEVAVDVSSGQAESLAVKIHNVLYPYRFTKEMIHSVKVLQQVDNKFIACLMSTRMDEDGRTGGNLLVLVDQHAAHERIRLEQLITDSYEKQDPQSAGRKKLLSSTIIPPLAITVSEEQRRLLRSYHKHLEDLGLELLFPDASDSLILVGKVPLCFVEREASELRRGRSTVTKSIVEELIREQVELLQTTGGIQGTLPLTVQKVLASQACHGAIKFNDRLSLEESCRLIEALSLSQLPFQCAHGRPSMLPLADLDHLEQEKQVKPNLAKLRKMVRAWHLFGKTEQNLQQPIRPCEPP", "length": 1443, "header": "tr|A0A1Y7VMP7-1|A0A1Y7VMP7_MOUSE Isoform 1 of MutL homolog 3 OS=Mus musculus OX=10090 GN=Mlh3 PE=3 SV=1 CANONICAL=A0A1Y7VMP7-1" }, "isoforms": [ { "isoform_ac": "A0A1Y7VJX4-1", "url": "https://www.uniprot.org/uniprot/A0A1Y7VMP7#A0A1Y7VJX4-1", "sequence": { "sequence": "VTLGRMVYINRMTGLSTFVAPTDDLHTACTKDLTTVAVDVLLGNDAVDAAAAAVSEPLQSLFSEWSNPVFARYPEVAVDVSSGQAESLAVKIHNVLYPYRFTKEMIHSVKVLQQVDNKFIACLMSTRMDEDGRTGGNLLVLVDQHAAHERIRLEQLITDSYEKQDPQSAGRKKLLSSTIIPPLAITVSEEQRRLLRN", "length": 197, "header": "tr|A0A1Y7VJX4-1|A0A1Y7VMP7_MOUSE Computationally mapped isoform of MutL homolog 3 OS=Mus musculus OX=10090 GN=Mlh3 PE=3 SV=1 CANONICAL=A0A1Y7VMP7-1" }, "locus": { "chromosome": "12", "start_pos": 85313058, "end_pos": 85287754, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000223230.2", "url": "https://www.ensembl.org/id/ENSMUST00000223230.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000152686.2", "url": "https://www.ensembl.org/id/ENSMUSP00000152686.2" } ] } }, { "isoform_ac": "A0A1Y7VMP7-1", "url": "https://www.uniprot.org/uniprot/A0A1Y7VMP7#A0A1Y7VMP7-1", "sequence": { "sequence": "MIRCLSDDVKTKLRSGLAISSLGQCVEELTLNSIDAEATCVAIRVNMETFQVQVIDNGLGMAGDDVEKVGNRYFTSKCHSVRDLENPAFYGFRGEALASIADMAGAVEISSKKNTTLKTFVKMFQNGKALATHEADLTRPSVGTTVTVYNLFYQFPVRRKSMDPRLEFEKVRQRVEALSLMHPSISFSLRNDVSGSMVLQLPKTKDICSRFCQIYGLGKSQKLREIRFKYKEFEFSGYISSEAHYNKNMQFLFVNRRLVLRTKLHKLIDFLLRKESIICRPKNGSASRQMNSSPRHRSASELHGIYVINVQCPFCEYDVCIEPAKTLIEFQSWDTVLICIQEGVKRFLKQEKLFVELSGEDIKEFNEDNGFSLFGTTLQTHVSTHEKCDQSSFREACNKILDSYEMFNLQSKAVKRIATLENKTRQNPGDSETIRKKTVGSLYTDASDGPCYSKSVESVLQDSNNSAYLEPRVSEEEVAKTSHSGENEKWKKSFLENKTSGRIHETSPKMFSSPIQMHHLLEEREADLEMQTISSTVNVMAANIPQNNDIPSQLEKWKDAPEVGCQPLPFETTLLRVRGTQRKKERRKKEPSSRGRVNVFSYGQVKLCSTGFITHVVQSEHAKSTETEHSFKNYARPGPVSAQETFGKRTHHAIETPDSSDLTSTLSKESSQPPNKRFCRTNTGYGTENKPVATDDNLALFQESCKESHTDRLLPDASSFPWCRYVSDGCRKIDKRGSFKQVVRRKLSLRSQVGSLEKFKRQYGKVSSSLDTEKDNNTEVRTHLDPQNEPDVLLKDKSHLDMSDGCEITTVEHSETCQPLSPILYPEKILFSKEDRLEQMPHLRESPITLEELSHCNRKADVEKSAASLASKLSKLKDSEKEMQTVGMTGHTSELPDSNPSWKDNSQCTRLDLDFCELLKNKLEKIESDMLPMADSATEDGPINKNSELHPNNTTDDTEKPETPLLFPCNDSKISRDSDVLIRTSEQPTGNPDSVGKVIMSQVEDGIGSQGGVCPQGDESKARSCSKNEPNAHCMDWQQHFDVTLGRMVYINRMTGLSTFVAPTDDLHTACTKDLTTVAVDVLLGNGAQYRCHPFRSDLVLPFLPRAQEERTMLRHNSNAVDAAAAAVSEPLQSLFSEWSNPVFARYPEVAVDVSSGQAESLAVKIHNVLYPYRFTKEMIHSVKVLQQVDNKFIACLMSTRMDEDGRTGGNLLVLVDQHAAHERIRLEQLITDSYEKQDPQSAGRKKLLSSTIIPPLAITVSEEQRRLLRSYHKHLEDLGLELLFPDASDSLILVGKVPLCFVEREASELRRGRSTVTKSIVEELIREQVELLQTTGGIQGTLPLTVQKVLASQACHGAIKFNDRLSLEESCRLIEALSLSQLPFQCAHGRPSMLPLADLDHLEQEKQVKPNLAKLRKMVRAWHLFGKTEQNLQQPIRPCEPP", "length": 1443, "header": "tr|A0A1Y7VMP7-1|A0A1Y7VMP7_MOUSE Isoform 1 of MutL homolog 3 OS=Mus musculus OX=10090 GN=Mlh3 PE=3 SV=1 CANONICAL=A0A1Y7VMP7-1" }, "locus": { "chromosome": "12", "start_pos": 85316184, "end_pos": 85282399, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000220854.2", "url": "https://www.ensembl.org/id/ENSMUST00000220854.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000152840.2", "url": "https://www.ensembl.org/id/ENSMUSP00000152840.2" } ] } }, { "isoform_ac": "Q68FG1-1", "url": "https://www.uniprot.org/uniprot/A0A1Y7VMP7#Q68FG1-1", "sequence": { "sequence": "MIRCLSDDVKTKLRSGLAISSLGQCVEELTLNSIDAEATCVAIRVNMETFQVQVIDNGLGMAGDDVEKVGNRYFTSKCHSVRDLENPAFYGFRGEALASIADMAGAVEISSKKNTTLKTFVKMFQNGKALATHEADLTRPSVGTTVTVYNLFYQFPVRRKSMDPRLEFEKVRQRVEALSLMHPSISFSLRNDVSGSMVLQLPKTKDICSRFCQIYGLGKSQKLREIRFKYKEFEFSGYISSEAHYNKNMQFLFVNRRLVLRTKLHKLIDFLLRKESIICRPKNGSASRQMNSSPRHRSASELHGIYVINVQCPFCEYDVCIEPAKTLIEFQSWDTVLICIQEGVKRFLKQEKLFVELSGEDIKEFNEDNGFSLFGTTLQTHVSTHEKCDQSSFREACNKILDSYEMFNLQSKAVKRIATLENKTRQNPGDSETIRKKTVGSLYTDASDGPCYSKSVESVLQDSNNSAYLEPRVSEEEVAKTSHSGENEKWKKSFLENKTSGRIHETSPKMFSSPIQMHHLLEEREADLEMQTISSTVNVMAANIPQNNDIPSQLEKWKDAPEVGCQPLPFETTLLRVRGTQRKKERRKKEPSSRGRVNVFSYGQVKLCSTGFITHVVQSEHAKSTETEHSFKNYARPGPVSAQETFGKRTHHAIETPDSSDLTSTLSKESSQPPNKRFCRTNTGYGTENKPVATDDNLALFQESCKESHTDRLLPDASSFPWCRYVSDGCRKIDKRGSFKQVVRRKLSLRSQVGSLEKFKRQYGKVSSSLDTEKDNNTEVRTHLDPQNEPDVLLKDKSHLDMSDGCEITTVEHSETCQPLSPILYPEKILFSKEDRLEQMPHLRESPITLEELSHCNRKADVEKSAASLASKLSKLKDSEKEMQTVGMTGHTSELPDSNPSWKDNSQCTRLDLDFCELLKNKLEKIESDMLPMADSATEDGPINKNSELHPNNTTDDTEKPETPLLFPCNDSKISRDSDVLIRTSEQPTGNPDSVGKVIMSQVEDGIGSQGGVCPQGDESKARSCSKNEPNAHCMDWQQHFDVTLGRMVYINRMTGLSTFVAPTDDLHTACTKDLTTVAVDVLLGNDAVDAAAAAVSEPLQSLFSEWSNPVFARYPEVAVDVSSGQAESLAVKIHNVLYPYRFTKEMIHSVKVLQQVDNKFIACLMSTRMDEDGRTGGNLLVLVDQHAAHERIRLEQLITDSYEKQDPQSAGRKKLLSSTIIPPLAITVSEEQRRLLRSYHKHLEDLGLELLFPDASDSLILVGKVPLCFVEREASELRRGRSTVTKSIVEELIREQVELLQTTGGIQGTLPLTVQKVLASQACHGAIKFNDRLSLEESCRLIEALSLSQLPFQCAHGRPSMLPLADLDHLEQEKQVKPNLAKLRKMVRAWHLFGKTEQNLQQPIRPCEPP", "length": 1411, "header": "tr|Q68FG1-1|A0A1Y7VMP7_MOUSE Computationally mapped isoform of MutL homolog 3 OS=Mus musculus OX=10090 GN=Mlh3 PE=3 SV=1 CANONICAL=A0A1Y7VMP7-1" }, "locus": { "chromosome": "12", "start_pos": 85316184, "end_pos": 85282399, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000166821.8", "url": "https://www.ensembl.org/id/ENSMUST00000166821.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000129900.2", "url": "https://www.ensembl.org/id/ENSMUSP00000129900.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Meiotic arrest and aneuploidy in MLH3-deficient mice.", "journal": "Nature genetics", "date": "2002", "authors": "Lipkin SM, Moens PB, Wang V, Lenzi M, Shanmugarajah D, Gilgeous A, Thomas J, Cheng J, Touchman JW, Green ED, Schwartzberg P, Collins FS, Cohen PE", "evidence": [ { "database": "RefSeq", "id": "NP_001291404", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291404" } ], "reference": [ { "type": "PubMed", "id": "12091911", "url": "https://glygen.org/publication/PubMed/12091911" } ] }, { "title": "The DNA mismatch-repair MLH3 protein interacts with MSH4 in meiotic cells, supporting a role for this MutL homolog in mammalian meiotic recombination.", "journal": "Human molecular genetics", "date": "2002", "authors": "Santucci-Darmanin S, Neyton S, Lespinasse F, Saunieres A, Gaudray P, Paquis-Flucklinger V", "evidence": [ { "database": "RefSeq", "id": "NP_001291404", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291404" } ], "reference": [ { "type": "PubMed", "id": "12095912", "url": "https://glygen.org/publication/PubMed/12095912" } ] }, { "title": "Transcript profiling during preimplantation mouse development.", "journal": "Developmental biology", "date": "2004", "authors": "Zeng F, Baldwin DA, Schultz RM", "evidence": [ { "database": "RefSeq", "id": "NP_001291404", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291404" } ], "reference": [ { "type": "PubMed", "id": "15282163", "url": "https://glygen.org/publication/PubMed/15282163" } ] }, { "title": "A mutation in the endonuclease domain of mouse MLH3 reveals novel roles for MutLgamma during crossover formation in meiotic prophase I.", "journal": "PLoS genetics", "date": "2019", "authors": "Toledo M, Sun X, Brieno-Enriquez MA, Raghavan V, Gray S, Pea J, Milano CR, Venkatesh A, Patel L, Borst PL, Alani E, Cohen PE", "evidence": [ { "database": "RefSeq", "id": "NP_001291404", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291404" } ], "reference": [ { "type": "PubMed", "id": "31170160", "url": "https://glygen.org/publication/PubMed/31170160" } ] }, { "title": "Unified single-cell analysis of testis gene regulation and pathology in five mouse strains.", "journal": "eLife", "date": "2019", "authors": "Jung M, Wells D, Rusch J, Ahmad S, Marchini J, Myers SR, Conrad DF", "evidence": [ { "database": "RefSeq", "id": "NP_001291404", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291404" } ], "reference": [ { "type": "PubMed", "id": "31237565", "url": "https://glygen.org/publication/PubMed/31237565" } ] }, { "title": "A point mutation in the nuclease domain of MLH3 eliminates repeat expansions in a mouse stem cell model of the Fragile X-related disorders.", "journal": "Nucleic acids research", "date": "2020", "authors": "Hayward BE, Steinbach PJ, Usdin K", "evidence": [ { "database": "RefSeq", "id": "NP_001291404", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291404" } ], "reference": [ { "type": "PubMed", "id": "32619224", "url": "https://glygen.org/publication/PubMed/32619224" } ] }, { "title": "Human MLH1/3 variants causing aneuploidy, pregnancy loss, and premature reproductive aging.", "journal": "Nature communications", "date": "2021", "authors": "Singh P, Fragoza R, Blengini CS, Tran TN, Pannafino G, Al-Sweel N, Schimenti KJ, Schindler K, Alani EA, Yu H, Schimenti JC", "evidence": [ { "database": "RefSeq", "id": "NP_001291404", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291404" } ], "reference": [ { "type": "PubMed", "id": "34408140", "url": "https://glygen.org/publication/PubMed/34408140" } ] } ], "pathway": [ { "id": "mmu:217716", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:217716", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D4ADG4-1", "protein_name": "MutL homolog 3", "gene_name": "Mlh3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MIRCLSDEVQAKLRSGLALSSLGQCVEELTLNSIDAEATCVAIRVNMETFQVQVIDNGLGMAGDDVEKVGNRYFTSKCHSVRDLENPTFYGFRGEALASIADMASAVEISSKKSTTLKTFVKMFQNGKALAAREADLTRPSVGTTVTVYNLFYQFPVRRKSMDPRLEFEKVRQRVEALSLMHPSISFSLRNDVSGSMILQLPKTKDICSRFCQIYGLGKSQKLREIHYKYKEFEFNGYISSEAHYNKNMQFLFVNRRLVLRTKLHKLIDFLLRKESIICRPKNGSASRQMNSSPRHRSASELHGIYVINVQCPFCEYDVCIEPAKTLIEFQNWDTVLICVQEGIKKFLKQEKLFVELSSEDIKEFNEDNGFSLIGTTLQTQSTHEKCDQSSFQEACNNILDSYEMFNLQSKAVKRIATLENRTTQNSGDSGAIRKKTEDSYTYESDDLGHRKTVESALYNSDSAYLGSRMSEEDIAKTSHAGENEKWKKSLLENRTSERPHETSPKMFSSPIQTHHPLEESEADLEIEMKSSTVNVMAANIPPNSEIQSQLEQLEDAPEVECQPLPFETTLLRAQGTLKKKERKKELSSHGRVNVFSYGQVKLCSTGFITHVVQREPAKSPETEQLFKNYARPGPVSAQEAFGNRTHHASETPDSSSLTSTLSKESTQPPHKRFCRTNTGYGTENKPVATDDNLALFQGSRKESHTDCFLPDTTSFPWCRNVSGGYKKKGKVGSFKHVVRRKLSLRSQIGSLEKFKRQYGKVNNSLAAEEDNDTDFRTHLEPHNEPDVLLKDKSLSDMSDGGEITPSEHSDGCQPLRPILYPETLSKEDRLEQRPSLRESPITLAELLHGNRKPSEVKKSTEALASKLSRLKDSEKEMQTMEMAGPVSERPDSDPSWKDNSQCARLDLNFCELYKNKLEKTESEVLPMPDSAPEDDSINKNSVLCSNSVTDDREKPETSLLLPCSDSKISKDSDVLIRVSEQQSGSPDSASREVTRQVEDSAGSQCGICSQSHGFKARSCSDNEESSTHSMDWQQHFDVTLGRTVYINRMTGLSTFVAPTDDIQTPCTKDLTTVAVDVLLGNGVQYRCHPFRSDLVLPFLPRAQEERTRRRHNRDAVDAAAVSEPLQSLFSEWSNPVFARYPEVAVDVSSGQAGSLAVKIHNVLYPYRFTKEMIHSVQVLQQVDNKFIACLMSSRTDGSGQAGGNLLVLVDQHAAHERVRLEQLITDSYEKQAPQSAGRKKLLSSTIIPPLAITVSEEQRRLLRSYHKHLEDLGLELLFPDASDSSILVGKVPLCFVEREANELRRGRSPVTKSIVEELIREQLELLQTTGGIQGTLPLTVQKVLASQACHGAIKFNDRLSLEESCRLIEALSLCQLPFQCAHGRPSMLPLADLDHLEQEKQVKPNLTKLRKMAHAWHLFGKAEGCDTKQEPQQPVPPCEPP", "length": 1442 }, "evidence": [ { "id": "41497595", "url": "http://www.informatics.jax.org/homology/41497595", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9UHC1-1", "protein_name": "DNA mismatch repair protein Mlh3", "gene_name": "MLH3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MIKCLSVEVQAKLRSGLAISSLGQCVEELALNSIDAEAKCVAVRVNMETFQVQVIDNGFGMGSDDVEKVGNRYFTSKCHSVQDLENPRFYGFRGEALANIADMASAVEISSKKNRTMKTFVKLFQSGKALKACEADVTRASAGTTVTVYNLFYQLPVRRKCMDPRLEFEKVRQRIEALSLMHPSISFSLRNDVSGSMVLQLPKTKDVCSRFCQIYGLGKSQKLREISFKYKEFELSGYISSEAHYNKNMQFLFVNKRLVLRTKLHKLIDFLLRKESIICKPKNGPTSRQMNSSLRHRSTPELYGIYVINVQCQFCEYDVCMEPAKTLIEFQNWDTLLFCIQEGVKMFLKQEKLFVELSGEDIKEFSEDNGFSLFDATLQKRVTSDERSNFQEACNNILDSYEMFNLQSKAVKRKTTAENVNTQSSRDSEATRKNTNDAFLYIYESGGPGHSKMTEPSLQNKDSSCSESKMLEQETIVASEAGENEKHKKSFLEHSSLENPCGTSLEMFLSPFQTPCHFEESGQDLEIWKESTTVNGMAANILKNNRIQNQPKRFKDATEVGCQPLPFATTLWGVHSAQTEKEKKKESSNCGRRNVFSYGRVKLCSTGFITHVVQNEKTKSTETEHSFKNYVRPGPTRAQETFGNRTRHSVETPDIKDLASTLSKESGQLPNKKNCRTNISYGLENEPTATYTMFSAFQEGSKKSQTDCILSDTSPSFPWYRHVSNDSRKTDKLIGFSKPIVRKKLSLSSQLGSLEKFKRQYGKVENPLDTEVEESNGVTTNLSLQVEPDILLKDKNRLENSDVCKITTMEHSDSDSSCQPASHILNSEKFPFSKDEDCLEQQMPSLRESPMTLKELSLFNRKPLDLEKSSESLASKLSRLKGSERETQTMGMMSRFNELPNSDSSRKDSKLCSVLTQDFCMLFNNKHEKTENGVIPTSDSATQDNSFNKNSKTHSNSNTTENCVISETPLVLPYNNSKVTGKDSDVLIRASEQQIGSLDSPSGMLMNPVEDATGDQNGICFQSEESKARACSETEESNTCCSDWQRHFDVALGRMVYVNKMTGLSTFIAPTEDIQAACTKDLTTVAVDVVLENGSQYRCQPFRSDLVLPFLPRARAERTVMRQDNRDTVDDTVSSESLQSLFSEWDNPVFARYPEVAVDVSSGQAESLAVKIHNILYPYRFTKGMIHSMQVLQQVDNKFIACLMSTKTEENGEAGGNLLVLVDQHAAHERIRLEQLIIDSYEKQQAQGSGRKKLLSSTLIPPLEITVTEEQRRLLWCYHKNLEDLGLEFVFPDTSDSLVLVGKVPLCFVEREANELRRGRSTVTKSIVEEFIREQLELLQTTGGIQGTLPLTVQKVLASQACHGAIKFNDGLSLQESCRLIEALSSCQLPFQCAHGRPSMLPLADIDHLEQEKQIKPNLTKLRKMAQAWRLFGKAECDTRQSLQQSMPPCEPP", "length": 1453 }, "evidence": [ { "id": "41497595", "url": "http://www.informatics.jax.org/homology/41497595", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "chiasma", "id": "GO:0005712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005712", "evidence": [ { "database": "UniProtKB", "id": "A0A1Y7VMP7", "url": "https://www.uniprot.org/uniprot/A0A1Y7VMP7" } ], "pmid": "17696610" }, { "name": "condensed nuclear chromosome", "id": "GO:0000794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000794", "evidence": [ { "database": "UniProtKB", "id": "A0A1Y7VMP7", "url": "https://www.uniprot.org/uniprot/A0A1Y7VMP7" } ], "pmid": "24891606" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0A1Y7VMP7", "url": "https://www.uniprot.org/uniprot/A0A1Y7VMP7" } ], "pmid": "" }, { "name": "condensed chromosome", "id": "GO:0000793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000793", "evidence": [ { "database": "UniProtKB", "id": "A0A1Y7VMP7", "url": "https://www.uniprot.org/uniprot/A0A1Y7VMP7" } ], "pmid": "12091911" }, { "name": "male germ cell nucleus", "id": "GO:0001673", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001673", "evidence": [ { "database": "UniProtKB", "id": "A0A1Y7VMP7", "url": "https://www.uniprot.org/uniprot/A0A1Y7VMP7" } ], "pmid": "17696610" }, { "name": "mismatch repair complex", "id": "GO:0032300", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032300", "evidence": [ { "database": "UniProtKB", "id": "A0A1Y7VMP7", "url": "https://www.uniprot.org/uniprot/A0A1Y7VMP7" } ], "pmid": "22164254" }, { "name": "synaptonemal complex", "id": "GO:0000795", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000795", "evidence": [ { "database": "UniProtKB", "id": "A0A1Y7VMP7", "url": "https://www.uniprot.org/uniprot/A0A1Y7VMP7" } ], "pmid": "16260499" } ] }, { 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