{
    "uniprot_canonical_ac": "A0A1W2PR82-1",
    "uniprot_ac": "A0A1W2PR82",
    "uniprot_id": "PERC1_HUMAN",
    "mass": {
        "chemical_mass": 29212.0,
        "monoisotopic_mass": 29212.0
    },
    "refseq": {},
    "gene_names": [
        {
            "name": "PERCC1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A1W2PR82",
            "id": "A0A1W2PR82"
        }
    ],
    "protein_names": [
        {
            "name": "Protein PERCC1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A1W2PR82#names_and_taxonomy",
            "id": "A0A1W2PR82"
        },
        {
            "name": "Proline and glutamage-rich protein with a coiled coil domain",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A1W2PR82#names_and_taxonomy",
            "id": "A0A1W2PR82"
        }
    ],
    "function": [
        {
            "annotation": "Plays a critical role in intestinal function (PubMed:31217582). Acts by promoting the development of enteroendocrine cells (EECs) of the gastrointestinal tract and pancreas (By similarity). It is thereby required for normal enteroendocrine peptide hormone secretion (By similarity).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A1W2PR82",
                    "url": "https://www.uniprot.org/uniprot/A0A1W2PR82#function"
                },
                {
                    "database": "PubMed",
                    "id": "A0A286YDK6",
                    "url": "https://glygen.org/publication/PubMed/A0A286YDK6"
                },
                {
                    "database": "PubMed",
                    "id": "31217582",
                    "url": "https://glygen.org/publication/PubMed/31217582"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "MIM:618662",
            "recommended_name": {
                "id": "MIM:618662",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/618662",
                "name": "Diarrhea 11, malabsorptive, congenital",
                "description": "Diarrhea 11, malabsorptive, congenital"
            },
            "synonyms": [],
            "evidence": [
                {
                    "id": "618662",
                    "database": "MIM",
                    "url": "https://www.omim.org/entry/618662"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Homo sapiens",
            "taxid": 9606,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A1W2PR82",
                    "url": "https://www.uniprot.org/uniprot/A0A1W2PR82"
                }
            ],
            "common_name": "Human"
        }
    ],
    "gene": [
        {
            "name": "PERCC1",
            "url": "https://www.uniprot.org/uniprot/A0A1W2PR82",
            "locus": {}
        }
    ],
    "crossref": [
        {
            "id": "ENSG00000284395",
            "url": "https://bgee.org/?page=gene&gene_id=ENSG00000284395",
            "database": "Bgee"
        },
        {
            "id": "A0A1W2PR82",
            "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0A1W2PR82",
            "database": "BioMuta"
        },
        {
            "id": "PERCC1",
            "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=PERCC1",
            "database": "GeneCards"
        },
        {
            "id": "52293",
            "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=52293",
            "database": "HGNC"
        },
        {
            "id": "618656",
            "url": "http://www.omim.org/entry/618656",
            "database": "MIM"
        },
        {
            "id": "618662",
            "url": "http://www.omim.org/entry/618662",
            "database": "MIM"
        },
        {
            "id": "NX_A0A1W2PR82",
            "url": "https://www.nextprot.org/entry/NX_A0A1W2PR82",
            "database": "neXtProt"
        },
        {
            "id": "YEDDRMS",
            "url": "https://omabrowser.org/oma/group/YEDDRMS/",
            "database": "OMA"
        },
        {
            "id": "1457597at2759",
            "url": "http://www.orthodb.org/?query=1457597at2759",
            "database": "OrthoDB"
        },
        {
            "id": "PR_A0A1W2PR82",
            "url": "http://purl.obolibrary.org/obo/PR_A0A1W2PR82",
            "database": "PRO"
        },
        {
            "id": "XP_011521082",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_011521082",
            "database": "RefSeq"
        },
        {
            "id": "A0A1W2PR82",
            "url": "https://www.uniprot.org/uniprot/A0A1W2PR82",
            "database": "UniProtKB"
        },
        {
            "id": "A0A1W2PR82-1",
            "url": "https://www.uniprot.org/uniprot/A0A1W2PR82-1",
            "database": "UniProtKB"
        }
    ],
    "sequence": {
        "sequence": "MAAGVIRPLCDFQLPLLRHHPFLPSDPEPPETSEEEEEEEEEEEEEEGEGEGLGGCGRILPSSGRAEATEEAAPEGPGSPETPLQLLRFSELISDDIRRYFGRKDKGQDPDACDVYADSRPPRSTARELYYADLVRLARGGSLEDEDTPEPRVPQGQVCRPGLSGDRAQPLGPLAELFDYGLQQYWGSRAAAGWSLTLERKYGHITPMAQRKLPPSFWKEPTPSPLGLLHPGTPDFSDLLASWSTEACPELPGRGTPALEGARPAEA",
        "length": 267,
        "header": "sp|A0A1W2PR82-1|PERC1_HUMAN Isoform 1 of Protein PERCC1  OS=Homo sapiens OX=9606 GN=PERCC1 PE=3 SV=1 CANONICAL=A0A1W2PR82-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A1W2PR82-1",
            "url": "https://www.uniprot.org/uniprot/A0A1W2PR82#A0A1W2PR82-1",
            "sequence": {
                "sequence": "MAAGVIRPLCDFQLPLLRHHPFLPSDPEPPETSEEEEEEEEEEEEEEGEGEGLGGCGRILPSSGRAEATEEAAPEGPGSPETPLQLLRFSELISDDIRRYFGRKDKGQDPDACDVYADSRPPRSTARELYYADLVRLARGGSLEDEDTPEPRVPQGQVCRPGLSGDRAQPLGPLAELFDYGLQQYWGSRAAAGWSLTLERKYGHITPMAQRKLPPSFWKEPTPSPLGLLHPGTPDFSDLLASWSTEACPELPGRGTPALEGARPAEA",
                "length": 267,
                "header": "sp|A0A1W2PR82-1|PERC1_HUMAN Isoform 1 of Protein PERCC1  OS=Homo sapiens OX=9606 GN=PERCC1 PE=3 SV=1 CANONICAL=A0A1W2PR82-1"
            },
            "locus": {
                "chromosome": "16",
                "start_pos": 1433394,
                "end_pos": 1432594,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENST00000640283.2",
                        "url": "https://www.ensembl.org/id/ENST00000640283.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSP00000492108.2",
                        "url": "https://www.ensembl.org/id/ENSP00000492108.2"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Noncoding deletions reveal a gene that is critical for intestinal function.",
            "journal": "Nature",
            "date": "2019",
            "authors": "Anikster Y., Pennacchio L.A., Zhu Y., Lancet D., Goldstein D.B., Kleta R., Stanescu H.C., Han Y., Shapiro R., Ruzzo E.K., Bar-Joseph I., Marek-Yagel D., Olender T., Oz-Levi D., Pras E., Reznik-Wolf H., Alkelai A., Weiss B., Nord A.S., Mayhew C.N., Pode-Shakked B., Tekman M., Visel A., Black B.L., Hartman C., Shamir R., de Laat W., Afzal V., Wells J.M., Barshack I., van Bueren K.L., Barnes R.M., Barozzi I., Coleman-Derr D., Dickel D.E., Imai D.M., Kuhar M.F., Milgrom R., Osterwalder M., Pitstick A., Schvimer M., Tatarskyy P., Vos E.S.M.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A1W2PR82",
                    "url": "https://www.uniprot.org/uniprot/A0A1W2PR82"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "31217582",
                    "url": "https://glygen.org/publication/PubMed/31217582"
                }
            ]
        }
    ],
    "pathway": [],
    "orthologs": [
        {
            "uniprot_canonical_ac": "A0A286YDK6-1",
            "protein_name": "Protein PERCC1",
            "gene_name": "Percc1",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MAAGVIRSVCDFRLPLPSHESFLPIDLEAPEISEEEEEEEEEEEEEEEEEEVDQDQQGEGSQGCGPDSQSSGVVPQDPSSPETPMQLLRFSELISGDIQRYFGRKDTGQDPDAQDIYADSQPASCSARDLYYADLVCLAQDGPPEDEEAAEFRMHLPGGPEGQVHRLGHRGDRVPPLGPLAELFDYGLRQFSRPRISACRRLRLERKYSHITPMTQRKLPPSFWKEPVPNPLGLLHVGTPDFSDLLASWSAEGGSELQSGGTQGLEGTQLAEV",
                "length": 273
            },
            "evidence": [
                {
                    "id": "A0A1W2PR82",
                    "url": "https://omabrowser.org/oma/group/A0A1W2PR82/",
                    "database": "OMA"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 2,
                "go_terms": [
                    {
                        "name": "digestive tract morphogenesis",
                        "id": "GO:0048546",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048546",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2PR82",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2PR82"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "enteroendocrine cell differentiation",
                        "id": "GO:0035883",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035883",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2PR82",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2PR82"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
        }
    ]
}