{
    "uniprot_canonical_ac": "A0A1W2PPF3-1",
    "uniprot_ac": "A0A1W2PPF3",
    "uniprot_id": "DUXB_HUMAN",
    "mass": {
        "chemical_mass": 40370.0,
        "monoisotopic_mass": 40370.0
    },
    "refseq": {},
    "gene_names": [
        {
            "name": "DUXB",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A1W2PPF3",
            "id": "A0A1W2PPF3"
        }
    ],
    "protein_names": [
        {
            "name": "Double homeobox protein B",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A1W2PPF3#names_and_taxonomy",
            "id": "A0A1W2PPF3"
        }
    ],
    "function": [],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Homo sapiens",
            "taxid": 9606,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A1W2PPF3",
                    "url": "https://www.uniprot.org/uniprot/A0A1W2PPF3"
                }
            ],
            "common_name": "Human"
        }
    ],
    "gene": [
        {
            "name": "DUXB",
            "url": "https://www.uniprot.org/uniprot/A0A1W2PPF3",
            "locus": {
                "chromosome": "16",
                "start_pos": 75701459,
                "end_pos": 75693929,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSG00000282757",
                        "url": "https://www.ensembl.org/id/ENSG00000282757"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSG00000282757",
            "url": "https://bgee.org/?page=gene&gene_id=ENSG00000282757",
            "database": "Bgee"
        },
        {
            "id": "A0A1W2PPF3",
            "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0A1W2PPF3",
            "database": "BioMuta"
        },
        {
            "id": "cd00086",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086",
            "database": "CDD"
        },
        {
            "id": "DUXB",
            "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=DUXB",
            "database": "GeneCards"
        },
        {
            "id": "33345",
            "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=33345",
            "database": "HGNC"
        },
        {
            "id": "IPR001356",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356",
            "database": "InterPro"
        },
        {
            "id": "IPR009057",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057",
            "database": "InterPro"
        },
        {
            "id": "IPR017970",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR017970",
            "database": "InterPro"
        },
        {
            "id": "618698",
            "url": "http://www.omim.org/entry/618698",
            "database": "MIM"
        },
        {
            "id": "NX_A0A1W2PPF3",
            "url": "https://www.nextprot.org/entry/NX_A0A1W2PPF3",
            "database": "neXtProt"
        },
        {
            "id": "PSTQAPW",
            "url": "https://omabrowser.org/oma/group/PSTQAPW/",
            "database": "OMA"
        },
        {
            "id": "PF00046",
            "url": "http://pfam.xfam.org/family/PF00046",
            "database": "Pfam"
        },
        {
            "id": "PR_A0A1W2PPF3",
            "url": "http://purl.obolibrary.org/obo/PR_A0A1W2PPF3",
            "database": "PRO"
        },
        {
            "id": "A0A1W2PPF3",
            "url": "https://www.uniprot.org/uniprot/A0A1W2PPF3",
            "database": "UniProtKB"
        },
        {
            "id": "A0A1W2PPF3-1",
            "url": "https://www.uniprot.org/uniprot/A0A1W2PPF3-1",
            "database": "UniProtKB"
        }
    ],
    "sequence": {
        "sequence": "MNLEGTSGGILQKEFWRNRIQYNQSQKDILQSWFQHDPFPDKAAREQLAKEIGVPESNIQVWFKNYRVKQRKLDYKCFSEKDQTQGHDQSQHLTQEYLPKEARQKQTFITWTQKNRLVQAFERNPFPDIATRKKLAEQTGLQESRIQMWFQKQRSLYLKKSRMEPMNLLVDDPNERPDATVGWHPINLFLPTDSSHYFSCSHSSSGHETLPPVLPSTQAPWDPFRFHVSQGPNVMIMQPTQAVQEGEKSDQPLIIPNHLLTLPILTKDLDTPTPFWLQYQEEHQNHKEHSGSGVPQVKSHSQPEPEHREQQPLNLGQFDISNILQRWDEICQALLAEWDPLKGTH",
        "length": 345,
        "header": "sp|A0A1W2PPF3-1|DUXB_HUMAN Isoform 1 of Double homeobox protein B  OS=Homo sapiens OX=9606 GN=DUXB PE=2 SV=1 CANONICAL=A0A1W2PPF3-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A1W2PPF3-1",
            "url": "https://www.uniprot.org/uniprot/A0A1W2PPF3#A0A1W2PPF3-1",
            "sequence": {
                "sequence": "MNLEGTSGGILQKEFWRNRIQYNQSQKDILQSWFQHDPFPDKAAREQLAKEIGVPESNIQVWFKNYRVKQRKLDYKCFSEKDQTQGHDQSQHLTQEYLPKEARQKQTFITWTQKNRLVQAFERNPFPDIATRKKLAEQTGLQESRIQMWFQKQRSLYLKKSRMEPMNLLVDDPNERPDATVGWHPINLFLPTDSSHYFSCSHSSSGHETLPPVLPSTQAPWDPFRFHVSQGPNVMIMQPTQAVQEGEKSDQPLIIPNHLLTLPILTKDLDTPTPFWLQYQEEHQNHKEHSGSGVPQVKSHSQPEPEHREQQPLNLGQFDISNILQRWDEICQALLAEWDPLKGTH",
                "length": 345,
                "header": "sp|A0A1W2PPF3-1|DUXB_HUMAN Isoform 1 of Double homeobox protein B  OS=Homo sapiens OX=9606 GN=DUXB PE=2 SV=1 CANONICAL=A0A1W2PPF3-1"
            },
            "locus": {
                "chromosome": "16",
                "start_pos": 75701418,
                "end_pos": 75693932,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENST00000633875.4",
                        "url": "https://www.ensembl.org/id/ENST00000633875.4"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSP00000491301.1",
                        "url": "https://www.ensembl.org/id/ENSP00000491301.1"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Novel PRD-like homeodomain transcription factors and retrotransposon elements in early human development.",
            "journal": "Nat. Commun.",
            "date": "2015",
            "authors": "Kere J., Katayama S., Hovatta O., Toehoenen V., Johnsson A., Buerglin T.R., Filippini-Cattaneo G., Jaconi M., Jouhilahti E.M., Linnarsson S., Madissoon E., Sheikhi M., Vesterlund L.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A1W2PPF3",
                    "url": "https://www.uniprot.org/uniprot/A0A1W2PPF3"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "26360614",
                    "url": "https://glygen.org/publication/PubMed/26360614"
                }
            ]
        },
        {
            "title": "Characterization and target genes of nine human PRD-like homeobox domain genes expressed exclusively in early embryos.",
            "journal": "Sci. Rep.",
            "date": "2016",
            "authors": "Kere J., Katayama S., Hovatta O., Toehoenen V., Krjutskov K., Einarsdottir E., Buerglin T.R., Jouhilahti E.M., Linnarsson S., Madissoon E., Vesterlund L., Lanner F., Maansson R., Petropoulos S.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A1W2PPF3",
                    "url": "https://www.uniprot.org/uniprot/A0A1W2PPF3"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "27412763",
                    "url": "https://glygen.org/publication/PubMed/27412763"
                }
            ]
        }
    ],
    "pathway": [],
    "orthologs": [],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 1,
                "go_terms": [
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2PPF3",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2PPF3"
                            }
                        ],
                        "pmid": "21873635"
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 1,
                "go_terms": [
                    {
                        "name": "regulation of transcription by RNA polymerase II",
                        "id": "GO:0006357",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2PPF3",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2PPF3"
                            }
                        ],
                        "pmid": "21873635"
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 2,
                "go_terms": [
                    {
                        "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding",
                        "id": "GO:0000977",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2PPF3",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2PPF3"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "DNA-binding transcription factor activity, RNA polymerase II-specific",
                        "id": "GO:0000981",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1W2PPF3",
                                "url": "https://www.uniprot.org/uniprot/A0A1W2PPF3"
                            }
                        ],
                        "pmid": "21873635"
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 23,
            "end_pos": 25,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "synthesized_glycans": [],
    "cluster_types": []
}