{ "uniprot_canonical_ac": "A0A1B0GSB0-1", "uniprot_ac": "A0A1B0GSB0", "uniprot_id": "A0A1B0GSB0_MOUSE", "mass": { "chemical_mass": 106248.0, "monoisotopic_mass": 106248.0 }, "refseq": { "ac": "NP_766497", "name": "scavenger receptor family member expressed on T cells 1 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766497" }, "gene_names": [ { "name": "Scart1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A1B0GSB0", "id": "A0A1B0GSB0" }, { "name": "B430307C05; Cd163l1; E430002D04Rik", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766497", "id": "NP_766497" }, { "name": "Cd163l1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A1B0GSB0", "id": "A0A1B0GSB0" }, { "name": "Scart1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766497", "id": "NP_766497" } ], "protein_names": [ { "name": "Scavenger receptor family member-expressed on T cells 1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A1B0GSB0#names_and_taxonomy", "id": "A0A1B0GSB0" }, { "name": "scavenger receptor cysteine-rich type 1 protein CD163c-alpha; CD163 molecule-like 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766497", "id": "NP_766497" }, { "name": "scavenger receptor family member expressed on T cells 1 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766497", "id": "NP_766497" } ], "function": [ { "annotation": "Described two novel surface receptors, SCART1 and SCART2", "evidence": [ { "database": "RefSeq", "id": "NP_766497", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766497" }, { "database": "PubMed", "id": "18641307", "url": "https://glygen.org/publication/PubMed/18641307" } ] }, { "annotation": "MSCART1 is highly related to the WC1 family of the SRCR superfamily.", "evidence": [ { "database": "RefSeq", "id": "NP_766497", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766497" }, { "database": "PubMed", "id": "19297026", "url": "https://glygen.org/publication/PubMed/19297026" } ] }, { "annotation": "Results show that SCART1 is a novel gammadelta T cell marker and it is therefore likely that SCART1 plays a role in the immune response.", "evidence": [ { "database": "RefSeq", "id": "NP_766497", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766497" }, { "database": "PubMed", "id": "20381152", "url": "https://glygen.org/publication/PubMed/20381152" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A0A1B0GSB0", "url": "https://www.uniprot.org/uniprot/A0A1B0GSB0" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Scart1", "url": "https://www.uniprot.org/uniprot/A0A1B0GSB0", "locus": {} } ], "crossref": [ { "id": "ENSMUSG00000025461", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000025461", "database": "Bgee" }, { "id": "244233", "url": "https://www.ncbi.nlm.nih.gov/gene/244233", "database": "GeneID" }, { "id": "IPR001190", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001190", "database": "InterPro" }, { "id": "IPR017448", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017448", "database": "InterPro" }, { "id": "IPR036772", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036772", "database": "InterPro" }, { "id": "mmu:244233", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:244233", "database": "KEGG Pathway" }, { "id": "2443796", "url": "http://www.informatics.jax.org/marker/MGI:2443796", "database": "MGI" }, { "id": "CCCAGWL", "url": "https://omabrowser.org/oma/group/CCCAGWL/", "database": "OMA" }, { "id": "PF00530", "url": "http://pfam.xfam.org/family/PF00530", "database": "Pfam" }, { "id": "NP_766497", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766497", "database": "RefSeq" }, { "id": "A0A1B0GSB0", "url": "https://www.uniprot.org/uniprot/A0A1B0GSB0", "database": "UniProtKB" }, { "id": "A0A1B0GSB0-1", "url": "https://www.uniprot.org/uniprot/A0A1B0GSB0-1", "database": "UniProtKB" }, { "id": "Q8CGY7", "url": "https://www.uniprot.org/uniprot/Q8CGY7", "database": "UniProtKB" }, { "id": "Q8CGY7-1", "url": "https://www.uniprot.org/uniprot/Q8CGY7-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MRTTLWPLSLGSLLTLGAALTGTSSEGDQGNLRLAHRQSTCDGVVLVRHQGEWGHLCNLEWTLAEASVVCRQLGCGPAVGAPKYVPLPGEMVRPWLHNVSCWGNESSLWECSLGAWSQRACPHEWVVVALCANGTFREIRLVKGHSPCAGLPEIMNVNGVDRLCGLHVEEATVFCRELQCGHALQAPRQDVGVSKYMTCKGTESTIRNCRLNNKLRGGCNLLLDAEVICSGHVEARLVGGEHSCAGRLEVLRGLTWGTICHADLDLPTAHVVCRELGCGIAVSTLGGAQFGQGSGPVWLEAFRCVGNESLLFHCPREPGHHCGHEQDAALTCSEFRLVNGSSDCEGRVELQVQGTWAPVCAANWDLADAMVLCHQLNCGNAVSVPPGGHFGDGDDLIWPDIFHCVGTEPHLLHCAASTLGAHGCVLGNTASTICSGLQDILRLRDGQSYCDGRVEISLDGSWGRVLDDAWDLHGASVVCRQLGCGEAQRAYDAPAPIFRRVPVGLSQVRCLGSETRLVHCNVSTSLLVPAGTLRDAGVVCSGSLRVRLAAGPGRCAGRVELFYQGSWGTVCDDAWDLQDAQVVCRQLDCGHALSAPRNAHFGAGTGHIWMDELHCLGNESSLWKCQSGSWGQHDCRHKEDAGVFCSESVALRLRGGTSGCVGWLDVLYNGSWGAVCSNALRDISLSIICRQLGCGDQGWLENRPSSGAGLGISWVDNIKCRNLHNATLWQCPSAPWNPHSCTQEEEVWINCEGTPQIALQDPAQTPNCSSPFGCLENSVLRVLGGEDGCSGRVELWHAGSWGTVCDDSWDLVDAEVVCRQLGCGQALAALGEASFGPGVGPVWLDEVECLGSEVTLEACQAEPWGHGDCTHKEDAGVRCAVKAQPSLCPTAPSLTPPSVAEVWKLSEIACLVLGCLLGIVFLVMIAQWCHIRDASMGAGMLGHLQSEGIYEDIEVDPVPKKEENTVSRLLMLEEGYDDAEEPEDQPTENDE", "length": 991, "header": "tr|A0A1B0GSB0-1|A0A1B0GSB0_MOUSE Isoform 1 of Scavenger receptor family member-expressed on T cells 1 OS=Mus musculus OX=10090 GN=Scart1 PE=1 SV=1 CANONICAL=A0A1B0GSB0-1" }, "isoforms": [ { "isoform_ac": "A0A1B0GSB0-1", "url": "https://www.uniprot.org/uniprot/A0A1B0GSB0#A0A1B0GSB0-1", "sequence": { "sequence": "MRTTLWPLSLGSLLTLGAALTGTSSEGDQGNLRLAHRQSTCDGVVLVRHQGEWGHLCNLEWTLAEASVVCRQLGCGPAVGAPKYVPLPGEMVRPWLHNVSCWGNESSLWECSLGAWSQRACPHEWVVVALCANGTFREIRLVKGHSPCAGLPEIMNVNGVDRLCGLHVEEATVFCRELQCGHALQAPRQDVGVSKYMTCKGTESTIRNCRLNNKLRGGCNLLLDAEVICSGHVEARLVGGEHSCAGRLEVLRGLTWGTICHADLDLPTAHVVCRELGCGIAVSTLGGAQFGQGSGPVWLEAFRCVGNESLLFHCPREPGHHCGHEQDAALTCSEFRLVNGSSDCEGRVELQVQGTWAPVCAANWDLADAMVLCHQLNCGNAVSVPPGGHFGDGDDLIWPDIFHCVGTEPHLLHCAASTLGAHGCVLGNTASTICSGLQDILRLRDGQSYCDGRVEISLDGSWGRVLDDAWDLHGASVVCRQLGCGEAQRAYDAPAPIFRRVPVGLSQVRCLGSETRLVHCNVSTSLLVPAGTLRDAGVVCSGSLRVRLAAGPGRCAGRVELFYQGSWGTVCDDAWDLQDAQVVCRQLDCGHALSAPRNAHFGAGTGHIWMDELHCLGNESSLWKCQSGSWGQHDCRHKEDAGVFCSESVALRLRGGTSGCVGWLDVLYNGSWGAVCSNALRDISLSIICRQLGCGDQGWLENRPSSGAGLGISWVDNIKCRNLHNATLWQCPSAPWNPHSCTQEEEVWINCEGTPQIALQDPAQTPNCSSPFGCLENSVLRVLGGEDGCSGRVELWHAGSWGTVCDDSWDLVDAEVVCRQLGCGQALAALGEASFGPGVGPVWLDEVECLGSEVTLEACQAEPWGHGDCTHKEDAGVRCAVKAQPSLCPTAPSLTPPSVAEVWKLSEIACLVLGCLLGIVFLVMIAQWCHIRDASMGAGMLGHLQSEGIYEDIEVDPVPKKEENTVSRLLMLEEGYDDAEEPEDQPTENDE", "length": 991, "header": "tr|A0A1B0GSB0-1|A0A1B0GSB0_MOUSE Isoform 1 of Scavenger receptor family member-expressed on T cells 1 OS=Mus musculus OX=10090 GN=Scart1 PE=1 SV=1 CANONICAL=A0A1B0GSB0-1" }, "locus": { "chromosome": "7", "start_pos": 139810376, "end_pos": 139798478, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000209398.2", "url": "https://www.ensembl.org/id/ENSMUST00000209398.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000147864.2", "url": "https://www.ensembl.org/id/ENSMUSP00000147864.2" } ] } }, { "isoform_ac": "Q8CGY7-1", "url": "https://www.uniprot.org/uniprot/A0A1B0GSB0#Q8CGY7-1", "sequence": { "sequence": "MRTTLWPLSLGSLLTLGAALTGTSSEGDQGNLRLAHRQSTCDGVVLVRHQGEWGHLCNLEWTLAEASVVCRQLGCGPAVGAPKYVPLPGEMVRPWLHNVSCWGNESSLWECSLGAWSQRACPHEWVVVALCANGTFREIRLVKGHSPCAGLPEIMNVNGVDRLCGLHVEEATVFCRELQCGHALQAPRQDVGVSKYMTCKGTESTIRNCRLNNKLRGGCNLLLDAEVICSGHVEARLVGGEHSCAGRLEVLRGLTWGTICHADLDLPTAHVVCRELGCGIAVSTLGGAQFGQGSGPVWLEAFRCVGNESLLFHCPREPGHHCGHEQDAALTCSEFRLVNGSSDCEGRVELQVQGTWAPVCAANWDLADAMVLCHQLNCGNAVSVPPGGHFGDGDDLIWPDIFHCVGTEPHLLHCAASTLGAHGCVLGNTASTICSGLQDILRLRDGQSYCDGRVEISLDGSWGRVLDDAWDLHGASVVCRQLGCGEAQRAYDAPAPIFRRVPVGLSQVRCLGSETRLVHCNVSTSLLVPAGTLRDAGVVCSGSLRVRLAAGPGRCAGRVELFYQGSWGTVCDDAWDLQDAQVVCRQLDCGHALSAPRNAHFGAGTGHIWMDELHCLGNESSLWKCQSGSWGQHDCRHKEDAGVFCSESVALRLRGGTSGCVGWLDVLYNGSWGAVCSNALRDISLSIICRQLGCGDQGWLENRPSSGAGLGISWVDNIKCRNLHNATLWQCPSAPWNPHSCTQEEEVWINCEGTPQIALQDPAQTPNCSSPFGCLENSVLRVLGGEDGCSGRVELWHAGSWGTVCDDSWDLVDAEVVCRQLGCGQALAALGEASFGPGVGPVWLDEVECLGSEVTLEACQAEPWGHGDCTHKEDAGVRCAGVSTTTALSPSLTPPSVAEVWKLSEIACLVLGCLLGIVFLVMIAQWCHIRDASMGAGMLGHLQSEGIYEDIEVDPVPKKEENTVSRLLMLEEGYDDAEEPEDQPTENDE", "length": 989, "header": "tr|Q8CGY7-1|Q8CGY7_MOUSE Computationally mapped isoform of Scavenger receptor cysteine-rich type 1 protein CD163c-alpha OS=Mus musculus OX=10090 GN=Scart1 PE=1 SV=1 CANONICAL=A0A1B0GSB0-1" }, "locus": { "chromosome": "7", "start_pos": 139810376, "end_pos": 139798478, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000084460.7", "url": "https://www.ensembl.org/id/ENSMUST00000084460.7" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000081497.7", "url": "https://www.ensembl.org/id/ENSMUSP00000081497.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "SCART scavenger receptors identify a novel subset of adult gammadelta T cells.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2008", "authors": "Kisielow J, Kopf M, Karjalainen K", "evidence": [ { "database": "RefSeq", "id": "NP_766497", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766497" } ], "reference": [ { "type": "PubMed", "id": "18641307", "url": "https://glygen.org/publication/PubMed/18641307" } ] }, { "title": "Cloning and characterization of SCART1, a novel scavenger receptor cysteine-rich type I transmembrane molecule.", "journal": "Mol. Immunol.", "date": "2009", "authors": "Holmskov U., Gronlund J., Hansen S., Fink D.R., Holm D.", "evidence": [ { "database": "UniProtKB", "id": "Q8CGY7", "url": "https://www.uniprot.org/uniprot/Q8CGY7" }, { "database": "RefSeq", "id": "NP_766497", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766497" } ], "reference": [ { "type": "PubMed", "id": "19297026", "url": "https://glygen.org/publication/PubMed/19297026" } ] }, { "title": "Elevated numbers of SCART1+ gammadelta T cells in skin inflammation and inflammatory bowel disease.", "journal": "Molecular immunology", "date": "2010", "authors": "Fink DR, Holm D, Schlosser A, Nielsen O, Latta M, Lozano F, Holmskov U", "evidence": [ { "database": "RefSeq", "id": "NP_766497", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766497" } ], "reference": [ { "type": "PubMed", "id": "20381152", "url": "https://glygen.org/publication/PubMed/20381152" } ] } ], "pathway": [ { "id": "mmu:244233", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:244233", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZR76-1", "protein_name": "Scavenger receptor family member expressed on T-cells 1", "gene_name": "Olr292", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRTTLWTLSLGSLLTLRAALIGTSSEDGQGNLRLAHRQSKCDGVVLVRHQGEWGHLCNLEWTLAEASVVCRQLGCGPAVGAPKYVPLPGEMVQPWLHNVSCWGNESSLWECSLGAWSQRACPHEWVVVALCANGTFREIRLVKGHSPCAGLPEIRNVNGVDRLCGLHVEEATVFCRELECGHALQAPRQDVGVSKYMTCKGTEPTIRNCRLNNKLRGGCNLLLDAEVVCSGHVEARLVGGDHSCSGRLEVLRGLTWGTVCHADLDLPTAHVICRELGCGMAVSTLRGAQFGQGSGPVWLEAFRCVGNESMLFHCPQEPGHHCGHNQDVALTCSEFRLVNGSSDCEGRVELQVQGAWAPLCAANWDLADAMVLCHQLNCGNAVSIPPGGHFGDGDAPIWPDVFHCVGTEPHLLHCPASTLGAHSCVLGNTASTICSGLQDTLRLRDGQSYCDGRVEISLNGSWGRVLDDIWDIRGASVVCRQLECGEAQGAYDAPAPGFRTAPVGLSQVRCLGSETHLMQCNVSTSLLVPAATLRDAGVVCSGSLRMRLAAGPGRCAGRVEVFYQGSWGTVCDDAWDLQDAQVVCRQLDCGHALSAPGNAHFGAGTGRIWMDELHCLGNESLLWKCQSGNWGQHDCRHKEDAGVFCSESVALRLRGGTSGCVGWLDVLYNGSWGAVCSNALRDISLSIMCRQLGCGDQGWLENRPSPGPGLGISWVDKIKCRKLHNATLWQCPSAPWNPHSCTQEEEVWINCEGLPQIGSQEPAQTPNCSSPLGCLEDSVLRVLGGEDGCSGRVELWHAGSWGTVCDDSWDLLDAQVVCRQLGCGQALAALEGAAFGPGMGPVWLDEVECLGSEVTLEACQAELWGHGDCTHKEDAGVRCAVKVQLFFCPTAPSLTPPPVAEAWNLPEVACLVLGCLLGIVFLAMIAQWCHIRDASMGSGMLGNLQSDGVYEDIEVVPVMKKEENAISRLLMLEDGYDDAEEPEGQPTESEEECNGHC", "length": 997 }, "evidence": [ { "id": "41505615", "url": "http://www.informatics.jax.org/homology/41505615", "database": "MGI" } ], "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "scavenger receptor activity", "id": "GO:0005044", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005044", "evidence": [ { "database": "UniProtKB", "id": "A0A1B0GSB0", "url": "https://www.uniprot.org/uniprot/A0A1B0GSB0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A1B0GSB0", "url": "https://www.uniprot.org/uniprot/A0A1B0GSB0" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A1B0GSB0", "url": "https://www.uniprot.org/uniprot/A0A1B0GSB0" } ], "pmid": "20381152" }, { "name": "brush border", "id": "GO:0005903", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005903", "evidence": [ { "database": "UniProtKB", "id": "A0A1B0GSB0", "url": "https://www.uniprot.org/uniprot/A0A1B0GSB0" } ], "pmid": "" }, { "name": "integral component of membrane", "id": "GO:0016021", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "evidence": [ { "database": "UniProtKB", "id": "A0A1B0GSB0", "url": "https://www.uniprot.org/uniprot/A0A1B0GSB0" } ], "pmid": "" }, { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "A0A1B0GSB0", "url": "https://www.uniprot.org/uniprot/A0A1B0GSB0" } ], "pmid": "21873635" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 104, "end_pos": 106, "annotation": "n_glycosylation_sequon" }, { "start_pos": 133, "end_pos": 135, "annotation": "n_glycosylation_sequon" }, { "start_pos": 307, "end_pos": 309, "annotation": "n_glycosylation_sequon" }, { "start_pos": 339, "end_pos": 341, "annotation": "n_glycosylation_sequon" }, { "start_pos": 521, "end_pos": 523, "annotation": "n_glycosylation_sequon" }, { "start_pos": 618, "end_pos": 620, "annotation": "n_glycosylation_sequon" }, { "start_pos": 669, "end_pos": 671, "annotation": "n_glycosylation_sequon" }, { "start_pos": 725, "end_pos": 727, "annotation": "n_glycosylation_sequon" }, { "start_pos": 767, "end_pos": 769, "annotation": "n_glycosylation_sequon" }, { "start_pos": 98, "end_pos": 100, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ] }