{ "uniprot_canonical_ac": "A0A0G2KB30-1", "uniprot_ac": "A0A0G2KB30", "uniprot_id": "A0A0G2KB30_RAT", "mass": { "chemical_mass": 73784.0, "monoisotopic_mass": 73784.0 }, "refseq": { "ac": "NP_001101022", "name": "F-box/LRR-repeat protein 19", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101022" }, "gene_names": [ { "name": "Fbxl19", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2KB30", "id": "A0A0G2KB30" }, { "name": "Fbxl19_predicted", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0G2KB30", "id": "A0A0G2KB30" }, { "name": "Fbxl19", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101022", "id": "NP_001101022" }, { "name": "rCG_39403", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0G2KB30", "id": "A0A0G2KB30" } ], "protein_names": [ { "name": "F-box and leucine-rich repeat protein 19", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0G2KB30#names_and_taxonomy", "id": "A0A0G2KB30" }, { "name": "F-box/LRR-repeat protein 19", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101022", "id": "NP_001101022" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KB30", "url": "https://www.uniprot.org/uniprot/A0A0G2KB30" } ], "common_name": "Rat" } ], "gene": [ { "name": "Fbxl19", "url": "https://www.uniprot.org/uniprot/A0A0G2KB30", "locus": { "chromosome": "1", "start_pos": 199196059, "end_pos": 199216391, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000018986", "url": "https://www.ensembl.org/id/ENSRNOG00000018986" } ] } } ], "crossref": [ { "id": "ENSRNOG00000018986", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000018986", "database": "Bgee" }, { "id": "308999", "url": "https://www.ncbi.nlm.nih.gov/gene/308999", "database": "GeneID" }, { "id": "IPR001810", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001810", "database": "InterPro" }, { "id": "IPR001965", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001965", "database": "InterPro" }, { "id": "IPR002857", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002857", "database": "InterPro" }, { "id": "IPR006553", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006553", "database": "InterPro" }, { "id": "IPR011011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011011", "database": "InterPro" }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro" }, { "id": "IPR019786", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019786", "database": "InterPro" }, { "id": "IPR019787", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019787", "database": "InterPro" }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro" }, { "id": "rno:308999", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:308999", "database": "KEGG Pathway" }, { "id": "TEIPNCW", "url": "https://omabrowser.org/oma/group/TEIPNCW/", "database": "OMA" }, { "id": "324938at2759", "url": "http://www.orthodb.org/?query=324938at2759", "database": "OrthoDB" }, { "id": "PF00646", "url": "http://pfam.xfam.org/family/PF00646", "database": "Pfam" }, { "id": "PF02008", "url": "http://pfam.xfam.org/family/PF02008", "database": "Pfam" }, { "id": "PF16866", "url": "http://pfam.xfam.org/family/PF16866", "database": "Pfam" }, { "id": "R-RNO-8951664", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8951664", "database": "Reactome" }, { "id": "R-RNO-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983168", "database": "Reactome" }, { "id": "NP_001101022", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101022", "database": "RefSeq" }, { "id": "1310989", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1310989", "database": "RGD" }, { "id": "A0A0G2KB30", "url": "https://www.uniprot.org/uniprot/A0A0G2KB30", "database": "UniProtKB" }, { "id": "A0A0G2KB30-1", "url": "https://www.uniprot.org/uniprot/A0A0G2KB30-1", "database": "UniProtKB" }, { "id": "A0A8I6G990", "url": "https://www.uniprot.org/uniprot/A0A8I6G990", "database": "UniProtKB" }, { "id": "A0A8I6G990-1", "url": "https://www.uniprot.org/uniprot/A0A8I6G990-1", "database": "UniProtKB" }, { "id": "D4A2L9", "url": "https://www.uniprot.org/uniprot/D4A2L9", "database": "UniProtKB" }, { "id": "D4A2L9-1", "url": "https://www.uniprot.org/uniprot/D4A2L9-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MSSSSRGPGAGARRRRTRCRRCRACVRTECGDCHFCRDMKKFGGPGRMKQSCLLRQCTAPVLPHTAVCLLCGEAGKEDTVEGEEEKFSLSLMECTICNEIVHPGCLKMGKAEGVINSEIPNCWECPRCTQEGRTSKDAGEGPGRRRADNGEEGANLGGGWKLTEEPPPPPPLPRRKGPLPAGPPPDDVPGPPKRKEREGGNEPPTPRKKVKGGRERHLKKVGGDACLLRGADPGSPGLLPPRVLNPSQAFSSCHPGLPPENWEKPKPPIASAEGPAVPSPSPQREKLERFKRMCQLLERVPDTSSSSSDSDSDSDSSGTSLSEDEAPGEARNGRRPARGSSGEKENRGGRRAIRPGSGGPLLSWPLGPAPPPRPPQLERHVVRPPPRSPEPDTLPLAAGSDHPLPRAAWLRVFQHLGPRELCVCMRVCRTWSRWCYDKRLWPRMDLSRRKSLTPPMLSGVVRRQPRALDLSWTGVSKKQLMWLLNRLQGLQELVLSGCSWLSVSALGSAPLPALRLLDLRWIEDVKDSQLRELLLPPPDTKPGQTESRGRLQGVAELRLAGLELTDASLRLLLRHAPQLSALDLSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHRLTDHCLPLFRRCPRLRRLDLRSCRQLSPEACARLAAAGPPGPFRCPEEKLLLKDS", "length": 674, "header": "tr|A0A0G2KB30-1|A0A0G2KB30_RAT Isoform 1 of F-box and leucine-rich repeat protein 19 OS=Rattus norvegicus OX=10116 GN=Fbxl19 PE=4 SV=1 CANONICAL=A0A0G2KB30-1" }, "isoforms": [ { "isoform_ac": "A0A0G2KB30-1", "url": "https://www.uniprot.org/uniprot/A0A0G2KB30#A0A0G2KB30-1", "sequence": { "sequence": "MSSSSRGPGAGARRRRTRCRRCRACVRTECGDCHFCRDMKKFGGPGRMKQSCLLRQCTAPVLPHTAVCLLCGEAGKEDTVEGEEEKFSLSLMECTICNEIVHPGCLKMGKAEGVINSEIPNCWECPRCTQEGRTSKDAGEGPGRRRADNGEEGANLGGGWKLTEEPPPPPPLPRRKGPLPAGPPPDDVPGPPKRKEREGGNEPPTPRKKVKGGRERHLKKVGGDACLLRGADPGSPGLLPPRVLNPSQAFSSCHPGLPPENWEKPKPPIASAEGPAVPSPSPQREKLERFKRMCQLLERVPDTSSSSSDSDSDSDSSGTSLSEDEAPGEARNGRRPARGSSGEKENRGGRRAIRPGSGGPLLSWPLGPAPPPRPPQLERHVVRPPPRSPEPDTLPLAAGSDHPLPRAAWLRVFQHLGPRELCVCMRVCRTWSRWCYDKRLWPRMDLSRRKSLTPPMLSGVVRRQPRALDLSWTGVSKKQLMWLLNRLQGLQELVLSGCSWLSVSALGSAPLPALRLLDLRWIEDVKDSQLRELLLPPPDTKPGQTESRGRLQGVAELRLAGLELTDASLRLLLRHAPQLSALDLSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHRLTDHCLPLFRRCPRLRRLDLRSCRQLSPEACARLAAAGPPGPFRCPEEKLLLKDS", "length": 674, "header": "tr|A0A0G2KB30-1|A0A0G2KB30_RAT Isoform 1 of F-box and leucine-rich repeat protein 19 OS=Rattus norvegicus OX=10116 GN=Fbxl19 PE=4 SV=1 CANONICAL=A0A0G2KB30-1" }, "locus": { "chromosome": "1", "start_pos": 182379290, "end_pos": 182360946, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000090428.2", "url": "https://www.ensembl.org/id/ENSRNOT00000090428.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000075629.1", "url": "https://www.ensembl.org/id/ENSRNOP00000075629.1" } ] } }, { "isoform_ac": "A0A8I6G990-1", "url": "https://www.uniprot.org/uniprot/A0A0G2KB30#A0A8I6G990-1", "sequence": { "sequence": "MSSSSRGPGAGARRRRTRCRRCRACVRTECGDCHFCRDMKKFGGPGRMKQSCLLRQCTAPVLPHTAVCLLCGEAGKEDTVEGEEEKFSLSLMECTICNEIVHPGCLKMGKAEGVINSEIPNCWECPRCTQEGRTSKVKGGRERHLKKKPKPPIASAEGPAVPSPSPQREKLERFKRMCQLLERVPDTSSSSSDSDSDSDSSGTSLSEDEAPGEARNGRRPARGSSGEKENRGGRRAIRPGSGGPLLSWPLGPAPPPRPPQLERHVVRPPPRSPEPDTLPLAAGSDHPLPRAAWLRVFQHLGPRELCVCMRVCRTWSRWCYDKRLWPRMDLSRRKSLTPPMLSGVVRRQPRALDLSWTGVSKKQLMWLLNRLQGLQELVLSGCSWLSVSALGSAPLPALRLLDLRWIEDVKDSQLRELLLPPPDTKPGQTESRGRLQGVAELRLAGLELTDASLRLLLRHAPQLSALDLSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHRLTDHCLPLFRRCPRLRRLDLRSCRQLSPEACARLAAAGPPGPFRCPEEKLLLKDS", "length": 558, "header": "tr|A0A8I6G990-1|A0A0G2KB30_RAT Computationally mapped isoform of F-box and leucine-rich repeat protein 19 OS=Rattus norvegicus OX=10116 GN=Fbxl19 PE=4 SV=1 CANONICAL=A0A0G2KB30-1" }, "locus": { "chromosome": "1", "start_pos": 182379290, "end_pos": 182360946, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000115334.1", "url": "https://www.ensembl.org/id/ENSRNOT00000115334.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000083596.1", "url": "https://www.ensembl.org/id/ENSRNOP00000083596.1" } ] } }, { "isoform_ac": "D4A2L9-1", "url": "https://www.uniprot.org/uniprot/A0A0G2KB30#D4A2L9-1", "sequence": { "sequence": "MSSSSRGPGAGARRRRTRCRRCRACVRTECGDCHFCRDMKKFGGPGRMKQSCLLRQCTAPVLPHTAVCLLCGEAGKEDTVEGEEEKFSLSLMECTICNEIVHPGCLKMGKAEGVINSEIPNCWECPRCTQEGRTSKVKGGRERHLKKKPKPPIASAEGPAVPSPSPQREKLERFKRMCQLLERVPDTSSSSSDSDSDSDSSGTSLSEDEAPGEARNGRRPARGSSGEKENRGGRRAIRPGSGGPLLSWPLGPAPPPRPPQLERHVVRPPPRSPEPDTLPLAAGSDHPLPRAAWLRVFQHLGPRELCVCMRVCRTWSRWCYDKRLWPRMDLSRRKSLTPPMLSGVVRRQPRALDLSWTGVSKKQLMWLLNRLQGQTESRGRLQGVAELRLAGLELTDASLRLLLRHAPQLSALDLSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHRLTDHCLPLFRRCPRLRRLDLRSCRQLSPEACARLAAAGPPGPFRCPEEKLLLKDS", "length": 504, "header": "tr|D4A2L9-1|A0A0G2KB30_RAT Computationally mapped isoform of F-box and leucine-rich repeat protein 19 OS=Rattus norvegicus OX=10116 GN=Fbxl19 PE=4 SV=1 CANONICAL=A0A0G2KB30-1" }, "locus": { "chromosome": "1", "start_pos": 182379290, "end_pos": 182360946, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000065187.2", "url": "https://www.ensembl.org/id/ENSRNOT00000065187.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000059635.1", "url": "https://www.ensembl.org/id/ENSRNOP00000059635.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system.", "journal": "The international journal of biochemistry & cell biology", "date": "2009", "authors": "Ebstein F, Lange N, Urban S, Seifert U, Kruger E, Kloetzel PM", "evidence": [ { "database": "RefSeq", "id": "NP_001101022", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101022" } ], "reference": [ { "type": "PubMed", "id": "19028597", "url": "https://glygen.org/publication/PubMed/19028597" } ] }, { "title": "F-box protein FBXL19-mediated ubiquitination and degradation of the receptor for IL-33 limits pulmonary inflammation.", "journal": "Nature immunology", "date": "2012", "authors": "Zhao J, Wei J, Mialki RK, Mallampalli DF, Chen BB, Coon T, Zou C, Mallampalli RK, Zhao Y", "evidence": [ { "database": "RefSeq", "id": "NP_001101022", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101022" } ], "reference": [ { "type": "PubMed", "id": "22660580", "url": "https://glygen.org/publication/PubMed/22660580" } ] } ], "pathway": [ { "id": "rno:308999", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:308999", "resource": "KEGG Pathway" }, { "id": "R-RNO-8951664", "name": "Neddylation", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8951664", "resource": "Reactome", "description": "Neddylation" }, { "id": "R-RNO-983168", "name": "Antigen processing: Ubiquitination & Proteasome degradation", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "Q6PB97-1", "protein_name": "F-box/LRR-repeat protein 19", "gene_name": "Fbxl19", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSSSRGPGAGARRRRTRCRRCRACVRTECGDCHFCRDMKKFGGPGRMKQSCLLRQCTAPVLPHTAVCLLCGEAGKEDTVEGEDEKFSLSLMECTICNEIVHPGCLKMGKAEGVINSEIPNCWECPRCTQEGRTSKDAGEGPGRRRADNGEEGANLGGGWKLTEEPPPPPPLPRRKGPLPAGPTPDDVPGPPKRKEREGGNEPPTPRKKVKGGRERHLKKVGGDACLLRGADPGSPGLLPPRVLNPSQAFSSCHPGLPPENWEKPKPPIASAEGPAVPSPSPQREKLERFKRMCQLLERVPDTSSSSSDSDSDSDSSGTSLSEDEAPGEARNGRRPARGSSGEKENRGGRRAIRPGTGGPLLSWPLGPAPPPRPPQLERHVVRPPPRSPEPDTLPLAAGSDHPLPRAAWLRVFQHLGPRELCVCMRVCRTWSRWCYDKRLWPRMDLSRRKSLTPPMLSGVVRRQPRALDLSWTGVSKKQLMWLLNRLQGLQELVLSGCSWLSVSALGSAPLPALRLLDLRWIEDVKDSQLRELLLPPPDTKPGQTESRGRLQGVAELRLAGLELTDASLRLLLRHAPQLSALDLSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHRLTDHCLPLFRRCPRLRRLDLRSCRQLSPEACARLAAAGPPGPFRCPEEKLLLKDS", "length": 674 }, "evidence": [ { "id": "41501883", "url": "http://www.informatics.jax.org/homology/41501883", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6PCT2-1", "protein_name": "F-box/LRR-repeat protein 19", "gene_name": "FBXL19", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGMKVPGKGESGPSALLTPPMSSSSRGPGAGARRRRTRCRRCRACVRTECGDCHFCRDMKKFGGPGRMKQSCLLRQCTAPVLPHTAVCLLCGEAGKEDTVEGEEEKFGLSLMECTICNEIVHPGCLKMGKAEGVINAEIPNCWECPRCTQEGRTSKDSGEGPGRRRADNGEEGASLGSGWKLTEEPPLPPPPPRRKGPLPAGPPPEDVPGPPKRKEREAGNEPPTPRKKVKGGRERHLKKVGGDACLLRGSDPGGPGLLPPRVLNPSQAFSSCHPGLPPENWEKPKPPLASAEGPAVPSPSPQREKLERFKRMCQLLERVPDTSSSSSDSDSDSDSSGTSLSEDEAPGEARNGRRPARGSSGEKENRGGRRAVRPGSGGPLLSWPLGPAPPPRPPQLERHVVRPPPRSPEPDTLPLAAGSDHPLPRAAWLRVFQHLGPRELCICMRVCRTWSRWCYDKRLWPRMDLSRRKSLTPPMLSGVVRRQPRALDLSWTGVSKKQLMWLLNRLQGLQELVLSGCSWLSVSALGSAPLPALRLLDLRWIEDVKDSQLRELLLPPPDTKPGQTESRGRLQGVAELRLAGLELTDASLRLLLRHAPQLSALDLSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHRLTDHCLPLFRRCPRLRRLDLRSCRQLSPEACARLAAAGPPGPFRCPEEKLLLKDS", "length": 694 }, "evidence": [ { "id": "41501883", "url": "http://www.informatics.jax.org/homology/41501883", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KB30", "url": "https://www.uniprot.org/uniprot/A0A0G2KB30" } ], "pmid": "21873635" }, { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KB30", "url": "https://www.uniprot.org/uniprot/A0A0G2KB30" } ], "pmid": "" }, { "name": "protein demethylation", "id": "GO:0006482", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006482", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KB30", "url": "https://www.uniprot.org/uniprot/A0A0G2KB30" } ], "pmid": "21873635" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KB30", "url": "https://www.uniprot.org/uniprot/A0A0G2KB30" } ], "pmid": "" }, { "name": "transcription coregulator activity", "id": "GO:0003712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003712", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KB30", "url": "https://www.uniprot.org/uniprot/A0A0G2KB30" } ], "pmid": "21873635" }, { "name": "histone demethylase activity", "id": "GO:0032452", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032452", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KB30", "url": "https://www.uniprot.org/uniprot/A0A0G2KB30" } ], "pmid": "21873635" }, { "name": "unmethylated CpG binding", "id": "GO:0045322", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045322", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KB30", "url": "https://www.uniprot.org/uniprot/A0A0G2KB30" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "SCF ubiquitin ligase complex", "id": "GO:0019005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019005", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KB30", "url": "https://www.uniprot.org/uniprot/A0A0G2KB30" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ] }