{ "uniprot_canonical_ac": "A0A0G2KAX0-1", "uniprot_ac": "A0A0G2KAX0", "uniprot_id": "A0A0G2KAX0_RAT", "mass": { "chemical_mass": 214001.0, "monoisotopic_mass": 214001.0 }, "refseq": { "ac": "XP_008768689", "name": "proteasome activator complex subunit 4 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008768689" }, "gene_names": [ { "name": "Psme4", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2KAX0", "id": "A0A0G2KAX0" }, { "name": "Psme4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008768689", "id": "XP_008768689" }, { "name": "rCG_23342", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0G2KAX0", "id": "A0A0G2KAX0" } ], "protein_names": [ { "name": "Proteasome activator subunit 4", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0G2KAX0#names_and_taxonomy", "id": "A0A0G2KAX0" }, { "name": "proteasome activator complex subunit 4 isoform X1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008768689", "id": "XP_008768689" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAX0", "url": "https://www.uniprot.org/uniprot/A0A0G2KAX0" } ], "common_name": "Rat" } ], "gene": [ { "name": "Psme4", "url": "https://www.uniprot.org/uniprot/A0A0G2KAX0", "locus": { "chromosome": "14", "start_pos": 115166416, "end_pos": 115269056, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000060340", "url": "https://www.ensembl.org/id/ENSRNOG00000060340" } ] } } ], "crossref": [ { "id": "ENSRNOG00000060340", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000060340", "database": "Bgee" }, { "id": "498433", "url": "https://www.ncbi.nlm.nih.gov/gene/498433", "database": "GeneID" }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro" }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro" }, { "id": "IPR021843", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021843", "database": "InterPro" }, { "id": "IPR032430", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032430", "database": "InterPro" }, { "id": "IPR035309", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035309", "database": "InterPro" }, { "id": "83617at2759", "url": "http://www.orthodb.org/?query=83617at2759", "database": "OrthoDB" }, { "id": "PTHR32170", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32170", "database": "PANTHER" }, { "id": "PF11919", "url": "http://pfam.xfam.org/family/PF11919", "database": "Pfam" }, { "id": "PF16507", "url": "http://pfam.xfam.org/family/PF16507", "database": "Pfam" }, { "id": "R-RNO-1169091", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1169091", "database": "Reactome" }, { "id": "R-RNO-1234176", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1234176", "database": "Reactome" }, { "id": "R-RNO-1236978", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1236978", "database": "Reactome" }, { "id": "R-RNO-174113", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-174113", "database": "Reactome" }, { "id": "R-RNO-174154", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-174154", "database": "Reactome" }, { "id": "R-RNO-174178", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-174178", "database": "Reactome" }, { "id": "R-RNO-174184", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-174184", "database": "Reactome" }, { "id": "R-RNO-195253", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-195253", "database": "Reactome" }, { "id": "R-RNO-2467813", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2467813", "database": "Reactome" }, { "id": "R-RNO-349425", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-349425", "database": "Reactome" }, { "id": "R-RNO-350562", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-350562", "database": "Reactome" }, { "id": "R-RNO-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-382556", "database": "Reactome" }, { "id": "R-RNO-450408", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-450408", "database": "Reactome" }, { "id": "R-RNO-4608870", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-4608870", "database": "Reactome" }, { "id": "R-RNO-4641257", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-4641257", "database": "Reactome" }, { "id": "R-RNO-4641258", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-4641258", "database": "Reactome" }, { "id": "R-RNO-5358346", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5358346", "database": "Reactome" }, { "id": "R-RNO-5607761", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5607761", "database": "Reactome" }, { "id": "R-RNO-5610780", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5610780", "database": "Reactome" }, { "id": "R-RNO-5610785", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5610785", "database": "Reactome" }, { "id": "R-RNO-5632684", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5632684", "database": "Reactome" }, { "id": "R-RNO-5658442", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5658442", "database": "Reactome" }, { "id": "R-RNO-5668541", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5668541", "database": "Reactome" }, { "id": "R-RNO-5676590", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5676590", "database": "Reactome" }, { "id": "R-RNO-5687128", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5687128", "database": "Reactome" }, { "id": "R-RNO-5689603", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5689603", "database": "Reactome" }, { "id": "R-RNO-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5689880", "database": "Reactome" }, { "id": "R-RNO-68949", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-68949", "database": "Reactome" }, { "id": "R-RNO-69017", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-69017", "database": "Reactome" }, { "id": "R-RNO-69481", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-69481", "database": "Reactome" }, { "id": "R-RNO-69601", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-69601", "database": "Reactome" }, { "id": "R-RNO-75815", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-75815", "database": "Reactome" }, { "id": "R-RNO-8852276", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8852276", "database": "Reactome" }, { "id": "R-RNO-8854050", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8854050", "database": "Reactome" }, { "id": "R-RNO-8939236", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8939236", "database": "Reactome" }, { "id": "R-RNO-8948751", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8948751", "database": "Reactome" }, { "id": "R-RNO-8951664", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8951664", "database": "Reactome" }, { "id": "R-RNO-9755511", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9755511", "database": "Reactome" }, { "id": "R-RNO-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983168", "database": "Reactome" }, { "id": "XP_008768689", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008768689", "database": "RefSeq" }, { "id": "1591971", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1591971", "database": "RGD" }, { "id": "A0A0G2K9R9", "url": "https://www.uniprot.org/uniprot/A0A0G2K9R9", "database": "UniProtKB" }, { "id": "A0A0G2K9R9-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K9R9-1", "database": "UniProtKB" }, { "id": "A0A0G2KAX0", "url": "https://www.uniprot.org/uniprot/A0A0G2KAX0", "database": "UniProtKB" }, { "id": "A0A0G2KAX0-1", "url": "https://www.uniprot.org/uniprot/A0A0G2KAX0-1", "database": "UniProtKB" }, { "id": "A0A8I5YBQ1", "url": "https://www.uniprot.org/uniprot/A0A8I5YBQ1", "database": "UniProtKB" }, { "id": "A0A8I5YBQ1-1", "url": "https://www.uniprot.org/uniprot/A0A8I5YBQ1-1", "database": "UniProtKB" }, { "id": "A0A8I5ZMB9", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMB9", "database": "UniProtKB" }, { "id": "A0A8I5ZMB9-1", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMB9-1", "database": "UniProtKB" }, { "id": "A0A8I6AIN2", "url": "https://www.uniprot.org/uniprot/A0A8I6AIN2", "database": "UniProtKB" }, { "id": "A0A8I6AIN2-1", "url": "https://www.uniprot.org/uniprot/A0A8I6AIN2-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MEAPERAGGGEPPEPGGRPVLGPRAFVPQKEIVYNKLLPYAERLDAESDLQLAQIKSNLGRAVQLQELWPGGLFWTRKLSTYIRLYGRKFSKEDHVLFIKLLYELVSIPKLEISMMQGFARLLINLLKKKELLSRDDLELPWRPLYDMVERILYSKTEHLRLNSFPKNIVPFILRDYKNHKRSLYRYHSSIENVLKTLVKSCRPYFPADATAEMLEEWRPLMCPFDVTMQKAVSYFEIFLPTSLPPELHHKGFKLWFDELIGLWVSVQNLPQWEGQLVNLFARLATDNIGYIDWDPYVPKIFTRILRSLNLPVGSSQVLVPRFLTNAYDIGHAVIWITAMMGGPSKLVQKHLAGLFNSITSFYHPSNNGRWLNKLMKLLQRLPNSVVRRLHRERFKKPSWLTPVPESHKLTDEDVTDFVQCIIQPVLLAMFSKTGSLEAAQALQNLALMRPELVIPPVLERTYPALETLTEPHQLTATLNCVIGVARSLVSGSKWFPEGPTHMLPLLMRALPGVDPNDFSKCMITFQFIGTFSTLVPLVDCSSVLQERNDLTEIEKELCSATAEFEDFVLQFMDRCFGLIESSTLEQTREETETEKMTHLESLVELGLSSTFSTILTQCSKDIFMVALQKVFNFSVSHIFETRVAGRMVADMCRAAVKCCPEESLKLFVPHCYGVITQLTMNDDVLNEEELDKELLWNLQLLSEITRVDGKKLLLYREQLVKILQRTLHLTCKQGYTLSCNLLHHLLRSTTLIYPTEYCSVPGGFNKPPSEYFPIKDWGKPGDLWNLGIQWHVPSSEEVSFAFYLLQSFLQPELIKLQRCGDGELEMSRDDILQSLTIVHNCLIGSGNLLPPLKGEPVTNLVPSMVSLEETKLYTGLEHDLSKENHREVIASVIRKLLSHILDNSEDDTKSLFLIIKIIGDLLQFQGSHKHEFDSRWKSFNLVKKSMENRLHGKKQHIRALLIDRVMLQHELRTLTVEGCEYKKIHQDMIRDLLRLSTSSYSQVRNKAQQTFFAALGAYNFCCRDIIPLVLEFLRPDRKDVTQQQFKGALYCLLGNHSGVCLANLHDWDCIVQTWPALVSSGLSQAMSLEKPSIVRLFDDLAEKIHRQYETIGLDFTIPKSCAAIAELLQQSKNPSISQTLLSPEKIKEGQKRQQDKNADAVRNYECLVNTLLDGVEQRNLPWKFEHIGIGLLSLLLRDDRVLPLRAIRFFVENLNHDAIVVRKMAISAVAGILKQLKRTHKKLTINPYEISGCPKPATVLAGDRPDNHWLHYDSKNIPRTKKEWESSCFVEKTHWGYYNWPKNMVVYAGVEEQPKLGRSREDMTEAEQIIYDRFSDPKFVEQLITFLSLEDRKGRDKFSPRRFCLFKGIFRNFDDAFLPVLKPHLERLVADSHESTQRCVAEIIAGLIRGSKHWTFEKVEKLWELLCPLLRTALSNMTVETYNDWGTCIATSCESRDPRKLHWLFELLLESPLSGEGGSFVDACRLYVLQGGLAQQEWRVPELLHRLLKYLEPKLTQVYKNVRERIGSVLTYIFMIDVSLPNTAPTTSPCIPEFTARVLEKLKPLTDVDEEIQNHVMEENGIGEEDERTQGIKLLKTILKWLMASAGRSFSTAVKEQLQLLPLFFKIAPVENDNSYDELKRDAKLCLSLMSQGLLYPQQVPLILQVLSQTARSSSWHARYTVLTYLQTMVFYNLFIFLNNEDAVKDIRWLIIRLLEDEQLEVREMAATTLSGLLQCNFLTMDSAMQSHFEQLCKTKLPKKRKRDPGSVGDTIPSAELVKRHAGVLGLGACVLSSPYDVPTWMPQLLMNLSAHLNDPQPIEMTVKKTLSNFRRTHHDNWQEHKQQFTDDQLLVLTDLLVSPCYYA", "length": 1865, "header": "tr|A0A0G2KAX0-1|A0A0G2KAX0_RAT Isoform 1 of Proteasome activator subunit 4 OS=Rattus norvegicus OX=10116 GN=Psme4 PE=1 SV=2 CANONICAL=A0A0G2KAX0-1" }, "isoforms": [ { "isoform_ac": "A0A0G2K9R9-1", "url": "https://www.uniprot.org/uniprot/A0A0G2KAX0#A0A0G2K9R9-1", "sequence": { "sequence": "MEAPERAGGGEPPEPGGRPVLGPRAFVPQKEIVYNKLLPYAERLDAESDLQLAQIKSNLGRAVQLQELWPGGLFWTRKLSTYIRLYGRKFSKEDHVLFIKLLYELVSIPKLEISMMQGFARLLINLLKKKELLSRDDLELPWRPLYDMVERILYSKTEHLRLNSFPNSIENVLKTLVKSCRPYFPADATAEMLEEWRPLMCPFDVTMQKAVSYFEIFLPTSLPPELHHKGFKLWFDELIGLWVSVQNLPQWEGQLVNLFARLATDNIGYIDWDPYVPKIFTRILRSLNLPVGSSQVLVPRFLTNAYDIGHAVIWITAMMGGPSKLVQKHLAGLFNSITSFYHPSNNGRWLNKLMKLLQRLPNSVVRRLHRERFKKPSWLTPVPESHKLTDEDVTDFVQCIIQPVLLAMFSKTGSLEAAQALQNLALMRPELVIPPVLERTYPALETLTEPHQLTATLNCVIGVARSLVSGSKWFPEGPTHMLPLLMRALPGVDPNDFSKCMITFQFIGTFSTLVPLVDCSSVLQERNDLTEIEKELCSATAEFEDFVLQFMDRCFGLIESSTLEQTREETETEKMTHLESLVELGLSSTFSTILTQCSKDIFMVALQKVFNFSVSHIFETRVAGRMVADMCRAAVKCCPEESLKLFVPHCYGVITQLTMNDDVLNEEELDKELLWNLQLLSEITRVDGKKLLLYREQLVKILQRTLHLTCKQGYTLSCNLLHHLLRSTTLIYPTEYCSVPGGFNKPPSEYFPIKDWGKPGDLWNLGIQWHVPSSEEVSFAFYLLQSFLQPELIKLQRCGDGELEMSRDDILQSLTIVHNCLIGSGNLLPPLKGEPVTNLVPSMVSLEETKLYTGLEHDLSKENHREVIASVIRKLLSHILDNSEDDTKSLFLIIKIIGDLLQFQGSHKHEFDSRWKSFNLVKKSMENRLHGKKQHIRALLIDRVMLQHELRTLTVEGCEYKKIHQDMIRDLLRLSTSSYSQVRNKAQQTFFAALGAYNFCCRDIIPLVLEFLRPDRKDVTQQQFKGALYCLLGNHSGVCLANLHDWDCIVQTWPALVSSGLSQAMSLEKPSIVRLFDDLAEKIHRQYETIGLDFTIPKSCAAIAELLQQSKNPSISQTLLSPEKIKEGQKRQQDKNADAVRNYECLVNTLLDGVEQRNLPWKFEHIGIGLLSLLLRDDRVLPLRAIRFFVENLNHDAIVVRKMAISAVAGILKQLKRTHKKLTINPYEISGCPKPATVLAGDRPDNHWLHYDSKNIPRTKKEWESSCFVEKTHWGYYNWPKNMVVYAGVEEQPKLGRSREDMTEAEQIIYDRFSDPKFVEQLITFLSLEDRKGRDKFSPRRFCLFKGIFRNFDDAFLPVLKPHLERLVADSHESTQRCVAEIIAGLIRGSKHWTFEKVEKLWELLCPLLRTALSNMTVETYNDWGTCIATSCESRDPRKLHWLFELLLESPLSGEGGSFVDACRLYVLQGGLAQQEWRVPELLHRLLKYLEPKLTQVYKNVRERIGSVLTYIFMIDVSLPNTAPTTSPCIPEFTARVLEKLKPLTDVDEEIQNHVMEENGIGEEDERTQGIKLLKTILKWLMASAGRSFSTAVKEQLQLLPLFFKIAPVENDNSYDELKRDAKLCLSLMSQGLLYPQQVPLILQVLSQTARSSSWHARYTVLTYLQTMVFYNLFIFLNNEDAVKDIRWLIIRLLEDEQLEVREMAATTLSGLLQCNFLTMDSAMQSHFEQLCKTKLPKKRKRDPGSVGDTIPSAELVKRHAGVLGLGACVLSSPYDVPTWMPQLLMNLSAHLNDPQPIEMTVKKTLSNFRRTHHDNWQEHKQQFTDDQLLVLTDLLVSPCYYA", "length": 1843, "header": "tr|A0A0G2K9R9-1|A0A0G2KAX0_RAT Computationally mapped isoform of Proteasome activator subunit 4 OS=Rattus norvegicus OX=10116 GN=Psme4 PE=1 SV=2 CANONICAL=A0A0G2KAX0-1" }, "locus": { "chromosome": "14", "start_pos": 104606617, "end_pos": 104505972, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000078329.2", "url": "https://www.ensembl.org/id/ENSRNOT00000078329.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000075103.2", "url": "https://www.ensembl.org/id/ENSRNOP00000075103.2" } ] } }, { "isoform_ac": "A0A0G2KAX0-1", "url": "https://www.uniprot.org/uniprot/A0A0G2KAX0#A0A0G2KAX0-1", "sequence": { "sequence": "MEAPERAGGGEPPEPGGRPVLGPRAFVPQKEIVYNKLLPYAERLDAESDLQLAQIKSNLGRAVQLQELWPGGLFWTRKLSTYIRLYGRKFSKEDHVLFIKLLYELVSIPKLEISMMQGFARLLINLLKKKELLSRDDLELPWRPLYDMVERILYSKTEHLRLNSFPKNIVPFILRDYKNHKRSLYRYHSSIENVLKTLVKSCRPYFPADATAEMLEEWRPLMCPFDVTMQKAVSYFEIFLPTSLPPELHHKGFKLWFDELIGLWVSVQNLPQWEGQLVNLFARLATDNIGYIDWDPYVPKIFTRILRSLNLPVGSSQVLVPRFLTNAYDIGHAVIWITAMMGGPSKLVQKHLAGLFNSITSFYHPSNNGRWLNKLMKLLQRLPNSVVRRLHRERFKKPSWLTPVPESHKLTDEDVTDFVQCIIQPVLLAMFSKTGSLEAAQALQNLALMRPELVIPPVLERTYPALETLTEPHQLTATLNCVIGVARSLVSGSKWFPEGPTHMLPLLMRALPGVDPNDFSKCMITFQFIGTFSTLVPLVDCSSVLQERNDLTEIEKELCSATAEFEDFVLQFMDRCFGLIESSTLEQTREETETEKMTHLESLVELGLSSTFSTILTQCSKDIFMVALQKVFNFSVSHIFETRVAGRMVADMCRAAVKCCPEESLKLFVPHCYGVITQLTMNDDVLNEEELDKELLWNLQLLSEITRVDGKKLLLYREQLVKILQRTLHLTCKQGYTLSCNLLHHLLRSTTLIYPTEYCSVPGGFNKPPSEYFPIKDWGKPGDLWNLGIQWHVPSSEEVSFAFYLLQSFLQPELIKLQRCGDGELEMSRDDILQSLTIVHNCLIGSGNLLPPLKGEPVTNLVPSMVSLEETKLYTGLEHDLSKENHREVIASVIRKLLSHILDNSEDDTKSLFLIIKIIGDLLQFQGSHKHEFDSRWKSFNLVKKSMENRLHGKKQHIRALLIDRVMLQHELRTLTVEGCEYKKIHQDMIRDLLRLSTSSYSQVRNKAQQTFFAALGAYNFCCRDIIPLVLEFLRPDRKDVTQQQFKGALYCLLGNHSGVCLANLHDWDCIVQTWPALVSSGLSQAMSLEKPSIVRLFDDLAEKIHRQYETIGLDFTIPKSCAAIAELLQQSKNPSISQTLLSPEKIKEGQKRQQDKNADAVRNYECLVNTLLDGVEQRNLPWKFEHIGIGLLSLLLRDDRVLPLRAIRFFVENLNHDAIVVRKMAISAVAGILKQLKRTHKKLTINPYEISGCPKPATVLAGDRPDNHWLHYDSKNIPRTKKEWESSCFVEKTHWGYYNWPKNMVVYAGVEEQPKLGRSREDMTEAEQIIYDRFSDPKFVEQLITFLSLEDRKGRDKFSPRRFCLFKGIFRNFDDAFLPVLKPHLERLVADSHESTQRCVAEIIAGLIRGSKHWTFEKVEKLWELLCPLLRTALSNMTVETYNDWGTCIATSCESRDPRKLHWLFELLLESPLSGEGGSFVDACRLYVLQGGLAQQEWRVPELLHRLLKYLEPKLTQVYKNVRERIGSVLTYIFMIDVSLPNTAPTTSPCIPEFTARVLEKLKPLTDVDEEIQNHVMEENGIGEEDERTQGIKLLKTILKWLMASAGRSFSTAVKEQLQLLPLFFKIAPVENDNSYDELKRDAKLCLSLMSQGLLYPQQVPLILQVLSQTARSSSWHARYTVLTYLQTMVFYNLFIFLNNEDAVKDIRWLIIRLLEDEQLEVREMAATTLSGLLQCNFLTMDSAMQSHFEQLCKTKLPKKRKRDPGSVGDTIPSAELVKRHAGVLGLGACVLSSPYDVPTWMPQLLMNLSAHLNDPQPIEMTVKKTLSNFRRTHHDNWQEHKQQFTDDQLLVLTDLLVSPCYYA", "length": 1865, "header": "tr|A0A0G2KAX0-1|A0A0G2KAX0_RAT Isoform 1 of Proteasome activator subunit 4 OS=Rattus norvegicus OX=10116 GN=Psme4 PE=1 SV=2 CANONICAL=A0A0G2KAX0-1" }, "locus": { "chromosome": "14", "start_pos": 104606617, "end_pos": 104505972, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000088916.2", "url": "https://www.ensembl.org/id/ENSRNOT00000088916.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000075558.2", "url": "https://www.ensembl.org/id/ENSRNOP00000075558.2" } ] } }, { "isoform_ac": "A0A8I5YBQ1-1", "url": "https://www.uniprot.org/uniprot/A0A0G2KAX0#A0A8I5YBQ1-1", "sequence": { "sequence": "MEAPERAGGGEPPEPGGRPVLGPRAFVPQKEIVYNKLLPYAERLDAESDLQLAQIKSNLGRAVQLQELWPGGLFWTRKLSTYIRLYGRKFSKEDHVLFIKLLYELVSIPKLEISMMQGFARLLINLLKKKELLSRDDLELPWRPLYDMVERILYSKTEHLRLNSFPKNIVPFILRDYKNHKRSLYRYHSSIENVLKTLVKSCRPYFPADATAEMLEEWRPLMCPFDVTMQKAVSYFEIFLPTSLPPELHHKGFKLWFDELIGLWVSVQNLPQWEGVSILSPHFFNFIFGVKYIFTRILRSLNLPVGSSQVLVPRFLTNAYDIGHAVIWITAMMGGPSKLVQKHLAGLFNSITSFYHPSNNGRWLNKLMKLLQRLPNSVVRRLHRERFKKPSWLTPVPESHKLTDEDVTDFVQCIIQPVLLAMFSKTGSLEAAQALQNLALMRPELVIPPVLERTYPALETLTEPHQLTATLNCVIGVARSLVSGSKWFPEGPTHMLPLLMRALPGVDPNDFSKCMITFQFIGTFSTLVPLVDCSSVLQERNDLTEIEKELCSATAEFEDFVALQKVFNFSVSHIFETRVAGRMVADMCRAAVKCCPEESLKLFVPHCYGVITQLTMNDDVLNEEELDKELLWNLQLLSEITRVDGKKLLLYREQLVKILQRTLHLTCKQGYTLSCNLLHHLLRSTTLIYPTEYCSVPGGFNKPPSEYFPIKDWGKPGDLWNLGIQWHVPSSEEVSFAFYLLQSFLQPELIKLQRCGDGELEMSRDDILQSLTIVHNCLIGHILDNSEDDTKSLFLIIKIIGDLLQFQGSHKHEFDSRWKSFNLVKKSMENRLHGKKQHIRALLIDRVMLQHELRTLTVEGCEYKKIHQDMIRDLLRLSTSSYSQVRNKAQQTFFAALGAYNFCCRDIIPLVLEFLRPDRKDVTQQQFKGALYCLLGNHSGVCLANLHDWDCIVQTWPALVSSGLSQAMSLEKPSIVRLFDDLAEKIHRQYETIGLDFTIPKSCAAIAELLQQSKNPSISQTLLSPEKIKEGQKRQQDKNADAVRNYECLVNTLLDGVEQRNLPWKFEHIGIGLLSLLLRDDRVLPLRAIRFFVENLNHDAIVVRKMAISAVAGILKQLKRTHKKLTINPYEISGCPKPATVLAGDRPDNHWLHYDSKNIPRTKKEWESSCFVEKTHWGYYNWPKNMVVYAGVEEQPKLGRSREDMTEAEQIIYDRFSDPKFVEQLITFLSLEDRKGRDKFSPRRFCLFKGIFRNFDDAFLPVLKPHLERLVADSHESTQRCVAEIIAGLIRGSKHWTFEKVEKLWELLCPLLRTALSNMTVETYNDWGTCIATSCESRDPRKLHWLFELLLESPLSGEGGSFVDACRLYVLQGGLAQQEWRVPELLHRLLKYLEPKLTQVYKNVRERIGSVLTYIFMIDVSLPNTAPTTSPCIPEFTARVLEKLKPLTDVDEEIQNHVMEENGIGEEDERTQGIKLLKTILKWLMASAGRSFSTAVKEQLQLLPLFFKIAPVENDNSYDELKRDAKLCLSLMSQGLLYPQQVPLILQVLSQTARSSSWHARYTVLTYLQTMVFYNLFIFLNNEDAVKDIRWLIIRLLEDEQLEVREMAATTLSGLLQCNFLTMDSAMQSHFEQLCKTKLPKKRKRDPGSVGDTIPSAELVKRHAGVLGLGACVLSSPYDVPTWMPQLLMNLSAHLNDPQPIEMTVKKTLSNFRRTHHDNWQEHKQQFTDDQLLVLTDLLVSPCYYA", "length": 1746, "header": "tr|A0A8I5YBQ1-1|A0A8I5YBQ1_RAT Computationally mapped isoform of Proteasome activator subunit 4 OS=Rattus norvegicus OX=10116 GN=Psme4 PE=1 SV=1 CANONICAL=A0A0G2KAX0-1" }, "locus": { "chromosome": "14", "start_pos": 104606617, "end_pos": 104505972, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000115695.1", "url": "https://www.ensembl.org/id/ENSRNOT00000115695.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000076541.1", "url": "https://www.ensembl.org/id/ENSRNOP00000076541.1" } ] } }, { "isoform_ac": "A0A8I5ZMB9-1", "url": "https://www.uniprot.org/uniprot/A0A0G2KAX0#A0A8I5ZMB9-1", "sequence": { "sequence": "MEAPERAGGGEPPEPGGRPVLGPRAFVPQKEIVYNKLLPYAERLDAESDLQLAQIKSNLGRAVQLQELWPGGLFWTRKLSTYIRLYGRKFSKEDHVLFIKLLYELVSIPKLEISMMQGFARLLINLLKKKELLSRDDLELPWRPLYDMVERILYSKTEHLRLNSFPKVFNSVVRYMETFSFFTRYFPADATAEMLEEWRPLMCPFDVTMQKAVSYFEIFLPTSLPPELHHKGFKLWFDELIGLWVSVQNLPQWEGVSILSPHFFNFIFGVKYIFTRILRSLNLPVGSSQVLVPRFLTNAYDIGHAVIWITAMMGGPSKLVQKHLAGLFNSITSFYHPSNNGRWLNKLMKLLQRLPNSVVRRLHRERFKKPSWLTPVPESHKLTDEDVTDFVQCIIQPVLLAMFSKTGSLEAAQALQNLALMRPELVIPPVLERTYPALETLTEPHQLTATLNCVIGVARSLVSGSKWFPEGPTHMLPLLMRALPGVDPNDFSKCMITFQFIGTFSTLVPLVDCSSVLQERNDLTEIEKELCSATAEFEDFVALQKVFNFSVSHIFETRVAGRMVADMCRAAVKCCPEESLKLFVPHCYGVITQLTMNDDVLNEEELDKELLWNLQLLSEITRVDGKKLLLYREQLVKILQRTLHLTCKQGYTLSCNLLHHLLRSTTLIYPTEYCSVPGGFNKPPSEYFPIKDWGKPGDLWNLGIQWHVPSSEEVSFAFYLLQSFLQPELIKLQRCGDGELEMSRDDILQSLTIVHNCLIGHILDNSEDDTKSLFLIIKIIGDLLQFQGSHKHEFDSRWKSFNLVKKSMENRLHGKKQHIRALLIDRVMLQHELRTLTVEGCEYKKIHQDMIRDLLRLSTSSYSQVRNKAQQTFFAALGAYNFCCRDIIPLVLEFLRPDRKDVTQQQFKGALYCLLGNHSGVCLANLHDWDCIVQTWPALVSSGLSQAMSLEKPSIVRLFDDLAEKIHRQYETIGLDFTIPKSCAAIAELLQQSKNPSISQTLLSPEKIKEGQKRQQDKNADAVRNYECLVNTLLDGVEQRNLPWKFEHIGIGLLSLLLRDDRVLPLRAIRFFVENLNHDAIVVRKMAISAVAGILKQLKRTHKKLTINPYEISGCPKPATVLAGDRPDNHWLHYDSKNIPRTKKEWESSCFVEKTHWGYYNWPKNMVVYAGVEEQPKLGRSREDMTEAEQIIYDRFSDPKFVEQLITFLSLEDRKGRDKFSPRRFCLFKGIFRNFDDAFLPVLKPHLERLVADSHESTQRCVAEIIAGLIRGSKHWTFEKVEKLWELLCPLLRTALSNMTVETYNDWGTCIATSCESRDPRKLHWLFELLLESPLSGEGGSFVDACRLYVLQGGLAQQEWRVPELLHRLLKYLEPKLTQVYKNVRERIGSVLTYIFMIDVSLPNTAPTTSPCIPEFTARVLEKLKPLTDVDEEIQNHVMEENGIGEEDERTQGIKLLKTILKWLMASAGRSFSTAVKEQLQLLPLFFKIAPVENDNSYDELKRDAKLCLSLMSQGLLYPQQVPLILQVLSQTARSSSWHARYTVLTYLQTMVFYNLFIFLNNEDAVKDIRWLIIRLLEDEQLEVREMAATTLSGLLQCNFLTMDSAMQSHFEQLCKTKLPKKRKRDPGSVGDTIPSAELVKRHAGVLGLGACVLSSPYDVPTWMPQLLMNLSAHLNDPQPIEMTVKKTLSNFRRTHHDNWQEHKQQFTDDQLLVLTDLLVSPCYYA", "length": 1726, "header": "tr|A0A8I5ZMB9-1|A0A0G2KAX0_RAT Computationally mapped isoform of Proteasome activator subunit 4 OS=Rattus norvegicus OX=10116 GN=Psme4 PE=1 SV=1 CANONICAL=A0A0G2KAX0-1" }, "locus": { "chromosome": "14", "start_pos": 104606617, "end_pos": 104505972, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000112883.1", "url": "https://www.ensembl.org/id/ENSRNOT00000112883.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000078904.1", "url": "https://www.ensembl.org/id/ENSRNOP00000078904.1" } ] } }, { "isoform_ac": "A0A8I6AIN2-1", "url": "https://www.uniprot.org/uniprot/A0A0G2KAX0#A0A8I6AIN2-1", "sequence": { "sequence": "MEAPERAGGGEPPEPGGRPVLGPRAFVPQKEIVYNKLLPYAERLDAESDLQLAQIKSNLGRAVQLQELWPGGLFWTRKLSTYIRLYGRKFSKEDHVLFIKLLYELVSIPKLEISMMQGFARLLINLLKKKELLSRDDLELPWRPLYDMVERILYSKTEHLRLNSFPNSIENVLKTLVKSCRPYFPADATAEMLEEWRPLMCPFDVTMQKAVSYFEIFLPTSLPPELHHKGFKLWFDELIGLWVSVQNLPQWEGQLVNLFARLATDNIGYIDWDPYVPKGGPSKLVQKHLAGLFNSITSFYHPSNNGRWLNKLMKLLQRLPNSVVRRLHRERFKKPSWLTPVPESHKLTDEDVTDFVQCIIQPVLLAMFSKTGSLEAAQALQNLALMRPELVIPPVLERTYPALETLTEPHQLTATLNCVIGVARSLVSGSKWFPEGPTHMLPLLMRALPGVDPNDFSKCMITFQFIGTFSTLVPLVDCSSVLQERNDLTEIEKELCSATAEFEDFVLQFMDRCFGLIESSTLEQTREETETEKMTHLESLVELGLSSTFSTILTQCSKDIFMVALQKVFNFSVSHIFETRVAGRMVADMCRAAVKCCPEESLKLFVPHCYGVITQLTMNDDVLNEEELDKELLWNLQLLSEITRVDGKKLLLYREQLVKILQRTLHLTCKQGYTLSCNLLHHLLRSTTLIYPTEYCSVPGGFNKPPSEYFPIKDWGKPGDLWNLGIQWHVPSSEEVSFAFYLLQSFLQPELIKLQRCGDGELEMSRDDILQSLTIVHNCLIGSGNLLPPLKGEPVTNLVPSMVSLEETKLYTGLEHDLSKENHREVIASVIRKLLSHILDNSEDDTKSLFLIIKIIGDLLQFQGSHKHEFDSRWKSFNLVKKSMENRLHGKKQHIRALLIDRVMLQHELRTLTVEGCEYKKIHQDMIRDLLRLSTSSYSQVRNKAQQTFFAALGAYNFCCRDIIPLVLEFLRPDRKDVTQQQFKGALYCLLGNHSGVCLANLHDWDCIVQTWPALVSSGLSQAMSLEKPSIVRLFDDLAEKIHRQYETIGLDFTIPKSCAAIAELLQQSKNPSISQTLLSPEKIKEGQKRQQDKNADAVRNYECLVNTLLDGVEQRNLPWKFEHIGIGLLSLLLRDDRVLPLRAIRFFVENLNHDAIVVRKMAISAVAGILKQLKRTHKKLTINPYEISGCPKPATVLAGDRPDNHWLHYDSKNIPRTKKEWESSCFVEKTHWGYYNWPKNMVVYAGVEEQPKLGRSREDMTEAEQIIYDRFSDPKFVEQLITFLSLEDRKGRDKFSPRRFCLFKGIFRNFDDAFLPVLKPHLERLVADSHESTQRCVAEIIAGLIRGSKHWTFEKVEKLWELLCPLLRTALSNMTVETYNDWGTCIATSCESRDPRKLHWLFELLLESPLSGEGGSFVDACRLYVLQGGLAQQEWRVPELLHRLLKYLEPKLTQVYKNVRERIGSVLTYIFMIDVSLPNTAPTTSPCIPEFTARVLEKLKPLTDVDEEIQNHVMEENGIGEEDERTQGIKLLKTILKWLMASAGRSFSTAVKEQLQLLPLFFKIAPVENDNSYDELKRDAKLCLSLMSQGLLYPQQVPLILQVLSQTARSSSWHARYTVLTYLQTMVFYNLFIFLNNEDAVKDIRWLIIRLLEDEQLEVREMAATTLSGLLQCNFLTMDSAMQSHFEQLCKTKLPKKRKRDPGSVGDTIPSAELVKRHAGVLGLGACVLSSPYDVPTWMPQLLMNLSAHLNDPQPIEMTVKKTLSNFRRTHHDNWQEHKQQFTDDQLLVLTDLLVSPCYYA", "length": 1802, "header": "tr|A0A8I6AIN2-1|A0A0G2KAX0_RAT Computationally mapped isoform of Proteasome activator subunit 4 OS=Rattus norvegicus OX=10116 GN=Psme4 PE=1 SV=1 CANONICAL=A0A0G2KAX0-1" }, "locus": { "chromosome": "14", "start_pos": 104606617, "end_pos": 104505972, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000110521.1", "url": "https://www.ensembl.org/id/ENSRNOT00000110521.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000092804.1", "url": "https://www.ensembl.org/id/ENSRNOP00000092804.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nat. Commun.", "date": "2012", "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K9R9", "url": "https://www.uniprot.org/uniprot/A0A0G2K9R9" }, { "database": "UniProtKB", "id": "A0A0G2KAX0", "url": "https://www.uniprot.org/uniprot/A0A0G2KAX0" } ], "reference": [ { "type": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" } ] } ], "pathway": [ { "id": "R-RNO-1169091", "name": "Activation of NF-kappaB in B cells", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1169091", "resource": "Reactome", "description": "Activation of NF-kappaB in B cells" }, { "id": "R-RNO-1234176", "name": "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1234176", "resource": "Reactome", "description": "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha" }, { "id": "R-RNO-1236978", "name": "Cross-presentation of soluble exogenous antigens (endosomes)", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1236978", "resource": "Reactome", "description": "Cross-presentation of soluble exogenous antigens (endosomes)" }, { "id": "R-RNO-174113", "name": "SCF-beta-TrCP mediated degradation of Emi1", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-174113", "resource": "Reactome", "description": "SCF-beta-TrCP mediated degradation of Emi1" }, { "id": "R-RNO-174154", "name": "APC/C:Cdc20 mediated degradation of Securin", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-174154", "resource": "Reactome", "description": "APC/C:Cdc20 mediated degradation of Securin" }, { "id": "R-RNO-174178", "name": "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-174178", "resource": "Reactome", "description": "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1" }, { "id": "R-RNO-174184", "name": "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-174184", "resource": "Reactome", "description": "Cdc20:Phospho-APC/C mediated degradation of Cyclin A" }, { "id": "R-RNO-195253", "name": "Degradation of beta-catenin by the destruction complex", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-195253", "resource": "Reactome", "description": "Degradation of beta-catenin by the destruction complex" }, { "id": "R-RNO-2467813", "name": "Separation of Sister Chromatids", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2467813", "resource": "Reactome", "description": "Separation of Sister Chromatids" }, { "id": "R-RNO-349425", "name": "Autodegradation of the E3 ubiquitin ligase COP1", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-349425", "resource": "Reactome", "description": "Autodegradation of the E3 ubiquitin ligase COP1" }, { "id": "R-RNO-350562", "name": "Regulation of ornithine decarboxylase (ODC)", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-350562", "resource": "Reactome", "description": "Regulation of ornithine decarboxylase (ODC)" }, { "id": "R-RNO-382556", "name": "ABC-family proteins mediated transport", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-382556", "resource": "Reactome", "description": "ABC-family proteins mediated transport" }, { "id": "R-RNO-450408", "name": "AUF1 (hnRNP D0) binds and destabilizes mRNA", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-450408", "resource": "Reactome", "description": "AUF1 (hnRNP D0) binds and destabilizes mRNA" }, { "id": "R-RNO-4608870", "name": "Asymmetric localization of PCP proteins", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-4608870", "resource": "Reactome", "description": "Asymmetric localization of PCP proteins" }, { "id": "R-RNO-4641257", "name": "Degradation of AXIN", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-4641257", "resource": "Reactome", "description": "Degradation of AXIN" }, { "id": "R-RNO-4641258", "name": "Degradation of DVL", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-4641258", "resource": "Reactome", "description": "Degradation of DVL" }, { "id": "R-RNO-5358346", "name": "Hedgehog ligand biogenesis", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5358346", "resource": "Reactome", "description": "Hedgehog ligand biogenesis" }, { "id": "R-RNO-5607761", "name": "Dectin-1 mediated noncanonical NF-kB signaling", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5607761", "resource": "Reactome", "description": "Dectin-1 mediated noncanonical NF-kB signaling" }, { "id": "R-RNO-5610780", "name": "Degradation of GLI1 by the proteasome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5610780", "resource": "Reactome", "description": "Degradation of GLI1 by the proteasome" }, { "id": "R-RNO-5610785", "name": "GLI3 is processed to GLI3R by the proteasome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5610785", "resource": "Reactome", "description": "GLI3 is processed to GLI3R by the proteasome" }, { "id": "R-RNO-5632684", "name": "Hedgehog 'on' state", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5632684", "resource": "Reactome", "description": "Hedgehog 'on' state" }, { "id": "R-RNO-5658442", "name": "Regulation of RAS by GAPs", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5658442", "resource": "Reactome", "description": "Regulation of RAS by GAPs" }, { "id": "R-RNO-5668541", "name": "TNFR2 non-canonical NF-kB pathway", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5668541", "resource": "Reactome", "description": "TNFR2 non-canonical NF-kB pathway" }, { "id": "R-RNO-5676590", "name": "NIK-->noncanonical NF-kB signaling", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5676590", "resource": "Reactome", "description": "NIK-->noncanonical NF-kB signaling" }, { "id": "R-RNO-5687128", "name": "MAPK6/MAPK4 signaling", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5687128", "resource": "Reactome", "description": "MAPK6/MAPK4 signaling" }, { "id": "R-RNO-5689603", "name": "UCH proteinases", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5689603", "resource": "Reactome", "description": "UCH proteinases" }, { "id": "R-RNO-5689880", "name": "Ub-specific processing proteases", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5689880", "resource": "Reactome", "description": "Ub-specific processing proteases" }, { "id": "R-RNO-68949", "name": "Orc1 removal from chromatin", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-68949", "resource": "Reactome", "description": "Orc1 removal from chromatin" }, { "id": "R-RNO-69017", "name": "CDK-mediated phosphorylation and removal of Cdc6", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-69017", "resource": "Reactome", "description": "CDK-mediated phosphorylation and removal of Cdc6" }, { "id": "R-RNO-69481", "name": "G2/M Checkpoints", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-69481", "resource": "Reactome", "description": "G2/M Checkpoints" }, { "id": "R-RNO-69601", "name": "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-69601", "resource": "Reactome", "description": "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A" }, { "id": "R-RNO-75815", "name": "Ubiquitin-dependent degradation of Cyclin D", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-75815", "resource": "Reactome", "description": "Ubiquitin-dependent degradation of Cyclin D" }, { "id": "R-RNO-8852276", "name": "The role of GTSE1 in G2/M progression after G2 checkpoint", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8852276", "resource": "Reactome", "description": "The role of GTSE1 in G2/M progression after G2 checkpoint" }, { "id": "R-RNO-8854050", "name": "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8854050", "resource": "Reactome", "description": "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis" }, { "id": "R-RNO-8939236", "name": "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8939236", "resource": "Reactome", "description": "RUNX1 regulates transcription of genes involved in differentiation of HSCs" }, { "id": "R-RNO-8948751", "name": "Regulation of PTEN stability and activity", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8948751", "resource": "Reactome", "description": "Regulation of PTEN stability and activity" }, { "id": "R-RNO-8951664", "name": "Neddylation", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8951664", "resource": "Reactome", "description": "Neddylation" }, { "id": "R-RNO-9755511", "name": "KEAP1-NFE2L2 pathway", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9755511", "resource": "Reactome", "description": "KEAP1-NFE2L2 pathway" }, { "id": "R-RNO-983168", "name": "Antigen processing: Ubiquitination & Proteasome degradation", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "Q14997-1", "protein_name": "Proteasome activator complex subunit 4", "gene_name": "PSME4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEPAERAGVGEPPEPGGRPEPGPRGFVPQKEIVYNKLLPYAERLDAESDLQLAQIKCNLGRAVQLQELWPGGLFWTRKLSTYIRLYGRKFSKEDHVLFIKLLYELVSIPKLEISMMQGFARLLINLLKKKELLSRADLELPWRPLYDMVERILYSKTEHLGLNWFPNSVENILKTLVKSCRPYFPADATAEMLEEWRPLMCPFDVTMQKAITYFEIFLPTSLPPELHHKGFKLWFDELIGLWVSVQNLPQWEGQLVNLFARLATDNIGYIDWDPYVPKIFTRILRSLNLPVGSSQVLVPRFLTNAYDIGHAVIWITAMMGGPSKLVQKHLAGLFNSITSFYHPSNNGRWLNKLMKLLQRLPNSVVRRLHRERYKKPSWLTPVPDSHKLTDQDVTDFVQCIIQPVLLAMFSKTGSLEAAQALQNLALMRPELVIPPVLERTYPALETLTEPHQLTATLSCVIGVARSLVSGGRWFPEGPTHMLPLLMRALPGVDPNDFSKCMITFQFIATFSTLVPLVDCSSVLQERNDLTEVERELCSATAEFEDFVLQFMDRCFGLIESSTLEQTREETETEKMTHLESLVELGLSSTFSTILTQCSKEIFMVALQKVFNFSTSHIFETRVAGRMVADMCRAAVKCCPEESLKLFVPHCCSVITQLTMNDDVLNDEELDKELLWNLQLLSEITRVDGRKLLLYREQLVKILQRTLHLTCKQGYTLSCNLLHHLLRSTTLIYPTEYCSVPGGFDKPPSEYFPIKDWGKPGDLWNLGIQWHVPSSEEVSFAFYLLDSFLQPELVKLQHCGDGKLEMSRDDILQSLTIVHNCLIGSGNLLPPLKGEPVTNLVPSMVSLEETKLYTGLEYDLSRENHREVIATVIRKLLNHILDNSEDDTKSLFLIIKIIGDLLQFQGSHKHEFDSRWKSFNLVKKSMENRLHGKKQHIRALLIDRVMLQHELRTLTVEGCEYKKIHQDMIRDLLRLSTSSYSQVRNKAQQTFFAALGAYNFCCRDIIPLVLEFLRPDRQGVTQQQFKGALYCLLGNHSGVCLANLHDWDCIVQTWPAIVSSGLSQAMSLEKPSIVRLFDDLAEKIHRQYETIGLDFTIPKSCVEIAELLQQSKNPSINQILLSPEKIKEGIKRQQEKNADALRNYENLVDTLLDGVEQRNLPWKFEHIGIGLLSLLLRDDRVLPLRAIRFFVENLNHDAIVVRKMAISAVAGILKQLKRTHKKLTINPCEISGCPKPTQIIAGDRPDNHWLHYDSKTIPRTKKEWESSCFVEKTHWGYYTWPKNMVVYAGVEEQPKLGRSREDMTEAEQIIFDHFSDPKFVEQLITFLSLEDRKGKDKFNPRRFCLFKGIFRNFDDAFLPVLKPHLEHLVADSHESTQRCVAEIIAGLIRGSKHWTFEKVEKLWELLCPLLRTALSNITVETYNDWGACIATSCESRDPRKLHWLFELLLESPLSGEGGSFVDACRLYVLQGGLAQQEWRVPELLHRLLKYLEPKLTQVYKNVRERIGSVLTYIFMIDVSLPNTTPTISPHVPEFTARILEKLKPLMDVDEEIQNHVMEENGIGEEDERTQGIKLLKTILKWLMASAGRSFSTAVTEQLQLLPLFFKIAPVENDNSYDELKRDAKLCLSLMSQGLLYPHQVPLVLQVLKQTARSSSWHARYTVLTYLQTMVFYNLFIFLNNEDAVKDIRWLVISLLEDEQLEVREMAATTLSGLLQCNFLTMDSPMQIHFEQLCKTKLPKKRKRDPGSVGDTIPSAELVKRHAGVLGLGACVLSSPYDVPTWMPQLLMNLSAHLNDPQPIEMTVKKTLSNFRRTHHDNWQEHKQQFTDDQLLVLTDLLVSPCYYA", "length": 1843 }, "evidence": [ { "id": "41492314", "url": "http://www.informatics.jax.org/homology/41492314", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q5SSW2-1", "protein_name": "Proteasome activator complex subunit 4", "gene_name": "Psme4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEAPERAGGGEPPEPGGRPVLGPRAFVPQKEIVYNKLLPYAERLDAESDLQLAQIKSNLGRAVQLQELWPGGLFWTRKLSTYIRLYGRKFSKEDHVLFIKLLYELVSIPKLEISMMQGFARLLINLLKKKELLSRDDLELPWRPLYDLVERILYSKTEHLRLNSFPNSIENVLKTLVKSCRPYFPADSTAEMLEEWRPLMCPFDVTMQKAISYFEIFLPTSLPPELHHKGFKLWFDELIGLWVSVQNLPQWEGQLVNLFARLATDNIGYIDWDPYVPKIFTRILRSLNLPVGSSQVLVPRFLTNAYDIGHAVIWITAMMGGPSKLVQKHLAGLFNSITSFYHPSNNGRWLNKLMKLLQRLPNSVVRRLHRERFKKPSWLTPVPESHKLTDEDVTDFVQCIIQPVLLAMFSKTGSLEAAQALQNLALMRPELVIPPVLERTYPALETLTEPHQLTATLNCVIGVARSLVSGSKWFPEGPTHMLPLLMRALPGVDPNDFSKCMITFQFIGTFSTLVPLVDCSSVLQERNDLTEIEKELCSATAEFEDFVLQFMDRCFGLIESSTLEQTREETETEKMTHLESLVELGLSSTFSTILTQCSKDIFMVALQKVFNFSVSHIFETRVAGRMVADMCRAAVKCCPEESLKLFVPHCYGVITQLTMNDDVLNEEELDKELLWNLQLLSEITRVDGKKLLLYREQLVKILQRTLHLTCKQGYTLSCNLLHHLLRSTTLIYPTEYCSVPGGFNKPPSEYFPVKDWGKPGDLWNLGIQWHVPSSEEVSFAFYLLDSFLQPELIKLQCCGDGELEMSRDDILQSLTIVHSCLIGSGNLLPPLKGEAVTNLVPSMVSLEETKLYTGLEHDLSRENYREVIASVIRKLLSHILDNSEDDTKSLFLIIKIIGDLLHFQGSHKHEFDSRWKSFNLVKKSMENRLHGKKQHIRALLIDRVMLQHELRTLTVEGCEYKKIHQDMIRDLLRLSTSSYSQVRNKAQQTFFAALGAYNFCCRDIIPLVLEFLRPDRKDVTQQQFKGALYCLLGNHSGVCLANLHDWDCIVQTWPALVSSGLSQAMSLEKPSIVRLFDDLAEKIHRQYETIGLDFTIPKSCAAIAELLQQSKNPSISQTLLSPEKIKEGQKRQQDKNADALRNYECLVNTLLDGVEQRNLPWKFEHIGIGLLSLLLRDDRVLPLRAIRFFVENLNHDAIVVRKMAISAVAGILKQLKRTHKKLTINPYEISGCPKPTKILAGDRPDNHWLHYDSKNIPRTKKEWESSCFVEKTHWGYYNWPKNMVVYAGVEEQPKLGRSREDMIEAEQIIYDRFSDPKFVEQLITFLSLEDRKGRDKFSPRRFCLFKGIFRNFDDAFLPVLKPHLERLVADSHESTQRCVAEIIAGLIRGSKHWTFEKVEKLWELLCPLLRTALSNMTVETYNDWGTCIATSCESRDPRKLHWLFELLLESPLSGEGGSFVDACRLYVLQGGLAQQEWRVPELLHRLLKYLEPKLTQVYKNVRERIGSVLTYIFMIDVSLPNTAPTTSPCIPEFTARVLEKLKPLTDVDEEIQNHVMEENGIGEEDERTQGIKLLKTILKWLMASAGRSFSTAVKEQLQLLPLFFKIAPVENDNSYDELKRDAKLCLSLMSQGLLYPQQVPLILQVLSQTARSSSWHARYTVLTYLQTMVFYNLFIFLNNEDAVKDIRWLIICLLEDEQLEVREMAATTLSGLLQCNFLTMDSAMQIHFEQLCKTKLPKKRKRDPGSVGDTIPSAELVKRHAGVLGLGACVLSSPYDVPTWMPQLLMNLSAHLNDPQPIEMTVKKTLSNFRRTHHDNWQEHKQQFTDDQLLVLTDLLVSPCYYA", "length": 1843 }, "evidence": [ { "id": "41492314", "url": "http://www.informatics.jax.org/homology/41492314", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "spermatoproteasome complex", "id": "GO:1990111", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990111", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAX0", "url": "https://www.uniprot.org/uniprot/A0A0G2KAX0" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAX0", "url": "https://www.uniprot.org/uniprot/A0A0G2KAX0" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAX0", "url": "https://www.uniprot.org/uniprot/A0A0G2KAX0" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAX0", "url": "https://www.uniprot.org/uniprot/A0A0G2KAX0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAX0", "url": "https://www.uniprot.org/uniprot/A0A0G2KAX0" } ], "pmid": "" }, { "name": "cellular response to DNA damage stimulus", "id": "GO:0006974", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006974", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAX0", "url": "https://www.uniprot.org/uniprot/A0A0G2KAX0" } ], "pmid": "" }, { "name": "spermatogenesis, exchange of chromosomal proteins", "id": "GO:0035093", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035093", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAX0", "url": "https://www.uniprot.org/uniprot/A0A0G2KAX0" } ], "pmid": "" }, { "name": "proteasomal ubiquitin-independent protein catabolic process", "id": "GO:0010499", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010499", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAX0", "url": "https://www.uniprot.org/uniprot/A0A0G2KAX0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "peptidase activator activity", "id": "GO:0016504", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016504", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAX0", "url": "https://www.uniprot.org/uniprot/A0A0G2KAX0" } ], "pmid": "" }, { "name": "lysine-acetylated histone binding", "id": "GO:0070577", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070577", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAX0", "url": "https://www.uniprot.org/uniprot/A0A0G2KAX0" } ], "pmid": "" }, { "name": "proteasome binding", "id": "GO:0070628", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070628", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAX0", "url": "https://www.uniprot.org/uniprot/A0A0G2KAX0" } ], "pmid": "21873635" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1056, "end_pos": 1058, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1437, "end_pos": 1439, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1809, "end_pos": 1811, "annotation": "n_glycosylation_sequon" }, { "start_pos": 633, "end_pos": 635, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ] }