{ "uniprot_canonical_ac": "A0A0G2KA90-1", "uniprot_ac": "A0A0G2KA90", "uniprot_id": "A0A0G2KA90_RAT", "mass": { "chemical_mass": 100103.0, "monoisotopic_mass": 100103.0 }, "refseq": {}, "gene_names": [ { "name": "Dsc1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2KA90", "id": "A0A0G2KA90" } ], "protein_names": [ { "name": "Desmocollin 1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0G2KA90#names_and_taxonomy", "id": "A0A0G2KA90" } ], "function": [ { "annotation": "Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KA90", "url": "https://www.uniprot.org/uniprot/A0A0G2KA90#function" }, { "database": "PubMed", "id": "RU004358", "url": "https://glygen.org/publication/PubMed/RU004358" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KA90", "url": "https://www.uniprot.org/uniprot/A0A0G2KA90" } ], "common_name": "Rat" } ], "gene": [ { "name": "Dsc1", "url": "https://www.uniprot.org/uniprot/A0A0G2KA90", "locus": { "chromosome": "18", "start_pos": 11906827, "end_pos": 11877561, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000056258", "url": "https://www.ensembl.org/id/ENSRNOG00000056258" } ] } } ], "crossref": [ { "id": "ENSRNOG00000056258", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000056258", "database": "Bgee" }, { "id": "IPR000233", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000233", "database": "InterPro" }, { "id": "IPR002126", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002126", "database": "InterPro" }, { "id": "IPR009122", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009122", "database": "InterPro" }, { "id": "IPR014868", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014868", "database": "InterPro" }, { "id": "IPR015919", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015919", "database": "InterPro" }, { "id": "IPR020894", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020894", "database": "InterPro" }, { "id": "IPR027397", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027397", "database": "InterPro" }, { "id": "QVTAIDH", "url": "https://omabrowser.org/oma/group/QVTAIDH/", "database": "OMA" }, { "id": "PF00028", "url": "http://pfam.xfam.org/family/PF00028", "database": "Pfam" }, { "id": "PF01049", "url": "http://pfam.xfam.org/family/PF01049", "database": "Pfam" }, { "id": "PF08758", "url": "http://pfam.xfam.org/family/PF08758", "database": "Pfam" }, { "id": "R-RNO-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6798695", "database": "Reactome" }, { "id": "R-RNO-6805567", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6805567", "database": "Reactome" }, { "id": "R-RNO-6809371", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6809371", "database": "Reactome" }, { "id": "1310768", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1310768", "database": "RGD" }, { "id": "A0A0G2KA90", "url": "https://www.uniprot.org/uniprot/A0A0G2KA90", "database": "UniProtKB" }, { "id": "A0A0G2KA90-1", "url": "https://www.uniprot.org/uniprot/A0A0G2KA90-1", "database": "UniProtKB" }, { "id": "A0A8I6GE75", "url": "https://www.uniprot.org/uniprot/A0A8I6GE75", "database": "UniProtKB" }, { "id": "A0A8I6GE75-1", "url": "https://www.uniprot.org/uniprot/A0A8I6GE75-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MAAACAAPGSTFSKQLLFLLLVLVLLCNACQKVSLQVPSHLKAEKPIGKVNLEECLKSPSLILSSDPAFRILEDGTIYATHDLLLSSEKRGFSILLSDSQGQEQKKLEIVLSAREKKAFRKRHTKEPVHKRSKRRWAPIPCSLMENSLGPFPQHVQRIQSDFSQNYSIFYSISGPGVDKEPFNLFYIEKDTGDIYCTRSIDREEYDQFMVYGYATTADGYAPEYPLPLLFKVEDDNDNAPYFETKLTVFSVPENCRYGTSVGQVTAIDKDEPGTLHTRLKYKILQQIPDHPKHFTVHPDTGVITTTTPLLDREKCDTYKLVMEVRDMGGQPFGLFTTGTITISLEDENDNSPCFTQSSYFAEVDENRIDVEILRMMVQDQDLPNTPHSKAVYKILQGNENGNFKITTDPNTNEGVLCVVKPLNYEVSRQVTLQISVLNEAQFTNAANTQPPTMCTATVTVKIKDRDEGPECLPPVKVIQSKDGLPAGQQLLGYKAMDPETSSGEGLRYKMVGDEDNWFEINESTGDLRTVKVLDRESKFVKNNQYNISVVAMDSVGRSCTGTLVVLLEDFNDHPPQIDKDITICQQEKDYAVLEPVDLDGPDNGPPFQFLLDNSSSKLWTLESQDGKRAILRQRHNLNYNYYSVPIQIQDRHGFSAKHVLSVRVCDCTIPSECRMAIEERDVKPNVILGKWAILAMVLGSALLLCILFTCFCVTTTKRTVKKCFPDDVAQQNLIVSNTEGPGEEVTEANIRLPTQTVNICDTSTSVGTLGGQGIKTQQNFEMVKGGYTLESNKGGGHHTLESSKGGVLGAADTGRYAYTDWQTFTQPRLGEKVYLCGQAEEHKHCDDYVRSYNYEGKGSMAGSVGCCSDRQEEEGLEFLDHLEPKFRTLAKTCVKK", "length": 896, "header": "tr|A0A0G2KA90-1|A0A0G2KA90_RAT Isoform 1 of Desmocollin 1 OS=Rattus norvegicus OX=10116 GN=Dsc1 PE=4 SV=2 CANONICAL=A0A0G2KA90-1" }, "isoforms": [ { "isoform_ac": "A0A0G2KA90-1", "url": "https://www.uniprot.org/uniprot/A0A0G2KA90#A0A0G2KA90-1", "sequence": { "sequence": "MAAACAAPGSTFSKQLLFLLLVLVLLCNACQKVSLQVPSHLKAEKPIGKVNLEECLKSPSLILSSDPAFRILEDGTIYATHDLLLSSEKRGFSILLSDSQGQEQKKLEIVLSAREKKAFRKRHTKEPVHKRSKRRWAPIPCSLMENSLGPFPQHVQRIQSDFSQNYSIFYSISGPGVDKEPFNLFYIEKDTGDIYCTRSIDREEYDQFMVYGYATTADGYAPEYPLPLLFKVEDDNDNAPYFETKLTVFSVPENCRYGTSVGQVTAIDKDEPGTLHTRLKYKILQQIPDHPKHFTVHPDTGVITTTTPLLDREKCDTYKLVMEVRDMGGQPFGLFTTGTITISLEDENDNSPCFTQSSYFAEVDENRIDVEILRMMVQDQDLPNTPHSKAVYKILQGNENGNFKITTDPNTNEGVLCVVKPLNYEVSRQVTLQISVLNEAQFTNAANTQPPTMCTATVTVKIKDRDEGPECLPPVKVIQSKDGLPAGQQLLGYKAMDPETSSGEGLRYKMVGDEDNWFEINESTGDLRTVKVLDRESKFVKNNQYNISVVAMDSVGRSCTGTLVVLLEDFNDHPPQIDKDITICQQEKDYAVLEPVDLDGPDNGPPFQFLLDNSSSKLWTLESQDGKRAILRQRHNLNYNYYSVPIQIQDRHGFSAKHVLSVRVCDCTIPSECRMAIEERDVKPNVILGKWAILAMVLGSALLLCILFTCFCVTTTKRTVKKCFPDDVAQQNLIVSNTEGPGEEVTEANIRLPTQTVNICDTSTSVGTLGGQGIKTQQNFEMVKGGYTLESNKGGGHHTLESSKGGVLGAADTGRYAYTDWQTFTQPRLGEKVYLCGQAEEHKHCDDYVRSYNYEGKGSMAGSVGCCSDRQEEEGLEFLDHLEPKFRTLAKTCVKK", "length": 896, "header": "tr|A0A0G2KA90-1|A0A0G2KA90_RAT Isoform 1 of Desmocollin 1 OS=Rattus norvegicus OX=10116 GN=Dsc1 PE=4 SV=2 CANONICAL=A0A0G2KA90-1" }, "locus": { "chromosome": "18", "start_pos": 11528193, "end_pos": 11502773, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000078207.2", "url": "https://www.ensembl.org/id/ENSRNOT00000078207.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000075307.2", "url": "https://www.ensembl.org/id/ENSRNOP00000075307.2" } ] } }, { "isoform_ac": "A0A8I6GE75-1", "url": "https://www.uniprot.org/uniprot/A0A0G2KA90#A0A8I6GE75-1", "sequence": { "sequence": "MAAACAAPGSTFSKQLLFLLLVLVLLCNACQKVSLQVPSHLKAEKPIGKVNLEECLKSPSLILSSDPAFRILEDGTIYATHDLLLSSEKRGFSILLSDSQGQEQKKLEIVLSAREKKAFRKRHTKEPVHKRSKRRWAPIPCSLMENSLGPFPQHVQRIQSDFSQNYSIFYSISGPGVDKEPFNLFYIEKDTGDIYCTRSIDREEYDQFMVYGYATTADGYAPEYPLPLLFKVEDDNDNAPYFETKLTVFSVPENCRYGTSVGQVTAIDKDEPGTLHTRLKYKILQQIPDHPKHFTVHPDTGVITTTTPLLDREKCDTYKLVMEVRDMGGQPFGLFTTGTITISLEDENDNSPCFTQSSYFAEVDENRIDVEILRMMVQDQDLPNTPHSKAVYKILQGNENGNFKITTDPNTNEGVLCVVKPLNYEVSRQVTLQISVLNEAQFTNAANTQPPTMCTATVTVKIKDRDEGPECLPPVKVIQSKDGLPAGQQLLGYKAMDPETSSGEGLRYKMVGDEDNWFEINESTGDLRTVKVLDRESKFVKNNQYNISVVAMDSVGRSCTGTLVVLLEDFNDHPPQIDKDITICQQEKDYAVLEPVDLDGPDNGPPFQFLLDNSSSKLWTLESQDGKRAILRQRHNLNYNYYSVPIQIQDRHGFSAKHVLSVRVCDCTIPSECRMAIEERDVKPNVILGKWAILAMVLGSALLLCILFTCFCVTTTKRTVKKCFPDDVAQQNLIVSNTEGPGEEVTEANIRLPTQTVNICDTSTSVGTLGGQGIKTQQNFEMVKGGYTLESNKGGGHHTLESSKGGVLGAADTGRYAYTDWQTFTQPRLGEESIRGHTLIKN", "length": 842, "header": "tr|A0A8I6GE75-1|A0A8I6GE75_RAT Computationally mapped isoform of Desmocollin 1 OS=Rattus norvegicus OX=10116 GN=Dsc1 PE=4 SV=1 CANONICAL=A0A0G2KA90-1" }, "locus": { "chromosome": "18", "start_pos": 11528193, "end_pos": 11503064, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000118489.1", "url": "https://www.ensembl.org/id/ENSRNOT00000118489.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000085728.1", "url": "https://www.ensembl.org/id/ENSRNOP00000085728.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-RNO-6798695", "name": "Neutrophil degranulation", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" }, { "id": "R-RNO-6805567", "name": "Keratinization", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6805567", "resource": "Reactome", "description": "Keratinization" }, { "id": "R-RNO-6809371", "name": "Formation of the cornified envelope", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6809371", "resource": "Reactome", "description": "Formation of the cornified envelope" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KA90", "url": "https://www.uniprot.org/uniprot/A0A0G2KA90" } ], "pmid": "" }, { "name": "cell-cell junction", "id": "GO:0005911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005911", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KA90", "url": "https://www.uniprot.org/uniprot/A0A0G2KA90" } ], "pmid": "21873635" }, { "name": "desmosome", "id": "GO:0030057", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030057", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KA90", "url": "https://www.uniprot.org/uniprot/A0A0G2KA90" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KA90", "url": "https://www.uniprot.org/uniprot/A0A0G2KA90" } ], "pmid": "21873635" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cell-cell adhesion", "id": "GO:0098609", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098609", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KA90", "url": "https://www.uniprot.org/uniprot/A0A0G2KA90" } ], "pmid": "21873635" }, { "name": "homophilic cell adhesion via plasma membrane adhesion molecules", "id": "GO:0007156", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007156", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KA90", "url": "https://www.uniprot.org/uniprot/A0A0G2KA90" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 165, "end_pos": 167, "annotation": "n_glycosylation_sequon" }, { "start_pos": 521, "end_pos": 523, "annotation": "n_glycosylation_sequon" }, { "start_pos": 546, "end_pos": 548, "annotation": "n_glycosylation_sequon" }, { "start_pos": 613, "end_pos": 615, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ] }