{ "uniprot_canonical_ac": "A0A0G2K950-1", "uniprot_ac": "A0A0G2K950", "uniprot_id": "A0A0G2K950_RAT", "mass": { "chemical_mass": 69950.0, "monoisotopic_mass": 69950.0 }, "refseq": { "ac": "XP_006231336", "name": "bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006231336" }, "gene_names": [ { "name": "Papss2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2K950", "id": "A0A0G2K950" }, { "name": "Papss2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006231336", "id": "XP_006231336" } ], "protein_names": [ { "name": "3'-phosphoadenosine 5'-phosphosulfate synthase 2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0G2K950#names_and_taxonomy", "id": "A0A0G2K950" }, { "name": "bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006231336", "id": "XP_006231336" }, { "name": "bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099845", "id": "NP_001099845" } ], "function": [], "disease": [ { "disease_id": "DOID:0050812", "recommended_name": { "id": "DOID:0050812", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050812", "name": "spondyloepimetaphyseal dysplasia, Pakistani type", "description": "A spondyloepimetaphyseal dysplasia that is characterized by short stature, short and bowed lower limbs, mild brachydactyly, kyphoscoliosis, abnormal gait, enlarged knee joints, precocious osteoarthropathy, and normal intelligence." }, "synonyms": [ { "id": "DOID:0050812", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050812", "name": "spondyloepimetaphyseal dysplasia Pakistani type", "description": "" }, { "id": "MONDO:0013019", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013019", "name": "spondyloepimetaphyseal dysplasia, Pakistani type", "description": "A spondyloepimetaphyseal dysplasia that is characterized by short stature, short and bowed lower limbs, mild brachydactyly, kyphoscoliosis, abnormal gait, enlarged knee joints, precocious osteoarthropathy, and normal intelligence." }, { "id": "MONDO:0013019", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013019", "name": "SEMD, Pakistani type", "description": "" }, { "id": "MONDO:0013019", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013019", "name": "BCYM4", "description": "" }, { "id": "MONDO:0013019", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013019", "name": "spondyloepimetaphyseal dysplasia, Pakistani type", "description": "" }, { "id": "MONDO:0013019", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013019", "name": "brachyolmia type 4 with mild epiphyseal and metaphyseal changes", "description": "" }, { "id": "MONDO:0013019", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013019", "name": "spondyloepimetaphyseal dysplasia Pakistani type", "description": "" }, { "id": "MONDO:0013019", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013019", "name": "spondylodysplasia and premature pubarche", "description": "" }, { "id": "MONDO:0013019", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013019", "name": "brachyolmia type 4 with mild epiphyseal and metaphyseal changes; BCYM4", "description": "" }, { "id": "MIM:612847", "resource": "MIM", "url": "https://www.omim.org/entry/612847", "name": "Brachyolmia type 4 with mild epiphyseal and metaphyseal changes", "description": "Brachyolmia type 4 with mild epiphyseal and metaphyseal changes" } ], "evidence": [ { "id": "0050812", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050812" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K950", "url": "https://www.uniprot.org/uniprot/A0A0G2K950" } ], "common_name": "Rat" } ], "gene": [ { "name": "Papss2", "url": "https://www.uniprot.org/uniprot/A0A0G2K950", "locus": { "chromosome": "1", "start_pos": 251145253, "end_pos": 251230715, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000011068", "url": "https://www.ensembl.org/id/ENSRNOG00000011068" } ] } } ], "crossref": [ { "id": "ENSRNOG00000011068", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000011068", "database": "Bgee" }, { "id": "cd00517", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00517", "database": "CDD" }, { "id": "cd02027", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02027", "database": "CDD" }, { "id": "294103", "url": "https://www.ncbi.nlm.nih.gov/gene/294103", "database": "GeneID" }, { "id": "IPR002650", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002650", "database": "InterPro" }, { "id": "IPR002891", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002891", "database": "InterPro" }, { "id": "IPR014729", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014729", "database": "InterPro" }, { "id": "IPR015947", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015947", "database": "InterPro" }, { "id": "IPR024951", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024951", "database": "InterPro" }, { "id": "IPR025980", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025980", "database": "InterPro" }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro" }, { "id": "rno:294103", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:294103", "database": "KEGG Pathway" }, { "id": "DQMYERP", "url": "https://omabrowser.org/oma/group/DQMYERP/", "database": "OMA" }, { "id": "528280at2759", "url": "http://www.orthodb.org/?query=528280at2759", "database": "OrthoDB" }, { "id": "PF01747", "url": "http://pfam.xfam.org/family/PF01747", "database": "Pfam" }, { "id": "PF14306", "url": "http://pfam.xfam.org/family/PF14306", "database": "Pfam" }, { "id": "R-RNO-174362", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-174362", "database": "Reactome" }, { "id": "NP_001099845", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099845", "database": "RefSeq" }, { "id": "XP_006231336", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006231336", "database": "RefSeq" }, { "id": "1307012", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1307012", "database": "RGD" }, { "id": "A0A0G2K950", "url": "https://www.uniprot.org/uniprot/A0A0G2K950", "database": "UniProtKB" }, { "id": "A0A0G2K950-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K950-1", "database": "UniProtKB" }, { "id": "B5DFH4", "url": "https://www.uniprot.org/uniprot/B5DFH4", "database": "UniProtKB" }, { "id": "B5DFH4-1", "url": "https://www.uniprot.org/uniprot/B5DFH4-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MSEIKKQKTDQQKSTNVVYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTISFALEEYLVSHAIPCYSLDGDNVRHGLNKNLGFSAGDREENIRRIAEVAKLFADAGLVCITSFISPFAKDRENARKIHESAGLPFFEIFVDAPLNICESRDVKGLYKRARAGEIKGFTGIDSNYEKPETPECVLKTNLSSVSDCVQQVVELLQEQSIVPHTTIKGIHELFVPENKIDQIRAELETLPSLPITKLDLQWVQILSEGWATPLKGFMREKEYLQTLHFDTLLDGVILRDGVINMSIPIVLPVSGDDKARLEGCSKFALMYEGRRVALLQDPEFYEHRKEERCSRVWGTASAKHPHIKMVMEGGDWLVGGDLQVLERIRWNDGLDQYRLTPLELKQKCKDMDADAVFAFQLRNPVHNGHALLMQDTRRRLLERGYKHPVLLLHPLGGWTKDDDVPLDWRMKQHAAVLEEGILDPKSTIVAIFPSPMLYAGPTEVQWHCRCRMIAGANFYIVGRDPAGMPHPETKKDLYEPTHGGKVLSMAPGLTSVEIIPFRVAAYNKIKKAMDFYDPARHDEFDFISGTRMRKLAREGEDPPDGFMAPKAWKVLTDYYRSLEKIN", "length": 619, "header": "tr|A0A0G2K950-1|A0A0G2K950_RAT Isoform 1 of 3'-phosphoadenosine 5'-phosphosulfate synthase 2 OS=Rattus norvegicus OX=10116 GN=Papss2 PE=1 SV=1 CANONICAL=A0A0G2K950-1" }, "isoforms": [ { "isoform_ac": "A0A0G2K950-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K950#A0A0G2K950-1", "sequence": { "sequence": "MSEIKKQKTDQQKSTNVVYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTISFALEEYLVSHAIPCYSLDGDNVRHGLNKNLGFSAGDREENIRRIAEVAKLFADAGLVCITSFISPFAKDRENARKIHESAGLPFFEIFVDAPLNICESRDVKGLYKRARAGEIKGFTGIDSNYEKPETPECVLKTNLSSVSDCVQQVVELLQEQSIVPHTTIKGIHELFVPENKIDQIRAELETLPSLPITKLDLQWVQILSEGWATPLKGFMREKEYLQTLHFDTLLDGVILRDGVINMSIPIVLPVSGDDKARLEGCSKFALMYEGRRVALLQDPEFYEHRKEERCSRVWGTASAKHPHIKMVMEGGDWLVGGDLQVLERIRWNDGLDQYRLTPLELKQKCKDMDADAVFAFQLRNPVHNGHALLMQDTRRRLLERGYKHPVLLLHPLGGWTKDDDVPLDWRMKQHAAVLEEGILDPKSTIVAIFPSPMLYAGPTEVQWHCRCRMIAGANFYIVGRDPAGMPHPETKKDLYEPTHGGKVLSMAPGLTSVEIIPFRVAAYNKIKKAMDFYDPARHDEFDFISGTRMRKLAREGEDPPDGFMAPKAWKVLTDYYRSLEKIN", "length": 619, "header": "tr|A0A0G2K950-1|A0A0G2K950_RAT Isoform 1 of 3'-phosphoadenosine 5'-phosphosulfate synthase 2 OS=Rattus norvegicus OX=10116 GN=Papss2 PE=1 SV=1 CANONICAL=A0A0G2K950-1" }, "locus": { "chromosome": "1", "start_pos": 230537716, "end_pos": 230454461, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000083555.2", "url": "https://www.ensembl.org/id/ENSRNOT00000083555.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000074860.1", "url": "https://www.ensembl.org/id/ENSRNOP00000074860.1" } ] } }, { "isoform_ac": "B5DFH4-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K950#B5DFH4-1", "sequence": { "sequence": "MSEIKKQKTDQQKSTNVVYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTISFALEEYLVSHAIPCYSLDGDNVRHGLNKNLGFSAGDREENIRRIAEVAKLFADAGLVCITSFISPFAKDRENARKIHESAGLPFFEIFVDAPLNICESRDVKGLYKRARAGEIKGFTGIDSNYEKPETPECVLKTNLSSVSDCVQQVVELLQEQSIVPHTTIKGIHELFVPENKIDQIRAELETLPSLPITKLDLQWVQILSEGWATPLKGFMREKEYLQTLHFDTLLDDGVINMSIPIVLPVSGDDKARLEGCSKFALMYEGRRVALLQDPEFYEHRKEERCSRVWGTASAKHPHIKMVMEGGDWLVGGDLQVLERIRWNDGLDQYRLTPLELKQKCKDMDADAVFAFQLRNPVHNGHALLMQDTRRRLLERGYKHPVLLLHPLGGWTKDDDVPLDWRMKQHAAVLEEGILDPKSTIVAIFPSPMLYAGPTEVQWHCRCRMIAGANFYIVGRDPAGMPHPETKKDLYEPTHGGKVLSMAPGLTSVEIIPFRVAAYNKIKKAMDFYDPARHDEFDFISGTRMRKLAREGEDPPDGFMAPKAWKVLTDYYRSLEKIN", "length": 614, "header": "tr|B5DFH4-1|B5DFH4_RAT Computationally mapped isoform of Papss2 protein OS=Rattus norvegicus OX=10116 GN=Papss2 PE=1 SV=1 CANONICAL=A0A0G2K950-1" }, "locus": { "chromosome": "1", "start_pos": 230537716, "end_pos": 230454461, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000014979.6", "url": "https://www.ensembl.org/id/ENSRNOT00000014979.6" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000014979.4", "url": "https://www.ensembl.org/id/ENSRNOP00000014979.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nat. Commun.", "date": "2012", "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K950", "url": "https://www.uniprot.org/uniprot/A0A0G2K950" }, { "database": "UniProtKB", "id": "B5DFH4", "url": "https://www.uniprot.org/uniprot/B5DFH4" } ], "reference": [ { "type": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" } ] } ], "pathway": [ { "id": "rno:294103", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:294103", "resource": "KEGG Pathway" }, { "id": "R-RNO-174362", "name": "Transport and synthesis of PAPS", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-174362", "resource": "Reactome", "description": "Transport and synthesis of PAPS" } ], "orthologs": [ { "uniprot_canonical_ac": "O88428-1", "protein_name": "Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2", "gene_name": "Papss2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSANFKMNHKRDQQKSTNVVYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTISFALEEYLVSHAIPCYSLDGDNVRHGLNKNLGFSAGDREENIRRIAEVARLFADAGLVCITSFISPFAKDRENARKIHESAGLPFFEIFVDAPLNICESRDVKGLYKRARAGEIKGFTGIDSDYEKPETPECVLKTNLSSVSDCVQQVVELLQEQNIVPHTTIKGIHELFVPENKVDQIRAEAETLPSLPITKLDLQWVQILSEGWATPLKGFMREKEYLQTLHFDTLLDGVVPRDGVINMSIPIVLPVSADDKARLEGCSKFALMYEGRRVALLQDPEFYEHRKEERCSRVWGTATAKHPHIKMVMESGDWLVGGDLQVLERIRWDDGLDQYRLTPLELKQKCKDMNADAVFAFQLRNPVHNGHALLMQDTRRRLLERGYKHPVLLLHPLGGWTKDDDVPLEWRMKQHAAVLEERVLDPKSTIVAIFPSPMLYAGPTEVQWHCRCRMIAGANFYIVGRDPAGMPHPETKKDLYEPTHGGKVLSMAPGLTSVEIIPFRVAAYNKIKKAMDFYDPARHEEFDFISGTRMRKLAREGEDPPDGFMAPKAWKVLTDYYRSLEKTN", "length": 621 }, "evidence": [ { "id": "41493571", "url": "http://www.informatics.jax.org/homology/41493571", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "O95340-1", "protein_name": "Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2", "gene_name": "PAPSS2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSGIKKQKTENQQKSTNVVYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTISFALEEYLVSHAIPCYSLDGDNVRHGLNRNLGFSPGDREENIRRIAEVAKLFADAGLVCITSFISPFAKDRENARKIHESAGLPFFEIFVDAPLNICESRDVKGLYKRARAGEIKGFTGIDSDYEKPETPERVLKTNLSTVSDCVHQVVELLQEQNIVPYTIIKDIHELFVPENKLDHVRAEAETLPSLSITKLDLQWVQVLSEGWATPLKGFMREKEYLQVMHFDTLLDDGVINMSIPIVLPVSAEDKTRLEGCSKFVLAHGGRRVAILRDAEFYEHRKEERCSRVWGTTCTKHPHIKMVMESGDWLVGGDLQVLEKIRWNDGLDQYRLTPLELKQKCKEMNADAVFAFQLRNPVHNGHALLMQDTRRRLLERGYKHPVLLLHPLGGWTKDDDVPLDWRMKQHAAVLEEGVLDPKSTIVAIFPSPMLYAGPTEVQWHCRSRMIAGANFYIVGRDPAGMPHPETKKDLYEPTHGGKVLSMAPGLTSVEIIPFRVAAYNKAKKAMDFYDPARHNEFDFISGTRMRKLAREGENPPDGFMAPKAWKVLTDYYRSLEKN", "length": 614 }, "evidence": [ { "id": "41493571", "url": "http://www.informatics.jax.org/homology/41493571", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K950", "url": "https://www.uniprot.org/uniprot/A0A0G2K950" } ], "pmid": "" }, { "name": "adenylylsulfate kinase activity", "id": "GO:0004020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004020", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K950", "url": "https://www.uniprot.org/uniprot/A0A0G2K950" } ], "pmid": "" }, { "name": "sulfate adenylyltransferase (ATP) activity", "id": "GO:0004781", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004781", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K950", "url": "https://www.uniprot.org/uniprot/A0A0G2K950" } ], "pmid": "" }, { "name": "selenate adenylyltransferase (ATP) activity", "id": "GO:0098616", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098616", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K950", "url": "https://www.uniprot.org/uniprot/A0A0G2K950" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "blood coagulation", "id": "GO:0007596", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007596", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K950", "url": "https://www.uniprot.org/uniprot/A0A0G2K950" } ], "pmid": "" }, { "name": "bone development", "id": "GO:0060348", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060348", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K950", "url": "https://www.uniprot.org/uniprot/A0A0G2K950" } ], "pmid": "" }, { "name": "hormone metabolic process", "id": "GO:0042445", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042445", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K950", "url": "https://www.uniprot.org/uniprot/A0A0G2K950" } ], "pmid": "" }, { "name": "sulfate assimilation", "id": "GO:0000103", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000103", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K950", "url": "https://www.uniprot.org/uniprot/A0A0G2K950" } ], "pmid": "" }, { "name": "3'-phosphoadenosine 5'-phosphosulfate biosynthetic process", "id": "GO:0050428", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050428", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K950", "url": "https://www.uniprot.org/uniprot/A0A0G2K950" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K950", "url": "https://www.uniprot.org/uniprot/A0A0G2K950" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 194, "end_pos": 196, "annotation": "n_glycosylation_sequon" }, { "start_pos": 297, "end_pos": 299, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ] }