{ "uniprot_canonical_ac": "A0A0G2K2Z2-1", "uniprot_ac": "A0A0G2K2Z2", "uniprot_id": "A0A0G2K2Z2_RAT", "mass": { "chemical_mass": 52378.0, "monoisotopic_mass": 52378.0 }, "refseq": {}, "gene_names": [ { "name": "Inpp5k", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2", "id": "A0A0G2K2Z2" } ], "protein_names": [ { "name": "Inositol-polyphosphate 5-phosphatase", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2#names_and_taxonomy", "id": "A0A0G2K2Z2" }, { "name": "3.1.3.56", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2#names_and_taxonomy", "id": "A0A0G2K2Z2" } ], "function": [], "disease": [ { "disease_id": "DOID:0080197", "recommended_name": { "id": "DOID:0080197", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080197", "name": "congenital muscular dystrophy with cataracts and intellectual disability", 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"A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "common_name": "Rat" } ], "gene": [ { "name": "Inpp5k", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2", "locus": { "chromosome": "10", "start_pos": 63776378, "end_pos": 63795899, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000056954", "url": "https://www.ensembl.org/id/ENSRNOG00000056954" } ] } } ], "crossref": [ { "id": "ENSRNOG00000056954", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000056954", "database": "Bgee" }, { "id": "IPR000300", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000300", "database": "InterPro" }, { "id": "IPR005135", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005135", "database": "InterPro" }, { "id": "IPR036691", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036691", "database": "InterPro" }, { "id": "IPR041611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041611", "database": "InterPro" }, { "id": "EHFRCIM", "url": 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"MTTASLRKPSAPKELMLSIHVVTWNVASAAPTVDLSDLLQLNNEDLNLDIYIIGLQEMNYGIISLLSDAAFEDPWSSFFMDMLSPLNLVKISQVRMQGLLLLVFAKYQHLPYIQIISTKSIPTGLYGYWGNKGGINICLKLYGYYVSIVNCHLPPHMYNNDQRLEHFDRILESLTFEGYDVPNILDHDLILWFGDMNFRIEDFGLLFVQECITKKRYKELWEKDQLFIAKKQDQLLREFQEGPLLFPPTYKFDRHSNNYDTSEKKRKPAWTDRILWRLKRQPAKANPSGFLLTQKDYVSHMTYSISDHKPVTGTFDLELNPLMSVPLITMMPEYLWTKENDMLINYTSTPEFLSSPWDWIGLYKVIWQVGMRHINDYVSYVWVGDNQVSRGNNPNQVYINISAIPDTEEQFLLCYYSNNLHSIVGISQPFKIPSGFFLREDTLSELEPQL", "length": 450, "header": "tr|A0A0G2K2Z2-1|A0A0G2K2Z2_RAT Isoform 1 of Inositol-polyphosphate 5-phosphatase OS=Rattus norvegicus OX=10116 GN=Inpp5k PE=1 SV=2 CANONICAL=A0A0G2K2Z2-1" }, "isoforms": [ { "isoform_ac": "A0A0G2K2Z2-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2#A0A0G2K2Z2-1", "sequence": { "sequence": "MTTASLRKPSAPKELMLSIHVVTWNVASAAPTVDLSDLLQLNNEDLNLDIYIIGLQEMNYGIISLLSDAAFEDPWSSFFMDMLSPLNLVKISQVRMQGLLLLVFAKYQHLPYIQIISTKSIPTGLYGYWGNKGGINICLKLYGYYVSIVNCHLPPHMYNNDQRLEHFDRILESLTFEGYDVPNILDHDLILWFGDMNFRIEDFGLLFVQECITKKRYKELWEKDQLFIAKKQDQLLREFQEGPLLFPPTYKFDRHSNNYDTSEKKRKPAWTDRILWRLKRQPAKANPSGFLLTQKDYVSHMTYSISDHKPVTGTFDLELNPLMSVPLITMMPEYLWTKENDMLINYTSTPEFLSSPWDWIGLYKVIWQVGMRHINDYVSYVWVGDNQVSRGNNPNQVYINISAIPDTEEQFLLCYYSNNLHSIVGISQPFKIPSGFFLREDTLSELEPQL", "length": 450, "header": "tr|A0A0G2K2Z2-1|A0A0G2K2Z2_RAT Isoform 1 of Inositol-polyphosphate 5-phosphatase OS=Rattus norvegicus OX=10116 GN=Inpp5k PE=1 SV=2 CANONICAL=A0A0G2K2Z2-1" }, "locus": { "chromosome": "10", "start_pos": 60495585, "end_pos": 60476021, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000090481.2", "url": "https://www.ensembl.org/id/ENSRNOT00000090481.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000072437.2", "url": "https://www.ensembl.org/id/ENSRNOP00000072437.2" } ] } }, { "isoform_ac": "A0A0G2K5K7-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2#A0A0G2K5K7-1", "sequence": { "sequence": "QKTKNKKKPKSMKQTCRHISNDHSPTVDLSDLLQLNNEDLNLDIYIIGLQEMNYGIISLLSDAAFEDPWSSFFMDMLSPLNLVKISQVRMQGLLLLVFAKYQHLPYIQIISTKSIPTGLYGYWGNKGGINICLKLYGYYVSIVNCHLPPHMYNNDQRLEHFDRILESLTFEGYDVPNILDHDLILWFGDMNFRIEDFGLLFVQECITKKRYKELWEKDQLFIAKKQDQLLREFQEGPLLFPPTYKFDRHSNNYDTSEKKRKPAWTDRILWRLKRQPAKANPSGFLLTQKDYVSHMTYSISDHKPVTGTFDLELNPLMSVPLITMMPEYLWTKENDMLINYTSTPEFLSSPWDWIGLYKVGMRHINDYVSYVWVGDNQVSRGNNPNQVYINISAIPDTEEQFLLCYYSNNLHSIVGISQPFKIPSGFFLREDTLSELEPQL", "length": 440, "header": "tr|A0A0G2K5K7-1|A0A0G2K5K7_RAT Computationally mapped isoform of Inositol-polyphosphate 5-phosphatase OS=Rattus norvegicus OX=10116 GN=Inpp5k PE=1 SV=2 CANONICAL=A0A0G2K2Z2-1" }, "locus": { "chromosome": "10", "start_pos": 60495585, "end_pos": 60477822, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000084496.2", "url": "https://www.ensembl.org/id/ENSRNOT00000084496.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000073462.2", "url": "https://www.ensembl.org/id/ENSRNOP00000073462.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-RNO-1660499", "name": "Synthesis of PIPs at the plasma membrane", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1660499", "resource": "Reactome", "description": "Synthesis of PIPs at the plasma membrane" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 35, "go_terms": [ { "name": "negative regulation of glucose transmembrane transport", "id": "GO:0010829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010829", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "negative regulation of insulin receptor signaling pathway", "id": "GO:0046627", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046627", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "dephosphorylation", "id": "GO:0016311", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016311", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "in utero embryonic development", "id": "GO:0001701", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001701", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "G protein-coupled receptor signaling pathway", "id": "GO:0007186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007186", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "cellular response to insulin stimulus", "id": "GO:0032869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032869", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "cellular response to cAMP", "id": "GO:0071320", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071320", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "protein localization to plasma membrane", "id": "GO:0072659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072659", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "negative regulation of protein phosphorylation", "id": "GO:0001933", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001933", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "negative regulation of protein kinase activity", "id": "GO:0006469", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006469", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "positive regulation of urine volume", "id": "GO:0035810", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035810", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "negative regulation of transcription, DNA-templated", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "cellular response to hormone stimulus", "id": "GO:0032870", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032870", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "glucose homeostasis", "id": "GO:0042593", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042593", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "positive regulation of transcription, DNA-templated", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "negative regulation of calcium ion transport", "id": "GO:0051926", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051926", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "response to insulin", "id": "GO:0032868", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032868", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "negative regulation of single stranded viral RNA replication via double stranded DNA intermediate", "id": "GO:0045869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045869", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "negative regulation of MAP kinase activity", "id": "GO:0043407", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043407", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "ruffle assembly", "id": "GO:0097178", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097178", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "regulation of glycogen biosynthetic process", "id": "GO:0005979", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005979", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "cellular response to tumor necrosis factor", "id": "GO:0071356", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071356", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "cellular response to epidermal growth factor stimulus", "id": "GO:0071364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071364", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "negative regulation of protein kinase B signaling", "id": "GO:0051898", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051898", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "negative regulation of stress fiber assembly", "id": "GO:0051497", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051497", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "negative regulation of peptidyl-serine phosphorylation", "id": "GO:0033137", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033137", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "negative regulation of peptidyl-threonine phosphorylation", "id": "GO:0010801", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010801", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "inositol phosphate dephosphorylation", "id": "GO:0046855", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046855", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "phosphatidylinositol dephosphorylation", "id": "GO:0046856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046856", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "negative regulation of dephosphorylation", "id": "GO:0035305", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035305", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "negative regulation by host of viral transcription", "id": "GO:0043922", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043922", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "negative regulation of protein targeting to membrane", "id": "GO:0090315", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090315", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "negative regulation of glycogen (starch) synthase activity", "id": "GO:2000466", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000466", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "negative regulation of glycogen biosynthetic process", "id": "GO:0045719", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045719", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "positive regulation of renal water transport", "id": "GO:2001153", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001153", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 11, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "neuron projection", "id": "GO:0043005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043005", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "ruffle membrane", "id": "GO:0032587", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032587", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "ruffle", "id": "GO:0001726", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001726", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "trans-Golgi network", "id": "GO:0005802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005802", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 10, "go_terms": [ { "name": "phosphatidylinositol phosphate 5-phosphatase activity", "id": "GO:0034595", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034595", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "vasopressin receptor activity", "id": "GO:0005000", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005000", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity", "id": "GO:0004439", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004439", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "inositol bisphosphate phosphatase activity", "id": "GO:0016312", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016312", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity", "id": "GO:0034485", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034485", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "phosphatidylinositol trisphosphate phosphatase activity", "id": "GO:0034594", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034594", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "inositol trisphosphate phosphatase activity", "id": "GO:0046030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046030", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "inositol-polyphosphate 5-phosphatase activity", "id": "GO:0004445", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004445", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "inositol-1,4,5-trisphosphate 5-phosphatase activity", "id": "GO:0052658", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052658", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity", "id": "GO:0052659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052659", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 345, "end_pos": 347, "annotation": "n_glycosylation_sequon" }, { "start_pos": 400, "end_pos": 402, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-RNO-1675949", "name": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P97573-1", "Q9JMC1-1", "A0A0G2K2Z2-1", "Q9WVR3-1" ], "evidence": [ { "id": "R-RNO-1675949", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1675949" } ] }, { "id": "R-RNO-1676177", "name": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9JMC1-1", "Q62910-1", "O55207-1", "A0A0G2K2Z2-1" ], "evidence": [ { "id": "R-RNO-1676177", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1676177" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A0G2K2Z2", "gene_name": "Inpp5k", "activity": [ { "ec_number": "3.1.3.56", "activity": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.", "evidence": [ { "id": "A0A0G2K2Z2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ] }, { "ec_number": "3.1.3.56", "activity": "", "evidence": [ { "id": "A0A0G2K2Z2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K2Z2" } ] } ] }, { "uniprot_ac": "O55207", "gene_name": "Synj2", "activity": [ { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "O55207", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55207" } ] }, { "ec_number": "3.1.3.36", "activity": "", "evidence": [ { "id": "O55207", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55207" } ] } ] }, { "uniprot_ac": "P97573", "gene_name": "Inpp5d", "activity": [ { "ec_number": "3.1.3.86", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.", "evidence": [ { "id": "P97573", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97573" } ] }, { "ec_number": "3.1.3.56", "activity": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.", "evidence": [ { "id": "P97573", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97573" } ] }, { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "P97573", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97573" } ] }, { "ec_number": "3.1.3.86", "activity": "", "evidence": [ { "id": "P97573", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97573" } ] } ] }, { "uniprot_ac": "Q62910", "gene_name": "Synj1", "activity": [ { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "Q62910", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62910" } ] }, { "ec_number": "3.1.3.36", "activity": "", "evidence": [ { "id": "Q62910", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62910" } ] } ] }, { "uniprot_ac": "Q9JMC1", "gene_name": "Inpp5j", "activity": [ { "ec_number": "3.1.3.56", "activity": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.", "evidence": [ { "id": "Q9JMC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JMC1" } ] }, { "ec_number": "3.1.3.56", "activity": "", "evidence": [ { "id": "Q9JMC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JMC1" } ] } ] }, { "uniprot_ac": "Q9WVR3", "gene_name": "Inppl1", "activity": [ { "ec_number": "3.1.3.86", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.", "evidence": [ { "id": "Q9WVR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WVR3" } ] }, { "ec_number": "3.1.3.86", "activity": "", "evidence": [ { "id": "Q9WVR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WVR3" } ] } ] } ], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ] }