{
    "uniprot_canonical_ac": "A0A0G2K048-1",
    "uniprot_ac": "A0A0G2K048",
    "uniprot_id": "A0A0G2K048_RAT",
    "mass": {
        "chemical_mass": 67109.0,
        "monoisotopic_mass": 67109.0
    },
    "refseq": {
        "ac": "NP_001041320",
        "name": "E3 ubiquitin-protein ligase DTX4 isoform 3 precursor",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041320"
    },
    "gene_names": [
        {
            "name": "Dtx4",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K048",
            "id": "A0A0G2K048"
        },
        {
            "name": "Dtx4",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041320",
            "id": "NP_001041320"
        },
        {
            "name": "LRRGT00037",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041320",
            "id": "NP_001041320"
        }
    ],
    "protein_names": [
        {
            "name": "E3 ubiquitin-protein ligase",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K048#names_and_taxonomy",
            "id": "A0A0G2K048"
        },
        {
            "name": "2.3.2.27",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K048#names_and_taxonomy",
            "id": "A0A0G2K048"
        },
        {
            "name": "E3 ubiquitin-protein ligase DTX4 isoform 3 precursor",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041320",
            "id": "NP_001041320"
        },
        {
            "name": "deltex 4 homolog; protein deltex-4; deltex homolog 4; E3 ubiquitin-protein ligase DTX4; deltex 4, E3 ubiquitin ligase",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041320",
            "id": "NP_001041320"
        }
    ],
    "function": [],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A0G2K048",
                    "url": "https://www.uniprot.org/uniprot/A0A0G2K048"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Dtx4",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K048",
            "locus": {
                "chromosome": "1",
                "start_pos": 228755866,
                "end_pos": 228732985,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000021086",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000021086"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000021086",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000021086",
            "database": "Bgee"
        },
        {
            "id": "cd09633",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09633",
            "database": "CDD"
        },
        {
            "id": "293774",
            "url": "https://www.ncbi.nlm.nih.gov/gene/293774",
            "database": "GeneID"
        },
        {
            "id": "IPR001841",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841",
            "database": "InterPro"
        },
        {
            "id": "IPR004170",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR004170",
            "database": "InterPro"
        },
        {
            "id": "IPR013083",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083",
            "database": "InterPro"
        },
        {
            "id": "IPR018123",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR018123",
            "database": "InterPro"
        },
        {
            "id": "IPR018957",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR018957",
            "database": "InterPro"
        },
        {
            "id": "IPR037197",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR037197",
            "database": "InterPro"
        },
        {
            "id": "IPR039396",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR039396",
            "database": "InterPro"
        },
        {
            "id": "IPR039398",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR039398",
            "database": "InterPro"
        },
        {
            "id": "IPR039399",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR039399",
            "database": "InterPro"
        },
        {
            "id": "rno:293774",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:293774",
            "database": "KEGG Pathway"
        },
        {
            "id": "EKQHPWV",
            "url": "https://omabrowser.org/oma/group/EKQHPWV/",
            "database": "OMA"
        },
        {
            "id": "600021at2759",
            "url": "http://www.orthodb.org/?query=600021at2759",
            "database": "OrthoDB"
        },
        {
            "id": "PTHR12622",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12622",
            "database": "PANTHER"
        },
        {
            "id": "PF00097",
            "url": "http://pfam.xfam.org/family/PF00097",
            "database": "Pfam"
        },
        {
            "id": "PF02825",
            "url": "http://pfam.xfam.org/family/PF02825",
            "database": "Pfam"
        },
        {
            "id": "PF18102",
            "url": "http://pfam.xfam.org/family/PF18102",
            "database": "Pfam"
        },
        {
            "id": "R-RNO-2122948",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2122948",
            "database": "Reactome"
        },
        {
            "id": "R-RNO-3134975",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3134975",
            "database": "Reactome"
        },
        {
            "id": "R-RNO-3270619",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3270619",
            "database": "Reactome"
        },
        {
            "id": "NP_001041320",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041320",
            "database": "RefSeq"
        },
        {
            "id": "1311767",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1311767",
            "database": "RGD"
        },
        {
            "id": "A0A0G2K048",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K048",
            "database": "UniProtKB"
        },
        {
            "id": "A0A0G2K048-1",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K048-1",
            "database": "UniProtKB"
        },
        {
            "id": "A0A8I6A316",
            "url": "https://www.uniprot.org/uniprot/A0A8I6A316",
            "database": "UniProtKB"
        },
        {
            "id": "A0A8I6A316-1",
            "url": "https://www.uniprot.org/uniprot/A0A8I6A316-1",
            "database": "UniProtKB"
        },
        {
            "id": "A0A8I6AQV0",
            "url": "https://www.uniprot.org/uniprot/A0A8I6AQV0",
            "database": "UniProtKB"
        },
        {
            "id": "A0A8I6AQV0-1",
            "url": "https://www.uniprot.org/uniprot/A0A8I6AQV0-1",
            "database": "UniProtKB"
        },
        {
            "id": "Q6TXG2",
            "url": "https://www.uniprot.org/uniprot/Q6TXG2",
            "database": "UniProtKB"
        },
        {
            "id": "Q6TXG2-1",
            "url": "https://www.uniprot.org/uniprot/Q6TXG2-1",
            "database": "UniProtKB"
        }
    ],
    "sequence": {
        "sequence": "MLLASAVVVWEWLNEHGRWRPYSPAVSHHIEAVVRAGPRAGGSVVLGQVDSRLAPYIIDLQSMNQFRQDTGTLRPVRRNYYDPSSAPGKGVVWEWENDNGSWTPYDMEVGITIQHAYEKQHPWIDLTSIGFSYIIDFSTMGQINRQTQRQRRVRRRLDLIYPMVTGTVPKAQSWPVSPGPATPSPAPPCSCPQCVLVMSVKAAVVHGSTGPLHPPAARKNIAPSGVGKLPQPPGPGAKPLDTTGTIRGPGKTAPSQVIRRQVSNTPAGVTVGSPASPQGSNRKTGRVALTTLNRSNLQRLAIAQSRVLIASGVPTVPVKNLNGSSPVNPALAGITGILMSAAGLPVCLTRPPKLVLHPPPVSKSEIKSIPGVSNTSRKTTKKQAKKGKTPEEVLKKYLQKVRHPPEEDCTICMERLTAPSGYKGPQPTVKPDLVGKLSKCGHIYHIYCLVAMYNNGNKDGSLQCPTCKTIYGVKTGTQPPGKMEYHLIPHSLPGHPDCKTIRIIYSIPPGIQGPEHPNPGKSFSARGFPRHCYLPDSEKGRKVLKLLLVAWDRRLIFAIGTSSTTGESDTVIWNEVHHKTEFGSNLTGHGYPDANYLDNVLAELAAQGISEDSTSQEKD",
        "length": 619,
        "header": "tr|A0A0G2K048-1|A0A0G2K048_RAT Isoform 1 of E3 ubiquitin-protein ligase  OS=Rattus norvegicus OX=10116 GN=Dtx4 PE=3 SV=2 CANONICAL=A0A0G2K048-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A0G2K048-1",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K048#A0A0G2K048-1",
            "sequence": {
                "sequence": "MLLASAVVVWEWLNEHGRWRPYSPAVSHHIEAVVRAGPRAGGSVVLGQVDSRLAPYIIDLQSMNQFRQDTGTLRPVRRNYYDPSSAPGKGVVWEWENDNGSWTPYDMEVGITIQHAYEKQHPWIDLTSIGFSYIIDFSTMGQINRQTQRQRRVRRRLDLIYPMVTGTVPKAQSWPVSPGPATPSPAPPCSCPQCVLVMSVKAAVVHGSTGPLHPPAARKNIAPSGVGKLPQPPGPGAKPLDTTGTIRGPGKTAPSQVIRRQVSNTPAGVTVGSPASPQGSNRKTGRVALTTLNRSNLQRLAIAQSRVLIASGVPTVPVKNLNGSSPVNPALAGITGILMSAAGLPVCLTRPPKLVLHPPPVSKSEIKSIPGVSNTSRKTTKKQAKKGKTPEEVLKKYLQKVRHPPEEDCTICMERLTAPSGYKGPQPTVKPDLVGKLSKCGHIYHIYCLVAMYNNGNKDGSLQCPTCKTIYGVKTGTQPPGKMEYHLIPHSLPGHPDCKTIRIIYSIPPGIQGPEHPNPGKSFSARGFPRHCYLPDSEKGRKVLKLLLVAWDRRLIFAIGTSSTTGESDTVIWNEVHHKTEFGSNLTGHGYPDANYLDNVLAELAAQGISEDSTSQEKD",
                "length": 619,
                "header": "tr|A0A0G2K048-1|A0A0G2K048_RAT Isoform 1 of E3 ubiquitin-protein ligase  OS=Rattus norvegicus OX=10116 GN=Dtx4 PE=3 SV=2 CANONICAL=A0A0G2K048-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 209491856,
                "end_pos": 209460823,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000083283.2",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000083283.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000071301.2",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000071301.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A8I6A316-1",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K048#A0A8I6A316-1",
            "sequence": {
                "sequence": "LYGLVFLLLVTSPVPTVPVKNLNGSSPVNPALAGITGILMSAAGLPVCLTRPPKLVLHPPPVSKSEIKSIPGVSNTSRKTTKKQAKKGKTPEEVLKKYLQKVRHPPEEDCTICMERLTAPSGYKGPQPTVKPDLVGKLSKCGHIYHIYCLVAMYNNGNKDGSLQCPTCKTIYGVKTGTQPPGKMEYHLIPHSLPGHPDCKTIRIIYSIPPGIQGPEHPNPGKSFSARGFPRHCYLPDSEKGRKVLKLLLVAWDRRLIFAIGTSSTTGESDTVIWNEVHHKTEFGSNLTGHGYPDANYLDNVLAELAAQGISEDSTSQEKD",
                "length": 320,
                "header": "tr|A0A8I6A316-1|A0A8I6A316_RAT Computationally mapped isoform of E3 ubiquitin-protein ligase  OS=Rattus norvegicus OX=10116 GN=Dtx4 PE=3 SV=1 CANONICAL=A0A0G2K048-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 209478098,
                "end_pos": 209460823,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000103725.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000103725.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000087356.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000087356.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A8I6AQV0-1",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K048#A0A8I6AQV0-1",
            "sequence": {
                "sequence": "MEIKTWIHRNWVPTVPVKNLNGSSPVNPALAGITGILMSAAGLPVCLTRPPKLVLHPPPVSKSEIKSIPGVSNTSRKTTKKQAKKGKTPEEVLKKYLQKVRHPPEEDCTICMERLTAPSGYKGPQPTVKPDLVGKLSKCGHIYHIYCLVAMYNNGNKDGSLQCPTCKTIYGVKTGTQPPGKMEYHLIPHSLPGHPDCKTIRIIYSIPPGIQGPEHPNPGKSFSARGFPRHCYLPDSEKGRKVLKLLLVAWDRRLIFAIGTSSTTGESDTVIWNEVHHKTEFGSNLTGHGYPDANYLDNVLAELAAQGISEDSTSQEKD",
                "length": 318,
                "header": "tr|A0A8I6AQV0-1|A0A8I6AQV0_RAT Computationally mapped isoform of E3 ubiquitin-protein ligase  OS=Rattus norvegicus OX=10116 GN=Dtx4 PE=3 SV=1 CANONICAL=A0A0G2K048-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 209480142,
                "end_pos": 209460823,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000101313.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000101313.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000097092.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000097092.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q6TXG2-1",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K048#Q6TXG2-1",
            "sequence": {
                "sequence": "MMMMVMMMMVVVVWVPTVPVKNLNGSSPVNPALAGITGILMSAAGLPVCLTRPPKLVLHPPPVSKSEIKSIPGVSNTSRKTTKKQAKKGKTPEEVLKKYLQKVRHPPEEDCTICMERLTAPSGYKGPQPTVKPDLVGKLSKCGHIYHIYCLVAMYNNGNKDGSLQCPTCKTIYGVKTGTQPPGKMEYHLIPHSLPGHPDCKTIRIIYSIPPGIQGPEHPNPGKSFSARGFPRHCYLPDSEKGRKVLKLLLVAWDRRLIFAIGTSSTTGESDTVIWNEVHHKTEFGSNLTGHGYPDANYLDNVLAELAAQGISEDSTSQEKD",
                "length": 321,
                "header": "tr|Q6TXG2-1|Q6TXG2_RAT Computationally mapped isoform of E3 ubiquitin-protein ligase  OS=Rattus norvegicus OX=10116 GN=Dtx4 PE=2 SV=1 CANONICAL=A0A0G2K048-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 209481073,
                "end_pos": 209460823,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000028626.7",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000028626.7"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000028626.5",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000028626.5"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [
        "enzyme"
    ],
    "publication": [
        {
            "title": "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.",
            "journal": "Briefings in bioinformatics",
            "date": "2011",
            "authors": "Gaudet P, Livstone MS, Lewis SE, Thomas PD",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001041320",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041320"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "21873635",
                    "url": "https://glygen.org/publication/PubMed/21873635"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "rno:293774",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:293774",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-RNO-2122948",
            "name": "Activated NOTCH1 Transmits Signal to the Nucleus",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2122948",
            "resource": "Reactome",
            "description": "Activated NOTCH1 Transmits Signal to the Nucleus"
        },
        {
            "id": "R-RNO-3134975",
            "name": "Regulation of innate immune responses to cytosolic DNA",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3134975",
            "resource": "Reactome",
            "description": "Regulation of innate immune responses to cytosolic DNA"
        },
        {
            "id": "R-RNO-3270619",
            "name": "IRF3-mediated induction of type I IFN",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3270619",
            "resource": "Reactome",
            "description": "IRF3-mediated induction of type I IFN"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q6PDK8-1",
            "protein_name": "E3 ubiquitin-protein ligase DTX4",
            "gene_name": "Dtx4",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MLLASAVVVWEWLNEHGRWRPYSPAVSHHIEAVVRAGPRAGGSVVLGQVDSRLAPYIIDLQSMNQFRQDTGTLRPVRRNYYDPSSAPGKGVVWEWENDNGSWTPYDMEVGITIQYAYEKQHPWIDLTSIGFSYIIDFSTMGQINRQTQRQRRVRRRLDLIYPMVTGTMPKTQSWPVSPGPATSSPAPPCSCPQCVLVMSVKAAVVHGGTGPPAVRKNMALSGVGKLPQPPGPGAKPLDTTGTIRGPGKTAPSQVIRRQVSNAPAGATVGSPASPQGSNRKTGRVALATLNRSNLQRLAIAQSRVLIASGVPTVPVKNLNGSSPVNPALAGITGILMSAAGLPVCLTRPPKLVLHPPPVSKSEIKSIPGVSNTSRKTTKKQAKKGKTPEEVLKKYLQKVRHPPEEDCTICMERLTAPSGYKGPQPTVKPDLVGKLSRCGHIYHIYCLVAMYNNGNKDGSLQCPTCKTIYGVKTGTQPPGKMEYHLIPHSLPGHPDCKTIRIIYSIPPGIQGPEHPNPGKSFSARGFPRHCYLPDSEKGRKVLKLLLVAWDRRLIFAIGTSSTTGESDTVIWNEVHHKTEFGSNLTGHGYPDANYLDNVLAELAAQGISEDSTSHEKD",
                "length": 616
            },
            "evidence": [
                {
                    "id": "41500765",
                    "url": "http://www.informatics.jax.org/homology/41500765",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "Q9Y2E6-1",
            "protein_name": "E3 ubiquitin-protein ligase DTX4",
            "gene_name": "DTX4",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MLLASAVVVWEWLNEHGRWRPYSPAVSHHIEAVVRAGPRAGGSVVLGQVDSRLAPYIIDLQSMNQFRQDTGTLRPVRRNYYDPSSAPGKGVVWEWENDNGSWTPYDMEVGITIQHAYEKQHPWIDLTSIGFSYVIDFNTMGQINRQTQRQRRVRRRLDLIYPMVTGTLPKAQSWPVSPGPATSPPMSPCSCPQCVLVMSVKAAVVNGSTGPLQLPVTRKNMPPPGVVKLPPLPGSGAKPLDSTGTIRGPLKTAPSQVIRRQASSMPTGTTMGSPASPPGPNSKTGRVALATLNRTNLQRLAIAQSRVLIASGVPTVPVKNLNGSSPVNPALAGITGILMSAAGLPVCLTRPPKLVLHPPPVSKSEIKSIPGVSNTSRKTTKKQAKKGKTPEEVLKKYLQKVRHPPDEDCTICMERLTAPSGYKGPQPTVKPDLVGKLSRCGHVYHIYCLVAMYNNGNKDGSLQCPTCKTIYGVKTGTQPPGKMEYHLIPHSLPGHPDCKTIRIIYSIPPGIQGPEHPNPGKSFSARGFPRHCYLPDSEKGRKVLKLLLVAWDRRLIFAIGTSSTTGESDTVIWNEVHHKTEFGSNLTGHGYPDANYLDNVLAELAAQGISEDSTAQEKD",
                "length": 619
            },
            "evidence": [
                {
                    "id": "41500765",
                    "url": "http://www.informatics.jax.org/homology/41500765",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 2,
                "go_terms": [
                    {
                        "name": "nucleoplasm",
                        "id": "GO:0005654",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K048",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K048"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "cytoplasm",
                        "id": "GO:0005737",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K048",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K048"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 2,
                "go_terms": [
                    {
                        "name": "Notch signaling pathway",
                        "id": "GO:0007219",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007219",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K048",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K048"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "protein ubiquitination",
                        "id": "GO:0016567",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K048",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K048"
                            }
                        ],
                        "pmid": "21873635"
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 3,
                "go_terms": [
                    {
                        "name": "metal ion binding",
                        "id": "GO:0046872",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K048",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K048"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ubiquitin protein ligase activity",
                        "id": "GO:0061630",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K048",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K048"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "zinc ion binding",
                        "id": "GO:0008270",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2K048",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2K048"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 293,
            "end_pos": 295,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 322,
            "end_pos": 324,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 374,
            "end_pos": 376,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 585,
            "end_pos": 587,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 99,
            "end_pos": 101,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [
        {
            "id": "R-RNO-1912357",
            "name": "ITCH ubiquitinates DTX",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "A0A0G2K048-1",
                "A0A8I5ZZU1-1",
                "A0A8I6A4D7-1",
                "G3V658-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-1912357",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1912357"
                }
            ]
        },
        {
            "id": "R-RNO-1980125",
            "name": "ITCH binds DTX",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "A0A0G2K048-1",
                "A0A8I5ZZU1-1",
                "A0A8I6A4D7-1",
                "G3V658-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-1980125",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1980125"
                }
            ]
        },
        {
            "id": "R-RNO-2396007",
            "name": "IRF3 is phosphorylated by TBK1",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytoplasmic vesicle membrane, cytosol",
            "input_participant_list": [],
            "output_participant_list": [
                "R-RNO-166258"
            ],
            "enzyme_list": [
                "A0A0G2K048-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-2396007",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2396007"
                }
            ]
        },
        {
            "id": "R-RNO-3249392",
            "name": "NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytoplasmic vesicle membrane, cytosol",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "A0A0G2K048-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-3249392",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3249392"
                }
            ]
        },
        {
            "id": "R-RNO-8948709",
            "name": "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "A0A0G2K048-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-8948709",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8948709"
                }
            ]
        }
    ],
    "reaction_participants": [
        {
            "participant_id": "R-RNO-166258",
            "participant_name": "phospho-Irf3 [cytosol]",
            "crossref": [
                {
                    "id": "ENSRNOT00000027786",
                    "database": "Ensembl",
                    "url": ""
                },
                {
                    "id": "XP_006229086.1",
                    "database": "RefSeq",
                    "url": ""
                },
                {
                    "id": "ENSRNOP00000027786",
                    "database": "Ensembl",
                    "url": ""
                },
                {
                    "id": "Q5XIB0",
                    "database": "UniProt",
                    "url": ""
                },
                {
                    "id": "XP_006229085.1",
                    "database": "RefSeq",
                    "url": ""
                },
                {
                    "id": "ENSRNOG00000043388",
                    "database": "Ensembl",
                    "url": ""
                },
                {
                    "id": "1549774",
                    "database": "RGD",
                    "url": ""
                },
                {
                    "id": "NP_001006970.1",
                    "database": "RefSeq",
                    "url": ""
                }
            ]
        }
    ],
    "reaction_enzymes": [
        {
            "uniprot_ac": "A0A0G2K048",
            "gene_name": "Dtx4",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "A0A0G2K048",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A0A0G2K048"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "A0A0G2K048",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A0A0G2K048"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "A0A8I5ZZU1",
            "gene_name": "Itch",
            "activity": [
                {
                    "ec_number": "2.3.2.26",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "A0A8I5ZZU1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A0A8I5ZZU1"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.26",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "A0A8I5ZZU1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A0A8I5ZZU1"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "A0A8I6A4D7",
            "gene_name": "Dtx1",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "A0A8I6A4D7",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A0A8I6A4D7"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "A0A8I6A4D7",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A0A8I6A4D7"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "G3V658",
            "gene_name": "Dtx2",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "G3V658",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/G3V658"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "G3V658",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/G3V658"
                        }
                    ]
                }
            ]
        }
    ],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        }
    ]
}