{ "uniprot_canonical_ac": "A0A0G2K047-1", "uniprot_ac": "A0A0G2K047", "uniprot_id": "ACSS3_RAT", "mass": { "chemical_mass": 74675.0, "monoisotopic_mass": 74675.0 }, "refseq": { "ac": "XP_006241364", "name": "acyl-CoA synthetase short-chain family member 3, mitochondrial isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006241364" }, "gene_names": [ { "name": "Acss3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2K047", "id": "A0A0G2K047" }, { "name": "Acss3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006241364", "id": "XP_006241364" }, { "name": "RGD1307051_predicted", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0G2K047", "id": "A0A0G2K047" }, { "name": "RGD1307051", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006241364", "id": "XP_006241364" }, { "name": "rCG_48886", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0G2K047", "id": "A0A0G2K047" } ], "protein_names": [ { "name": "Acyl-CoA synthetase short-chain family member 3, mitochondrial", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2K047#names_and_taxonomy", "id": "A0A0G2K047" }, { "name": "6.2.1.17", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0G2K047#names_and_taxonomy", "id": "A0A0G2K047" }, { "name": "6.2.1.1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0G2K047#names_and_taxonomy", "id": "A0A0G2K047" }, { "name": "Acetate--CoA ligase 3", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0G2K047#names_and_taxonomy", "id": "A0A0G2K047" }, { "name": "Acyl-CoA synthetase short-chain family member 3", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0G2K047#names_and_taxonomy", "id": "A0A0G2K047" }, { "name": "Propionate--CoA ligase", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0G2K047#names_and_taxonomy", "id": "A0A0G2K047" }, { "name": "acetate--CoA ligase 3; propionate--CoA ligase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101561", "id": "NP_001101561" }, { "name": "acyl-CoA synthetase short-chain family member 3, mitochondrial isoform X1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006241364", "id": "XP_006241364" }, { "name": "acyl-CoA synthetase short-chain family member 3, mitochondrial", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101561", "id": "NP_001101561" } ], "function": [ { "annotation": "Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:28003429). Propionate is the preferred substrate but can also utilize acetate and butyrate with a much lower affinity (PubMed:28003429).", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K047", "url": "https://www.uniprot.org/uniprot/A0A0G2K047#function" }, { "database": "PubMed", "id": "28003429", "url": "https://glygen.org/publication/PubMed/28003429" } ] }, { "annotation": "The results suggested that ACSS3 is a liver mitochondrial matrix enzyme with high affinity to propionic acid, and its expression level is upregulated under ketogenic conditions.", "evidence": [ { "database": "RefSeq", "id": "NP_001101561", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101561" }, { "database": "PubMed", "id": "28003429", "url": "https://glygen.org/publication/PubMed/28003429" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K047", "url": "https://www.uniprot.org/uniprot/A0A0G2K047" } ], "common_name": "Rat" } ], "gene": [ { "name": "Acss3", "url": "https://www.uniprot.org/uniprot/A0A0G2K047", "locus": { "chromosome": "7", "start_pos": 49250957, "end_pos": 49047013, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000004448", "url": "https://www.ensembl.org/id/ENSRNOG00000004448" } ] } } ], "crossref": [ { "id": "ENSRNOG00000004448", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000004448", "database": "Bgee" }, { "id": "6.2.1.17", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=6.2.1.17&UniProtAcc=A0A0G2K047", "database": "BRENDA" }, { "id": "314800", "url": "https://www.ncbi.nlm.nih.gov/gene/314800", "database": "GeneID" }, { "id": "A0A0G2K047", "url": "https://www.ebi.ac.uk/intact/interactors/id:A0A0G2K047*", "database": "IntAct" }, { "id": "IPR000873", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000873", "database": "InterPro" }, { "id": "IPR020845", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020845", "database": "InterPro" }, { "id": "IPR025110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025110", "database": "InterPro" }, { "id": "IPR032387", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032387", "database": "InterPro" }, { "id": "IPR042099", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042099", "database": "InterPro" }, { "id": "IPR045851", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045851", "database": "InterPro" }, { "id": "rno:314800", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:314800", "database": "KEGG Pathway" }, { "id": "YVFVMGR", "url": "https://omabrowser.org/oma/group/YVFVMGR/", "database": "OMA" }, { "id": "288915at2759", "url": "http://www.orthodb.org/?query=288915at2759", "database": "OrthoDB" }, { "id": "PF00501", "url": "http://pfam.xfam.org/family/PF00501", "database": "Pfam" }, { "id": "PF13193", "url": "http://pfam.xfam.org/family/PF13193", "database": "Pfam" }, { "id": "PF16177", "url": "http://pfam.xfam.org/family/PF16177", "database": "Pfam" }, { "id": "PR_A0A0G2K047", "url": "http://purl.obolibrary.org/obo/PR_A0A0G2K047", "database": "PRO" }, { "id": "R-RNO-77111", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-77111", "database": "Reactome" }, { "id": "NP_001101561", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101561", "database": "RefSeq" }, { "id": "XP_006241364", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006241364", "database": "RefSeq" }, { "id": "1307051", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1307051", "database": "RGD" }, { "id": "20373", "url": "https://www.rhea-db.org/rhea/20373", "database": "Rhea" }, { "id": "23176", "url": "https://www.rhea-db.org/rhea/23176", "database": "Rhea" }, { "id": "46172", "url": "https://www.rhea-db.org/rhea/46172", "database": "Rhea" }, { "id": "A0A0G2K047", "url": "https://www.uniprot.org/uniprot/A0A0G2K047", "database": "UniProtKB" }, { "id": "A0A0G2K047-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K047-1", "database": "UniProtKB" }, { "id": "D3ZGU2", "url": "https://www.uniprot.org/uniprot/D3ZGU2", "database": "UniProtKB" }, { "id": "D3ZGU2-1", "url": "https://www.uniprot.org/uniprot/D3ZGU2-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MKPSWLQCRKVTGAGTLGAPLPGSPSVRGAGVARRALVAGFGGRGCRALTTSSGGGEYKTHFAASVADPERFWGKAAEQISWYKPWTKTLENRYPPSTSWFVEGMLNICYNAIDRHIENGQGDKIAIIYDSPVTDTKATISYKEVLEQVSKLAGVLVKQGVKKGDTVVIYMPMIPQAIYAMLACARIGAIHSLIFGGFASKELSTRIDHVKPKVVVTASFGIEPGRKVEYMPLLEEALRIGQHKPDRLLIYNRPNMEKVPLMSGRDLDWEEEMAKAQSHDCVPVLSEHPLYILYTSGTTGLPKGVVRPTGGYAVMLNWTMSSIYGLKPGEVWWAASDLGWVVGHSYICYGPLLHGNTTVLYEGKPVGTPDAGAYFRVLAEHGVAALFTAPTAIRAIRQQDPGAALGKQYSLTRFKTLFVAGERCDVETLEWSKKVFRVPVLDHWWQTETGSPITASCIGLGNSKTPPPGQAGKCVPGYNVMILDDNMQKLKARSLGNIVVKLPLPPGAFSGLWKNQEAFKHLYFEKFPGYYDTMDAGYMDEEGYLYVMSRVDDVINVAGHRISAGAIEESVLSHGTVTDCAVVGKEDPLKGHVPLALCVLKKDVNATEEQVLEEIVKHVRQSIGPVAAFRNAVFVKQLPKTRSGKIPRSTLSALVNGKPYKVTPTIEDPSIFGHIEEVLKQAL", "length": 683, "header": "sp|A0A0G2K047-1|ACSS3_RAT Isoform 1 of Acyl-CoA synthetase short-chain family member 3, mitochondrial OS=Rattus norvegicus OX=10116 GN=Acss3 PE=1 SV=1 CANONICAL=A0A0G2K047-1" }, "isoforms": [ { "isoform_ac": "A0A0G2K047-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K047#A0A0G2K047-1", "sequence": { "sequence": "MKPSWLQCRKVTGAGTLGAPLPGSPSVRGAGVARRALVAGFGGRGCRALTTSSGGGEYKTHFAASVADPERFWGKAAEQISWYKPWTKTLENRYPPSTSWFVEGMLNICYNAIDRHIENGQGDKIAIIYDSPVTDTKATISYKEVLEQVSKLAGVLVKQGVKKGDTVVIYMPMIPQAIYAMLACARIGAIHSLIFGGFASKELSTRIDHVKPKVVVTASFGIEPGRKVEYMPLLEEALRIGQHKPDRLLIYNRPNMEKVPLMSGRDLDWEEEMAKAQSHDCVPVLSEHPLYILYTSGTTGLPKGVVRPTGGYAVMLNWTMSSIYGLKPGEVWWAASDLGWVVGHSYICYGPLLHGNTTVLYEGKPVGTPDAGAYFRVLAEHGVAALFTAPTAIRAIRQQDPGAALGKQYSLTRFKTLFVAGERCDVETLEWSKKVFRVPVLDHWWQTETGSPITASCIGLGNSKTPPPGQAGKCVPGYNVMILDDNMQKLKARSLGNIVVKLPLPPGAFSGLWKNQEAFKHLYFEKFPGYYDTMDAGYMDEEGYLYVMSRVDDVINVAGHRISAGAIEESVLSHGTVTDCAVVGKEDPLKGHVPLALCVLKKDVNATEEQVLEEIVKHVRQSIGPVAAFRNAVFVKQLPKTRSGKIPRSTLSALVNGKPYKVTPTIEDPSIFGHIEEVLKQAL", "length": 683, "header": "sp|A0A0G2K047-1|ACSS3_RAT Isoform 1 of Acyl-CoA synthetase short-chain family member 3, mitochondrial OS=Rattus norvegicus OX=10116 GN=Acss3 PE=1 SV=1 CANONICAL=A0A0G2K047-1" }, "locus": { "chromosome": "7", "start_pos": 42450143, "end_pos": 42243920, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000082141", "url": "https://www.ensembl.org/id/ENSRNOT00000082141" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000071300", "url": "https://www.ensembl.org/id/ENSRNOP00000071300" } ] } }, { "isoform_ac": "D3ZGU2-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K047#D3ZGU2-1", "sequence": { "sequence": "MKPSWLQCRKVTGAGTLGAPLPGSPSVRGAGVARRALVAGFGGRGCRALTTSSGGGEYKTHFAASVADPERFWGKAAEQISWYKPWTKTLENRYPPSTSWFVEGMLNICYNAIDRHIENGQGDKIAIIYDSPVTDTKATISYKEVLEQVSKLAGVLVKQGVKKGDTVVIYMPMIPQAIYAMLACARIGAIHSLIFGGFASKELSTRIDHVKPKVVVTASFGIEPGRKVEYMPLLEEALRIGQHKPDRLLIYNRPNMEKVPLMSGRDLDWEEEMAKAQSHDCVPVLSEHPLYILYTSGTTGLPKGVVRPTGGYAVMLNWTMSSIYGLKPGEVWWAASDLGWVVGHSYICYGPLLHGNTTVLYEGKPVGTPDAGAYFRVLAEHGVAALFTAPTAIRAIRQQDPGAALGKQYSLTRFKTLFVAGERCDVETLEWSKKVFRVPVLDHWWQTETGSPITASCIGLGNSKTPPPGQAGKCVPGYNGSYLSYNSVMSLTSPAMKK", "length": 498, "header": "tr|D3ZGU2-1|D3ZGU2_RAT Computationally mapped isoform of Acyl-CoA synthetase short-chain family member 3, mitochondrial OS=Rattus norvegicus OX=10116 GN=Acss3 PE=1 SV=1 CANONICAL=A0A0G2K047-1" }, "locus": { "chromosome": "7", "start_pos": 42450143, "end_pos": 42269693, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000066975.2", "url": "https://www.ensembl.org/id/ENSRNOT00000066975.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000062459.1", "url": "https://www.ensembl.org/id/ENSRNOP00000062459.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Molecular cloning of rat acss3 and characterization of mammalian propionyl-CoA synthetase in the liver mitochondrial matrix.", "journal": "J. Biochem.", "date": "2017", "authors": "Takahashi Y., Yamashita H., Yoshimura Y., Araki A., Maruta H.", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K047", "url": "https://www.uniprot.org/uniprot/A0A0G2K047" }, { "database": "RefSeq", "id": "NP_001101561", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101561" } ], "reference": [ { "type": "PubMed", "id": "28003429", "url": "https://glygen.org/publication/PubMed/28003429" } ] } ], "pathway": [ { "id": "rno:314800", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:314800", "resource": "KEGG Pathway" }, { "id": "R-RNO-77111", "name": "Synthesis of Ketone Bodies", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-77111", "resource": "Reactome", "description": "Synthesis of Ketone Bodies" } ], "orthologs": [ { "uniprot_canonical_ac": "Q14DH7-1", "protein_name": "Acyl-CoA synthetase short-chain family member 3, mitochondrial", "gene_name": "Acss3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKPSWLQCRKVTGAGTLGAPLPGSPSVRGAAVTRRALVAGFGGRGCRALTTGSGGEYKTHFAASVADPERFWGKAAEQISWYKPWTKTLESRYPPSTSWFVEGMLNICYNAIDRHIENGQGDKIAIIYDSPVTDTKATISYKEVLEQVSKLAGVLVKQGVKKGDTVVIYMPMIPQAIYTMLACARIGAIHSLIFGGFASKELSTRIDHAKPKVVVTASFGIEPGRKVEYIPLLEEALRIGQHRPDRVLIYSRPNMEKVPLMSGRDLDWEEEMAKAQSHDCVPVLSEHPLYILYTSGTTGLPKGVVRPTGGYAVMLNWTMSSIYGLKPGEVWWAASDLGWVVGHSYICYGPLLHGNTTVLYEGKPVGTPDAGAYFRVLAEHGVAALFTAPTAIRAIRQQDPGAALGKQYSLTRFKTLFVAGERCDVETLEWSKKVFRVPVLDHWWQTETGSPITASCIGLGNSKTPPPGQAGKCVPGYNVMILDDNMQKLKARSLGNIVVKLPLPPGAFSGLWKNQEAFKHLYFEKFPGYYDTMDAGYMDEEGYLYVMSRVDDVINVAGHRISAGAIEESVLSHGTVADCAVVGKEDPLKGHVPLALCVLKKDVNASEEQVLEEIVKHVRQSIGPVAAFRNAVFVKQLPKTRSGKIPRSTLSALVNGKPYKVTPTIEDPSIFGHIEEVLKQAV", "length": 682 }, "evidence": [ { "id": "41490942", "url": "http://www.informatics.jax.org/homology/41490942", "database": "MGI" }, { "id": "A0A0G2K047", "url": "https://omabrowser.org/oma/group/A0A0G2K047/", "database": "OMA" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H6R3-1", "protein_name": "Acyl-CoA synthetase short-chain family member 3, mitochondrial", "gene_name": "ACSS3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKPSWLQCRKVTSAGGLGGPLPGSSPARGAGAALRALVVPGPRGGLGGRGCRALSSGSGSEYKTHFAASVTDPERFWGKAAEQISWYKPWTKTLENKHSPSTRWFVEGMLNICYNAVDRHIENGKGDKIAIIYDSPVTNTKATFTYKEVLEQVSKLAGVLVKHGIKKGDTVVIYMPMIPQAMYTMLACARIGAIHSLIFGGFASKELSSRIDHVKPKVVVTASFGIEPGRRVEYVPLVEEALKIGQHKPDKILIYNRPNMEAVPLAPGRDLDWDEEMAKAQSHDCVPVLSEHPLYILYTSGTTGLPKGVIRPTGGYAVMLHWSMSSIYGLQPGEVWWAASDLGWVVGHSYICYGPLLHGNTTVLYEGKPVGTPDAGAYFRVLAEHGVAALFTAPTAIRAIRQQDPGAALGKQYSLTRFKTLFVAGERCDVETLEWSKNVFRVPVLDHWWQTETGSPITASCVGLGNSKTPPPGQAGKSVPGYNVMILDDNMQKLKARCLGNIVVKLPLPPGAFSGLWKNQEAFKHLYFEKFPGYYDTMDAGYMDEEGYLYVMSRVDDVINVAGHRISAGAIEESILSHGTVADCAVVGKEDPLKGHVPLALCVLRKDINATEEQVLEEIVKHVRQNIGPVAAFRNAVFVKQLPKTRSGKIPRSALSAIVNGKPYKITSTIEDPSIFGHVEEMLKQA", "length": 686 }, "evidence": [ { "id": "41490942", "url": "http://www.informatics.jax.org/homology/41490942", "database": "MGI" }, { "id": "A0A0G2K047", "url": "https://omabrowser.org/oma/group/A0A0G2K047/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K047", "url": "https://www.uniprot.org/uniprot/A0A0G2K047" } ], "pmid": "" }, { "name": "butyrate-CoA ligase activity", "id": "GO:0047760", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047760", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K047", "url": "https://www.uniprot.org/uniprot/A0A0G2K047" } ], "pmid": "28003429" }, { "name": "acetate-CoA ligase activity", "id": "GO:0003987", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003987", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K047", "url": "https://www.uniprot.org/uniprot/A0A0G2K047" } ], "pmid": "28003429" }, { "name": "propionate-CoA ligase activity", "id": "GO:0050218", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050218", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K047", "url": "https://www.uniprot.org/uniprot/A0A0G2K047" } ], "pmid": "28003429" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K047", "url": "https://www.uniprot.org/uniprot/A0A0G2K047" } ], "pmid": "28003429" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "lipid metabolic process", "id": "GO:0006629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006629", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K047", "url": "https://www.uniprot.org/uniprot/A0A0G2K047" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 317, "end_pos": 319, "annotation": "n_glycosylation_sequon" }, { "start_pos": 356, "end_pos": 358, "annotation": "n_glycosylation_sequon" }, { "start_pos": 605, "end_pos": 607, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "20373", "name": "", "equation": "ATP + CoA + propanoate = AMP + diphosphate + propanoyl-CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0G2K047-1", "Q6SKG1-1", "D3ZZN3-1", "A0A8I6GJ11-1", "Q9NR19-1", "Q53FZ2-1", "Q9H6R3-1", "Q9NUB1-1", "Q3UNX5-1", "Q14DH7-1", "Q9QXG4-1", "Q99NB1-1" ], "evidence": [ { "id": "20373", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/20373" } ] }, { "id": "23176", "name": "", "equation": "acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0G2K047-1", "D3ZZN3-1", "A0A8I6GJ11-1", "Q9NR19-1", "Q9H6R3-1", "Q9NUB1-1", "Q14689-1", "Q14DH7-1", "Q9QXG4-1", "Q99NB1-1", "Q8BWT5-1", "Q9VP61-1" ], "evidence": [ { "id": "23176", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/23176" } ] }, { "id": "46172", "name": "", "equation": "ATP + butanoate + CoA = AMP + butanoyl-CoA + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0G2K047-1", "O70490-1", "Q6SKG1-1", "Q08AH3-1", "Q53FZ2-1", "Q9H6R3-1", "Q08AH1-1", "Q68CK6-1", "Q3UNX5-1", "Q8K0L3-1", "Q14DH7-1", "Q91VA0-1" ], "evidence": [ { "id": "46172", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/46172" } ] }, { "id": "R-RNO-8875071", "name": "ACSS3 ligates CoA to CH3COO-", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [ "R-ALL-113593", "R-ALL-113539" ], "output_participant_list": [], "enzyme_list": [ "A0A0G2K047-1" ], "evidence": [ { "id": "R-RNO-8875071", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8875071" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-113539", "participant_name": "CH3COO- [mitochondrial matrix]", "crossref": [ { "id": "C00033", "database": "COMPOUND", "url": "" }, { "id": "30089", "database": "ChEBI", "url": "" }, { "id": "C00033", "database": "COMPOUND", "url": "" }, { "id": "30089", "database": "ChEBI", "url": "" }, { "id": "C00033", "database": "COMPOUND", "url": "" }, { "id": "30089", "database": "ChEBI", "url": "" }, { "id": "C00033", "database": "COMPOUND", "url": "" }, { "id": "30089", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-113593", "participant_name": "ATP [mitochondrial matrix]", "crossref": [ { "id": "C00002", "database": "COMPOUND", "url": "" }, { "id": "30616", "database": "ChEBI", "url": "" }, { "id": "000004261765", "database": "ZINC", "url": "" }, { "id": "C00002", "database": "COMPOUND", "url": "" }, { "id": "30616", "database": "ChEBI", "url": "" }, { "id": "000004261765", "database": "ZINC", "url": "" }, { "id": "C00002", "database": "COMPOUND", "url": "" }, { "id": "30616", "database": "ChEBI", "url": "" }, { "id": "000004261765", "database": "ZINC", "url": "" }, { "id": "C00002", "database": "COMPOUND", "url": "" }, { "id": "30616", "database": "ChEBI", "url": "" }, { "id": "000004261765", "database": "ZINC", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A0G2K047", "gene_name": "Acss3", "activity": [ { "ec_number": "6.2.1.1", "activity": "acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "A0A0G2K047", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K047" } ] }, { "ec_number": "6.2.1.17", "activity": "ATP + CoA + propanoate = AMP + diphosphate + propanoyl-CoA.", "evidence": [ { "id": "A0A0G2K047", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K047" } ] }, { "ec_number": "6.2.1.1", "activity": "", "evidence": [ { "id": "A0A0G2K047", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K047" } ] } ] }, { "uniprot_ac": "A0A8I6GJ11", "gene_name": "Acss2", "activity": [ { "ec_number": "6.2.1.17", "activity": "ATP + CoA + propanoate = AMP + diphosphate + propanoyl-CoA.", "evidence": [ { "id": "A0A8I6GJ11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GJ11" } ] }, { "ec_number": "6.2.1.17", "activity": "", "evidence": [ { "id": "A0A8I6GJ11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GJ11" } ] } ] }, { "uniprot_ac": "D3ZZN3", "gene_name": "Acss1", "activity": [ { "ec_number": "6.2.1.1", "activity": "acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "D3ZZN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZZN3" } ] }, { "ec_number": "6.2.1.1", "activity": "", "evidence": [ { "id": "D3ZZN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZZN3" } ] } ] }, { "uniprot_ac": "O70490", "gene_name": "Acsm2", "activity": [ { "ec_number": "6.2.1.2", "activity": "a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O70490", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70490" } ] }, { "ec_number": "6.2.1.25", "activity": "ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate.", "evidence": [ { "id": "O70490", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70490" } ] }, { "ec_number": "6.2.1.2", "activity": "", "evidence": [ { "id": "O70490", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70490" } ] } ] }, { "uniprot_ac": "Q08AH1", "gene_name": "ACSM1", "activity": [ { "ec_number": "6.2.1.2", "activity": "a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q08AH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08AH1" } ] }, { "ec_number": "6.2.1.25", "activity": "ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate.", "evidence": [ { "id": "Q08AH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08AH1" } ] }, { "ec_number": "6.2.1.2", "activity": "", "evidence": [ { "id": "Q08AH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08AH1" } ] } ] }, { "uniprot_ac": "Q08AH3", "gene_name": "ACSM2A", "activity": [ { "ec_number": "6.2.1.2", "activity": "a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q08AH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08AH3" } ] }, { "ec_number": "6.2.1.25", "activity": "ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate.", "evidence": [ { "id": "Q08AH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08AH3" } ] }, { "ec_number": "6.2.1.2", "activity": "", "evidence": [ { "id": "Q08AH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08AH3" } ] } ] }, { "uniprot_ac": "Q14689", "gene_name": "DIP2A", "activity": [ { "ec_number": "6.2.1.1", "activity": "acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q14689", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14689" } ] }, { "ec_number": "6.2.1.1", "activity": "", "evidence": [ { "id": "Q14689", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14689" } ] } ] }, { "uniprot_ac": "Q14DH7", "gene_name": "Acss3", "activity": [ { "ec_number": "6.2.1.1", "activity": "acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q14DH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14DH7" } ] }, { "ec_number": "6.2.1.17", "activity": "ATP + CoA + propanoate = AMP + diphosphate + propanoyl-CoA.", "evidence": [ { "id": "Q14DH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14DH7" } ] }, { "ec_number": "6.2.1.1", "activity": "", "evidence": [ { "id": "Q14DH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14DH7" } ] } ] }, { "uniprot_ac": "Q3UNX5", "gene_name": "Acsm3", "activity": [ { "ec_number": "6.2.1.2", "activity": "a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q3UNX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UNX5" } ] }, { "ec_number": "6.2.1.17", "activity": "ATP + CoA + propanoate = AMP + diphosphate + propanoyl-CoA.", "evidence": [ { "id": "Q3UNX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UNX5" } ] }, { "ec_number": "6.2.1.2", "activity": "", "evidence": [ { "id": "Q3UNX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UNX5" } ] } ] }, { "uniprot_ac": "Q53FZ2", "gene_name": "ACSM3", "activity": [ { "ec_number": "6.2.1.2", "activity": "a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q53FZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q53FZ2" } ] }, { "ec_number": "6.2.1.17", "activity": "ATP + CoA + propanoate = AMP + diphosphate + propanoyl-CoA.", "evidence": [ { "id": "Q53FZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q53FZ2" } ] }, { "ec_number": "6.2.1.2", "activity": "", "evidence": [ { "id": "Q53FZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q53FZ2" } ] } ] }, { "uniprot_ac": "Q68CK6", "gene_name": "ACSM2B", "activity": [ { "ec_number": "6.2.1.2", "activity": "a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q68CK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q68CK6" } ] }, { "ec_number": "6.2.1.25", "activity": "ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate.", "evidence": [ { "id": "Q68CK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q68CK6" } ] }, { "ec_number": "6.2.1.2", "activity": "", "evidence": [ { "id": "Q68CK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q68CK6" } ] } ] }, { "uniprot_ac": "Q6SKG1", "gene_name": "Acsm3", "activity": [ { "ec_number": "6.2.1.2", "activity": "a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q6SKG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6SKG1" } ] }, { "ec_number": "6.2.1.17", "activity": "ATP + CoA + propanoate = AMP + diphosphate + propanoyl-CoA.", "evidence": [ { "id": "Q6SKG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6SKG1" } ] }, { "ec_number": "6.2.1.2", "activity": "", "evidence": [ { "id": "Q6SKG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6SKG1" } ] } ] }, { "uniprot_ac": "Q8BWT5", "gene_name": "Dip2a", "activity": [ { "ec_number": "6.2.1.1", "activity": "acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q8BWT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BWT5" } ] }, { "ec_number": "6.2.1.1", "activity": "", "evidence": [ { "id": "Q8BWT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BWT5" } ] } ] }, { "uniprot_ac": "Q8K0L3", "gene_name": "Acsm2", "activity": [ { "ec_number": "6.2.1.2", "activity": "a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q8K0L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K0L3" } ] }, { "ec_number": "6.2.1.25", "activity": "ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate.", "evidence": [ { "id": "Q8K0L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K0L3" } ] }, { "ec_number": "6.2.1.2", "activity": "", "evidence": [ { "id": "Q8K0L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K0L3" } ] } ] }, { "uniprot_ac": "Q91VA0", "gene_name": "Acsm1", "activity": [ { "ec_number": "6.2.1.2", "activity": "a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q91VA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91VA0" } ] }, { "ec_number": "6.2.1.25", "activity": "ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate.", "evidence": [ { "id": "Q91VA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91VA0" } ] }, { "ec_number": "6.2.1.2", "activity": "", "evidence": [ { "id": "Q91VA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91VA0" } ] } ] }, { "uniprot_ac": "Q99NB1", "gene_name": "Acss1", "activity": [ { "ec_number": "6.2.1.1", "activity": "acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q99NB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99NB1" } ] }, { "ec_number": "6.2.1.17", "activity": "ATP + CoA + propanoate = AMP + diphosphate + propanoyl-CoA.", "evidence": [ { "id": "Q99NB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99NB1" } ] }, { "ec_number": "6.2.1.1", "activity": "", "evidence": [ { "id": "Q99NB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99NB1" } ] } ] }, { "uniprot_ac": "Q9H6R3", "gene_name": "ACSS3", "activity": [ { "ec_number": "6.2.1.1", "activity": "acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q9H6R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H6R3" } ] }, { "ec_number": "6.2.1.17", "activity": "ATP + CoA + propanoate = AMP + diphosphate + propanoyl-CoA.", "evidence": [ { "id": "Q9H6R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H6R3" } ] }, { "ec_number": "6.2.1.1", "activity": "", "evidence": [ { "id": "Q9H6R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H6R3" } ] }, { "ec_number": "6.2.1.17", "activity": "", "evidence": [ { "id": "Q9H6R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H6R3" } ] } ] }, { "uniprot_ac": "Q9NR19", "gene_name": "ACSS2", "activity": [ { "ec_number": "6.2.1.1", "activity": "acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q9NR19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NR19" } ] }, { "ec_number": "6.2.1.17", "activity": "ATP + CoA + propanoate = AMP + diphosphate + propanoyl-CoA.", "evidence": [ { "id": "Q9NR19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NR19" } ] }, { "ec_number": "6.2.1.1", "activity": "", "evidence": [ { "id": "Q9NR19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NR19" } ] } ] }, { "uniprot_ac": "Q9NUB1", "gene_name": "ACSS1", "activity": [ { "ec_number": "6.2.1.1", "activity": "acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q9NUB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NUB1" } ] }, { "ec_number": "6.2.1.17", "activity": "ATP + CoA + propanoate = AMP + diphosphate + propanoyl-CoA.", "evidence": [ { "id": "Q9NUB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NUB1" } ] }, { "ec_number": "6.2.1.1", "activity": "", "evidence": [ { "id": "Q9NUB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NUB1" } ] } ] }, { "uniprot_ac": "Q9QXG4", "gene_name": "Acss2", "activity": [ { "ec_number": "6.2.1.1", "activity": "acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q9QXG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QXG4" } ] }, { "ec_number": "6.2.1.17", "activity": "ATP + CoA + propanoate = AMP + diphosphate + propanoyl-CoA.", "evidence": [ { "id": "Q9QXG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QXG4" } ] }, { "ec_number": "6.2.1.1", "activity": "", "evidence": [ { "id": "Q9QXG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QXG4" } ] }, { "ec_number": "6.2.1.17", "activity": "", "evidence": [ { "id": "Q9QXG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QXG4" } ] } ] }, { "uniprot_ac": "Q9VP61", "gene_name": "AcCoAS", "activity": [ { "ec_number": "6.2.1.1", "activity": "acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q9VP61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VP61" } ] }, { "ec_number": "6.2.1.1", "activity": "", "evidence": [ { "id": "Q9VP61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VP61" } ] } ] } ], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ] }