{
    "uniprot_canonical_ac": "A0A0G2JYA3-1",
    "uniprot_ac": "A0A0G2JYA3",
    "uniprot_id": "A0A0G2JYA3_RAT",
    "mass": {
        "chemical_mass": 59836.0,
        "monoisotopic_mass": 59836.0
    },
    "refseq": {
        "ac": "XP_006234982",
        "name": "signal peptide peptidase-like 2A isoform X1",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006234982"
    },
    "gene_names": [
        {
            "name": "Sppl2a",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JYA3",
            "id": "A0A0G2JYA3"
        },
        {
            "name": "RGD1563001_predicted",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JYA3",
            "id": "A0A0G2JYA3"
        },
        {
            "name": "RGD1563001",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006234982",
            "id": "XP_006234982"
        },
        {
            "name": "Sppl2a",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006234982",
            "id": "XP_006234982"
        },
        {
            "name": "rCG_26538",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JYA3",
            "id": "A0A0G2JYA3"
        }
    ],
    "protein_names": [
        {
            "name": "Signal peptide peptidase-like 2A",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JYA3#names_and_taxonomy",
            "id": "A0A0G2JYA3"
        },
        {
            "name": "signal peptide peptidase-like 2A isoform X1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006234982",
            "id": "XP_006234982"
        },
        {
            "name": "signal peptide peptidase-like 2A precursor",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101240",
            "id": "NP_001101240"
        }
    ],
    "function": [],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A0G2JYA3",
                    "url": "https://www.uniprot.org/uniprot/A0A0G2JYA3"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Sppl2a",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JYA3",
            "locus": {
                "chromosome": "3",
                "start_pos": 119405453,
                "end_pos": 119361655,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000011652",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000011652"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000011652",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000011652",
            "database": "Bgee"
        },
        {
            "id": "3.4.23.B24",
            "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.4.23.B24&UniProtAcc=A0A0G2JYA3",
            "database": "BRENDA"
        },
        {
            "id": "CHEMBL4105913",
            "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL4105913",
            "database": "ChEMBL"
        },
        {
            "id": "311401",
            "url": "https://www.ncbi.nlm.nih.gov/gene/311401",
            "database": "GeneID"
        },
        {
            "id": "IPR003137",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR003137",
            "database": "InterPro"
        },
        {
            "id": "IPR006639",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR006639",
            "database": "InterPro"
        },
        {
            "id": "IPR007369",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR007369",
            "database": "InterPro"
        },
        {
            "id": "rno:311401",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:311401",
            "database": "KEGG Pathway"
        },
        {
            "id": "LSKDYCM",
            "url": "https://omabrowser.org/oma/group/LSKDYCM/",
            "database": "OMA"
        },
        {
            "id": "535101at2759",
            "url": "http://www.orthodb.org/?query=535101at2759",
            "database": "OrthoDB"
        },
        {
            "id": "PTHR12174",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12174",
            "database": "PANTHER"
        },
        {
            "id": "PF02225",
            "url": "http://pfam.xfam.org/family/PF02225",
            "database": "Pfam"
        },
        {
            "id": "PF04258",
            "url": "http://pfam.xfam.org/family/PF04258",
            "database": "Pfam"
        },
        {
            "id": "R-RNO-5357905",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5357905",
            "database": "Reactome"
        },
        {
            "id": "NP_001101240",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101240",
            "database": "RefSeq"
        },
        {
            "id": "XP_006234982",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006234982",
            "database": "RefSeq"
        },
        {
            "id": "1563001",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1563001",
            "database": "RGD"
        },
        {
            "id": "A0A0G2JYA3",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JYA3",
            "database": "UniProtKB"
        },
        {
            "id": "A0A0G2JYA3-1",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JYA3-1",
            "database": "UniProtKB"
        },
        {
            "id": "D3ZNG3",
            "url": "https://www.uniprot.org/uniprot/D3ZNG3",
            "database": "UniProtKB"
        },
        {
            "id": "D3ZNG3-1",
            "url": "https://www.uniprot.org/uniprot/D3ZNG3-1",
            "database": "UniProtKB"
        }
    ],
    "sequence": {
        "sequence": "MGLLHSLHAPAAALLWSCLLGLSAAQEAILHASANGVSSLSKDYCMYYNNNWTRLPSSLENATSLSLMNLTGTPLCHLSDIPPDGIKNKAVVVHWGPCHFLEKAKIAQEGGAAALLIANNSVLIPSSRNKSAFQNVTILIAVITQKDFNDMKETLGDDITVKMYSPSWPNFDYTLVVIFVIAVFTVALGGYWSGLIELESMKAVEDAEDREARKKKEDYLTFSPLTVVLFVVICCVMIVLLYFFYKWLVYVMIAIFCIASATSLYNCLAALIHRMPCGQCTILCCGKNIKVSLIFLSGLCISVAVVWAVFRNEDRWAWILQDILGIAFCLNLIKTMKLPNFMSCVILLGLLLIYDVFFVFITPFITKNGESIMVELAAGPFENAEKNDGNFVEATALHSAPHEKLPVVIRVPKLMDYSVMSVCSVPVSVLGFGDIIVPGLLIAYCRRFDVQTGSSIYYISSTIAYAVGMIITFVVLMVMKTGQPALLYLVPCTLITASIVAWSRKEMKKFWKGSSYQVMDYLDYSTNEENPAATDEQIVQQ",
        "length": 541,
        "header": "tr|A0A0G2JYA3-1|A0A0G2JYA3_RAT Isoform 1 of Signal peptide peptidase-like 2A  OS=Rattus norvegicus OX=10116 GN=Sppl2a PE=3 SV=2 CANONICAL=A0A0G2JYA3-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A0G2JYA3-1",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JYA3#A0A0G2JYA3-1",
            "sequence": {
                "sequence": "MGLLHSLHAPAAALLWSCLLGLSAAQEAILHASANGVSSLSKDYCMYYNNNWTRLPSSLENATSLSLMNLTGTPLCHLSDIPPDGIKNKAVVVHWGPCHFLEKAKIAQEGGAAALLIANNSVLIPSSRNKSAFQNVTILIAVITQKDFNDMKETLGDDITVKMYSPSWPNFDYTLVVIFVIAVFTVALGGYWSGLIELESMKAVEDAEDREARKKKEDYLTFSPLTVVLFVVICCVMIVLLYFFYKWLVYVMIAIFCIASATSLYNCLAALIHRMPCGQCTILCCGKNIKVSLIFLSGLCISVAVVWAVFRNEDRWAWILQDILGIAFCLNLIKTMKLPNFMSCVILLGLLLIYDVFFVFITPFITKNGESIMVELAAGPFENAEKNDGNFVEATALHSAPHEKLPVVIRVPKLMDYSVMSVCSVPVSVLGFGDIIVPGLLIAYCRRFDVQTGSSIYYISSTIAYAVGMIITFVVLMVMKTGQPALLYLVPCTLITASIVAWSRKEMKKFWKGSSYQVMDYLDYSTNEENPAATDEQIVQQ",
                "length": 541,
                "header": "tr|A0A0G2JYA3-1|A0A0G2JYA3_RAT Isoform 1 of Signal peptide peptidase-like 2A  OS=Rattus norvegicus OX=10116 GN=Sppl2a PE=3 SV=2 CANONICAL=A0A0G2JYA3-1"
            },
            "locus": {
                "chromosome": "3",
                "start_pos": 114193187,
                "end_pos": 114152786,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000090355.2",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000090355.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000070578.2",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000070578.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "D3ZNG3-1",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JYA3#D3ZNG3-1",
            "sequence": {
                "sequence": "MGLLHSLHAPAAALLWSCLLGLSAAQEAILHASANGVSSLSKDYCMYYNNNWTRLPSSLENATSLSLMNLTGTPLCHLSDIPPDGIKNKAVVVHWGPCHFLEKAKIAQEGGAAALLIANNSVLIPSSRNKSAFQNVTILIAVITQKDFNDMKETLGDDITVKMYSPSWPNFDYTLVVIFVIAVFTVALGGYWSGLIELESMKAVEDAEDREARKKKEDYLTFSPLTVVLFVVICCVMIVLLYFFYKWLVYVMIAIFCIASATSLYNCLAALIHRMPCGQCTILCCGKNIKVSLIFLSGLCISVAVVWAVFRNEDRWAWILQDILGIAFCLNLIKTMKLPNFMSCVILLGLLLIYDVFFVFITPFITKNGESIMVELAAGPFENAEKLPVVIRVPKLMDYSVMSVCSVPVSVLGFGDIIVPGLLIAYCRRFDVQTGSSIYYISSTIAYAVGMIITFVVLMVMKTGQPALLYLVPCTLITASIVAWSRKEMKKFWKGSSYQVMDYLDYSTNEENPAATDEQIVQQ",
                "length": 523,
                "header": "tr|D3ZNG3-1|A0A0G2JYA3_RAT Computationally mapped isoform of Signal peptide peptidase-like 2A  OS=Rattus norvegicus OX=10116 GN=Sppl2a PE=3 SV=3 CANONICAL=A0A0G2JYA3-1"
            },
            "locus": {
                "chromosome": "3",
                "start_pos": 114193187,
                "end_pos": 114152786,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000015568.7",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000015568.7"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000015568.6",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000015568.6"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [],
    "pathway": [
        {
            "id": "rno:311401",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:311401",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-RNO-5357905",
            "name": "Regulation of TNFR1 signaling",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5357905",
            "resource": "Reactome",
            "description": "Regulation of TNFR1 signaling"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q8TCT8-1",
            "protein_name": "Signal peptide peptidase-like 2A",
            "gene_name": "SPPL2A",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MGPQRRLSPAGAALLWGFLLQLTAAQEAILHASGNGTTKDYCMLYNPYWTALPSTLENATSISLMNLTSTPLCNLSDIPPVGIKSKAVVVPWGSCHFLEKARIAQKGGAEAMLVVNNSVLFPPSGNRSEFPDVKILIAFISYKDFRDMNQTLGDNITVKMYSPSWPNFDYTMVVIFVIAVFTVALGGYWSGLVELENLKAVTTEDREMRKKKEEYLTFSPLTVVIFVVICCVMMVLLYFFYKWLVYVMIAIFCIASAMSLYNCLAALIHKIPYGQCTIACRGKNMEVRLIFLSGLCIAVAVVWAVFRNEDRWAWILQDILGIAFCLNLIKTLKLPNFKSCVILLGLLLLYDVFFVFITPFITKNGESIMVELAAGPFGNNEKLPVVIRVPKLIYFSVMSVCLMPVSILGFGDIIVPGLLIAYCRRFDVQTGSSYIYYVSSTVAYAIGMILTFVVLVLMKKGQPALLYLVPCTLITASVVAWRRKEMKKFWKGNSYQMMDHLDCATNEENPVISGEQIVQQ",
                "length": 520
            },
            "evidence": [
                {
                    "id": "41505890",
                    "url": "http://www.informatics.jax.org/homology/41505890",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9JJF9-1",
            "protein_name": "Signal peptide peptidase-like 2A",
            "gene_name": "Sppl2a",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MGLLHSLHAPAAALLWSCLLGLAAAQEAILHASTNGVSSLSKDYCMYYNNNWTRLPSSLENATSLSLMNLTGTALCHLSDIPPDGIRNKAVVVHWGPCHFLEKARIAQEGGAAALLIANNSVLIPSSRNKSTFQNVTVLIAVITQKDFKDMKETLGDDITVKMYSPSWPNFDYTLVVIFVIAVFTVALGGYWSGLIELENMKSVEDAEDRETRKKKDDYLTFSPLTVVVFVVICCIMIVLLYFFYRWLVYVMIAIFCIASSMSLYNCLSALIHRMPCGQCTILCCGKNIKVSLIFLSGLCISVAVVWAVFRNEDRWAWILQDILGIAFCLNLIKTMKLPNFMSCVILLGLLLIYDVFFVFITPFITKNGESIMVELAAGPFENAEKLPVVIRVPKLMGYSVMSVCSVPVSVLGFGDIIVPGLLIAYCRRFDVQTGSSIYYISSTIAYAVGMIITFVVLMVMKTGQPALLYLVPCTLITVSVVAWSRKEMKKFWKGSSYQVMDHLDYSTNEENPVTTDEQIVQQ",
                "length": 523
            },
            "evidence": [
                {
                    "id": "41505890",
                    "url": "http://www.informatics.jax.org/homology/41505890",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 8,
                "go_terms": [
                    {
                        "name": "integral component of cytoplasmic side of endoplasmic reticulum membrane",
                        "id": "GO:0071458",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071458",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JYA3",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JYA3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "plasma membrane",
                        "id": "GO:0005886",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JYA3",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JYA3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "membrane",
                        "id": "GO:0016020",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JYA3",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JYA3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "lysosomal membrane",
                        "id": "GO:0005765",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JYA3",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JYA3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "late endosome membrane",
                        "id": "GO:0031902",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031902",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JYA3",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JYA3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "integral component of lumenal side of endoplasmic reticulum membrane",
                        "id": "GO:0071556",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071556",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JYA3",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JYA3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "late endosome",
                        "id": "GO:0005770",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005770",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JYA3",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JYA3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "Golgi-associated vesicle membrane",
                        "id": "GO:0030660",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030660",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JYA3",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JYA3"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 4,
                "go_terms": [
                    {
                        "name": "membrane protein ectodomain proteolysis",
                        "id": "GO:0006509",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006509",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JYA3",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JYA3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of immune response",
                        "id": "GO:0050776",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050776",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JYA3",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JYA3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "membrane protein intracellular domain proteolysis",
                        "id": "GO:0031293",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031293",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JYA3",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JYA3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "membrane protein proteolysis",
                        "id": "GO:0033619",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033619",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JYA3",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JYA3"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 2,
                "go_terms": [
                    {
                        "name": "protein homodimerization activity",
                        "id": "GO:0042803",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JYA3",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JYA3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "aspartic endopeptidase activity, intramembrane cleaving",
                        "id": "GO:0042500",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042500",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JYA3",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JYA3"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 119,
            "end_pos": 121,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 129,
            "end_pos": 131,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 135,
            "end_pos": 137,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 51,
            "end_pos": 53,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 61,
            "end_pos": 63,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 69,
            "end_pos": 71,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        }
    ]
}