{ "uniprot_canonical_ac": "A0A0G2JXM2-1", "uniprot_ac": "A0A0G2JXM2", "uniprot_id": "A0A0G2JXM2_RAT", "mass": { "chemical_mass": 80578.0, "monoisotopic_mass": 80578.0 }, "refseq": { "ac": "NP_001101580", "name": "cyclin-T1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101580" }, "gene_names": [ { "name": "Ccnt1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2JXM2", "id": "A0A0G2JXM2" }, { "name": "Ccnt1_predicted", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0G2JXM2", "id": "A0A0G2JXM2" }, { "name": "Ccnt1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101580", "id": "NP_001101580" }, { "name": "rCG_50579", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0G2JXM2", "id": "A0A0G2JXM2" } ], "protein_names": [ { "name": "Cyclin-T1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2JXM2#names_and_taxonomy", "id": "A0A0G2JXM2" }, { "name": "cyclin-T1-like", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101580", "id": "NP_001101580" }, { "name": "cyclin-T1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101580", "id": "NP_001101580" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JXM2", "url": "https://www.uniprot.org/uniprot/A0A0G2JXM2" } ], "common_name": "Rat" } ], "gene": [ { "name": "Ccnt1", "url": "https://www.uniprot.org/uniprot/A0A0G2JXM2", "locus": { "chromosome": "7", "start_pos": 140245723, "end_pos": 140219551, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000053054", "url": "https://www.ensembl.org/id/ENSRNOG00000053054" } ] } } ], "crossref": [ { "id": "ENSRNOG00000053054", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000053054", "database": "Bgee" }, { "id": "ENSRNOG00000055738", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000055738", "database": "Bgee" }, { "id": "cd00043", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00043", "database": "CDD" }, { "id": "315291", "url": "https://www.ncbi.nlm.nih.gov/gene/315291", "database": "GeneID" }, { "id": "IPR006671", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006671", "database": "InterPro" }, { "id": "IPR013763", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013763", "database": "InterPro" }, { "id": "IPR028863", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028863", "database": "InterPro" }, { "id": "IPR036915", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036915", "database": "InterPro" }, { "id": "IPR043198", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043198", "database": "InterPro" }, { "id": "rno:315291", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:315291", "database": "KEGG Pathway" }, { "id": "PSMFEYR", "url": "https://omabrowser.org/oma/group/PSMFEYR/", "database": "OMA" }, { "id": "VKREYAS", "url": "https://omabrowser.org/oma/group/VKREYAS/", "database": "OMA" }, { "id": "1437076at2759", "url": "http://www.orthodb.org/?query=1437076at2759", "database": "OrthoDB" }, { "id": "PTHR10026", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10026", "database": "PANTHER" }, { "id": "PTHR10026:SF42", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10026:SF42", "database": "PANTHER" }, { "id": "PF00134", "url": "http://pfam.xfam.org/family/PF00134", "database": "Pfam" }, { "id": "R-RNO-112382", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-112382", "database": "Reactome" }, { "id": "R-RNO-2173796", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2173796", "database": "Reactome" }, { "id": "R-RNO-674695", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-674695", "database": "Reactome" }, { "id": "R-RNO-6796648", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6796648", "database": "Reactome" }, { "id": "R-RNO-6807505", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6807505", "database": "Reactome" }, { "id": "R-RNO-75955", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-75955", "database": "Reactome" }, { "id": "R-RNO-9018519", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9018519", "database": "Reactome" }, { "id": "NP_001101580", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101580", "database": "RefSeq" }, { "id": "1311151", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1311151", "database": "RGD" }, { "id": "A0A0G2JXM2", "url": "https://www.uniprot.org/uniprot/A0A0G2JXM2", "database": "UniProtKB" }, { "id": "A0A0G2JXM2-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JXM2-1", "database": "UniProtKB" }, { "id": "A0A8I6G622", "url": "https://www.uniprot.org/uniprot/A0A8I6G622", "database": "UniProtKB" }, { "id": "A0A8I6G622-1", "url": "https://www.uniprot.org/uniprot/A0A8I6G622-1", "database": "UniProtKB" }, { "id": "D3ZC98", "url": "https://www.uniprot.org/uniprot/D3ZC98", "database": "UniProtKB" }, { "id": "D3ZC98-1", "url": "https://www.uniprot.org/uniprot/D3ZC98-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MEGERKNNNKRWYFTREQLENSPSRRFGVDSDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFHRYSMAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPSRLKRIRNWRAYQAAMKTKPDDRGADENTSEQTILNMISQTSSDTTIAGLMSMSAASTGAVPSLPASEESSSSLTSVDMLQGERWLSSQPPFKLEASQGHRTSENLALIGVDHSLQHDGSNAFVSQKQTSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHDSHSSVILKMPIEGSENPERPFLDKADKSALKMRLPVAGGDKAASSKPEEIKMRIKVHSAGDKHNSVEDSVAKSREHKEKQRTHPSNHHHHHNHHSHKHSHLQLPVGPVSKRPSDPKHSSQTSTLAHKTYSLSSTLSSSSSTRKRGPPEETGAAVFDHPAKIAKSTKSSSLNFPFPPLPTMTQLPGHSSDTSGLPFSQPSCKTRVPHVKLDKGPPGANGHNTTQSIDYQDTVNMLHSLLSAQGVQPTQPPAFEFVHSYGEYMNPRAAGISRSGNTDKPRPPPLPSEPPPPLPPLPK", "length": 724, "header": "tr|A0A0G2JXM2-1|A0A0G2JXM2_RAT Isoform 1 of Cyclin-T1 OS=Rattus norvegicus OX=10116 GN=Ccnt1 PE=1 SV=2 CANONICAL=A0A0G2JXM2-1" }, "isoforms": [ { "isoform_ac": "A0A0G2JXM2-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JXM2#A0A0G2JXM2-1", "sequence": { "sequence": "MEGERKNNNKRWYFTREQLENSPSRRFGVDSDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFHRYSMAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPSRLKRIRNWRAYQAAMKTKPDDRGADENTSEQTILNMISQTSSDTTIAGLMSMSAASTGAVPSLPASEESSSSLTSVDMLQGERWLSSQPPFKLEASQGHRTSENLALIGVDHSLQHDGSNAFVSQKQTSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHDSHSSVILKMPIEGSENPERPFLDKADKSALKMRLPVAGGDKAASSKPEEIKMRIKVHSAGDKHNSVEDSVAKSREHKEKQRTHPSNHHHHHNHHSHKHSHLQLPVGPVSKRPSDPKHSSQTSTLAHKTYSLSSTLSSSSSTRKRGPPEETGAAVFDHPAKIAKSTKSSSLNFPFPPLPTMTQLPGHSSDTSGLPFSQPSCKTRVPHVKLDKGPPGANGHNTTQSIDYQDTVNMLHSLLSAQGVQPTQPPAFEFVHSYGEYMNPRAAGISRSGNTDKPRPPPLPSEPPPPLPPLPK", "length": 724, "header": "tr|A0A0G2JXM2-1|A0A0G2JXM2_RAT Isoform 1 of Cyclin-T1 OS=Rattus norvegicus OX=10116 GN=Ccnt1 PE=1 SV=2 CANONICAL=A0A0G2JXM2-1" }, "locus": { "chromosome": "7", "start_pos": 129717820, "end_pos": 129691648, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000077672.2", "url": "https://www.ensembl.org/id/ENSRNOT00000077672.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000070328.2", "url": "https://www.ensembl.org/id/ENSRNOP00000070328.2" } ] } }, { "isoform_ac": "A0A8I6G622-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JXM2#A0A8I6G622-1", "sequence": { "sequence": "MEGERKNNNKRWYFTREQLENSPSRRFGVDSDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFHRYSMAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRDCTMSQTGKGTESQLL", "length": 181, "header": "tr|A0A8I6G622-1|A0A0G2JXM2_RAT Computationally mapped isoform of Cyclin-T1 OS=Rattus norvegicus OX=10116 GN=Ccnt1 PE=1 SV=1 CANONICAL=A0A0G2JXM2-1" }, "locus": { "chromosome": "7", "start_pos": 129717820, "end_pos": 129699369, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000110064.1", "url": "https://www.ensembl.org/id/ENSRNOT00000110064.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000081516.1", "url": "https://www.ensembl.org/id/ENSRNOP00000081516.1" } ] } }, { "isoform_ac": "D3ZC98-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JXM2#D3ZC98-1", "sequence": { "sequence": "MEGERKNNNKRWYFTREQLENSPSRRFGVDSDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFHRYSMAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACAYQAAMKTKPDDRGADENTSEQTILNMISQTSSDTTIAGLMSMSAASTGAVPSLPASEESSSSLTSVDMLQGERWLSSQPPFKLEASQGHRTSENLALIGVDHSLQHDGSNAFVSQKQTSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHDSHSSVILKMPIEGSENPERPFLDKADKSALKMRLPVAGGDKAASSKPEEIKMRIKVHSAGDKHNSVEDSVAKSREHKEKQRTHPSNHHHHHNHHSHKHSHLQLPVGPVSKRPSDPKHSSQTSTLAHKTYSLSSTLSSSSSTRKRGPPEETGAAVFDHPAKIAKSTKSSSLNFPFPPLPTMTQLPGHSSDTSGLPFSQPSCKTRVPHVKLDKGPPGANGHNTTQSIDYQDTVNMLHSLLSAQGVQPTQPPAFEFVHSYGEYMNPRAAGISRSGNTDKPRPPPLPSEPPPPLPPLPK", "length": 663, "header": "tr|D3ZC98-1|D3ZC98_RAT Computationally mapped isoform of Cyclin-T1 OS=Rattus norvegicus OX=10116 GN=Ccnt1 PE=1 SV=1 CANONICAL=A0A0G2JXM2-1" }, "locus": { "chromosome": "7", "start_pos": 129717820, "end_pos": 129691648, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000088999.2", "url": "https://www.ensembl.org/id/ENSRNOT00000088999.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000073281.1", "url": "https://www.ensembl.org/id/ENSRNOP00000073281.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "The human I-mfa domain-containing protein, HIC, interacts with cyclin T1 and modulates P-TEFb-dependent transcription.", "journal": "Molecular and cellular biology", "date": "2003", "authors": "Young TM, Wang Q, Pe'ery T, Mathews MB", "evidence": [ { "database": "RefSeq", "id": "NP_001101580", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101580" } ], "reference": [ { "type": "PubMed", "id": "12944466", "url": "https://glygen.org/publication/PubMed/12944466" } ] }, { "title": "Activation of cardiac Cdk9 represses PGC-1 and confers a predisposition to heart failure.", "journal": "The EMBO journal", "date": "2004", "authors": "Sano M, Wang SC, Shirai M, Scaglia F, Xie M, Sakai S, Tanaka T, Kulkarni PA, Barger PM, Youker KA, Taffet GE, Hamamori Y, Michael LH, Craigen WJ, Schneider MD", "evidence": [ { "database": "RefSeq", "id": "NP_001101580", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101580" } ], "reference": [ { "type": "PubMed", "id": "15297879", "url": "https://glygen.org/publication/PubMed/15297879" } ] }, { "title": "Transcriptional activity and substrate recognition of cyclin T2 from P-TEFb.", "journal": "Gene", "date": "2004", "authors": "Kurosu T, Zhang F, Peterlin BM", "evidence": [ { "database": "RefSeq", "id": "NP_001101580", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101580" } ], "reference": [ { "type": "PubMed", "id": "15563843", "url": "https://glygen.org/publication/PubMed/15563843" } ] }, { "title": "Multiple functions of Ldb1 required for beta-globin activation during erythroid differentiation.", "journal": "Blood", "date": "2010", "authors": "Song SH, Kim A, Ragoczy T, Bender MA, Groudine M, Dean A", "evidence": [ { "database": "RefSeq", "id": "NP_001101580", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101580" } ], "reference": [ { "type": "PubMed", "id": "20570862", "url": "https://glygen.org/publication/PubMed/20570862" } ] }, { "title": "Protective effect of berberine on antioxidant enzymes and positive transcription elongation factor b expression in diabetic rat liver.", "journal": "Fitoterapia", "date": "2011", "authors": "Zhou JY, Zhou SW", "evidence": [ { "database": "RefSeq", "id": "NP_001101580", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101580" } ], "reference": [ { "type": "PubMed", "id": "20828602", "url": "https://glygen.org/publication/PubMed/20828602" } ] }, { "title": "Cyclin K-containing kinase complexes maintain self-renewal in murine embryonic stem cells.", "journal": "The Journal of biological chemistry", "date": "2012", "authors": "Dai Q, Lei T, Zhao C, Zhong J, Tang YZ, Chen B, Yang J, Li C, Wang S, Song X, Li L, Li Q", "evidence": [ { "database": "RefSeq", "id": "NP_001101580", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101580" } ], "reference": [ { "type": "PubMed", "id": "22547058", "url": "https://glygen.org/publication/PubMed/22547058" } ] }, { "title": "Identification of multiple cyclin subunits of human P-TEFb.", "journal": "Genes & development", "date": "1998", "authors": "Peng J, Zhu Y, Milton JT, Price DH", "evidence": [ { "database": "RefSeq", "id": "NP_001101580", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101580" } ], "reference": [ { "type": "PubMed", "id": "9499409", "url": "https://glygen.org/publication/PubMed/9499409" } ] } ], "pathway": [ { "id": "rno:315291", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:315291", "resource": "KEGG Pathway" }, { "id": "R-RNO-112382", "name": "Formation of RNA Pol II elongation complex", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-112382", "resource": "Reactome", "description": "Formation of RNA Pol II elongation complex" }, { "id": "R-RNO-2173796", "name": "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2173796", "resource": "Reactome", "description": "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription" }, { "id": "R-RNO-674695", "name": "RNA Polymerase II Pre-transcription Events", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-674695", "resource": "Reactome", "description": "RNA Polymerase II Pre-transcription Events" }, { "id": "R-RNO-6796648", "name": "TP53 Regulates Transcription of DNA Repair Genes", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6796648", "resource": "Reactome", "description": "TP53 Regulates Transcription of DNA Repair Genes" }, { "id": "R-RNO-6807505", "name": "RNA polymerase II transcribes snRNA genes", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6807505", "resource": "Reactome", "description": "RNA polymerase II transcribes snRNA genes" }, { "id": "R-RNO-75955", "name": "RNA Polymerase II Transcription Elongation", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-75955", "resource": "Reactome", "description": "RNA Polymerase II Transcription Elongation" }, { "id": "R-RNO-9018519", "name": "Estrogen-dependent gene expression", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9018519", "resource": "Reactome", "description": "Estrogen-dependent gene expression" } ], "orthologs": [ { "uniprot_canonical_ac": "O60563-1", "protein_name": "Cyclin-T1", "gene_name": "CCNT1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK", "length": 726 }, "evidence": [ { "id": "41500159", "url": "http://www.informatics.jax.org/homology/41500159", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q9QWV9-1", "protein_name": "Cyclin-T1", "gene_name": "Ccnt1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEGERKNNNKRWYFTREQLENSPSRRFGVDSDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFHRYSMAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPSRLKRIRNWRAYQAAMKTKPDDRGADENTSEQTILNMISQTSSDTTIAGLMSMSTASTSAVPSLPSSEESSSSLTSVDMLQGERWLSSQPPFKLEAAQGHRTSESLALIGVDHSLQQDGSSAFGSQKQASKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHDSHSSVILKMPIESSENPERPFLDKADKSALKMRLPVASGDKAVSSKPEEIKMRIKVHSAGDKHNSIEDSVTKSREHKEKQRTHPSNHHHHHNHHSHRHSHLQLPAGPVSKRPSDPKHSSQTSTLAHKTYSLSSTLSSSSSTRKRGPPEETGAAVFDHPAKIAKSTKSSLNFPFPPLPTMTQLPGHSSDTSGLPFSQPSCKTRVPHMKLDKGPPGANGHNATQSIDYQDTVNMLHSLLSAQGVQPTQAPAFEFVHSYGEYMNPRAGAISSRSGTTDKPRPPPLPSEPPPPLPPLPK", "length": 724 }, "evidence": [ { "id": "41500159", "url": "http://www.informatics.jax.org/homology/41500159", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 10, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JXM2", "url": "https://www.uniprot.org/uniprot/A0A0G2JXM2" } ], "pmid": "" }, { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JXM2", "url": "https://www.uniprot.org/uniprot/A0A0G2JXM2" } ], "pmid": "" }, { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JXM2", "url": "https://www.uniprot.org/uniprot/A0A0G2JXM2" } ], "pmid": "" }, { "name": "transcription cis-regulatory region binding", "id": "GO:0000976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000976", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JXM2", "url": "https://www.uniprot.org/uniprot/A0A0G2JXM2" } ], "pmid": "" }, { "name": "RNA polymerase binding", "id": "GO:0070063", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070063", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JXM2", "url": "https://www.uniprot.org/uniprot/A0A0G2JXM2" } ], "pmid": "" }, { "name": "snRNA binding", "id": "GO:0017069", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017069", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JXM2", "url": "https://www.uniprot.org/uniprot/A0A0G2JXM2" } ], "pmid": "" }, { "name": "7SK snRNA binding", "id": "GO:0097322", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097322", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JXM2", "url": "https://www.uniprot.org/uniprot/A0A0G2JXM2" } ], "pmid": "" }, { "name": "cyclin-dependent protein serine/threonine kinase regulator activity", "id": "GO:0016538", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016538", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JXM2", "url": "https://www.uniprot.org/uniprot/A0A0G2JXM2" } ], "pmid": "21873635" }, { "name": "cyclin-dependent protein serine/threonine kinase activator activity", "id": "GO:0061575", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061575", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JXM2", "url": "https://www.uniprot.org/uniprot/A0A0G2JXM2" } ], "pmid": "21873635" }, { "name": "DNA-binding transcription factor binding", "id": "GO:0140297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140297", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JXM2", "url": "https://www.uniprot.org/uniprot/A0A0G2JXM2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JXM2", "url": "https://www.uniprot.org/uniprot/A0A0G2JXM2" } ], "pmid": "" }, { "name": "cyclin/CDK positive transcription elongation factor complex", "id": "GO:0008024", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008024", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JXM2", "url": "https://www.uniprot.org/uniprot/A0A0G2JXM2" } ], "pmid": "" }, { "name": "P-TEFb complex", "id": "GO:0070691", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070691", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JXM2", "url": "https://www.uniprot.org/uniprot/A0A0G2JXM2" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JXM2", "url": "https://www.uniprot.org/uniprot/A0A0G2JXM2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 11, "go_terms": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JXM2", "url": "https://www.uniprot.org/uniprot/A0A0G2JXM2" } ], "pmid": "21873635" }, { "name": "protein phosphorylation", "id": "GO:0006468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006468", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JXM2", "url": "https://www.uniprot.org/uniprot/A0A0G2JXM2" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JXM2", "url": "https://www.uniprot.org/uniprot/A0A0G2JXM2" } ], "pmid": "" }, { "name": "response to xenobiotic stimulus", "id": "GO:0009410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009410", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JXM2", "url": "https://www.uniprot.org/uniprot/A0A0G2JXM2" } ], "pmid": "20828602" }, { "name": "positive regulation by host of viral transcription", "id": "GO:0043923", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043923", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JXM2", "url": "https://www.uniprot.org/uniprot/A0A0G2JXM2" } ], "pmid": "" }, { "name": "positive regulation of transcription elongation from RNA polymerase II promoter", "id": "GO:0032968", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032968", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JXM2", "url": "https://www.uniprot.org/uniprot/A0A0G2JXM2" } ], "pmid": "" }, { "name": "negative regulation of mRNA polyadenylation", "id": "GO:1900364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900364", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JXM2", "url": "https://www.uniprot.org/uniprot/A0A0G2JXM2" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription, elongation", "id": "GO:0032786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032786", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JXM2", "url": "https://www.uniprot.org/uniprot/A0A0G2JXM2" } ], "pmid": "21873635" }, { "name": "phosphorylation of RNA polymerase II C-terminal domain serine 5 residues involved in positive regulation of transcription elongation from RNA polymerase II promoter", "id": "GO:1903654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903654", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JXM2", "url": "https://www.uniprot.org/uniprot/A0A0G2JXM2" } ], "pmid": "" }, { "name": "phosphorylation of RNA polymerase II C-terminal domain serine 2 residues involved in positive regulation of transcription elongation from RNA polymerase II promoter", "id": "GO:1903655", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903655", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JXM2", "url": "https://www.uniprot.org/uniprot/A0A0G2JXM2" } ], "pmid": "" }, { "name": "transcription, DNA-templated", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JXM2", "url": "https://www.uniprot.org/uniprot/A0A0G2JXM2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 277, "end_pos": 279, "annotation": "n_glycosylation_sequon" }, { "start_pos": 53, "end_pos": 55, "annotation": "n_glycosylation_sequon" }, { "start_pos": 649, "end_pos": 651, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ] }