{
    "uniprot_canonical_ac": "A0A0G2JWH3-1",
    "uniprot_ac": "A0A0G2JWH3",
    "uniprot_id": "A0A0G2JWH3_RAT",
    "mass": {
        "chemical_mass": 155590.0,
        "monoisotopic_mass": 155590.0
    },
    "refseq": {},
    "gene_names": [
        {
            "name": "Ncapd2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JWH3",
            "id": "A0A0G2JWH3"
        }
    ],
    "protein_names": [
        {
            "name": "Condensin complex subunit 1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JWH3#names_and_taxonomy",
            "id": "A0A0G2JWH3"
        }
    ],
    "function": [
        {
            "annotation": "Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A0G2JWH3",
                    "url": "https://www.uniprot.org/uniprot/A0A0G2JWH3#function"
                },
                {
                    "database": "PubMed",
                    "id": "PIRNR017127",
                    "url": "https://glygen.org/publication/PubMed/PIRNR017127"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:0070296",
            "recommended_name": {
                "id": "DOID:0070296",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0070296",
                "name": "primary autosomal recessive microcephaly",
                "description": "A primary microcephaly characterized by microcephaly present at birth, where the brain is small but has normal architecture, and nonprogressive mental retardation that has_material_basis_in an autosomal recessive mutation."
            },
            "synonyms": [
                {
                    "id": "DOID:0070296",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0070296",
                    "name": "MCPH",
                    "description": ""
                },
                {
                    "id": "MONDO:0009617",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009617",
                    "name": "microcephaly 1, primary, autosomal recessive",
                    "description": "Any autosomal recessive primary microcephaly in which the cause of the disease is a mutation in the MCPH1 gene."
                },
                {
                    "id": "MONDO:0009617",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009617",
                    "name": "premature chromosome condensation with microcephaly and mental retardation",
                    "description": ""
                },
                {
                    "id": "MONDO:0009617",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009617",
                    "name": "autosomal recessive primary microcephaly caused by mutation in MCPH1",
                    "description": ""
                },
                {
                    "id": "MONDO:0009617",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009617",
                    "name": "MCPH1 autosomal recessive primary microcephaly",
                    "description": ""
                },
                {
                    "id": "MONDO:0009617",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009617",
                    "name": "premature chromosome condensation syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0009617",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009617",
                    "name": "PCC syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0009617",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009617",
                    "name": "microcephaly 1, primary, autosomal recessive; MCPH1",
                    "description": ""
                },
                {
                    "id": "MONDO:0009617",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009617",
                    "name": "microcephaly 1, primary, autosomal recessive",
                    "description": ""
                },
                {
                    "id": "MONDO:0009617",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009617",
                    "name": "MCPH1",
                    "description": ""
                },
                {
                    "id": "MIM:251200",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/251200",
                    "name": "Microcephaly 1, primary, autosomal recessive",
                    "description": "Microcephaly 1, primary, autosomal recessive"
                }
            ],
            "evidence": [
                {
                    "id": "0070296",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070296"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A0G2JWH3",
                    "url": "https://www.uniprot.org/uniprot/A0A0G2JWH3"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Ncapd2",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JWH3",
            "locus": {
                "chromosome": "4",
                "start_pos": 157704596,
                "end_pos": 157683077,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000055300",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000055300"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000055300",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000055300",
            "database": "Bgee"
        },
        {
            "id": "IPR007673",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR007673",
            "database": "InterPro"
        },
        {
            "id": "IPR011989",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989",
            "database": "InterPro"
        },
        {
            "id": "IPR016024",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024",
            "database": "InterPro"
        },
        {
            "id": "IPR024324",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR024324",
            "database": "InterPro"
        },
        {
            "id": "IPR026971",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR026971",
            "database": "InterPro"
        },
        {
            "id": "IPR032682",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR032682",
            "database": "InterPro"
        },
        {
            "id": "RNCVLQI",
            "url": "https://omabrowser.org/oma/group/RNCVLQI/",
            "database": "OMA"
        },
        {
            "id": "PTHR14222",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14222",
            "database": "PANTHER"
        },
        {
            "id": "PTHR14222:SF2",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14222:SF2",
            "database": "PANTHER"
        },
        {
            "id": "PF12717",
            "url": "http://pfam.xfam.org/family/PF12717",
            "database": "Pfam"
        },
        {
            "id": "PF12922",
            "url": "http://pfam.xfam.org/family/PF12922",
            "database": "Pfam"
        },
        {
            "id": "R-RNO-2514853",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2514853",
            "database": "Reactome"
        },
        {
            "id": "1562596",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1562596",
            "database": "RGD"
        },
        {
            "id": "A0A0G2JWH3",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JWH3",
            "database": "UniProtKB"
        },
        {
            "id": "A0A0G2JWH3-1",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JWH3-1",
            "database": "UniProtKB"
        }
    ],
    "sequence": {
        "sequence": "MSPHNFEFHLPLSPEELLKSRGVNQYVVQEVLPIKHLPTQLRAFQSAFRAQGPLAILDHFDTIYSIIHHFRSIEPGLKEDTLEFLMKVVSCHSQELSSILDDAALSGSDRSAHLNALKMNCYALIRLLESFENMTSQTGLIDLDIGGKGKKARAKTALGFVWEEERQPVLELLTQLLQLDIRHLWSHSVIEEEFVSLVTGCCYRLLENPTISHQKNRSTKEAIAHLLGVALVRYNHMLSATVKIIQMLQHFEHLPSVLVAAVTLWATDYGMKSIVGEIVREIGQKCPQEMSRDTAGAKGFAAFLTELAERIPAALMSSMCMLLDHLDGENYMMRNAVLAAMAEMILQVLNGDQLEESARETRDQFLDILQAHGHDVNSFVRSRVLQLFTRIVQQKALPLTRFQAVVALAVGRLADKSVLVCKNAIQLLASFLANNPFSCKLSDTDLAGPLQKEIQKLQEMRAQRRTAAASAALDSEEEWEAMLPELKSTVQQLLKLPQEEAEQQIADGETAEEVKGRIHQLLARASYKQAILLTREATSRFQESEPFSHTEPEEKDFLNLLGVIFKGPEASTHESPRHTDPGLTGSKDSPSVPEPEGSQRDDELLKQEMLVQYLQDAYSFSQKITEAIGVISKMMYENTTTVVQEVIEFFVMVFQFGVPQALFGVRRMLPLIWSKELGVREAVLNAYRQLYLSPKGDSARATAQALIQNLSLLLVDASVGTIQCLEEILCEFVQKDEIKPAVIQLLWERATEKVPCSPLERCSSVMLLGMMARGKPEIVGSNLDTLVKVGLDEKFPQDYRLAQQVCLAIANISDRRKPSLGERHPPFRLPQEHKLFERLQEMVTKGFAHPDPFWIPFKEVAVTLTYQLAEGPDVICSQMLQGCAKQALEKLEKNTTEGDSKETAPKLPTFLLMNLLSLAGDVALQQLVHLEQAVSGELGRRRVLREEQEHRTKVPKEKTTSSETTMEEELGLVGATADDTEAELVRSICEKELLDGTQVLAAFVPLLLKVCNNPGAYSNPELSAAASLALGKFCMISAPFCDSQLRLLFTMLEKSSLPTVRSNLMVATGDLAIRFPNLVDPWTPHLYARLRDPAQQVRRTAGLVMTHLILKDMVKVKGQVSEMAVLLIDPVPQIAALAKNFFNELSHKGNAIYNLLPDIISRLSDPEGGVGEEPFHTIMKQLLSYITKDKQTESLVEKLCQRFRTARTERQYRDLAYCVSQLPLTERGLHKMLDNFDCFGDKLIDESVFSAFLSIVGKLRRGAKPEGKAVIDEFEQKLRACHTRGMDGIEELETGQGGSQRALSAKKPSAVSRQQPLTSVDSDNDFVTPKPRRTKPRRPQTQQRKSQRKAKVVFSSDESSEDELSAEMTEEETPKKTTPIRRASAQRHRS",
        "length": 1390,
        "header": "tr|A0A0G2JWH3-1|A0A0G2JWH3_RAT Isoform 1 of Condensin complex subunit 1  OS=Rattus norvegicus OX=10116 GN=Ncapd2 PE=1 SV=2 CANONICAL=A0A0G2JWH3-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A0G2JWH3-1",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JWH3#A0A0G2JWH3-1",
            "sequence": {
                "sequence": "MSPHNFEFHLPLSPEELLKSRGVNQYVVQEVLPIKHLPTQLRAFQSAFRAQGPLAILDHFDTIYSIIHHFRSIEPGLKEDTLEFLMKVVSCHSQELSSILDDAALSGSDRSAHLNALKMNCYALIRLLESFENMTSQTGLIDLDIGGKGKKARAKTALGFVWEEERQPVLELLTQLLQLDIRHLWSHSVIEEEFVSLVTGCCYRLLENPTISHQKNRSTKEAIAHLLGVALVRYNHMLSATVKIIQMLQHFEHLPSVLVAAVTLWATDYGMKSIVGEIVREIGQKCPQEMSRDTAGAKGFAAFLTELAERIPAALMSSMCMLLDHLDGENYMMRNAVLAAMAEMILQVLNGDQLEESARETRDQFLDILQAHGHDVNSFVRSRVLQLFTRIVQQKALPLTRFQAVVALAVGRLADKSVLVCKNAIQLLASFLANNPFSCKLSDTDLAGPLQKEIQKLQEMRAQRRTAAASAALDSEEEWEAMLPELKSTVQQLLKLPQEEAEQQIADGETAEEVKGRIHQLLARASYKQAILLTREATSRFQESEPFSHTEPEEKDFLNLLGVIFKGPEASTHESPRHTDPGLTGSKDSPSVPEPEGSQRDDELLKQEMLVQYLQDAYSFSQKITEAIGVISKMMYENTTTVVQEVIEFFVMVFQFGVPQALFGVRRMLPLIWSKELGVREAVLNAYRQLYLSPKGDSARATAQALIQNLSLLLVDASVGTIQCLEEILCEFVQKDEIKPAVIQLLWERATEKVPCSPLERCSSVMLLGMMARGKPEIVGSNLDTLVKVGLDEKFPQDYRLAQQVCLAIANISDRRKPSLGERHPPFRLPQEHKLFERLQEMVTKGFAHPDPFWIPFKEVAVTLTYQLAEGPDVICSQMLQGCAKQALEKLEKNTTEGDSKETAPKLPTFLLMNLLSLAGDVALQQLVHLEQAVSGELGRRRVLREEQEHRTKVPKEKTTSSETTMEEELGLVGATADDTEAELVRSICEKELLDGTQVLAAFVPLLLKVCNNPGAYSNPELSAAASLALGKFCMISAPFCDSQLRLLFTMLEKSSLPTVRSNLMVATGDLAIRFPNLVDPWTPHLYARLRDPAQQVRRTAGLVMTHLILKDMVKVKGQVSEMAVLLIDPVPQIAALAKNFFNELSHKGNAIYNLLPDIISRLSDPEGGVGEEPFHTIMKQLLSYITKDKQTESLVEKLCQRFRTARTERQYRDLAYCVSQLPLTERGLHKMLDNFDCFGDKLIDESVFSAFLSIVGKLRRGAKPEGKAVIDEFEQKLRACHTRGMDGIEELETGQGGSQRALSAKKPSAVSRQQPLTSVDSDNDFVTPKPRRTKPRRPQTQQRKSQRKAKVVFSSDESSEDELSAEMTEEETPKKTTPIRRASAQRHRS",
                "length": 1390,
                "header": "tr|A0A0G2JWH3-1|A0A0G2JWH3_RAT Isoform 1 of Condensin complex subunit 1  OS=Rattus norvegicus OX=10116 GN=Ncapd2 PE=1 SV=2 CANONICAL=A0A0G2JWH3-1"
            },
            "locus": {
                "chromosome": "4",
                "start_pos": 157990562,
                "end_pos": 157969043,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000083016.2",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000083016.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000069882.2",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000069882.2"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.",
            "journal": "Nat. Commun.",
            "date": "2012",
            "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A0G2JWH3",
                    "url": "https://www.uniprot.org/uniprot/A0A0G2JWH3"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "22673903",
                    "url": "https://glygen.org/publication/PubMed/22673903"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "R-RNO-2514853",
            "name": "Condensation of Prometaphase Chromosomes",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2514853",
            "resource": "Reactome",
            "description": "Condensation of Prometaphase Chromosomes"
        }
    ],
    "orthologs": [],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 6,
                "go_terms": [
                    {
                        "name": "positive regulation of chromosome separation",
                        "id": "GO:1905820",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905820",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JWH3",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JWH3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of chromosome segregation",
                        "id": "GO:0051984",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051984",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JWH3",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JWH3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cell division",
                        "id": "GO:0051301",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JWH3",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JWH3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "mitotic chromosome condensation",
                        "id": "GO:0007076",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007076",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JWH3",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JWH3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "meiotic chromosome condensation",
                        "id": "GO:0010032",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010032",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JWH3",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JWH3"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "positive regulation of chromosome condensation",
                        "id": "GO:1905821",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905821",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JWH3",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JWH3"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 7,
                "go_terms": [
                    {
                        "name": "condensed nuclear chromosome",
                        "id": "GO:0000794",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000794",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JWH3",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JWH3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nucleoplasm",
                        "id": "GO:0005654",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JWH3",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JWH3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytosol",
                        "id": "GO:0005829",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JWH3",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JWH3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "condensed chromosome",
                        "id": "GO:0000793",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000793",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JWH3",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JWH3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "condensin complex",
                        "id": "GO:0000796",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000796",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JWH3",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JWH3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "pronucleus",
                        "id": "GO:0045120",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045120",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JWH3",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JWH3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "condensed chromosome, centromeric region",
                        "id": "GO:0000779",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000779",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JWH3",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JWH3"
                            }
                        ],
                        "pmid": "21873635"
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 1,
                "go_terms": [
                    {
                        "name": "histone binding",
                        "id": "GO:0042393",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042393",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JWH3",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JWH3"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 133,
            "end_pos": 135,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 216,
            "end_pos": 218,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 638,
            "end_pos": 640,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 709,
            "end_pos": 711,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 811,
            "end_pos": 813,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 894,
            "end_pos": 896,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "synthesized_glycans": [],
    "cluster_types": []
}