{ "uniprot_canonical_ac": "A0A0G2JUX4-1", "uniprot_ac": "A0A0G2JUX4", "uniprot_id": "A0A0G2JUX4_RAT", "mass": { "chemical_mass": 159609.0, "monoisotopic_mass": 159609.0 }, "refseq": { "ac": "XP_006230108", "name": "ubiquitin carboxyl-terminal hydrolase 47 isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006230108" }, "gene_names": [ { "name": "Usp47", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2JUX4", "id": "A0A0G2JUX4" }, { "name": "Usp47", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101012", "id": "NP_001101012" } ], "protein_names": [ { "name": "Ubiquitin carboxyl-terminal hydrolase 47", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2JUX4#names_and_taxonomy", "id": "A0A0G2JUX4" }, { "name": "3.4.19.12", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0G2JUX4#names_and_taxonomy", "id": "A0A0G2JUX4" }, { "name": "Deubiquitinating enzyme 47", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0G2JUX4#names_and_taxonomy", "id": "A0A0G2JUX4" }, { "name": "Ubiquitin thioesterase 47", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0G2JUX4#names_and_taxonomy", "id": "A0A0G2JUX4" }, { "name": "Ubiquitin-specific-processing protease 47", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0G2JUX4#names_and_taxonomy", "id": "A0A0G2JUX4" }, { "name": "ubiquitin carboxyl-terminal hydrolase 47 isoform X3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006230108", "id": "XP_006230108" }, { "name": "ubiquitin carboxyl-terminal hydrolase 47", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101012", "id": "NP_001101012" }, { "name": "ubiquitin specific protease 47", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101012", "id": "NP_001101012" } ], "function": [ { "annotation": "USP47 promotes apoptosis in rat myocardial cells after ischemia/reperfusion injury via NF-kappaB activation.", "evidence": [ { "database": "RefSeq", "id": "NP_001101012", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101012" }, { "database": "PubMed", "id": "32761659", "url": "https://glygen.org/publication/PubMed/32761659" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JUX4", "url": "https://www.uniprot.org/uniprot/A0A0G2JUX4" } ], "common_name": "Rat" } ], "gene": [ { "name": "Usp47", "url": "https://www.uniprot.org/uniprot/A0A0G2JUX4", "locus": { "chromosome": "1", "start_pos": 176854653, "end_pos": 176937763, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000026754", "url": "https://www.ensembl.org/id/ENSRNOG00000026754" } ] } } ], "crossref": [ { "id": "ENSRNOG00000026754", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000026754", "database": "Bgee" }, { "id": "308896", "url": "https://www.ncbi.nlm.nih.gov/gene/308896", "database": "GeneID" }, { "id": "IPR001394", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001394", "database": "InterPro" }, { "id": "IPR018200", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018200", "database": "InterPro" }, { "id": "IPR028889", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028889", "database": "InterPro" }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro" }, { "id": "IPR038765", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038765", "database": "InterPro" }, { "id": "IPR045578", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045578", "database": "InterPro" }, { "id": "rno:308896", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:308896", "database": "KEGG Pathway" }, { "id": "FLCEWIV", "url": "https://omabrowser.org/oma/group/FLCEWIV/", "database": "OMA" }, { "id": "77113at2759", "url": "http://www.orthodb.org/?query=77113at2759", "database": "OrthoDB" }, { "id": "PF00443", "url": "http://pfam.xfam.org/family/PF00443", "database": "Pfam" }, { "id": "PF19718", "url": "http://pfam.xfam.org/family/PF19718", "database": "Pfam" }, { "id": "R-RNO-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5689880", "database": "Reactome" }, { "id": "NP_001101012", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101012", "database": "RefSeq" }, { "id": "XP_006230108", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006230108", "database": "RefSeq" }, { "id": "1310411", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1310411", "database": "RGD" }, { "id": "A0A0G2JUX4", "url": "https://www.uniprot.org/uniprot/A0A0G2JUX4", "database": "UniProtKB" }, { "id": "A0A0G2JUX4-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JUX4-1", "database": "UniProtKB" }, { "id": "A0A8I6A571", "url": "https://www.uniprot.org/uniprot/A0A8I6A571", "database": "UniProtKB" }, { "id": "A0A8I6A571-1", "url": "https://www.uniprot.org/uniprot/A0A8I6A571-1", "database": "UniProtKB" }, { "id": "A0A8I6AAW7", "url": "https://www.uniprot.org/uniprot/A0A8I6AAW7", "database": "UniProtKB" }, { "id": "A0A8I6AAW7-1", "url": "https://www.uniprot.org/uniprot/A0A8I6AAW7-1", "database": "UniProtKB" }, { "id": "F1MAA1", "url": "https://www.uniprot.org/uniprot/F1MAA1", "database": "UniProtKB" }, { "id": "F1MAA1-1", "url": "https://www.uniprot.org/uniprot/F1MAA1-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MVPGEENQLVPKEDVFWRCRQNIFDEMKKKFLQIENAAEEPRVLCIIQDTTNSKTVNERITVNLPASTPVRKLFEDVANKVGYINGTFDLTWGNGINTADLAPLDHTSDKSLLDANFEPGKKNFLHLTDKDGEQPQMLLDDSSHVDDSVHDRFIGPLPREGSVASTSDYVSQSYSYSSILNKSETGYVGLVNQAMTCYLNSLLQTLFMTPEFRNALYKWEFEESEEDPVTSIPYQLQRLFVLLQTSKKRAIETTDVTRSFGWDSSEAWQQHDVQELCRVMFDALEQKWKQTEQADLINELYQGKLKDYVRCLECGYEGWRIDTYLDIPLVIRPYGSSQAFASVEEALHAFIQPEILDGPNQYFCERCKKKCDARKGLRFLHFPYLLTLQLKRFDFDYTTMHRIKLNDRMSFPEELDMSTFIDIEDEKSPQTESCTDSGAENEGSCHSDQMSNDFSTDDAVDEGICLESSTGSEKISKPGLEKVEMAETDQRKDSIQFQLGEPNSLMYELFSVMVHSGSAAGGHYYACIKSFSDDQWYSFNDQHVSRITQEDIKKTHGGSSGSRGYYSSAFASSTNAYMLIYRLKDPTRNAKFLEVDEYPEHIKNLVQKERELEEQEKRQREIERNTCKIKLFCLHPVKQVMMENKLEVHKDKTLKEAVEMAYKMMDLEDVIPLDCCRLVKYDEFHDYLERSYEGEEDTPMGLLLGGVKSTYMFDLLLETRKPDQIFQSYKPGEVMVKVHVVDLKAETVAAPVTVRAYLNQTVLEFKQLISKATHLPAEPMRIVLERCYNDLRLLSMPSKTLKAEGFFRSNKVFVESSETVDHQAAFTDSHLWKLLDRHANTIRLFVLLPEQSPGSYSKRTAYQKAGGDSGNVDDDCERAKGPAGSLKSVDAILEESTEKLKSLSLQQQQDGDNGDSSKSTETSDFENIESPLNERGSSTSVDNRELEQHIQTSDPENFQSEERSDSDVNNDRSTSSVDSDILSSSHSSDTLCNADSAQIPLANGLDSHSITSSRRTKANEGKKETWDTAEEDSGTDSEYDESGKSRGEMQYMYFKADPYTADEGSGEGHKWLMVHVDKRITLAAFKQHLEPFVGVLSSHFKVFRVYTSNQEFETVRLNETLSSFSDDNKITIRLGRALKKGEYRVKVCQLLVNEQEPCKFLLDAVFAKGMTVRQSKEELIPQLREQCGLDLSIDRFRLRKKTWKNPGTVFLDYHIYEEDINISSNWEVFLEVLDGVEKMKSMSQLAILTRRWRPSEMKLDPFQELVLESNSVDELREKLSEISGIPLEDIEFAKGRGTFPCDISVLDIHQDLDWNPKVSTLNVWPLYICDDGAVIFYRDRTEEVMELTDEQRNELMKKESSRLQKTGHRVTYSPRKEKALKIYLDGAPNKDVAQD", "length": 1395, "header": "tr|A0A0G2JUX4-1|A0A0G2JUX4_RAT Isoform 1 of Ubiquitin carboxyl-terminal hydrolase 47 OS=Rattus norvegicus OX=10116 GN=Usp47 PE=1 SV=2 CANONICAL=A0A0G2JUX4-1" }, "isoforms": [ { "isoform_ac": "A0A0G2JUX4-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JUX4#A0A0G2JUX4-1", "sequence": { "sequence": "MVPGEENQLVPKEDVFWRCRQNIFDEMKKKFLQIENAAEEPRVLCIIQDTTNSKTVNERITVNLPASTPVRKLFEDVANKVGYINGTFDLTWGNGINTADLAPLDHTSDKSLLDANFEPGKKNFLHLTDKDGEQPQMLLDDSSHVDDSVHDRFIGPLPREGSVASTSDYVSQSYSYSSILNKSETGYVGLVNQAMTCYLNSLLQTLFMTPEFRNALYKWEFEESEEDPVTSIPYQLQRLFVLLQTSKKRAIETTDVTRSFGWDSSEAWQQHDVQELCRVMFDALEQKWKQTEQADLINELYQGKLKDYVRCLECGYEGWRIDTYLDIPLVIRPYGSSQAFASVEEALHAFIQPEILDGPNQYFCERCKKKCDARKGLRFLHFPYLLTLQLKRFDFDYTTMHRIKLNDRMSFPEELDMSTFIDIEDEKSPQTESCTDSGAENEGSCHSDQMSNDFSTDDAVDEGICLESSTGSEKISKPGLEKVEMAETDQRKDSIQFQLGEPNSLMYELFSVMVHSGSAAGGHYYACIKSFSDDQWYSFNDQHVSRITQEDIKKTHGGSSGSRGYYSSAFASSTNAYMLIYRLKDPTRNAKFLEVDEYPEHIKNLVQKERELEEQEKRQREIERNTCKIKLFCLHPVKQVMMENKLEVHKDKTLKEAVEMAYKMMDLEDVIPLDCCRLVKYDEFHDYLERSYEGEEDTPMGLLLGGVKSTYMFDLLLETRKPDQIFQSYKPGEVMVKVHVVDLKAETVAAPVTVRAYLNQTVLEFKQLISKATHLPAEPMRIVLERCYNDLRLLSMPSKTLKAEGFFRSNKVFVESSETVDHQAAFTDSHLWKLLDRHANTIRLFVLLPEQSPGSYSKRTAYQKAGGDSGNVDDDCERAKGPAGSLKSVDAILEESTEKLKSLSLQQQQDGDNGDSSKSTETSDFENIESPLNERGSSTSVDNRELEQHIQTSDPENFQSEERSDSDVNNDRSTSSVDSDILSSSHSSDTLCNADSAQIPLANGLDSHSITSSRRTKANEGKKETWDTAEEDSGTDSEYDESGKSRGEMQYMYFKADPYTADEGSGEGHKWLMVHVDKRITLAAFKQHLEPFVGVLSSHFKVFRVYTSNQEFETVRLNETLSSFSDDNKITIRLGRALKKGEYRVKVCQLLVNEQEPCKFLLDAVFAKGMTVRQSKEELIPQLREQCGLDLSIDRFRLRKKTWKNPGTVFLDYHIYEEDINISSNWEVFLEVLDGVEKMKSMSQLAILTRRWRPSEMKLDPFQELVLESNSVDELREKLSEISGIPLEDIEFAKGRGTFPCDISVLDIHQDLDWNPKVSTLNVWPLYICDDGAVIFYRDRTEEVMELTDEQRNELMKKESSRLQKTGHRVTYSPRKEKALKIYLDGAPNKDVAQD", "length": 1395, "header": "tr|A0A0G2JUX4-1|A0A0G2JUX4_RAT Isoform 1 of Ubiquitin carboxyl-terminal hydrolase 47 OS=Rattus norvegicus OX=10116 GN=Usp47 PE=1 SV=2 CANONICAL=A0A0G2JUX4-1" }, "locus": { "chromosome": "1", "start_pos": 166234066, "end_pos": 166152561, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000087461.2", "url": "https://www.ensembl.org/id/ENSRNOT00000087461.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000069266.2", "url": "https://www.ensembl.org/id/ENSRNOP00000069266.2" } ] } }, { "isoform_ac": "A0A8I6A571-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JUX4#A0A8I6A571-1", "sequence": { "sequence": "GSPGCRQNIFDEMKKKFLQIENAAEEPRVLCIIQDTTNSKTVNERITVNLPASTPVRKLFEDVANKVGYINGTFDLTWGNGINTADLAPLDHTSDKSLLDANFEPGKKNFLHLTDKDGEQPQMLLDDSSHVDDSVHDRFIGPLPREGSVASTSDYVSQSYSYSSILNKSETGYVGLVNQAMTCYLNSLLQTLFMTPEFRNALYKWEFEESEEDPVTSIPYQLQRLFVLLQTSKKRAIETTDVTRSFGWDSSEAWQQHDVQELCRVMFDALEQKWKQTEQADLINELYQGKLKDYVRCLECGYEGWRIDTYLDIPLVIRPYGSSQAFASVEEALHAFIQPEILDGPNQYFCERCKKKCDARKGLRFLHFPYLLTLQLKRFDFDYTTMHRIKLNDRMSFPEELDMSTFIDIEDEKSPQTESCTDSGAENEGSCHSDQMSNDFSTDDAVDEGICLESSTGSEKISKPGLEKNSLMYELFSVMVHSGSAAGGHYYACIKSFSDDQWYSFNDQHVSRITQEDIKKTHGGSSGSRGYYSSAFASSTNAYMLIYRLKDPTRNAKFLEVDEYPEHIKNLVQKERELEEQEKRQREIERNTCKIKLFCLHPVKQVMMENKLEVHKDKTLKEAVEMAYKMMDLEDVIPLDCCRLVKYDEFHDYLERSYEGEEDTPMGLLLGGVKSTYMFDLLLETRKPDQIFQSYKPGEVMVKVHVVDLKAETVAAPVTVRAYLNQTVLEFKQLISKATHLPAEPMRIVLERCYNDLRLLSMPSKTLKAEGFFRSNKVFVESSETVDHQAAFTDSHLWKLLDRHANTIRLFVLLPEQSPGSYSKRTAYQKAGGDSGNVDDDCERAKGPAGSLKSVDAILEESTEKLKSLSLQQQQDGDNGDSSKSTETSDFENIESPLNERGSSTSVDNRELEQHIQTSDPENFQSEERSDSDVNNDRSTSSVDSDILSSSHSSDTLCNADSAQIPLANGLDSHSITSSRRTKANEGKKETWDTAEEDSGTDSEYDESGKSRGEMQYMYFKADPYTADEGSGEGHKWLMVHVDKRITLAAFKQHLEPFVGVLSSHFKVFRVYTSNQEFETVRLNETLSSFSDDNKITIRLGRALKKGEYRVKVCQLLVNEQEPCKFLLDAVFAKGMTVRQSKEELIPQLREQCGLDLSIDRFRLRKKTWKNPGTVFLDYHIYEEDINISSNWEVFLEVLDGVEKMKSMSQLAILTRRWRPSEMKLDPFQELVLESNSVDELREKLSEISGIPLEDIEFAKGRGTFPCDISVLDIHQDLDWNPKVSTLNVWPLYICDDGAVIFYRDRTEEVMELTDEQRNELMKKESSRLQKTGHRVTYSPRKEKALKIYLDGAPNKDVAQD", "length": 1361, "header": "tr|A0A8I6A571-1|A0A8I6A571_RAT Computationally mapped isoform of Ubiquitin carboxyl-terminal hydrolase 47 OS=Rattus norvegicus OX=10116 GN=Usp47 PE=1 SV=1 CANONICAL=A0A0G2JUX4-1" }, "locus": { "chromosome": "1", "start_pos": 166234066, "end_pos": 166176133, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000097971.1", "url": "https://www.ensembl.org/id/ENSRNOT00000097971.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000088486.1", "url": "https://www.ensembl.org/id/ENSRNOP00000088486.1" } ] } }, { "isoform_ac": "A0A8I6AAW7-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JUX4#A0A8I6AAW7-1", "sequence": { "sequence": "DYKNAAEEPRVLCIIQDTTNSKTVNERITVNLPASTPVRKLFEDVANKVGYINGTFDLTWGNGINTADLAPLDHTSDKSLLDANFEPGKKNFLHLTDKDGEQPQMLLDDSSHVDDSVHDRFIGPLPREGSVASTSDYVSQSYSYSSILNKSETGYVGLVNQAMTCYLNSLLQTLFMTPEFRNALYKWEFEESEEDPVTSIPYQLQRLFVLLQTSKKRAIETTDVTRSFGWDSSEAWQQHDVQELCRVMFDALEQKWKQTEQADLINELYQGKLKDYVRCLECGYEGWRIDTYLDIPLVIRPYGSSQAFASVEEALHAFIQPEILDGPNQYFCERCKKKCDARKGLRFLHFPYLLTLQLKRFDFDYTTMHRIKLNDRMSFPEELDMSTFIDIEDEKSPQTESCTDSGAENEGSCHSDQMSNDFSTDDAVDEGICLESSTGSEKISKPGLEKNSLMYELFSVMVHSGSAAGGHYYACIKSFSDDQWYSFNDQHVSRITQEDIKKTHGGSSGSRGYYSSAFASSTNAYMLIYRLKDPTRNAKFLEVDEYPEHIKNLVQKERELEEQEKRQREIERNTCKIKLFCLHPVKQVMMENKLEVHKDKTLKEAVEMAYKMMDLEDVIPLDCCRLVKYDEFHDYLERSYEGEEDTPMGLLLGGVKSTYMFDLLLETRKPDQIFQSYKPGEVMVKVHVVDLKAETVAAPVTVRAYLNQTVLEFKQLISKATHLPAEPMRIVLERCYNDLRLLSMPSKTLKAEGFFRSNKVFVESSETVDHQAAFTDSHLWKLLDRHANTIRLFVLLPEQSPGSYSKRTAYQKAGGDSGNVDDDCERAKGPAGSLKSVDAILEESTEKLKSLSLQQQQDGDNGDSSKSTETSDFENIESPLNERGSSTSVDNRELEQHIQTSDPENFQSEERSDSDVNNDRSTSSVDSDILSSSHSSDTLCNADSAQIPLANGLDSHSITSSRRTKANEGKKETWDTAEEDSGTDSEYDESGKSRGEMQYMYFKADPYTADEGSGEGHKWLMVHVDKRITLAAFKQHLEPFVGVLSSHFKVFRVYTSNQEFETVRLNETLSSFSDDNKITIRLGRALKKGEYRVKVCQLLVNEQEPCKFLLDAVFAKGMTVRQSKEELIPQLREQCGLDLSIDRFRLRKKTWKNPGTVFLDYHIYEEDINISSNWEVFLEVLDGVEKMKSMSQLAILTRRWRPSEMKLDPFQELVLESNSVDELREKLSEISGIPLEDIEFAKGRGTFPCDISVLDIHQDLDWNPKVSTLNVWPLYICDDGAVIFYRDRTEEVMELTDEQRNELMKKESSRLQKTGHRVTYSPRKEKALKIYLDGAPNKDVAQD", "length": 1343, "header": "tr|A0A8I6AAW7-1|A0A8I6AAW7_RAT Computationally mapped isoform of Ubiquitin carboxyl-terminal hydrolase 47 OS=Rattus norvegicus OX=10116 GN=Usp47 PE=1 SV=1 CANONICAL=A0A0G2JUX4-1" }, "locus": { "chromosome": "1", "start_pos": 166234066, "end_pos": 166182998, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000116456.1", "url": "https://www.ensembl.org/id/ENSRNOT00000116456.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000088488.1", "url": "https://www.ensembl.org/id/ENSRNOP00000088488.1" } ] } }, { "isoform_ac": "F1MAA1-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JUX4#F1MAA1-1", "sequence": { "sequence": "MVPGEENQLVPKEIENAAEEPRVLCIIQDTTNSKTVNERITVNLPASTPVRKLFEDVANKVGYINGTFDLTWGNGINTADLAPLDHTSDKSLLDANFEPGKKNFLHLTDKDGEQPQMLLDDSSHVDDSVHDRFIGPLPREGSVASTSDYVSQSYSYSSILNKSETGYVGLVNQAMTCYLNSLLQTLFMTPEFRNALYKWEFEESEEDPVTSIPYQLQRLFVLLQTSKKRAIETTDVTRSFGWDSSEAWQQHDVQELCRVMFDALEQKWKQTEQADLINELYQGKLKDYVRCLECGYEGWRIDTYLDIPLVIRPYGSSQAFASVEEALHAFIQPEILDGPNQYFCERCKKKCDARKGLRFLHFPYLLTLQLKRFDFDYTTMHRIKLNDRMSFPEELDMSTFIDIEDEKSPQTESCTDSGAENEGSCHSDQMSNDFSTDDAVDEGICLESSTGSEKISKPGLEKNSLMYELFSVMVHSGSAAGGHYYACIKSFSDDQWYSFNDQHVSRITQEDIKKTHGGSSGSRGYYSSAFASSTNAYMLIYRLKDPTRNAKFLEVDEYPEHIKNLVQKERELEEQEKRQREIERNTCKIKLFCLHPVKQVMMENKLEVHKDKTLKEAVEMAYKMMDLEDVIPLDCCRLVKYDEFHDYLERSYEGEEDTPMGLLLGGVKSTYMFDLLLETRKPDQIFQSYKPGEVMVKVHVVDLKAETVAAPVTVRAYLNQTVLEFKQLISKATHLPAEPMRIVLERCYNDLRLLSMPSKTLKAEGFFRSNKVFVESSETVDHQAAFTDSHLWKLLDRHANTIRLFVLLPEQSPGSYSKRTAYQKAGGDSGNVDDDCERAKGPAGSLKSVDAILEESTEKLKSLSLQQQQDGDNGDSSKSTETSDFENIESPLNERGSSTSVDNRELEQHIQTSDPENFQSEERSDSDVNNDRSTSSVDSDILSSSHSSDTLCNADSAQIPLANGLDSHSITSSRRTKANEGKKETWDTAEEDSGTDSEYDESGKSRGEMQYMYFKADPYTADEGSGEGHKWLMVHVDKRITLAAFKQHLEPFVGVLSSHFKVFRVYTSNQEFETVRLNETLSSFSDDNKITIRLGRALKKGEYRVKVCQLLVNEQEPCKFLLDAVFAKGMTVRQSKEELIPQLREQCGLDLSIDRFRLRKKTWKNPGTVFLDYHIYEEDINISSNWEVFLEVLDGVEKMKSMSQLAILTRRWRPSEMKLDPFQELVLESNSVDELREKLSEISGIPLEDIEFAKGRGTFPCDISVLDIHQDLDWNPKVSTLNVWPLYICDDGAVIFYRDRTEEVMELTDEQRNELMKKESSRLQKTGHRVTYSPRKEKALKIYLDGAPNKDVAQD", "length": 1355, "header": "tr|F1MAA1-1|A0A0G2JUX4_RAT Computationally mapped isoform of Ubiquitin carboxyl-terminal hydrolase 47 OS=Rattus norvegicus OX=10116 GN=Usp47 PE=1 SV=1 CANONICAL=A0A0G2JUX4-1" }, "locus": { "chromosome": "1", "start_pos": 166234066, "end_pos": 166152561, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000065712.3", "url": "https://www.ensembl.org/id/ENSRNOT00000065712.3" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000058846.1", "url": "https://www.ensembl.org/id/ENSRNOP00000058846.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "The ubiquitin-specific protease USP47 is a novel beta-TRCP interactor regulating cell survival.", "journal": "Oncogene", "date": "2010", "authors": "Peschiaroli A, Skaar JR, Pagano M, Melino G", "evidence": [ { "database": "RefSeq", "id": "NP_001101012", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101012" } ], "reference": [ { "type": "PubMed", "id": "19966869", "url": "https://glygen.org/publication/PubMed/19966869" } ] }, { "title": "USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA polymerase beta.", "journal": "Molecular cell", "date": "2011", "authors": "Parsons JL, Dianova II, Khoronenkova SV, Edelmann MJ, Kessler BM, Dianov GL", "evidence": [ { "database": "RefSeq", "id": "NP_001101012", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101012" } ], "reference": [ { "type": "PubMed", "id": "21362556", "url": "https://glygen.org/publication/PubMed/21362556" } ] }, { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nat. Commun.", "date": "2012", "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "evidence": [ { "database": "UniProtKB", "id": "F1MAA1", "url": "https://www.uniprot.org/uniprot/F1MAA1" }, { "database": "UniProtKB", "id": "A0A0G2JUX4", "url": "https://www.uniprot.org/uniprot/A0A0G2JUX4" } ], "reference": [ { "type": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" } ] }, { "title": "Deubiquitinase USP47/UBP64E Regulates beta-Catenin Ubiquitination and Degradation and Plays a Positive Role in Wnt Signaling.", "journal": "Molecular and cellular biology", "date": "2015", "authors": "Shi J, Liu Y, Xu X, Zhang W, Yu T, Jia J, Liu C", "evidence": [ { "database": "RefSeq", "id": "NP_001101012", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101012" } ], "reference": [ { "type": "PubMed", "id": "26169834", "url": "https://glygen.org/publication/PubMed/26169834" } ] }, { "title": "USP47 promotes apoptosis in rat myocardial cells after ischemia/reperfusion injury via NF-kappaB activation.", "journal": "Biotechnology and applied biochemistry", "date": "2021", "authors": "Hu Y, Ma Z, Chen Z, Chen B", "evidence": [ { "database": "RefSeq", "id": "NP_001101012", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101012" } ], "reference": [ { "type": "PubMed", "id": "32761659", "url": "https://glygen.org/publication/PubMed/32761659" } ] } ], "pathway": [ { "id": "rno:308896", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:308896", "resource": "KEGG Pathway" }, { "id": "R-RNO-5689880", "name": "Ub-specific processing proteases", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5689880", "resource": "Reactome", "description": "Ub-specific processing proteases" } ], "orthologs": [ { "uniprot_canonical_ac": "Q8BY87-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 47", "gene_name": "Usp47", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVPGEENQLVPKEDVFWRCRQNIFDEMKKKFLQIENAAEEPRVLCIIQDTTNSKTVSERITLNLPASTPVRKLFEDVANKVGYINGTFDLTRENGVTTADMAPLDHTSDKSLLDANFEPGKKNFLHLTDKDGEPPQMLLEDSNNVDDSVHDRFIGPLPREGSVASTNDYVSQNYSYSSILNKSETGYVGLVNQAMTCYLNSLLQTLFMTPEFRNALYKWEFEDSEEDPVTSIPYQLQRLFVLLQTSKKRAIETTDVTRSFGWDSSEAWQQHDVQELCRVMFDALEQKWKQTEQADLINELYQGKLKDYVRCLECGYEGWRIDTYLDIPLVIRPYGSSQAFASVEEALHAFIQPEILDGPNQYFCERCKKKCDARKGLRFLHFPYLLTLQLKRFDFDYTTMHRIKLNDRMSFPEELDMSTFIDIEDEKSPQTESCTDSGAENEGSCHSDQMSNDFSTDDAVDEGICLESSSGSEKISKPGLEKNSLMYELFSVMVHSGSAAGGHYYACIKSFSDDQWYSFNDQHVSRITQEDIKKTHGGSSGSRGYYSSAFASSTNAYMLIYRLKDPTRNAKFLEVDEYPEHIKNLVQKERELEEQEKRQREIERNTCKIKLFCLHPVKQVMMENKLEVHKDKTLKEAVEMAYKMMDLEDVIPLDCCRLVKYDEFHDYLERSYEGEEDTPMGLLLGGVKSTYMFDLLLETRKPDQIFQSYKPGEVMVKVHVVDLKAETVAAPVTVRAYLNQTVTEFKQLISKATHLPADSMRIVLERCYNDLRLLSMPSKTLKAEGFFRSNKVFVESSETVDHQAAFTDSHLWKLLDRHANTIRLFVLLPEQSPGSYSKRTAYQKAGGDSGNVDDDCERVKGPAGNLKSVDAILEESTEKLKSLSLQQQQQDGDNGDSSKSTETSDFENIESPLNERGSSTSVDNRELEQHIQTSDPENFQSEERSDSDVNNDRSTSSVDSDILSSSHSSDTLCNADSAQIPLANGLDSHSITSSRRTKANEGKKETWDTAEEDSGTDSEYDESGKSRGDMQYMYFKADPYTADEGSGEGHKWLMVHVDKRITLAAFKQHLEPFVGVLSSHFKVFRVYTSNQEFETVRLNETLSSFSDDNKITIRLGRALKKGEYRVKVCQLLVNEQEPCKFLLDAVFAKGMTVRQSKEELIPQLREQCGLDLSIDRFRLRKKTWKNPGTVFLDYHIYEEDINISSNWEVFLEVLDGVEKMKSMSQLAILTRRWRPAEMKLDPFQELVLESNSVDELREKLSEISGIPLEDIEFAKGRGTFPCDISVLDIHQDLDWNPKVSTLNVWPLYICDDGAVIFYRDRTEEVMELTDEQRNELMKKESSRLQKTGHRVTYSPRKEKALKIYLDGAPNKDVAQD", "length": 1376 }, "evidence": [ { "id": "41498660", "url": "http://www.informatics.jax.org/homology/41498660", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96K76-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 47", "gene_name": "USP47", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVPGEENQLVPKEDVFWRCRQNIFDEMKKKFLQIENAAEEPRVLCIIQDTTNSKTVNERITLNLPASTPVRKLFEDVANKVGYINGTFDLVWGNGINTADMAPLDHTSDKSLLDANFEPGKKNFLHLTDKDGEQPQILLEDSSAGEDSVHDRFIGPLPREGSGGSTSDYVSQSYSYSSILNKSETGYVGLVNQAMTCYLNSLLQTLFMTPEFRNALYKWEFEESEEDPVTSIPYQLQRLFVLLQTSKKRAIETTDVTRSFGWDSSEAWQQHDVQELCRVMFDALEQKWKQTEQADLINELYQGKLKDYVRCLECGYEGWRIDTYLDIPLVIRPYGSSQAFASVEEALHAFIQPEILDGPNQYFCERCKKKCDARKGLRFLHFPYLLTLQLKRFDFDYTTMHRIKLNDRMTFPEELDMSTFIDVEDEKSPQTESCTDSGAENEGSCHSDQMSNDFSNDDGVDEGICLETNSGTEKISKSGLEKNSLIYELFSVMVHSGSAAGGHYYACIKSFSDEQWYSFNDQHVSRITQEDIKKTHGGSSGSRGYYSSAFASSTNAYMLIYRLKDPARNAKFLEVDEYPEHIKNLVQKERELEEQEKRQREIERNTCKIKLFCLHPTKQVMMENKLEVHKDKTLKEAVEMAYKMMDLEEVIPLDCCRLVKYDEFHDYLERSYEGEEDTPMGLLLGGVKSTYMFDLLLETRKPDQVFQSYKPGEVMVKVHVVDLKAESVAAPITVRAYLNQTVTEFKQLISKAIHLPAETMRIVLERCYNDLRLLSVSSKTLKAEGFFRSNKVFVESSETLDYQMAFADSHLWKLLDRHANTIRLFVLLPEQSPVSYSKRTAYQKAGGDSGNVDDDCERVKGPVGSLKSVEAILEESTEKLKSLSLQQQQDGDNGDSSKSTETSDFENIESPLNERDSSASVDNRELEQHIQTSDPENFQSEERSDSDVNNDRSTSSVDSDILSSSHSSDTLCNADNAQIPLANGLDSHSITSSRRTKANEGKKETWDTAEEDSGTDSEYDESGKSRGEMQYMYFKAEPYAADEGSGEGHKWLMVHVDKRITLAAFKQHLEPFVGVLSSHFKVFRVYASNQEFESVRLNETLSSFSDDNKITIRLGRALKKGEYRVKVYQLLVNEQEPCKFLLDAVFAKGMTVRQSKEELIPQLREQCGLELSIDRFRLRKKTWKNPGTVFLDYHIYEEDINISSNWEVFLEVLDGVEKMKSMSQLAVLSRRWKPSEMKLDPFQEVVLESSSVDELREKLSEISGIPLDDIEFAKGRGTFPCDISVLDIHQDLDWNPKVSTLNVWPLYICDDGAVIFYRDKTEELMELTDEQRNELMKKESSRLQKTGHRVTYSPRKEKALKIYLDGAPNKDLTQD", "length": 1375 }, "evidence": [ { "id": "41498660", "url": "http://www.informatics.jax.org/homology/41498660", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JUX4", "url": "https://www.uniprot.org/uniprot/A0A0G2JUX4" } ], "pmid": "21873635" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JUX4", "url": "https://www.uniprot.org/uniprot/A0A0G2JUX4" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JUX4", "url": "https://www.uniprot.org/uniprot/A0A0G2JUX4" } ], "pmid": "21873635" }, { "name": "SCF ubiquitin ligase complex", "id": "GO:0019005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019005", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JUX4", "url": "https://www.uniprot.org/uniprot/A0A0G2JUX4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 16, "go_terms": [ { "name": "protein deubiquitination", "id": "GO:0016579", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016579", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JUX4", "url": "https://www.uniprot.org/uniprot/A0A0G2JUX4" } ], "pmid": "21873635" }, { "name": "positive regulation of cell growth", "id": "GO:0030307", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030307", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JUX4", "url": "https://www.uniprot.org/uniprot/A0A0G2JUX4" } ], "pmid": "" }, { "name": "negative regulation of apoptotic process", "id": "GO:0043066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JUX4", "url": "https://www.uniprot.org/uniprot/A0A0G2JUX4" } ], "pmid": "" }, { "name": "negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage", "id": "GO:1902230", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902230", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JUX4", "url": "https://www.uniprot.org/uniprot/A0A0G2JUX4" } ], "pmid": "" }, { "name": "base-excision repair", "id": "GO:0006284", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006284", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JUX4", "url": "https://www.uniprot.org/uniprot/A0A0G2JUX4" } ], "pmid": "" }, { "name": "negative regulation of cysteine-type endopeptidase activity involved in apoptotic process", "id": "GO:0043154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043154", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JUX4", "url": "https://www.uniprot.org/uniprot/A0A0G2JUX4" } ], "pmid": "" }, { "name": "negative regulation of transcription, DNA-templated", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JUX4", "url": "https://www.uniprot.org/uniprot/A0A0G2JUX4" } ], "pmid": "" }, { "name": "cellular response to DNA damage stimulus", "id": "GO:0006974", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006974", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JUX4", "url": "https://www.uniprot.org/uniprot/A0A0G2JUX4" } ], "pmid": "" }, { "name": "regulation of protein stability", "id": "GO:0031647", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031647", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JUX4", "url": "https://www.uniprot.org/uniprot/A0A0G2JUX4" } ], "pmid": "21873635" }, { "name": "positive regulation of canonical Wnt signaling pathway", "id": "GO:0090263", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090263", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JUX4", "url": "https://www.uniprot.org/uniprot/A0A0G2JUX4" } ], "pmid": "" }, { "name": "response to xenobiotic stimulus", "id": "GO:0009410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009410", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JUX4", "url": "https://www.uniprot.org/uniprot/A0A0G2JUX4" } ], "pmid": "" }, { "name": "cellular response to UV", "id": "GO:0034644", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034644", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JUX4", "url": "https://www.uniprot.org/uniprot/A0A0G2JUX4" } ], "pmid": "" }, { "name": "negative regulation of G2/M transition of mitotic cell cycle", "id": "GO:0010972", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010972", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JUX4", "url": "https://www.uniprot.org/uniprot/A0A0G2JUX4" } ], "pmid": "" }, { "name": "monoubiquitinated protein deubiquitination", "id": "GO:0035520", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035520", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JUX4", "url": "https://www.uniprot.org/uniprot/A0A0G2JUX4" } ], "pmid": "" }, { "name": "ubiquitin-dependent protein catabolic process", "id": "GO:0006511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JUX4", "url": "https://www.uniprot.org/uniprot/A0A0G2JUX4" } ], "pmid": "" }, { "name": "intrinsic apoptotic signaling pathway in response to DNA damage", "id": "GO:0008630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008630", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JUX4", "url": "https://www.uniprot.org/uniprot/A0A0G2JUX4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "cysteine-type endopeptidase activity", "id": "GO:0004197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004197", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JUX4", "url": "https://www.uniprot.org/uniprot/A0A0G2JUX4" } ], "pmid": "21873635" }, { "name": "cysteine-type deubiquitinase activity", "id": "GO:0004843", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004843", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JUX4", "url": "https://www.uniprot.org/uniprot/A0A0G2JUX4" } ], "pmid": "" }, { "name": "deubiquitinase activity", "id": "GO:0101005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0101005", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JUX4", "url": "https://www.uniprot.org/uniprot/A0A0G2JUX4" } ], "pmid": "" }, { "name": "WD40-repeat domain binding", "id": "GO:0071987", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071987", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JUX4", "url": "https://www.uniprot.org/uniprot/A0A0G2JUX4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1118, "end_pos": 1120, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1221, "end_pos": 1223, "annotation": "n_glycosylation_sequon" }, { "start_pos": 181, "end_pos": 183, "annotation": "n_glycosylation_sequon" }, { "start_pos": 759, "end_pos": 761, "annotation": "n_glycosylation_sequon" }, { "start_pos": 85, "end_pos": 87, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-RNO-5696947", "name": "USP47 deubiquitinates POLB", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06766-1", "A0A0G2JUX4-1" ], "evidence": [ { "id": "R-RNO-5696947", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5696947" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A0G2JUX4", "gene_name": "Usp47", "activity": [ { "ec_number": "3.4.19.12", "activity": "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).", "evidence": [ { "id": "A0A0G2JUX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JUX4" } ] }, { "ec_number": "3.4.19.12", "activity": "", "evidence": [ { "id": "A0A0G2JUX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JUX4" } ] } ] }, { "uniprot_ac": "P06766", "gene_name": "Polb", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P06766", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06766" } ] }, { "ec_number": "4.2.99.-", "activity": "", "evidence": [ { "id": "P06766", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06766" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "P06766", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06766" } ] } ] } ], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ] }