{ "uniprot_canonical_ac": "A0A0G2JTY4-1", "uniprot_ac": "A0A0G2JTY4", "uniprot_id": "A0A0G2JTY4_RAT", "mass": { "chemical_mass": 115656.0, "monoisotopic_mass": 115656.0 }, "refseq": { "ac": "NP_001101917", "name": "nuclear factor of activated T-cells, cytoplasmic 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101917" }, "gene_names": [ { "name": "Nfatc3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4", "id": "A0A0G2JTY4" }, { "name": "Nfatc3_predicted", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4", "id": "A0A0G2JTY4" }, { "name": "rCG_51043", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4", "id": "A0A0G2JTY4" } ], "protein_names": [ { "name": "Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 (Predicted), isoform CRA_b", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4#names_and_taxonomy", "id": "A0A0G2JTY4" }, { "name": "Nuclear factor of-activated T-cells 3", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4#names_and_taxonomy", "id": "A0A0G2JTY4" }, { "name": "T cell transcription factor NFAT4; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101917", "id": "NP_001101917" }, { "name": "nuclear factor of activated T-cells, cytoplasmic 3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101917", "id": "NP_001101917" } ], "function": [ { "annotation": "AKAP79/150 LZ motif functions to recruit NFAT to the L-type calcium channels signaling complex to promote its activation by AKAP-anchored calcineurin.", "evidence": [ { "database": "RefSeq", "id": "NP_001101917", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101917" }, { "database": "PubMed", "id": "31091162", "url": "https://glygen.org/publication/PubMed/31091162" } ] }, { "annotation": "MicroRNA153 attenuates hypoxiainduced excessive proliferation and migration of pulmonary arterial smooth muscle cells by targeting ROCK1 and NFATc3.", "evidence": [ { "database": "RefSeq", "id": "NP_001101917", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101917" }, { "database": "PubMed", "id": "33495839", "url": "https://glygen.org/publication/PubMed/33495839" } ] }, { "annotation": "The activation of TRPV3 aggravated pathological cardiac hypertrophy through calcineurin/NFATc3 signalling pathway and correlated with the protein expression levels of calcineurin, phosphorylated CaMKII and NFATc3, revealing that TRPV3 might be a potential therapeutic target for cardiac hypertrophy.", "evidence": [ { "database": "RefSeq", "id": "NP_001101917", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101917" }, { "database": "PubMed", "id": "30299584", "url": "https://glygen.org/publication/PubMed/30299584" } ] }, { "annotation": "This study is the first time that radiation-induced activation of NFAT3/c4 has been recorded.", "evidence": [ { "database": "RefSeq", "id": "NP_001101917", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101917" }, { "database": "PubMed", "id": "28992110", "url": "https://glygen.org/publication/PubMed/28992110" } ] }, { "annotation": "We demonstrate that TRPC3-NFATc3 signaling is modulated by P.E. and critically regulates ventricular CF phenotype and MF. These findings strongly argue for P.E., through TRPC3 targeting, as potential and interesting therapeutics for MF management.", "evidence": [ { "database": "RefSeq", "id": "NP_001101917", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101917" }, { "database": "PubMed", "id": "30318928", "url": "https://glygen.org/publication/PubMed/30318928" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "common_name": "Rat" } ], "gene": [ { "name": "Nfatc3", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4", "locus": { "chromosome": "19", "start_pos": 38039564, "end_pos": 38114003, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000054264", "url": "https://www.ensembl.org/id/ENSRNOG00000054264" } ] } } ], "crossref": [ { "id": "ENSRNOG00000054264", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000054264", "database": "Bgee" }, { "id": "361400", "url": "https://www.ncbi.nlm.nih.gov/gene/361400", "database": "GeneID" }, { "id": "IPR002909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002909", "database": "InterPro" }, { "id": "IPR008366", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008366", "database": "InterPro" }, { "id": "IPR008967", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008967", "database": "InterPro" }, { "id": "IPR011539", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011539", "database": "InterPro" }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro" }, { "id": "IPR014756", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014756", "database": "InterPro" }, { "id": "IPR032397", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032397", "database": "InterPro" }, { "id": "IPR037059", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037059", "database": "InterPro" }, { "id": "rno:361400", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:361400", "database": "KEGG Pathway" }, { "id": "QGHKSYE", "url": "https://omabrowser.org/oma/group/QGHKSYE/", "database": "OMA" }, { "id": "95502at2759", "url": "http://www.orthodb.org/?query=95502at2759", "database": "OrthoDB" }, { "id": "PTHR12533", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12533", "database": "PANTHER" }, { "id": "PF00554", "url": "http://pfam.xfam.org/family/PF00554", "database": "Pfam" }, { "id": "PF16179", "url": "http://pfam.xfam.org/family/PF16179", "database": "Pfam" }, { "id": "R-RNO-2025928", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2025928", "database": "Reactome" }, { "id": "R-RNO-2871809", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2871809", "database": "Reactome" }, { "id": "R-RNO-5607763", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5607763", "database": "Reactome" }, { "id": "NP_001101917", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101917", "database": "RefSeq" }, { "id": "XP_006255575", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006255575", "database": "RefSeq" }, { "id": "1308692", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1308692", "database": "RGD" }, { "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4", "database": "UniProtKB" }, { "id": "A0A0G2JTY4-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4-1", "database": "UniProtKB" }, { "id": "A0A8I6AB55", "url": "https://www.uniprot.org/uniprot/A0A8I6AB55", "database": "UniProtKB" }, { "id": "A0A8I6AB55-1", "url": "https://www.uniprot.org/uniprot/A0A8I6AB55-1", "database": "UniProtKB" }, { "id": "D3ZU59", "url": "https://www.uniprot.org/uniprot/D3ZU59", "database": "UniProtKB" }, { "id": "D3ZU59-1", "url": "https://www.uniprot.org/uniprot/D3ZU59-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MTTANCGAHDELDFKLVFGEDGAPTPVSQVSRPADLEPDDCASIYIFNVDPPPSTLNSSLGLPHHGLLQSHSSVLSPSFQLQGFKNYEGTDDISESKYSSLSGPKPFECPSIQITSISPNCHQETDAHEDDLHVNDPEREYLERPSRDHLYLPLEPSYRESSLSPSPASSVSSRSWFSDASSCESLSHIYDDVDSELNEAAARFTLGSPLTSPGGSPGGCPGEESWHQQYGPGHSLSPRQSPCHSPRSSITDENWLSPRPASGPSSRPTSPCGKRRHSSAEVCYAGSLSPHHSPVPSPGHSPRGSVTEDTWLTAPVHTGSGLSPAPFPFQYCVETDIPLKTRKTSDDQAAILPGKLEVCSDDQGSLSPSRETSVDDGLGSQYPLKKDSSGDQFLSVPSPFTWSKPKPGHTPIFRTSSLPPLDWPLPTHFGQCELKIEVQPKTHHRAHYETEGSRGAVKASTGGHPVVKLLGYSEKPINLQMFIGTADDRYLRPHAFYQVHRITGKTVATASQEIIIASTKVLEIPLLPENNMSASIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGKVLSLQIASIPVECSQRSAQELPHIEKYSINSCSVNGGHEMIVTGSNFLPESKIIFLEKGQDGRPHWEAEGKIIREKCQGGHIVLEVPPYHNPAVTSAVQVHFYLCNGKRKKSQSQRFTYTPVLMKQEQREDTDLSSVPSLPVPHSAQTQRPSSDTGHPHDSALSAPRSLICPVQPAYASMITSTHLPQLQCRDEGAGKEQHIIPSSVMHQPFQVTPTSPMGSSYQSIQTNMYNGPTCLPMNPASSQEFDPVLFQQDAALSNLVNLGCQPLSPIPFHSSNSDATGHLLAHSPHSVQTPPHLQSMGYHCSSAGQRSLSSPVAAQVTGQPSSHLQPITYCPSHPGSATAASPAASHALSSSPISGPPSPQLQSMPYQSPSSGTASSPSPVTRMHSGQHSTQAQSTGQGGLSVPSSLVCHSLCDPASFPPGGAAVSIKPEPEDQEPNFATIGLQDITLDDVNEIIGRDMSQITVSQGPEVIRDAPLPGPESPDVMSSNSAQ", "length": 1076, "header": "tr|A0A0G2JTY4-1|A0A0G2JTY4_RAT Isoform 1 of Nuclear factor of-activated T-cells 3 OS=Rattus norvegicus OX=10116 GN=Nfatc3 PE=1 SV=1 CANONICAL=A0A0G2JTY4-1" }, "isoforms": [ { "isoform_ac": "A0A0G2JTY4-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4#A0A0G2JTY4-1", "sequence": { "sequence": "MTTANCGAHDELDFKLVFGEDGAPTPVSQVSRPADLEPDDCASIYIFNVDPPPSTLNSSLGLPHHGLLQSHSSVLSPSFQLQGFKNYEGTDDISESKYSSLSGPKPFECPSIQITSISPNCHQETDAHEDDLHVNDPEREYLERPSRDHLYLPLEPSYRESSLSPSPASSVSSRSWFSDASSCESLSHIYDDVDSELNEAAARFTLGSPLTSPGGSPGGCPGEESWHQQYGPGHSLSPRQSPCHSPRSSITDENWLSPRPASGPSSRPTSPCGKRRHSSAEVCYAGSLSPHHSPVPSPGHSPRGSVTEDTWLTAPVHTGSGLSPAPFPFQYCVETDIPLKTRKTSDDQAAILPGKLEVCSDDQGSLSPSRETSVDDGLGSQYPLKKDSSGDQFLSVPSPFTWSKPKPGHTPIFRTSSLPPLDWPLPTHFGQCELKIEVQPKTHHRAHYETEGSRGAVKASTGGHPVVKLLGYSEKPINLQMFIGTADDRYLRPHAFYQVHRITGKTVATASQEIIIASTKVLEIPLLPENNMSASIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGKVLSLQIASIPVECSQRSAQELPHIEKYSINSCSVNGGHEMIVTGSNFLPESKIIFLEKGQDGRPHWEAEGKIIREKCQGGHIVLEVPPYHNPAVTSAVQVHFYLCNGKRKKSQSQRFTYTPVLMKQEQREDTDLSSVPSLPVPHSAQTQRPSSDTGHPHDSALSAPRSLICPVQPAYASMITSTHLPQLQCRDEGAGKEQHIIPSSVMHQPFQVTPTSPMGSSYQSIQTNMYNGPTCLPMNPASSQEFDPVLFQQDAALSNLVNLGCQPLSPIPFHSSNSDATGHLLAHSPHSVQTPPHLQSMGYHCSSAGQRSLSSPVAAQVTGQPSSHLQPITYCPSHPGSATAASPAASHALSSSPISGPPSPQLQSMPYQSPSSGTASSPSPVTRMHSGQHSTQAQSTGQGGLSVPSSLVCHSLCDPASFPPGGAAVSIKPEPEDQEPNFATIGLQDITLDDVNEIIGRDMSQITVSQGPEVIRDAPLPGPESPDVMSSNSAQ", "length": 1076, "header": "tr|A0A0G2JTY4-1|A0A0G2JTY4_RAT Isoform 1 of Nuclear factor of-activated T-cells 3 OS=Rattus norvegicus OX=10116 GN=Nfatc3 PE=1 SV=1 CANONICAL=A0A0G2JTY4-1" }, "locus": { "chromosome": "19", "start_pos": 34032608, "end_pos": 33960933, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000087491.2", "url": "https://www.ensembl.org/id/ENSRNOT00000087491.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000068890.1", "url": "https://www.ensembl.org/id/ENSRNOP00000068890.1" } ] } }, { "isoform_ac": "A0A8I6AB55-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4#A0A8I6AB55-1", "sequence": { "sequence": "MTTANCGAHDELDFKLVFGEDGAPTPVSQVSRPADLEPDDCASIYIFNVDPPPSTLNSSLGLPHHGLLQSHSSVLSPSFQLQGFKNYEGTDDISESKYSSLSGPKPFECPSIQITSISPNCHQETDAHEDDLHVNDPEREYLERPSRDHLYLPLEPSYRESSLSPSPASSVSSRSWFSDASSCESLSHIYDDVDSELNEAAARFTLGSPLTSPGGSPGGCPGEESWHQQYGPGHSLSPRQSPCHSPRSSITDENWLSPRPASGPSSRPTSPCGKRRHSSAEVCYAGSLSPHHSPVPSPGHSPRGSVTEDTWLTAPVHTGSGLSPAPFPFQYCVETDIPLKTRKTSDDQAAILPGKLEVCSDDQGSLSPSRETSVDDGLGSQYPLKKDSSGDQFLSVPSPFTWSKPKPGHTPIFRTSSLPPLDWPLPTHFGQCELKIEVQPKTHHRAHYETEGSRGAVKASTGGHPVVKLLGYSEKPINLQMFIGTADDRYLRPHAFYQVHRITGKTVATASQEIIIASTKVLEIPLLPENNMSASIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGKVLSLQIASIPVECSQRSAQELPHIEKYSINSCSVNGGHEMIVTGSNFLPESKIIFLEKGQDGRPHWEAEGKIIREKCQGGHIVLEVPPYHNPAVTSAVQVHFYLCNGKRKKSQSQRFTYTPVLMKQEQREDTDLSSVPSLPVPHSAQTQRPSSDTGHPHDSALSAPRSLICPVQPAYASMITSTHLPQLQCRDEGAGKEQHIIPSSVMHQPFQVTPTSPMGSSYQSIQTNMYNGPTCLPMNPASSQEFDPVLFQQDAALSNLVNLGCQPLSPIPFHSSNSDATGHLLAHSPHSVQTPPHLQSMGYHCSSAGQRSLSSPVAAQVTGQPSSHLQPITYCPSHPGSATAASPAASHALSSSPISGPPSPQLQSMPYQSPSSGTASSPSPVTRMHSGQHSTQAQSTGQGGLSVPSSLVCHSLCDPASFPPGGAAVSIKPEPEDQEPNFATIGLQDITLDDGGTVGNQKGELSQRNSK", "length": 1052, "header": "tr|A0A8I6AB55-1|A0A0G2JTY4_RAT Computationally mapped isoform of Nuclear factor of-activated T-cells 3 OS=Rattus norvegicus OX=10116 GN=Nfatc3 PE=1 SV=1 CANONICAL=A0A0G2JTY4-1" }, "locus": { "chromosome": "19", "start_pos": 34031365, "end_pos": 33960933, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000105048.1", "url": "https://www.ensembl.org/id/ENSRNOT00000105048.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000090103.1", "url": "https://www.ensembl.org/id/ENSRNOP00000090103.1" } ] } }, { "isoform_ac": "D3ZU59-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4#D3ZU59-1", "sequence": { "sequence": "MTTANCGAHDELDFKLVFGEDGAPTPVSQVSRPADLEPDDCASIYIFNVDPPPSTLNSSLGLPHHGLLQSHSSVLSPSFQLQGFKNYEGTDDISESKYSSLSGPKPFECPSIQITSISPNCHQETDAHEDDLHVNDPEREYLERPSRDHLYLPLEPSYRESSLSPSPASSVSSRSWFSDASSCESLSHIYDDVDSELNEAAARFTLGSPLTSPGGSPGGCPGEESWHQQYGPGHSLSPRQSPCHSPRSSITDENWLSPRPASGPSSRPTSPCGKRRHSSAEVCYAGSLSPHHSPVPSPGHSPRGSVTEDTWLTAPVHTGSGLSPAPFPFQYCVETDIPLKTRKTSDDQAAILPGKLEVCSDDQGSLSPSRETSVDDGLGSQYPLKKDSSGDQFLSVPSPFTWSKPKPGHTPIFRTSSLPPLDWPLPTHFGQCELKIEVQPKTHHRAHYETEGSRGAVKASTGGHPVVKLLGYSEKPINLQMFIGTADDRYLRPHAFYQVHRITGKTVATASQEIIIASTKVLEIPLLPENNMSASIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGKVLSLQIASIPVECSQRSAQELPHIEKYSINSCSVNGGHEMIVTGSNFLPESKIIFLEKGQDGRPHWEAEGKIIREKCQGGHIVLEVPPYHNPAVTSAVQVHFYLCNGKRKKSQSQRFTYTPVLMKQEQREDTDLSSVPSLPVPHSAQTQRPSSDTGHPHDSALSAPRSLICPVQPAYASMITSTHLPQLQCRDEGAGKEQHIIPSSVMHQPFQVTPTSPMGSSYQSIQTNMYNGPTCLPMNPASSQEFDPVLFQQDAALSNLVNLGCQPLSPIPFHSSNSDATGHLLAHSPHSVQTPPHLQSMGYHCSSAGQRSLSSPVAAQVTGQPSSHLQPITYCPSHPGSATAASPAASHALSSSPISGPPSPQLQSMPYQSPSSGTASSPSPVTRMHSGQHSTQAQSTGQGGLSVPSSLVCHSLCDPASFPPGGAAVSIKPEPEDQEPNFATIGLQDITLDDDQFMSDLEHQPSGSTEKWPNHSEFSCPVPFWRI", "length": 1068, "header": "tr|D3ZU59-1|D3ZU59_RAT Computationally mapped isoform of Nuclear factor of-activated T-cells 3 OS=Rattus norvegicus OX=10116 GN=Nfatc3 PE=1 SV=1 CANONICAL=A0A0G2JTY4-1" }, "locus": { "chromosome": "19", "start_pos": 34021886, "end_pos": 33960933, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000089783.2", "url": "https://www.ensembl.org/id/ENSRNOT00000089783.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000069756.1", "url": "https://www.ensembl.org/id/ENSRNOP00000069756.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nat. Commun.", "date": "2012", "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" }, { "database": "UniProtKB", "id": "D3ZU59", "url": "https://www.uniprot.org/uniprot/D3ZU59" } ], "reference": [ { "type": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" } ] }, { "title": "NFAT3/c4-mediated excitotoxicity in hippocampal apoptosis during radiation-induced brain injury.", "journal": "Journal of radiation research", "date": "2017", "authors": "Xu M, Fan Q, Zhang J, Chen Y, Xu R, Chen L, Zhao P, Tian Y", "evidence": [ { "database": "RefSeq", "id": "NP_001101917", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101917" } ], "reference": [ { "type": "PubMed", "id": "28992110", "url": "https://glygen.org/publication/PubMed/28992110" } ] }, { "title": "Activation of transient receptor potential vanilloid 3 channel (TRPV3) aggravated pathological cardiac hypertrophy via calcineurin/NFATc3 pathway in rats.", "journal": "Journal of cellular and molecular medicine", "date": "2018", "authors": "Zhang Q, Qi H, Cao Y, Shi P, Song C, Ba L, Chen Y, Gao J, Li S, Li B, Sun H", "evidence": [ { "database": "RefSeq", "id": "NP_001101917", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101917" } ], "reference": [ { "type": "PubMed", "id": "30299584", "url": "https://glygen.org/publication/PubMed/30299584" } ] }, { "title": "Transient Receptor Potential Canonical 3 and Nuclear Factor of Activated T Cells C3 Signaling Pathway Critically Regulates Myocardial Fibrosis.", "journal": "Antioxidants & redox signaling", "date": "2019", "authors": "Saliba Y, Jebara V, Hajal J, Maroun R, Chacar S, Smayra V, Abramowitz J, Birnbaumer L, Fares N", "evidence": [ { "database": "RefSeq", "id": "NP_001101917", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101917" } ], "reference": [ { "type": "PubMed", "id": "30318928", "url": "https://glygen.org/publication/PubMed/30318928" } ] }, { "title": "AKAP79/150 recruits the transcription factor NFAT to regulate signaling to the nucleus by neuronal L-type Ca(2+) channels.", "journal": "Molecular biology of the cell", "date": "2019", "authors": "Murphy JG, Crosby KC, Dittmer PJ, Sather WA, Dell'Acqua ML", "evidence": [ { "database": "RefSeq", "id": "NP_001101917", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101917" } ], "reference": [ { "type": "PubMed", "id": "31091162", "url": "https://glygen.org/publication/PubMed/31091162" } ] }, { "title": "MicroRNA153 attenuates hypoxiainduced excessive proliferation and migration of pulmonary arterial smooth muscle cells by targeting ROCK1 and NFATc3.", "journal": "Molecular medicine reports", "date": "2021", "authors": "Zhao M, Wang W, Lu Y, Wang N, Kong D, Shan L", "evidence": [ { "database": "RefSeq", "id": "NP_001101917", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101917" } ], "reference": [ { "type": "PubMed", "id": "33495839", "url": "https://glygen.org/publication/PubMed/33495839" } ] } ], "pathway": [ { "id": "rno:361400", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:361400", "resource": "KEGG Pathway" }, { "id": "R-RNO-2025928", "name": "Calcineurin activates NFAT", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2025928", "resource": "Reactome", "description": "Calcineurin activates NFAT" }, { "id": "R-RNO-2871809", "name": "FCERI mediated Ca+2 mobilization", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2871809", "resource": "Reactome", "description": "FCERI mediated Ca+2 mobilization" }, { "id": "R-RNO-5607763", "name": "CLEC7A (Dectin-1) induces NFAT activation", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5607763", "resource": "Reactome", "description": "CLEC7A (Dectin-1) induces NFAT activation" } ], "orthologs": [ { "uniprot_canonical_ac": "P97305-1", "protein_name": "Nuclear factor of activated T-cells, cytoplasmic 3", "gene_name": "Nfatc3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": 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"length": 1075 }, "evidence": [ { "id": "41497201", "url": "http://www.informatics.jax.org/homology/41497201", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 23, "go_terms": [ { "name": "myotube cell development", "id": "GO:0014904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014904", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "negative regulation of vascular associated smooth muscle cell differentiation", "id": "GO:1905064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905064", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "21873635" }, { "name": "heart development", "id": "GO:0007507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007507", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "response to hypoxia", "id": "GO:0001666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001666", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "blood vessel remodeling", "id": "GO:0001974", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001974", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "regulation of transcription, DNA-templated", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "cellular response to calcium ion", "id": "GO:0071277", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071277", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "positive regulation of transcription, DNA-templated", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "15016802" }, { "name": "skeletal muscle fiber development", "id": "GO:0048741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048741", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "thymus development", "id": "GO:0048538", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048538", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "cardiac muscle hypertrophy in response to stress", "id": "GO:0014898", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014898", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "branching involved in blood vessel morphogenesis", "id": "GO:0001569", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001569", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "smooth muscle cell differentiation", "id": "GO:0051145", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051145", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "regulation of store-operated calcium entry", "id": "GO:2001256", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001256", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "myotube differentiation", "id": "GO:0014902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014902", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "T cell differentiation", "id": "GO:0030217", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030217", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "calcineurin-NFAT signaling cascade", "id": "GO:0033173", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033173", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "muscle cell development", "id": "GO:0055001", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055001", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "cellular response to lithium ion", "id": "GO:0071285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071285", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "cellular respiration", "id": "GO:0045333", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045333", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "negative regulation of miRNA transcription", "id": "GO:1902894", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902894", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 9, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "21873635" }, { "name": "sequence-specific DNA binding", "id": 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"https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "15644446" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4" } ], "pmid": "15644446" }, { "name": "transcription regulator complex", "id": "GO:0005667", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005667", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JTY4", "url": 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