{ "uniprot_canonical_ac": "A0A0G2JFS9-1", "uniprot_ac": "A0A0G2JFS9", "uniprot_id": "A0A0G2JFS9_MOUSE", "mass": { "chemical_mass": 45187.0, "monoisotopic_mass": 45187.0 }, "refseq": {}, "gene_names": [ { "name": "Atg4a-ps", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2JFS9", "id": "A0A0G2JFS9" } ], "protein_names": [ { "name": "Cysteine protease", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2JFS9#names_and_taxonomy", "id": "A0A0G2JFS9" }, { "name": "3.4.22.-", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0G2JFS9#names_and_taxonomy", "id": "A0A0G2JFS9" } ], "function": [ { "annotation": "Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JFS9", "url": "https://www.uniprot.org/uniprot/A0A0G2JFS9#function" }, { "database": "PubMed", "id": "RU363115", "url": "https://glygen.org/publication/PubMed/RU363115" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JFS9", "url": "https://www.uniprot.org/uniprot/A0A0G2JFS9" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Atg4a-ps", "url": "https://www.uniprot.org/uniprot/A0A0G2JFS9", "locus": { "chromosome": "3", "start_pos": 103646068, "end_pos": 103643954, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000087119", "url": "https://www.ensembl.org/id/ENSMUSG00000087119" } ] } } ], "crossref": [ { "id": "ENSMUSG00000087119", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000087119", "database": "Bgee" }, { "id": "IPR005078", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005078", "database": "InterPro" }, { "id": "IPR033474", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033474", "database": "InterPro" }, { "id": "IPR038765", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038765", "database": "InterPro" }, { "id": "3615624", "url": "http://www.informatics.jax.org/marker/MGI:3615624", "database": "MGI" }, { "id": "DIRTMAF", "url": "https://omabrowser.org/oma/group/DIRTMAF/", "database": "OMA" }, { "id": "PTHR22624", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22624", "database": "PANTHER" }, { "id": "PTHR22624:SF35", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22624:SF35", "database": "PANTHER" }, { "id": "PF03416", "url": "http://pfam.xfam.org/family/PF03416", "database": "Pfam" }, { "id": "67548", "url": "https://www.rhea-db.org/rhea/67548", "database": "Rhea" }, { "id": "A0A0G2JFS9", "url": "https://www.uniprot.org/uniprot/A0A0G2JFS9", "database": "UniProtKB" }, { "id": "A0A0G2JFS9-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JFS9-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MESVMSKYENQILIFPDYLEEFPDTDELVWILGKQHPFKTEKSKLLSDISARLWFTYRRKFSPIGGTGPSSDAGWGCMLRCGQMMLAQALICRHLGRDWNWERQKEQPKEYQRILQCFLDRKDCCYSIHQMAQMGVGEGKSIGEWFGPNTVAQVIKKLTLFDEWNSLAVYVSMDNTVVIEDIKKMCCVLPVGAADPAGDFLTVSNQSRDTSVPCSAWKPLLLIVPLRLGINQINPVYVEAFKECFKMPQSLGALGGKPNNAYYFIGFLGDELIFLDPHTTQTFVDIEESGLVDDQTFHCLQSPQRMSILNLDPSVALGFFCKEEKDFDNWCSLVQKEILKENLRMFELVQKHPSHWPPFVPPAKPEVTTTGAEFIESTEQLEDFELEEDFEILSVG", "length": 396, "header": "tr|A0A0G2JFS9-1|A0A0G2JFS9_MOUSE Isoform 1 of Cysteine protease OS=Mus musculus OX=10090 GN=Atg4a-ps PE=3 SV=1 CANONICAL=A0A0G2JFS9-1" }, "isoforms": [ { "isoform_ac": "A0A0G2JFS9-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JFS9#A0A0G2JFS9-1", "sequence": { "sequence": "MESVMSKYENQILIFPDYLEEFPDTDELVWILGKQHPFKTEKSKLLSDISARLWFTYRRKFSPIGGTGPSSDAGWGCMLRCGQMMLAQALICRHLGRDWNWERQKEQPKEYQRILQCFLDRKDCCYSIHQMAQMGVGEGKSIGEWFGPNTVAQVIKKLTLFDEWNSLAVYVSMDNTVVIEDIKKMCCVLPVGAADPAGDFLTVSNQSRDTSVPCSAWKPLLLIVPLRLGINQINPVYVEAFKECFKMPQSLGALGGKPNNAYYFIGFLGDELIFLDPHTTQTFVDIEESGLVDDQTFHCLQSPQRMSILNLDPSVALGFFCKEEKDFDNWCSLVQKEILKENLRMFELVQKHPSHWPPFVPPAKPEVTTTGAEFIESTEQLEDFELEEDFEILSVG", "length": 396, "header": "tr|A0A0G2JFS9-1|A0A0G2JFS9_MOUSE Isoform 1 of Cysteine protease OS=Mus musculus OX=10090 GN=Atg4a-ps PE=3 SV=1 CANONICAL=A0A0G2JFS9-1" }, "locus": { "chromosome": "3", "start_pos": 103553339, "end_pos": 103552152, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000117271.3", "url": "https://www.ensembl.org/id/ENSMUST00000117271.3" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000143291.2", "url": "https://www.ensembl.org/id/ENSMUSP00000143291.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JFS9", "url": "https://www.uniprot.org/uniprot/A0A0G2JFS9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JFS9", "url": "https://www.uniprot.org/uniprot/A0A0G2JFS9" } ], "pmid": "" }, { "name": "lipid metabolic process", "id": "GO:0006629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006629", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JFS9", "url": "https://www.uniprot.org/uniprot/A0A0G2JFS9" } ], "pmid": "" }, { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JFS9", "url": "https://www.uniprot.org/uniprot/A0A0G2JFS9" } ], "pmid": "" }, { "name": "autophagy", "id": "GO:0006914", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006914", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JFS9", "url": "https://www.uniprot.org/uniprot/A0A0G2JFS9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cysteine-type endopeptidase activity", "id": "GO:0004197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004197", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JFS9", "url": "https://www.uniprot.org/uniprot/A0A0G2JFS9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 205, "end_pos": 207, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "67548", "name": "", "equation": "[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "M0R5T6-1", "B1H274-1", "A0A0G2QC33-1", "A0A8I5ZXZ8-1", "Q86TL0-1", "Q9Y4P1-1", "Q96DT6-1", "Q8WYN0-1", "Q8C9S8-1", "Q8BGV9-1", "Q8BGE6-1", "A0A0G2JFS9-1", "Q811C2-1", "Q9VF80-1", "Q9VPW2-1" ], "evidence": [ { "id": "67548", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/67548" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A0G2JFS9", "gene_name": "Atg4a-ps", "activity": [ { "ec_number": "3.4.22.-", "activity": "", "evidence": [ { "id": "A0A0G2JFS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JFS9" } ] } ] }, { "uniprot_ac": "A0A0G2QC33", "gene_name": "Atg4b", "activity": [ { "ec_number": "3.4.22.-", "activity": "", "evidence": [ { "id": "A0A0G2QC33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2QC33" } ] } ] }, { "uniprot_ac": "A0A8I5ZXZ8", "gene_name": "Atg4c", "activity": [ { "ec_number": "3.4.22.-", "activity": "", "evidence": [ { "id": "A0A8I5ZXZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZXZ8" } ] } ] }, { "uniprot_ac": "B1H274", "gene_name": "Atg4a", "activity": [ { "ec_number": "3.4.22.-", "activity": "", "evidence": [ { "id": "B1H274", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1H274" } ] } ] }, { "uniprot_ac": "M0R5T6", "gene_name": "Atg4d", "activity": [ { "ec_number": "3.4.22.-", "activity": "", "evidence": [ { "id": "M0R5T6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0R5T6" } ] } ] }, { "uniprot_ac": "Q811C2", "gene_name": "Atg4c", "activity": [ { "ec_number": "3.4.22.-", "activity": "", "evidence": [ { "id": "Q811C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q811C2" } ] } ] }, { "uniprot_ac": "Q86TL0", "gene_name": "ATG4D", "activity": [ { "ec_number": "3.4.22.-", "activity": "", "evidence": [ { "id": "Q86TL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86TL0" } ] } ] }, { "uniprot_ac": "Q8BGE6", "gene_name": "Atg4b", "activity": [ { "ec_number": "3.4.22.-", "activity": "", "evidence": [ { "id": "Q8BGE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BGE6" } ] } ] }, { "uniprot_ac": "Q8BGV9", "gene_name": "Atg4d", "activity": [ { "ec_number": "3.4.22.-", "activity": "", "evidence": [ { "id": "Q8BGV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BGV9" } ] } ] }, { "uniprot_ac": "Q8C9S8", "gene_name": "Atg4a", "activity": [ { "ec_number": "3.4.22.-", "activity": "", "evidence": [ { "id": "Q8C9S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8C9S8" } ] } ] }, { "uniprot_ac": "Q8WYN0", "gene_name": "ATG4A", "activity": [ { "ec_number": "3.4.22.-", "activity": "", "evidence": [ { "id": "Q8WYN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WYN0" } ] } ] }, { "uniprot_ac": "Q96DT6", "gene_name": "ATG4C", "activity": [ { "ec_number": "3.4.22.-", "activity": "", "evidence": [ { "id": "Q96DT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96DT6" } ] } ] }, { "uniprot_ac": "Q9VF80", "gene_name": "Atg4b", "activity": [ { "ec_number": "3.4.22.-", "activity": "", "evidence": [ { "id": "Q9VF80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VF80" } ] } ] }, { "uniprot_ac": "Q9VPW2", "gene_name": "Atg4a", "activity": [ { "ec_number": "3.4.22.-", "activity": "", "evidence": [ { "id": "Q9VPW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VPW2" } ] } ] }, { "uniprot_ac": "Q9Y4P1", "gene_name": "ATG4B", "activity": [ { "ec_number": "3.4.22.-", "activity": "", "evidence": [ { "id": "Q9Y4P1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y4P1" } ] } ] } ], "synthesized_glycans": [], "cluster_types": [] }