{ "uniprot_canonical_ac": "A0A0G2JDS2-1", "uniprot_ac": "A0A0G2JDS2", "uniprot_id": "A0A0G2JDS2_MOUSE", "mass": { "chemical_mass": 47746.0, "monoisotopic_mass": 47746.0 }, "refseq": { "ac": "NP_001074285", "name": "chitinase like precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074285" }, "gene_names": [ { "name": "Chil5", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2JDS2", "id": "A0A0G2JDS2" }, { "name": "Bclp; Bclp1; Bclp2; Chi3l7", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074285", "id": "NP_001074285" }, { "name": "Chil5", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074285", "id": "NP_001074285" } ], "protein_names": [ { "name": "Chitinase-like 5", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0G2JDS2#names_and_taxonomy", "id": "A0A0G2JDS2" }, { "name": "chitinase like precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074285", "id": "NP_001074285" }, { "name": "chitinase like protein 2; chitinase 3-like 7", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074285", "id": "NP_001074285" } ], "function": [], "disease": [ { "disease_id": "DOID:0050127", "recommended_name": { "id": "DOID:0050127", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050127", "name": "sinusitis", "description": "A paranasal sinus disease involving inflammation of the paranasal sinuses resulting from bacterial, fungal, viral infection, allergic or autoimmune issues. Symptoms can include fever, weakness, fatigue, cough and congestion. There may also be mucus drainage in the back of the throat, called postnasal drip." }, "synonyms": [], "evidence": [ { "id": "0050127", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050127" } ] }, { "disease_id": "DOID:2841", "recommended_name": { "id": "DOID:2841", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2841", "name": "asthma", "description": "A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing." }, "synonyms": [ { "id": "DOID:2841", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2841", "name": "Exercise induced asthma", "description": "" }, { "id": "DOID:2841", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2841", "name": "bronchial hyperreactivity", "description": "" }, { "id": "DOID:2841", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2841", "name": "chronic obstructive asthma", "description": "" }, { "id": "DOID:2841", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2841", "name": "chronic obstructive asthma with acute exacerbation", "description": "" }, { "id": "DOID:2841", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2841", "name": "chronic obstructive asthma with status asthmaticus", "description": "" }, { "id": "DOID:2841", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2841", "name": "exercise-induced asthma", "description": "" }, { "id": "MONDO:0010940", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010940", "name": "inherited susceptibility to asthma", "description": "" }, { "id": "MONDO:0010940", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010940", "name": "asthma-related traits, susceptibility to", "description": "" }, { "id": "MONDO:0010940", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010940", "name": "asthma, diminished response to Antileukotriene treatment 1N", "description": "" }, { "id": "MONDO:0010940", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010940", "name": "asthma, protection against", "description": "" }, { "id": "MONDO:0010940", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010940", "name": "asthma, susceptibility to", "description": "" }, { "id": "MONDO:0010940", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010940", "name": "asthma, bronchial", "description": "" }, { "id": "MIM:600807", "resource": "MIM", "url": "https://www.omim.org/entry/600807", "name": "Asthma", "description": "Asthma" } ], "evidence": [ { "id": "2841", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2841" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JDS2", "url": "https://www.uniprot.org/uniprot/A0A0G2JDS2" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Chil5", "url": "https://www.uniprot.org/uniprot/A0A0G2JDS2", "locus": { "chromosome": "3", "start_pos": 106032814, "end_pos": 106016919, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000043873", "url": "https://www.ensembl.org/id/ENSMUSG00000043873" } ] } } ], "crossref": [ { "id": "ENSMUSG00000043873", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000043873", "database": "Bgee" }, { "id": "229687", "url": "https://www.ncbi.nlm.nih.gov/gene/229687", "database": "GeneID" }, { "id": "IPR001223", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001223", "database": "InterPro" }, { "id": "IPR011583", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011583", "database": "InterPro" }, { "id": "IPR017853", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017853", "database": "InterPro" }, { "id": "IPR029070", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029070", "database": "InterPro" }, { "id": "mmu:229687", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:229687", "database": "KEGG Pathway" }, { "id": "2676649", "url": "http://www.informatics.jax.org/marker/MGI:2676649", "database": "MGI" }, { "id": "WTGSQYY", "url": "https://omabrowser.org/oma/group/WTGSQYY/", "database": "OMA" }, { "id": "826687at2759", "url": "http://www.orthodb.org/?query=826687at2759", "database": "OrthoDB" }, { "id": "PF00704", "url": "http://pfam.xfam.org/family/PF00704", "database": "Pfam" }, { "id": "NP_001074285", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074285", "database": "RefSeq" }, { "id": "A0A0G2JDS2", "url": "https://www.uniprot.org/uniprot/A0A0G2JDS2", "database": "UniProtKB" }, { "id": "A0A0G2JDS2-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JDS2-1", "database": "UniProtKB" }, { "id": "F7AQE8", "url": "https://www.uniprot.org/uniprot/F7AQE8", "database": "UniProtKB" }, { "id": "F7AQE8-1", "url": "https://www.uniprot.org/uniprot/F7AQE8-1", "database": "UniProtKB" }, { "id": "F7D8T8", "url": "https://www.uniprot.org/uniprot/F7D8T8", "database": "UniProtKB" }, { "id": "F7D8T8-1", "url": "https://www.uniprot.org/uniprot/F7D8T8-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MTKLILVTGLALLLNPQLGSAYQLMCYYNNVAQNRPKLGSFNPADIDPCLCTHLIYAFAGMQNNKVTMRSMNDLTDYQALNTLKSRNVQLKTLLAIGGRDFGPAPFSAMVSTPHNQQTFINSAIKFLRQYGFDGLNLDWQFPGSRGSPSRDKHLFTVLVQKIREAFELEAIENKSPRLMVTATVAGVISTIQSGYEIPQLSHFLDYIQVMTYNLHGSQDGYTGENSPLYKSLNDTGINTLLNVDYIMTYWNENGAAPEKLIVGFPAYGQTFTLSDPSNNGISAPTASAGTLGPYTEESGTWAYYEICSFLNDGATEAWDSAQEVPYAYQGNKWVGYDNVKSFRIKAEWLKQNNLGGAMLWTLDMDDFTGSFCNQGQFPLTSTLKNALLVYSTSCMASVSDLQQVNAPLYSGNRNWKRGSKAMDSVSPVPRE", "length": 431, "header": "tr|A0A0G2JDS2-1|A0A0G2JDS2_MOUSE Isoform 1 of Chitinase-like 5 OS=Mus musculus OX=10090 GN=Chil5 PE=4 SV=1 CANONICAL=A0A0G2JDS2-1" }, "isoforms": [ { "isoform_ac": "A0A0G2JDS2-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JDS2#A0A0G2JDS2-1", "sequence": { "sequence": "MTKLILVTGLALLLNPQLGSAYQLMCYYNNVAQNRPKLGSFNPADIDPCLCTHLIYAFAGMQNNKVTMRSMNDLTDYQALNTLKSRNVQLKTLLAIGGRDFGPAPFSAMVSTPHNQQTFINSAIKFLRQYGFDGLNLDWQFPGSRGSPSRDKHLFTVLVQKIREAFELEAIENKSPRLMVTATVAGVISTIQSGYEIPQLSHFLDYIQVMTYNLHGSQDGYTGENSPLYKSLNDTGINTLLNVDYIMTYWNENGAAPEKLIVGFPAYGQTFTLSDPSNNGISAPTASAGTLGPYTEESGTWAYYEICSFLNDGATEAWDSAQEVPYAYQGNKWVGYDNVKSFRIKAEWLKQNNLGGAMLWTLDMDDFTGSFCNQGQFPLTSTLKNALLVYSTSCMASVSDLQQVNAPLYSGNRNWKRGSKAMDSVSPVPRE", "length": 431, "header": "tr|A0A0G2JDS2-1|A0A0G2JDS2_MOUSE Isoform 1 of Chitinase-like 5 OS=Mus musculus OX=10090 GN=Chil5 PE=4 SV=1 CANONICAL=A0A0G2JDS2-1" }, "locus": { "chromosome": "3", "start_pos": 105940130, "end_pos": 105924451, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000200146.2", "url": "https://www.ensembl.org/id/ENSMUST00000200146.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000142477.2", "url": "https://www.ensembl.org/id/ENSMUSP00000142477.2" } ] } }, { "isoform_ac": "F7AQE8-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JDS2#F7AQE8-1", "sequence": { "sequence": "GRDFGPAPFSAMVSTPHNQQTFINSAIKFLRQYGFDGLNLDWQFPGSRGSPSRDKHLFTVLVQDYIMTYWNENGAAPEKLIVGFPAYGQTFTLSDPSNNGISAPTASAGTLGPYTEESGTWAYYEICSFLNDGATEAWDSAQEVPYAYQGNKWVGYDNVKSFRIKAEWLKQNNLGGAMLWTLDMDDFTGSFCNQGQFPLTSTLKNALLVYSTSCMASVSDLQQVNAPLYSGNRNWKRGSKAMDSVSPVPRE", "length": 251, "header": "tr|F7AQE8-1|A0A0G2JDS2_MOUSE Computationally mapped isoform of Chitinase-like 5 OS=Mus musculus OX=10090 GN=Chil5 PE=4 SV=1 CANONICAL=A0A0G2JDS2-1" }, "locus": { "chromosome": "3", "start_pos": 105932227, "end_pos": 105924451, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000066537.10", "url": "https://www.ensembl.org/id/ENSMUST00000066537.10" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000065043.5", "url": "https://www.ensembl.org/id/ENSMUSP00000065043.5" } ] } }, { "isoform_ac": "F7D8T8-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JDS2#F7D8T8-1", "sequence": { "sequence": "XGGRDFGPAPFSAMVSTPHNQQTFINSAIKFLRQYGFDGLNLDWQFPGSRGSPSRDKHLFTVLVQLPRLHPGHDLQSPWLPRWLYWGKQPTLQIPK", "length": 96, "header": "tr|F7D8T8-1|A0A0G2JDS2_MOUSE Computationally mapped isoform of Chitinase-like 5 OS=Mus musculus OX=10090 GN=Chil5 PE=4 SV=1 CANONICAL=A0A0G2JDS2-1" }, "locus": { "chromosome": "3", "start_pos": 105932232, "end_pos": 105926935, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000054973.8", "url": "https://www.ensembl.org/id/ENSMUST00000054973.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000052345.4", "url": "https://www.ensembl.org/id/ENSMUSP00000052345.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects.", "journal": "Human molecular genetics", "date": "2006", "authors": "Desai J, Shannon ME, Johnson MD, Ruff DW, Hughes LA, Kerley MK, Carpenter DA, Johnson DK, Rinchik EM, Culiat CT", "evidence": [ { "database": "RefSeq", "id": "NP_001074285", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074285" } ], "reference": [ { "type": "PubMed", "id": "16537572", "url": "https://glygen.org/publication/PubMed/16537572" } ] } ], "pathway": [ { "id": "mmu:229687", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:229687", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q9BZP6-1", "protein_name": "Acidic mammalian chitinase", "gene_name": "CHIA", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTKLILLTGLVLILNLQLGSAYQLTCYFTNWAQYRPGLGRFMPDNIDPCLCTHLIYAFAGRQNNEITTIEWNDVTLYQAFNGLKNKNSQLKTLLAIGGWNFGTAPFTAMVSTPENRQTFITSVIKFLRQYEFDGLDFDWEYPGSRGSPPQDKHLFTVLVQEMREAFEQEAKQINKPRLMVTAAVAAGISNIQSGYEIPQLSQYLDYIHVMTYDLHGSWEGYTGENSPLYKYPTDTGSNAYLNVDYVMNYWKDNGAPAEKLIVGFPTYGHNFILSNPSNTGIGAPTSGAGPAGPYAKESGIWAYYEICTFLKNGATQGWDAPQEVPYAYQGNVWVGYDNIKSFDIKAQWLKHNKFGGAMVWAIDLDDFTGTFCNQGKFPLISTLKKALGLQSASCTAPAQPIEPITAAPSGSGNGSGSSSSGGSSGGSGFCAVRANGLYPVANNRNAFWHCVNGVTYQQNCQAGLVFDTSCDCCNWA", "length": 476 }, "evidence": [ { "id": "41488680", "url": "http://www.informatics.jax.org/homology/41488680", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JDS2", "url": "https://www.uniprot.org/uniprot/A0A0G2JDS2" } ], "pmid": "21873635" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JDS2", "url": "https://www.uniprot.org/uniprot/A0A0G2JDS2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "carbohydrate metabolic process", "id": "GO:0005975", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005975", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JDS2", "url": "https://www.uniprot.org/uniprot/A0A0G2JDS2" } ], "pmid": "" }, { "name": "positive regulation of chemokine production", "id": "GO:0032722", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032722", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JDS2", "url": "https://www.uniprot.org/uniprot/A0A0G2JDS2" } ], "pmid": "" }, { "name": "production of molecular mediator involved in inflammatory response", "id": "GO:0002532", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002532", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JDS2", "url": "https://www.uniprot.org/uniprot/A0A0G2JDS2" } ], "pmid": "" }, { "name": "chitin catabolic process", "id": "GO:0006032", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006032", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JDS2", "url": "https://www.uniprot.org/uniprot/A0A0G2JDS2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "kinase binding", "id": "GO:0019900", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019900", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JDS2", "url": "https://www.uniprot.org/uniprot/A0A0G2JDS2" } ], "pmid": "" }, { "name": "chitin binding", "id": "GO:0008061", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008061", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JDS2", "url": "https://www.uniprot.org/uniprot/A0A0G2JDS2" } ], "pmid": "21873635" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 173, "end_pos": 175, "annotation": "n_glycosylation_sequon" }, { "start_pos": 233, "end_pos": 235, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ] }