{
    "uniprot_canonical_ac": "A0A096MJS6-1",
    "uniprot_ac": "A0A096MJS6",
    "uniprot_id": "A0A096MJS6_RAT",
    "mass": {
        "chemical_mass": 18844.0,
        "monoisotopic_mass": 18844.0
    },
    "refseq": {
        "ac": "NP_001017467",
        "name": "lymphocyte antigen 6E precursor",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017467"
    },
    "gene_names": [
        {
            "name": "Ly6e",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A096MJS6",
            "id": "A0A096MJS6"
        },
        {
            "name": "LOC362934",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A096MJS6",
            "id": "A0A096MJS6"
        },
        {
            "name": "Ly6e",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017467",
            "id": "NP_001017467"
        },
        {
            "name": "rCG_59814",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A096MJS6",
            "id": "A0A096MJS6"
        }
    ],
    "protein_names": [
        {
            "name": "Lymphocyte antigen 6 family member E",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A096MJS6#names_and_taxonomy",
            "id": "A0A096MJS6"
        },
        {
            "name": "lymphocyte antigen 6E precursor",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017467",
            "id": "NP_001017467"
        },
        {
            "name": "lymphocyte antigen 6E; lymphocyte antigen 6 complex, locus E",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017467",
            "id": "NP_001017467"
        }
    ],
    "function": [],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A096MJS6",
                    "url": "https://www.uniprot.org/uniprot/A0A096MJS6"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Ly6e",
            "url": "https://www.uniprot.org/uniprot/A0A096MJS6",
            "locus": {
                "chromosome": "7",
                "start_pos": 116355698,
                "end_pos": 116359862,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000007091",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000007091"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000007091",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000007091",
            "database": "Bgee"
        },
        {
            "id": "cd00117",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00117",
            "database": "CDD"
        },
        {
            "id": "362934",
            "url": "https://www.ncbi.nlm.nih.gov/gene/362934",
            "database": "GeneID"
        },
        {
            "id": "IPR016054",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR016054",
            "database": "InterPro"
        },
        {
            "id": "IPR045860",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR045860",
            "database": "InterPro"
        },
        {
            "id": "rno:362934",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:362934",
            "database": "KEGG Pathway"
        },
        {
            "id": "CSPICPG",
            "url": "https://omabrowser.org/oma/group/CSPICPG/",
            "database": "OMA"
        },
        {
            "id": "1493078at2759",
            "url": "http://www.orthodb.org/?query=1493078at2759",
            "database": "OrthoDB"
        },
        {
            "id": "PF00021",
            "url": "http://pfam.xfam.org/family/PF00021",
            "database": "Pfam"
        },
        {
            "id": "R-RNO-163125",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-163125",
            "database": "Reactome"
        },
        {
            "id": "NP_001017467",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017467",
            "database": "RefSeq"
        },
        {
            "id": "1565342",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1565342",
            "database": "RGD"
        },
        {
            "id": "A0A096MJS6",
            "url": "https://www.uniprot.org/uniprot/A0A096MJS6",
            "database": "UniProtKB"
        },
        {
            "id": "A0A096MJS6-1",
            "url": "https://www.uniprot.org/uniprot/A0A096MJS6-1",
            "database": "UniProtKB"
        },
        {
            "id": "Q6AY73",
            "url": "https://www.uniprot.org/uniprot/Q6AY73",
            "database": "UniProtKB"
        },
        {
            "id": "Q6AY73-1",
            "url": "https://www.uniprot.org/uniprot/Q6AY73-1",
            "database": "UniProtKB"
        }
    ],
    "sequence": {
        "sequence": "MRTGPTGLGTELGHLELPLPTTRCQQGSGQERPKASLACDLQQMSAASSMRVFLPVLLAALLGVEQVHSLMCFSCTDQKNNINCLWPVSCSSTDNYCITLSAAAGFGNVNLGYTLNKGCSPTCPRENININLGVASVNSYCCQSSFCNFSTAGLGLRASIPLLGLGLLLSLLAVLRLSP",
        "length": 179,
        "header": "tr|A0A096MJS6-1|A0A096MJS6_RAT Isoform 1 of Lymphocyte antigen 6 family member E  OS=Rattus norvegicus OX=10116 GN=Ly6e PE=4 SV=2 CANONICAL=A0A096MJS6-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A096MJS6-1",
            "url": "https://www.uniprot.org/uniprot/A0A096MJS6#A0A096MJS6-1",
            "sequence": {
                "sequence": "MRTGPTGLGTELGHLELPLPTTRCQQGSGQERPKASLACDLQQMSAASSMRVFLPVLLAALLGVEQVHSLMCFSCTDQKNNINCLWPVSCSSTDNYCITLSAAAGFGNVNLGYTLNKGCSPTCPRENININLGVASVNSYCCQSSFCNFSTAGLGLRASIPLLGLGLLLSLLAVLRLSP",
                "length": 179,
                "header": "tr|A0A096MJS6-1|A0A096MJS6_RAT Isoform 1 of Lymphocyte antigen 6 family member E  OS=Rattus norvegicus OX=10116 GN=Ly6e PE=4 SV=2 CANONICAL=A0A096MJS6-1"
            },
            "locus": {
                "chromosome": "7",
                "start_pos": 106939070,
                "end_pos": 106936997,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000076790.3",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000076790.3"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000068244.2",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000068244.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q6AY73-1",
            "url": "https://www.uniprot.org/uniprot/A0A096MJS6#Q6AY73-1",
            "sequence": {
                "sequence": "MSAASSMRVFLPVLLAALLGVEQVHSLMCFSCTDQKNNINCLWPVSCSSTDNYCITLSAAAGFGNVNLGYTLNKGCSPTCPRENININLGVASVNSYCCQSSFCNFSTAGLGLRASIPLLGLGLLLSLLAVLRLSP",
                "length": 136,
                "header": "tr|Q6AY73-1|Q6AY73_RAT Computationally mapped isoform of Similar to lymphocyte antigen 6 complex, locus E, isoform CRA_a  OS=Rattus norvegicus OX=10116 GN=Ly6e PE=2 SV=1 CANONICAL=A0A096MJS6-1"
            },
            "locus": {
                "chromosome": "7",
                "start_pos": 106939070,
                "end_pos": 106938165,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000009333.7",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000009333.7"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000009333.3",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000009333.3"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Essential role for the lymphostromal plasma membrane Ly-6 superfamily molecule thymic shared antigen 1 in development of the embryonic adrenal gland.",
            "journal": "Molecular and cellular biology",
            "date": "2002",
            "authors": "Zammit DJ, Berzins SP, Gill JW, Randle-Barrett ES, Barnett L, Koentgen F, Lambert GW, Harvey RP, Boyd RL, Classon BJ",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001017467",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017467"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "11784869",
                    "url": "https://glygen.org/publication/PubMed/11784869"
                }
            ]
        },
        {
            "title": "Mechanisms of inhibition and potentiation of alpha4beta2 nicotinic acetylcholine receptors by members of the Ly6 protein family.",
            "journal": "The Journal of biological chemistry",
            "date": "2015",
            "authors": "Wu M, Puddifoot CA, Taylor P, Joiner WJ",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001017467",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017467"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "26276394",
                    "url": "https://glygen.org/publication/PubMed/26276394"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "rno:362934",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:362934",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-RNO-163125",
            "name": "Post-translational modification: synthesis of GPI-anchored proteins",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-163125",
            "resource": "Reactome",
            "description": "Post-translational modification: synthesis of GPI-anchored proteins"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q16553-1",
            "protein_name": "Lymphocyte antigen 6E",
            "gene_name": "LY6E",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MKIFLPVLLAALLGVERASSLMCFSCLNQKSNLYCLKPTICSDQDNYCVTVSASAGIGNLVTFGHSLSKTCSPACPIPEGVNVGVASMGISCCQSFLCNFSAADGGLRASVTLLGAGLLLSLLPALLRFGP",
                "length": 131
            },
            "evidence": [
                {
                    "id": "41504024",
                    "url": "http://www.informatics.jax.org/homology/41504024",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q64253-1",
            "protein_name": "Lymphocyte antigen 6E",
            "gene_name": "Ly6e",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MSATSNMRVFLPVLLAALLGMEQVHSLMCFSCTDQKNNINCLWPVSCQEKDHYCITLSAAAGFGNVNLGYTLNKGCSPICPSENVNLNLGVASVNSYCCQSSFCNFSAAGLGLRASIPLLGLGLLLSLLALLQLSP",
                "length": 136
            },
            "evidence": [
                {
                    "id": "41504024",
                    "url": "http://www.informatics.jax.org/homology/41504024",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 8,
                "go_terms": [
                    {
                        "name": "epinephrine secretion",
                        "id": "GO:0048242",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048242",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A096MJS6",
                                "url": "https://www.uniprot.org/uniprot/A0A096MJS6"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "in utero embryonic development",
                        "id": "GO:0001701",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001701",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A096MJS6",
                                "url": "https://www.uniprot.org/uniprot/A0A096MJS6"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "acetylcholine receptor signaling pathway",
                        "id": "GO:0095500",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0095500",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A096MJS6",
                                "url": "https://www.uniprot.org/uniprot/A0A096MJS6"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "norepinephrine metabolic process",
                        "id": "GO:0042415",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042415",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A096MJS6",
                                "url": "https://www.uniprot.org/uniprot/A0A096MJS6"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "adrenal gland development",
                        "id": "GO:0030325",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030325",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A096MJS6",
                                "url": "https://www.uniprot.org/uniprot/A0A096MJS6"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "organ growth",
                        "id": "GO:0035265",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035265",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A096MJS6",
                                "url": "https://www.uniprot.org/uniprot/A0A096MJS6"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ventricular cardiac muscle tissue morphogenesis",
                        "id": "GO:0055010",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055010",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A096MJS6",
                                "url": "https://www.uniprot.org/uniprot/A0A096MJS6"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of viral entry into host cell",
                        "id": "GO:0046597",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046597",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A096MJS6",
                                "url": "https://www.uniprot.org/uniprot/A0A096MJS6"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 4,
                "go_terms": [
                    {
                        "name": "plasma membrane",
                        "id": "GO:0005886",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A096MJS6",
                                "url": "https://www.uniprot.org/uniprot/A0A096MJS6"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "integral component of membrane",
                        "id": "GO:0016021",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A096MJS6",
                                "url": "https://www.uniprot.org/uniprot/A0A096MJS6"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "synapse",
                        "id": "GO:0045202",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A096MJS6",
                                "url": "https://www.uniprot.org/uniprot/A0A096MJS6"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "anchored component of membrane",
                        "id": "GO:0031225",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031225",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A096MJS6",
                                "url": "https://www.uniprot.org/uniprot/A0A096MJS6"
                            }
                        ],
                        "pmid": "21873635"
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 2,
                "go_terms": [
                    {
                        "name": "acetylcholine receptor binding",
                        "id": "GO:0033130",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033130",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A096MJS6",
                                "url": "https://www.uniprot.org/uniprot/A0A096MJS6"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "acetylcholine receptor inhibitor activity",
                        "id": "GO:0030550",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030550",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A096MJS6",
                                "url": "https://www.uniprot.org/uniprot/A0A096MJS6"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 148,
            "end_pos": 150,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        }
    ]
}