{
    "uniprot_canonical_ac": "A0A096LPJ9-1",
    "uniprot_ac": "A0A096LPJ9",
    "uniprot_id": "A0A096LPJ9_HUMAN",
    "mass": {
        "chemical_mass": 14267.0,
        "monoisotopic_mass": 14267.0
    },
    "refseq": {},
    "gene_names": [
        {
            "name": "CRYAA2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A096LPJ9",
            "id": "A0A096LPJ9"
        }
    ],
    "protein_names": [
        {
            "name": "Alpha-crystallin A chain",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A096LPJ9#names_and_taxonomy",
            "id": "A0A096LPJ9"
        }
    ],
    "function": [
        {
            "annotation": "May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A096LPJ9",
                    "url": "https://www.uniprot.org/uniprot/A0A096LPJ9#function"
                },
                {
                    "database": "PubMed",
                    "id": "PIRNR036514",
                    "url": "https://glygen.org/publication/PubMed/PIRNR036514"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Homo sapiens",
            "taxid": 9606,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A096LPJ9",
                    "url": "https://www.uniprot.org/uniprot/A0A096LPJ9"
                }
            ],
            "common_name": "Human"
        }
    ],
    "gene": [
        {
            "name": "CRYAA2",
            "url": "https://www.uniprot.org/uniprot/A0A096LPJ9",
            "locus": {
                "chromosome": "21",
                "start_pos": 6560714,
                "end_pos": 6564489,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSG00000276076",
                        "url": "https://www.ensembl.org/id/ENSG00000276076"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSG00000276076",
            "url": "https://bgee.org/?page=gene&gene_id=ENSG00000276076",
            "database": "Bgee"
        },
        {
            "id": "51901",
            "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=51901",
            "database": "HGNC"
        },
        {
            "id": "IPR001436",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001436",
            "database": "InterPro"
        },
        {
            "id": "IPR002068",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR002068",
            "database": "InterPro"
        },
        {
            "id": "IPR008978",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR008978",
            "database": "InterPro"
        },
        {
            "id": "IPR012274",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR012274",
            "database": "InterPro"
        },
        {
            "id": "PTHR45640",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45640",
            "database": "PANTHER"
        },
        {
            "id": "PTHR45640:SF14",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45640:SF14",
            "database": "PANTHER"
        },
        {
            "id": "PF00011",
            "url": "http://pfam.xfam.org/family/PF00011",
            "database": "Pfam"
        },
        {
            "id": "A0A096LPJ9",
            "url": "https://www.uniprot.org/uniprot/A0A096LPJ9",
            "database": "UniProtKB"
        },
        {
            "id": "A0A096LPJ9-1",
            "url": "https://www.uniprot.org/uniprot/A0A096LPJ9-1",
            "database": "UniProtKB"
        }
    ],
    "sequence": {
        "sequence": "MDAPPPHPTTGLLSEPRVRSDRDKFVIFLDVKHFSPEDLTVKVQDDFVEIHGKHNERQDDHGYISREFHRRYRLPSNVDQSALSCSLSADGMLTFCGPKIQTGLDATHAERAIPVSREEKPTSAPSS",
        "length": 127,
        "header": "tr|A0A096LPJ9-1|A0A096LPJ9_HUMAN Isoform 1 of Alpha-crystallin A chain  OS=Homo sapiens OX=9606 GN=CRYAA2 PE=3 SV=1 CANONICAL=A0A096LPJ9-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A096LPJ9-1",
            "url": "https://www.uniprot.org/uniprot/A0A096LPJ9#A0A096LPJ9-1",
            "sequence": {
                "sequence": "MDAPPPHPTTGLLSEPRVRSDRDKFVIFLDVKHFSPEDLTVKVQDDFVEIHGKHNERQDDHGYISREFHRRYRLPSNVDQSALSCSLSADGMLTFCGPKIQTGLDATHAERAIPVSREEKPTSAPSS",
                "length": 127,
                "header": "tr|A0A096LPJ9-1|A0A096LPJ9_HUMAN Isoform 1 of Alpha-crystallin A chain  OS=Homo sapiens OX=9606 GN=CRYAA2 PE=3 SV=1 CANONICAL=A0A096LPJ9-1"
            },
            "locus": {
                "chromosome": "21",
                "start_pos": 6563961,
                "end_pos": 6561487,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENST00000624019.3",
                        "url": "https://www.ensembl.org/id/ENST00000624019.3"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSP00000485653.1",
                        "url": "https://www.ensembl.org/id/ENSP00000485653.1"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [],
    "pathway": [],
    "orthologs": [],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 2,
                "go_terms": [
                    {
                        "name": "nucleoplasm",
                        "id": "GO:0005654",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A096LPJ9",
                                "url": "https://www.uniprot.org/uniprot/A0A096LPJ9"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytosol",
                        "id": "GO:0005829",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A096LPJ9",
                                "url": "https://www.uniprot.org/uniprot/A0A096LPJ9"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 2,
                "go_terms": [
                    {
                        "name": "metal ion binding",
                        "id": "GO:0046872",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A096LPJ9",
                                "url": "https://www.uniprot.org/uniprot/A0A096LPJ9"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "structural constituent of eye lens",
                        "id": "GO:0005212",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005212",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A096LPJ9",
                                "url": "https://www.uniprot.org/uniprot/A0A096LPJ9"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "synthesized_glycans": [],
    "cluster_types": []
}