{ "bcoid": "GLY_000638", "title": "Fruitfly Protein Enzyme Annotation (UniProtKB)", "description": "The Fruitfly Protein Enzyme Annotation (UniProtKB) dataset contains fruitfly [taxid:7227] enzyme annotations ...", "filename": "fruitfly_protein_enzyme_annotation_uniprotkb.csv", "filetype": "csv", "categories": { "species": "Drosophila melanogaster", "molecule": "Protein", "tags": "enzyme annotation", "file_type": "csv", "status": "Reviewed", "scope": "internal" }, "minitable": { "content": [ [ "Q9W1K5-1...", "1.11.-.-..." ], [ "Q8T4G5-1...", "3.4.24.-..." ] ], "headers": [ "uniprotkb_ca...", "enzyme_ec..." ], "colwidth": [ "40%", "20%" ] }, "sampledata": { "type": "table", "data": [ [ { "type": "string", "label": "uniprotkb_canonical_ac" }, { "type": "string", "label": "enzyme_ec" }, { "type": "string", "label": "enzyme_activity" } ], [ "Q9W1K5-1", "1.11.-.-", "" ], [ "Q8T4G5-1", "3.4.24.-", "" ], [ "Q9V6L0-1", "1.14.11.27", "2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + L-lysyl(36)-[histone H3] + 2 succinate." ], [ "Q9VYQ5-1", "1.14.-.-", "" ], [ "Q9VFJ0-1", "1.14.-.-", "" ], [ "Q9VYQ7-1", "1.14.-.-", "" ], [ "Q9VYQ8-1", "3.4.19.12", "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)." ], [ "Q9VYQ8-1", "3.4.19.12", "" ], [ "Q8MT18-1", "1.1.1.41", "D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH." ], [ "Q9W459-1", "1.2.1.84", "2 H(+) + hexadecanoyl-CoA + 2 NADPH = CoA + hexadecan-1-ol + 2 NADP(+)." ], [ "Q9W459-1", "1.2.1.84", "" ], [ "Q9VG40-1", "1.14.-.-", "" ], [ "Q6WV20-1", "2.4.1.41", "L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP." ], [ "Q6WV20-1", "2.4.1.41", "" ], [ "Q9VG42-1", "2.1.1.20", "glycine + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + sarcosine." ], [ "Q9VG42-1", "2.1.1.20", "" ], [ "Q05825-1", "7.1.2.2", "ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate." ], [ "Q05825-1", "7.1.2.2", "" ], [ "P27619-1", "3.6.5.5", "GTP + H2O = GDP + H(+) + phosphate." ], [ "P27619-1", "3.6.5.5", "" ], [ "P45843-1", "7.6.2.-", "" ], [ "Q9VYQ3-1", "3.4.19.12", "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)." ], [ "Q9VYQ3-1", "3.4.19.12", "" ], [ "Q9VKZ8-1", "3.4.19.12", "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)." ], [ "Q9VKZ8-1", "3.4.19.12", "" ], [ "Q7JYW9-1", "2.7.1.-", "" ], [ "Q95RP8-1", "2.4.1.-", "" ], [ "Q7K3B7-1", "4.1.-.-", "" ], [ "P19109-1", "3.6.4.13", "ATP + H2O = ADP + H(+) + phosphate." ], [ "P19109-1", "3.6.4.13", "" ], [ "Q8IA42-1", "2.4.1.-", "" ], [ "B7Z001-1", "3.1.-.-", "" ], [ "B7Z001-1", "1.-.-.-", "" ], [ "B7Z001-1", "2.3.1.85", "acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH = a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP(+)." ], [ "P40793-1", "3.6.5.2", "GTP + H2O = GDP + H(+) + phosphate." ], [ "P40793-1", "3.6.5.2", "" ], [ "Q8INF2-1", "2.7.7.41", "a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate." ], [ "Q8INF2-1", "2.7.7.41", "" ], [ "Q7K3B9-1", "2.1.1.346", "adenosine in U6 snRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine in U6 snRNA + S-adenosyl-L-homocysteine." ], [ "Q7K3B9-1", "2.1.1.346", "" ], [ "Q9VVL8-1", "6.1.1.2", "ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)." ], [ "Q9VVL8-1", "6.1.1.2", "" ], [ "A8JNU6-1", "1.2.4.2", "(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H(+) = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2." ], [ "A8JNU6-1", "1.2.4.2", "" ], [ "E2QD98-1", "2.7.4.8", "ATP + dGMP = ADP + dGDP." ], [ "P07140-1", "3.1.1.-", "" ], [ "Q03042-1", "2.7.11.12", "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]." ], [ "Q03042-1", "2.7.11.12", "" ], [ "Q03043-1", "2.7.11.12", "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]." ], [ "Q03043-1", "2.7.11.12", "" ], [ "Q6NP69-1", "2.5.1.18", "glutathione + RX = a halide anion + an S-substituted glutathione + H(+)." ], [ "Q9VSZ5-1", "2.7.7.78", "GDP-alpha-D-glucose + phosphate = alpha-D-glucose 1-phosphate + GDP + H(+)." ], [ "Q9VSZ5-1", "2.7.7.78", "" ], [ "Q9V979-1", "1.14.-.-", "" ], [ "Q9VA02-1", "1.2.4.2", "(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H(+) = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2." ], [ "Q9VA02-1", "1.2.4.2", "" ], [ "Q9V7Y2-1", "4.1.2.27", "sphinganine 1-phosphate = hexadecanal + phosphoethanolamine." ], [ "Q9V7Y2-1", "4.1.2.27", "" ], [ "Q9VQQ0-1", "5.2.1.8", "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)." ], [ "Q9VQQ0-1", "5.2.1.8", "" ], [ "P55824-1", "3.4.19.12", "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)." ], [ "P55824-1", "3.4.19.12", "" ], [ "Q9VA09-1", "4.6.1.2", "GTP = 3',5'-cyclic GMP + diphosphate." ], [ "Q9VA09-1", "4.6.1.2", "" ], [ "Q7KVJ6-1", "6.2.1.3", "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate." ], [ "Q7K3P0-1", "6.1.1.16", "ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)." ], [ "Q7K3P0-1", "6.1.1.16", "" ], [ "Q6NN40-1", "2.1.1.-", "" ], [ "Q6NN40-1", "2.1.1.354", "L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine." ], [ "Q7KRY6-1", "2.7.11.1", "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]." ], [ "Q7KRY6-1", "2.7.11.1", "" ], [ "Q9VIZ3-1", "3.6.4.13", "ATP + H2O = ADP + H(+) + phosphate." ], [ "Q9V3Z2-1", "3.4.21.-", "" ], [ "P40421-1", "3.1.3.16", "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate." ], [ "P40421-1", "3.1.3.16", "" ], [ "A1ZBC4-1", "2.7.11.1", "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]." ], [ "A1ZBC4-1", "2.7.11.1", "" ], [ "Q7JXB5-1", "4.1.1.32", "ITP + oxaloacetate = CO2 + IDP + phosphoenolpyruvate." ], [ "Q7JXB5-1", "4.1.1.32", "" ], [ "B7Z126-1", "2.7.11.-", "" ], [ "Q8MZG9-1", "1.1.1.300", "all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH." ], [ "Q9VUR0-1", "3.4.22.-", "" ], [ "Q6WV16-1", "2.4.1.-", "" ], [ "P30189-1", "5.6.2.1", "ATP-independent breakage of single-stranded DNA, followed by passage and rejoining." ] ] }, "readme": "Name\n - Fruitfly Protein Enzyme Annotation (UniProtKB)\n\nVersion\n - v-x.x.x\n\nCreated on\n - 2022-08-30T14:44:26.008676\n\nModified on\n - 2022-08-30T14:44:56.088725\n\nCreated by\n - Jeet Vora [jeetvora@gwu.edu], Robel Kahsay [rykahsay@gwu.edu], Karina Martinez [karinamartinez@gwu.edu]\n\nAuthors\n - Maria Martin [martin@ebi.ac.uk], Preethi Vasudev [pvasudev@ebi.ac.uk]\n\nChecksum\n - \n\nUsability Domain\n - The Fruitfly Protein Enzyme Annotation (UniProtKB) dataset contains fruitfly [taxid:7227] enzyme annotations for UniProtKB canonical accessions. The dataset contains ec numbers and enzyme activity that describes the enzymatic reactions. The dataset is derived form 2019-09 UniprotKB release. If you use this dataset please give proper attribution to UniProtKB and GlyGen\n\nDescription Domain\n Keywords\n - enzyme annotation\n - enzyme \n - UniProtKB\n - enzyme activity\n - EC number\n\n Pipeline Steps\n - Step-1: The script extracts the enzyme annotation triples from the triplestore for the UniProtKB canonical sequnces asnd extracts as a dataset in a csv format\n\nExecution Domain\n Scripts - https://github.com/glygener/glygen-backend-integration/blob/master/dataset-maker/make-protein-dataset.py\n\n\n Software Prerequisites\n Name: Python\n Version: 2.7.5\n URI: https://www.python.org/download/releases/2.7.5/\n\nI/O Domain\n Input Subdomain\n Name: uniprot-proteome-drosophila-melanogaster.nt\n URI: https:/data.glygen.org/ln2downloads/ebi/2022_03/uniprot-proteome-drosophila-melanogaster.nt\n Output Subdomain\n Name: fruitfly_protein_enzyme_annotation_uniprotkb.csv\n URI: https:/data.glygen.org/ln2releases/data/v-2.0.2/reviewed/fruitfly_protein_enzyme_annotation_uniprotkb.csv\n Name: fruitfly_protein_enzyme_annotation_uniprotkb.stat.csv\n URI: https:/data.glygen.org/ln2releases/data/v-2.0.2/reviewed/fruitfly_protein_enzyme_annotation_uniprotkb.stat.csv\n\nFields\n Name: \"uniprotkb_canonical_ac\"\n Description: \"\"\n Unique Values: \"2753\"\n Name: \"enzyme_ec\"\n Description: \"Enzyme Commision number assigned to an enzyme by Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB)\"\n Unique Values: \"915\"\n Name: \"enzyme_activity\"\n Description: \"The catalytic reaction activity of an enzyme in UniProtKB\"\n Unique Values: \"790\"", "downloadurl": "/ln2data/releases/data/v-2.0.2/reviewed/fruitfly_protein_enzyme_annotation_uniprotkb.csv" }