{
    "disease_id": "DOID:0110786",
    "recommended_name": {
        "id": "DOID:0110786",
        "resource": "Disease Ontology",
        "url": "http://disease-ontology.org/term/DOID:0110786",
        "name": "hereditary spastic paraplegia 35",
        "description": "A hereditary spastic paraplegia that has_material_basis_in mutation in the FA2H gene on chromosome 16q23.1."
    },
    "synonyms": [
        {
            "id": "DOID:0110786",
            "resource": "Disease Ontology",
            "url": "http://disease-ontology.org/term/DOID:0110786",
            "name": "FAHN",
            "description": ""
        },
        {
            "id": "DOID:0110786",
            "resource": "Disease Ontology",
            "url": "http://disease-ontology.org/term/DOID:0110786",
            "name": "leukodystrophy, dysmyelinating and spastic paraparesis with or without dystonia",
            "description": ""
        },
        {
            "id": "DOID:0110786",
            "resource": "Disease Ontology",
            "url": "http://disease-ontology.org/term/DOID:0110786",
            "name": "SPG35",
            "description": ""
        },
        {
            "id": "DOID:0110786",
            "resource": "Disease Ontology",
            "url": "http://disease-ontology.org/term/DOID:0110786",
            "name": "autosomal recessive spastic paraplegia 35",
            "description": ""
        },
        {
            "id": "DOID:0110786",
            "resource": "Disease Ontology",
            "url": "http://disease-ontology.org/term/DOID:0110786",
            "name": "autosomal recessive spastic paraplegia type 35",
            "description": ""
        },
        {
            "id": "DOID:0110786",
            "resource": "Disease Ontology",
            "url": "http://disease-ontology.org/term/DOID:0110786",
            "name": "fatty acid hydroxylase-associated neurodegeneration",
            "description": ""
        },
        {
            "id": "MONDO:0012866",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012866",
            "name": "hereditary spastic paraplegia 35",
            "description": "Autosomal recessive spastic paraplegia type 35 is a rare form of hereditary spastic paraplegia characterized by childhood (exceptionally adolescent) onset of a complex phenotype presenting with lower limb (followed by upper limb) spasticity with hyperreflexia and extensor plantar responses, with additional manifestations including progressive dysarthria, dystonia, mild cognitive decline, extrapyramidal features, optic atrophy and seizures. White matter abnormalities and brain iron accumulation have also been observed on brain magnetic resonance imaging."
        },
        {
            "id": "MONDO:0012866",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012866",
            "name": "fatty acid hydroxylase-associated neurodegeneration",
            "description": ""
        },
        {
            "id": "MONDO:0012866",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012866",
            "name": "autosomal recessive spastic paraplegia type 35",
            "description": ""
        },
        {
            "id": "MONDO:0012866",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012866",
            "name": "leukodystrophy, dysmyelinating and spastic paraparesis with or without dystonia",
            "description": ""
        },
        {
            "id": "MONDO:0012866",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012866",
            "name": "spastic paraplegia 35, autosomal recessive",
            "description": ""
        },
        {
            "id": "MONDO:0012866",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012866",
            "name": "autosomal recessive spastic paraplegia 35",
            "description": ""
        },
        {
            "id": "MONDO:0012866",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012866",
            "name": "FA2H hereditary spastic paraplegia",
            "description": ""
        },
        {
            "id": "MONDO:0012866",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012866",
            "name": "hereditary spastic paraplegia caused by mutation in FA2H",
            "description": ""
        },
        {
            "id": "MONDO:0012866",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012866",
            "name": "leukodystrophy, dysmyelinating, and spastic paraparesis with or without dystonia",
            "description": ""
        },
        {
            "id": "MONDO:0012866",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012866",
            "name": "spastic paraplegia 35, autosomal recessive; SPG35",
            "description": ""
        },
        {
            "id": "MONDO:0012866",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012866",
            "name": "hereditary spastic paraplegia type 35",
            "description": ""
        },
        {
            "id": "MONDO:0012866",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012866",
            "name": "FAHN",
            "description": ""
        },
        {
            "id": "MONDO:0012866",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012866",
            "name": "SPG35",
            "description": ""
        },
        {
            "id": "MIM:612319",
            "resource": "MIM",
            "url": "https://www.omim.org/entry/612319",
            "name": "Spastic paraplegia 35, autosomal recessive, with or without neurodegeneration",
            "description": "Spastic paraplegia 35, autosomal recessive, with or without neurodegeneration"
        }
    ]
}