{
    "disease_id": "DOID:0090030",
    "recommended_name": {
        "id": "DOID:0090030",
        "resource": "Disease Ontology",
        "url": "http://disease-ontology.org/term/DOID:0090030",
        "name": "corticosteroid-binding globulin deficiency",
        "description": "An adrenal gland disease characterized by decreased levels of serum corticosteroid-binding globulin and cortisol, and in some cases hypo- or hypertension, and muscle fatigue that has_material_basis_in heterozygous or homozygous mutation in the SERPINA6 gene on chromosome 14q32."
    },
    "synonyms": [
        {
            "id": "DOID:0090030",
            "resource": "Disease Ontology",
            "url": "http://disease-ontology.org/term/DOID:0090030",
            "name": "CBG deficiency",
            "description": ""
        },
        {
            "id": "DOID:0090030",
            "resource": "Disease Ontology",
            "url": "http://disease-ontology.org/term/DOID:0090030",
            "name": "transcortin deficiency",
            "description": ""
        },
        {
            "id": "MONDO:0012675",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012675",
            "name": "corticosteroid-binding globulin deficiency",
            "description": "Corticosteroid-binding globulin deficiency is a genetic disorder characterized by extreme tiredness (fatigue), particularly after physical exertion, and low blood pressure (hypotension). Corticosteroid-binding globulin (CBG) is a protein primarily produced in the liver that attaches to cortisol , a hormone with numerous functions, including maintaining blood sugar levels, protecting the body from stress, and suppressing inflammation.When cortisol is needed in the body, CBG delivers the cortisol where it is needed and releases it. Signs and symptoms of CBG deficiency vary. While some individuals may experience no symptoms, others are found to have a fatty liver and chronic pain. Some people with CBG deficiency also have chronic fatigue syndrome . CGB deficiency is caused by mutations in the SERPINA6 gene. The SERPINA6 gene is commonly also referred to as the CBG gene. Both autosomal dominant and autosomal recessive inheritance have been reported.While there is still no cure, treatment options will depend on the type and severity of symptoms present and may involve several specialists."
        },
        {
            "id": "MONDO:0012675",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012675",
            "name": "CBG deficiency",
            "description": ""
        },
        {
            "id": "MONDO:0012675",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012675",
            "name": "transcortin deficiency",
            "description": ""
        },
        {
            "id": "MONDO:0012675",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012675",
            "name": "corticosteroid-binding globulin deficiency",
            "description": ""
        },
        {
            "id": "MONDO:0012675",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012675",
            "name": "corticosteroid-binding globulin, elevated",
            "description": ""
        },
        {
            "id": "MONDO:0012675",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012675",
            "name": "Transcortin deficiency",
            "description": ""
        },
        {
            "id": "MONDO:0012675",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012675",
            "name": "Cbg deficiency",
            "description": ""
        },
        {
            "id": "MIM:611489",
            "resource": "MIM",
            "url": "https://www.omim.org/entry/611489",
            "name": "Corticosteroid-binding globulin deficiency",
            "description": "Corticosteroid-binding globulin deficiency"
        }
    ]
}