{
    "disease_id": "DOID:0070271",
    "recommended_name": {
        "id": "DOID:0070271",
        "resource": "Disease Ontology",
        "url": "http://disease-ontology.org/term/DOID:0070271",
        "name": "Lynch syndrome 1",
        "description": "A Lynch syndrome that has_material_basis_in heterozygous mutations in the MSH2 gene on chromosome 2p21-p16."
    },
    "synonyms": [
        {
            "id": "DOID:0070271",
            "resource": "Disease Ontology",
            "url": "http://disease-ontology.org/term/DOID:0070271",
            "name": "FCC1",
            "description": ""
        },
        {
            "id": "DOID:0070271",
            "resource": "Disease Ontology",
            "url": "http://disease-ontology.org/term/DOID:0070271",
            "name": "HNPCC1",
            "description": ""
        },
        {
            "id": "DOID:0070271",
            "resource": "Disease Ontology",
            "url": "http://disease-ontology.org/term/DOID:0070271",
            "name": "familial nonpolyposis colon cancer type 1",
            "description": ""
        },
        {
            "id": "DOID:0070271",
            "resource": "Disease Ontology",
            "url": "http://disease-ontology.org/term/DOID:0070271",
            "name": "hereditary nonpolyposis colorectal cancer type 1",
            "description": ""
        },
        {
            "id": "MONDO:0007356",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0007356",
            "name": "Lynch syndrome 1",
            "description": "A rare genetic neoplastic syndrome with an autosomal dominant pattern of inheritance but incomplete penetrance. It is associated with a greater than 70 % risk of developing colorectal carcinoma. It is caused by a mutation in one of the mismatch repair genes: MSH2, MLH1, MSH6 or PMS2. It usually manifests at age 50 or younger with multiple synchronous or metachronous colorectal carcinomas. Clinical course is rapidly progressive. Prognosis is variable with a high risk for the development of additional colorectal carcinomas. However, survival is significantly better than non-HNPCC carcinomas of equivalent stage."
        },
        {
            "id": "MONDO:0007356",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0007356",
            "name": "Lynch syndrome type 1",
            "description": ""
        },
        {
            "id": "MONDO:0007356",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0007356",
            "name": "COCA1",
            "description": ""
        },
        {
            "id": "MONDO:0007356",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0007356",
            "name": "colorectal cancer, hereditary nonpolyposis, type 1",
            "description": ""
        },
        {
            "id": "MONDO:0007356",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0007356",
            "name": "LYNCH syndrome I",
            "description": ""
        },
        {
            "id": "MONDO:0007356",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0007356",
            "name": "hereditary nonpolyposis colorectal cancer type 1",
            "description": ""
        },
        {
            "id": "MONDO:0007356",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0007356",
            "name": "familial non-polyposis colon cancer type 1",
            "description": ""
        },
        {
            "id": "MONDO:0007356",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0007356",
            "name": "Lynch 1 syndrome",
            "description": ""
        },
        {
            "id": "MONDO:0007356",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0007356",
            "name": "colon cancer, familial nonpolyposis, type 1",
            "description": ""
        },
        {
            "id": "MONDO:0007356",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0007356",
            "name": "HNPCC1",
            "description": ""
        },
        {
            "id": "MONDO:0007356",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0007356",
            "name": "Lynch syndrome 2",
            "description": ""
        },
        {
            "id": "MONDO:0007356",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0007356",
            "name": "Hereditary non-polyposis colon cancer type 1",
            "description": ""
        },
        {
            "id": "MIM:120435",
            "resource": "MIM",
            "url": "https://www.omim.org/entry/120435",
            "name": "Hereditary non-polyposis colorectal cancer 1",
            "description": "Hereditary non-polyposis colorectal cancer 1"
        }
    ]
}