{ "uniprot_canonical_ac": "A5H300-1", "uniprot_ac": "A5H300", "uniprot_id": "A5H300_RAT", "mass": { "chemical_mass": 119272.0, "monoisotopic_mass": 119272.0 }, "refseq": { "ac": "NP_001094479", "name": "toll-like receptor 8 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094479" }, "gene_names": [ { "name": "Tlr8", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A5H300", "id": "A5H300" }, { "name": "Tlr8", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094479", "id": "NP_001094479" } ], "protein_names": [ { "name": "Toll-like receptor 8", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A5H300#names_and_taxonomy", "id": "A5H300" }, { "name": "toll-like receptor 8 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094479", "id": "NP_001094479" } ], "function": [ { "annotation": "Aortic angiogenesis is preceded by an immune reaction with overexpression of Toll-like receptors (TLRs) and TLR-inducible genes.", "evidence": [ { "database": "RefSeq", "id": "NP_001094479", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094479" }, { "database": "PubMed", "id": "24091496", "url": "https://glygen.org/publication/PubMed/24091496" } ] }, { "annotation": "MicroRNA-18a-5p mitigates oxygen-glucose-deprivation/reoxygenation-induced injury through suppression of TLRs/NF-kappaB signaling by targeting TLR8 in PC12 cells.", "evidence": [ { "database": "RefSeq", "id": "NP_001094479", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094479" }, { "database": "PubMed", "id": "32815784", "url": "https://glygen.org/publication/PubMed/32815784" } ] } ], "disease": [ { "disease_id": "DOID:1273", "recommended_name": { "id": "DOID:1273", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1273", "name": "respiratory syncytial virus infectious disease", "description": "A viral infectious disease that results_in infection located_in upper respiratory tract or located_in lower respiratory tract, has_material_basis_in Human respiratory syncytial virus, which is transmitted_by droplet spread of nasal secretions from an infected person while coughing or sneezing, or transmitted_by contaminated fomites. The infection has_symptom runny nose, has_symptom fever, has_symptom cough, has_symptom wheezing, and has_symptom respiratory distress." }, "synonyms": [], "evidence": [ { "id": "1273", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1273" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A5H300", "url": "https://www.uniprot.org/uniprot/A5H300" } ], "common_name": "Rat" } ], "gene": [ { "name": "Tlr8", "url": "https://www.uniprot.org/uniprot/A5H300", "locus": { "chromosome": "X", "start_pos": 28539158, "end_pos": 28562803, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000045992", "url": "https://www.ensembl.org/id/ENSRNOG00000045992" } ] } } ], "crossref": [ { "id": "ENSRNOG00000045992", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000045992", "database": "Bgee" }, { "id": "CHEMBL4105765", "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL4105765", "database": "ChEMBL" }, { "id": "684440", "url": "https://www.ncbi.nlm.nih.gov/gene/684440", "database": "GeneID" }, { "id": "IPR000157", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000157", "database": "InterPro" }, { "id": "IPR000483", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000483", "database": "InterPro" }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro" }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro" }, { "id": "IPR027175", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027175", "database": "InterPro" }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro" }, { "id": "IPR035897", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035897", "database": "InterPro" }, { "id": "rno:684440", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:684440", "database": "KEGG Pathway" }, { "id": "HDIACLN", "url": "https://omabrowser.org/oma/group/HDIACLN/", "database": "OMA" }, { "id": "96378at2759", "url": "http://www.orthodb.org/?query=96378at2759", "database": "OrthoDB" }, { "id": "PTHR47410:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47410:SF1", "database": "PANTHER" }, { "id": "PF00560", "url": "http://pfam.xfam.org/family/PF00560", "database": "Pfam" }, { "id": "PF01582", "url": "http://pfam.xfam.org/family/PF01582", "database": "Pfam" }, { "id": "PF13855", "url": "http://pfam.xfam.org/family/PF13855", "database": "Pfam" }, { "id": "PR_A5H300", "url": "http://purl.obolibrary.org/obo/PR_A5H300", "database": "PRO" }, { "id": "R-RNO-1679131", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1679131", "database": "Reactome" }, { "id": "NP_001094479", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094479", "database": "RefSeq" }, { "id": "1590327", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1590327", "database": "RGD" }, { "id": "A5H300", "url": "https://www.uniprot.org/uniprot/A5H300", "database": "UniProtKB" }, { "id": "A5H300-1", "url": "https://www.uniprot.org/uniprot/A5H300-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MSPQSWILTCFCLLSSGTSAVFLKGNFSRSYPCDEKRHNALVTAECNHRQLHEVPQTIGKYVTDVDLSDNTIMHITNESFQKFRNLTKINLNHNAKQQHPNENKNGMNITEGAFLSLRNLTELLLEDNQLYTIPAGLPESLKELSLIQNNIFQVTKNNTFGLRNLERLYLGWNCYFKCNQIFKVEDGAFNNLINLKLLSLSFNNLFSVPPKLPSSLSKLFLSNAKISTITQEDFKGLEHLILLDLSGNCPRCFNAPFPCESCNLSASIRIHPLAFQNLTQLRFLNLSSTSLRTIPSTWFDNLTNLKELHLEFNYLVQEIASGAFLTKLPSLQTLDLSFNFIHKEYLQYITISPNFSMLRSLRKLHLKGYVFRELKKEHFKPLQNLPNLTTINLGINFIEKIDFKAFQDFPNLKVIYLSGNRIASVIDGTDHSSWRNRLRKPLSTDYDEFDPHMNFYHSTEPLIKPQCTTYGKALDLSLNNIFVIGKSQFEGFQDIACLNLSFNANGQVLNGTEFSSMPHIKYLDLTNNRLDFDDNQTFSDLHDLEVLDLSHNAHYFSIAGVTHRLGFIQNLIKLKVLNLSHNGIYTLTDEYKLQSKSLKELVFSGNRLDRLWNANDGKYWSIFTSLETLTRLDLSYNNLQQIPNEAFLNLPQSLQELHINDNRLRFFNWTLLQYFPHLHVLDLGRNELYFLTNCLSKFTHSLKTLLLNHNHFSHLPAGFLSEARNLVYLDLSFNTIKMINKSSLQTETKTNLSVLDLQGNHFDCTCDISDFRSWLEENPHVRIPRLVDVICSNPGDQRWKSVMSLDLTTCVSDTTAAILFFFTFLTTSTVLLAALVHHLFYWDVWFIYHMCSAKLRGYRSSSTSQTFYDAYISYDTKDASVTDWVINELRYHLEESEDKSVLLCLEERDWDPGLPIIDNLMQSINQSKKTIFVLTKKYAKSWNFKTAFYLALQRLMDENMDVIIFILLEPVLQYSQYLRLRQRICKSSILQWPNNPKAENLFWQSLKNVVLTENDSRYDNLYIDSIRQY", "length": 1029, "header": "tr|A5H300-1|A5H300_RAT Isoform 1 of Toll-like receptor 8 OS=Rattus norvegicus OX=10116 GN=Tlr8 PE=2 SV=1 CANONICAL=A5H300-1" }, "isoforms": [ { "isoform_ac": "A5H300-1", "url": "https://www.uniprot.org/uniprot/A5H300#A5H300-1", "sequence": { "sequence": "MSPQSWILTCFCLLSSGTSAVFLKGNFSRSYPCDEKRHNALVTAECNHRQLHEVPQTIGKYVTDVDLSDNTIMHITNESFQKFRNLTKINLNHNAKQQHPNENKNGMNITEGAFLSLRNLTELLLEDNQLYTIPAGLPESLKELSLIQNNIFQVTKNNTFGLRNLERLYLGWNCYFKCNQIFKVEDGAFNNLINLKLLSLSFNNLFSVPPKLPSSLSKLFLSNAKISTITQEDFKGLEHLILLDLSGNCPRCFNAPFPCESCNLSASIRIHPLAFQNLTQLRFLNLSSTSLRTIPSTWFDNLTNLKELHLEFNYLVQEIASGAFLTKLPSLQTLDLSFNFIHKEYLQYITISPNFSMLRSLRKLHLKGYVFRELKKEHFKPLQNLPNLTTINLGINFIEKIDFKAFQDFPNLKVIYLSGNRIASVIDGTDHSSWRNRLRKPLSTDYDEFDPHMNFYHSTEPLIKPQCTTYGKALDLSLNNIFVIGKSQFEGFQDIACLNLSFNANGQVLNGTEFSSMPHIKYLDLTNNRLDFDDNQTFSDLHDLEVLDLSHNAHYFSIAGVTHRLGFIQNLIKLKVLNLSHNGIYTLTDEYKLQSKSLKELVFSGNRLDRLWNANDGKYWSIFTSLETLTRLDLSYNNLQQIPNEAFLNLPQSLQELHINDNRLRFFNWTLLQYFPHLHVLDLGRNELYFLTNCLSKFTHSLKTLLLNHNHFSHLPAGFLSEARNLVYLDLSFNTIKMINKSSLQTETKTNLSVLDLQGNHFDCTCDISDFRSWLEENPHVRIPRLVDVICSNPGDQRWKSVMSLDLTTCVSDTTAAILFFFTFLTTSTVLLAALVHHLFYWDVWFIYHMCSAKLRGYRSSSTSQTFYDAYISYDTKDASVTDWVINELRYHLEESEDKSVLLCLEERDWDPGLPIIDNLMQSINQSKKTIFVLTKKYAKSWNFKTAFYLALQRLMDENMDVIIFILLEPVLQYSQYLRLRQRICKSSILQWPNNPKAENLFWQSLKNVVLTENDSRYDNLYIDSIRQY", "length": 1029, "header": "tr|A5H300-1|A5H300_RAT Isoform 1 of Toll-like receptor 8 OS=Rattus norvegicus OX=10116 GN=Tlr8 PE=2 SV=1 CANONICAL=A5H300-1" }, "locus": { "chromosome": "X", "start_pos": 28562650, "end_pos": 28559564, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000073535", "url": "https://www.ensembl.org/id/ENSRNOT00000073535" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000066040", "url": "https://www.ensembl.org/id/ENSRNOP00000066040" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "A five-amino-acid motif in the undefined region of the TLR8 ectodomain is required for species-specific ligand recognition.", "journal": "Mol. Immunol.", "date": "2010", "authors": "Liu J., Xu C., Luo Y., Hsu L.C., Xiang R., Chuang T.H.", "evidence": [ { "database": "UniProtKB", "id": "A5H300", "url": "https://www.uniprot.org/uniprot/A5H300" } ], "reference": [ { "type": "PubMed", "id": "20004021", "url": "https://glygen.org/publication/PubMed/20004021" } ] }, { "title": "Regulation of angiogenesis, mural cell recruitment and adventitial macrophage behavior by Toll-like receptors.", "journal": "Angiogenesis", "date": "2014", "authors": "Aplin AC, Ligresti G, Fogel E, Zorzi P, Smith K, Nicosia RF", "evidence": [ { "database": "RefSeq", "id": "NP_001094479", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094479" } ], "reference": [ { "type": "PubMed", "id": "24091496", "url": "https://glygen.org/publication/PubMed/24091496" } ] }, { "title": "MicroRNA-18a-5p mitigates oxygen-glucose-deprivation/reoxygenation-induced injury through suppression of TLRs/NF-kappaB signaling by targeting TLR8 in PC12 cells.", "journal": "Bioscience, biotechnology, and biochemistry", "date": "2020", "authors": "Lu YY, Ma XJ, Yang YN", "evidence": [ { "database": "RefSeq", "id": "NP_001094479", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094479" } ], "reference": [ { "type": "PubMed", "id": "32815784", "url": "https://glygen.org/publication/PubMed/32815784" } ] } ], "pathway": [ { "id": "rno:684440", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:684440", "resource": "KEGG Pathway" }, { "id": "R-RNO-1679131", "name": "Trafficking and processing of endosomal TLR", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1679131", "resource": "Reactome", "description": "Trafficking and processing of endosomal TLR" } ], "orthologs": [ { "uniprot_canonical_ac": "P58682-1", "protein_name": "Toll-like receptor 8", "gene_name": "Tlr8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MENMPPQSWILTCFCLLSSGTSAIFHKANYSRSYPCDEIRHNSLVIAECNHRQLHEVPQTIGKYVTNIDLSDNAITHITKESFQKLQNLTKIDLNHNAKQQHPNENKNGMNITEGALLSLRNLTVLLLEDNQLYTIPAGLPESLKELSLIQNNIFQVTKNNTFGLRNLERLYLGWNCYFKCNQTFKVEDGAFKNLIHLKVLSLSFNNLFYVPPKLPSSLRKLFLSNAKIMNITQEDFKGLENLTLLDLSGNCPRCYNAPFPCTPCKENSSIHIHPLAFQSLTQLLYLNLSSTSLRTIPSTWFENLSNLKELHLEFNYLVQEIASGAFLTKLPSLQILDLSFNFQYKEYLQFINISSNFSKLRSLKKLHLRGYVFRELKKKHFEHLQSLPNLATINLGINFIEKIDFKAFQNFSKLDVIYLSGNRIASVLDGTDYSSWRNRLRKPLSTDDDEFDPHVNFYHSTKPLIKPQCTAYGKALDLSLNNIFIIGKSQFEGFQDIACLNLSFNANTQVFNGTEFSSMPHIKYLDLTNNRLDFDDNNAFSDLHDLEVLDLSHNAHYFSIAGVTHRLGFIQNLINLRVLNLSHNGIYTLTEESELKSISLKELVFSGNRLDRLWNANDGKYWSIFKSLQNLIRLDLSYNNLQQIPNGAFLNLPQSLQELLISGNKLRFFNWTLLQYFPHLHLLDLSRNELYFLPNCLSKFAHSLETLLLSHNHFSHLPSGFLSEARNLVHLDLSFNTIKMINKSSLQTKMKTNLSILELHGNYFDCTCDISDFRSWLDENLNITIPKLVNVICSNPGDQKSKSIMSLDLTTCVSDTTAAVLFFLTFLTTSMVMLAALVHHLFYWDVWFIYHMCSAKLKGYRTSSTSQTFYDAYISYDTKDASVTDWVINELRYHLEESEDKSVLLCLEERDWDPGLPIIDNLMQSINQSKKTIFVLTKKYAKSWNFKTAFYLALQRLMDENMDVIIFILLEPVLQYSQYLRLRQRICKSSILQWPNNPKAENLFWQSLKNVVLTENDSRYDDLYIDSIRQY", "length": 1032 }, "evidence": [ { "id": "44054", "url": "http://www.informatics.jax.org/homology/44054", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NR97-1", "protein_name": "Toll-like receptor 8", "gene_name": "TLR8", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MENMFLQSSMLTCIFLLISGSCELCAEENFSRSYPCDEKKQNDSVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDIGDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFITTMVMLAALAHHLFYWDVWFIYNVCLAKVKGYRSLSTSQTFYDAYISYDTKDASVTDWVINELRYHLEESRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAFYLALQRLMDENMDVIIFILLEPVLQHSQYLRLRQRICKSSILQWPDNPKAEGLFWQTLRNVVLTENDSRYNNMYVDSIKQY", "length": 1041 }, "evidence": [ { "id": "44054", "url": "http://www.informatics.jax.org/homology/44054", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 19, "go_terms": [ { "name": "positive regulation of interferon-alpha production", "id": "GO:0032727", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032727", "evidence": [ { "database": "UniProtKB", "id": "A5H300", "url": "https://www.uniprot.org/uniprot/A5H300" } ], "pmid": "" }, { "name": "immune response", "id": "GO:0006955", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", "evidence": [ { "database": "UniProtKB", "id": "A5H300", "url": "https://www.uniprot.org/uniprot/A5H300" } ], "pmid": "21873635" }, { "name": "inflammatory response", "id": "GO:0006954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006954", "evidence": [ { "database": "UniProtKB", "id": "A5H300", "url": "https://www.uniprot.org/uniprot/A5H300" } ], "pmid": "" }, { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "A5H300", "url": "https://www.uniprot.org/uniprot/A5H300" } ], "pmid": "" }, { "name": "defense response to virus", "id": "GO:0051607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051607", "evidence": [ { "database": "UniProtKB", "id": "A5H300", "url": "https://www.uniprot.org/uniprot/A5H300" } ], "pmid": "" }, { "name": "positive regulation of interleukin-6 production", "id": "GO:0032755", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032755", "evidence": [ { "database": "UniProtKB", "id": "A5H300", "url": "https://www.uniprot.org/uniprot/A5H300" } ], "pmid": "" }, { "name": "response to virus", "id": "GO:0009615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009615", "evidence": [ { "database": "UniProtKB", "id": "A5H300", "url": "https://www.uniprot.org/uniprot/A5H300" } ], "pmid": "" }, { "name": "positive regulation of interferon-gamma production", "id": "GO:0032729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032729", "evidence": [ { "database": "UniProtKB", "id": "A5H300", "url": "https://www.uniprot.org/uniprot/A5H300" } ], "pmid": "" }, { "name": "cellular response to mechanical stimulus", "id": "GO:0071260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071260", "evidence": [ { "database": "UniProtKB", "id": "A5H300", "url": "https://www.uniprot.org/uniprot/A5H300" } ], "pmid": "" }, { "name": "positive regulation of interleukin-8 production", "id": "GO:0032757", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032757", "evidence": [ { "database": "UniProtKB", "id": "A5H300", "url": "https://www.uniprot.org/uniprot/A5H300" } ], "pmid": "" }, { "name": "regulation of protein phosphorylation", "id": "GO:0001932", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001932", "evidence": [ { "database": "UniProtKB", "id": "A5H300", "url": "https://www.uniprot.org/uniprot/A5H300" } ], "pmid": "" }, { "name": "I-kappaB kinase/NF-kappaB signaling", "id": "GO:0007249", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007249", "evidence": [ { "database": "UniProtKB", "id": "A5H300", "url": "https://www.uniprot.org/uniprot/A5H300" } ], "pmid": "" }, { "name": "negative regulation of interleukin-12 production", "id": "GO:0032695", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032695", "evidence": [ { "database": "UniProtKB", "id": "A5H300", "url": "https://www.uniprot.org/uniprot/A5H300" } ], "pmid": "" }, { "name": "positive regulation of interleukin-1 beta production", "id": "GO:0032731", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032731", "evidence": [ { "database": "UniProtKB", "id": "A5H300", "url": "https://www.uniprot.org/uniprot/A5H300" } ], "pmid": "" }, { "name": "toll-like receptor signaling pathway", "id": "GO:0002224", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002224", "evidence": [ { "database": "UniProtKB", "id": "A5H300", "url": "https://www.uniprot.org/uniprot/A5H300" } ], "pmid": "21873635" }, { "name": "positive regulation of innate immune response", "id": "GO:0045089", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045089", "evidence": [ { "database": "UniProtKB", "id": "A5H300", "url": "https://www.uniprot.org/uniprot/A5H300" } ], "pmid": "" }, { "name": "MyD88-dependent toll-like receptor signaling pathway", "id": "GO:0002755", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002755", "evidence": [ { "database": "UniProtKB", "id": "A5H300", "url": "https://www.uniprot.org/uniprot/A5H300" } ], "pmid": "" }, { "name": "positive regulation of interferon-beta production", "id": "GO:0032728", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032728", "evidence": [ { "database": "UniProtKB", "id": "A5H300", "url": "https://www.uniprot.org/uniprot/A5H300" } ], "pmid": "" }, { "name": "toll-like receptor 8 signaling pathway", "id": "GO:0034158", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034158", "evidence": [ { "database": "UniProtKB", "id": "A5H300", "url": "https://www.uniprot.org/uniprot/A5H300" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A5H300", "url": "https://www.uniprot.org/uniprot/A5H300" } ], "pmid": "" }, { "name": "transmembrane signaling receptor activity", "id": "GO:0004888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004888", "evidence": [ { "database": "UniProtKB", "id": "A5H300", "url": "https://www.uniprot.org/uniprot/A5H300" } ], "pmid": "" }, { "name": "double-stranded RNA binding", "id": "GO:0003725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003725", "evidence": [ { "database": "UniProtKB", "id": "A5H300", "url": "https://www.uniprot.org/uniprot/A5H300" } ], "pmid": "" }, { "name": "single-stranded RNA binding", "id": "GO:0003727", "url": 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