{
    "uniprot_canonical_ac": "A4QPC6-1",
    "uniprot_ac": "A4QPC6",
    "uniprot_id": "BT2A2_MOUSE",
    "mass": {
        "chemical_mass": 58455.0,
        "monoisotopic_mass": 58455.0
    },
    "refseq": {
        "ac": "NP_001276543",
        "name": "butyrophilin subfamily 2 member A2 isoform 2 precursor",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276543"
    },
    "gene_names": [
        {
            "name": "Btn2a2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A4QPC6",
            "id": "A4QPC6"
        },
        {
            "name": "Btn2; D030063K05",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276543",
            "id": "NP_001276543"
        },
        {
            "name": "Btn2a2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276543",
            "id": "NP_001276543"
        }
    ],
    "protein_names": [
        {
            "name": "Butyrophilin subfamily 2 member A2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A4QPC6#names_and_taxonomy",
            "id": "A4QPC6"
        },
        {
            "name": "butyrophilin 2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276544",
            "id": "NP_001276544"
        },
        {
            "name": "butyrophilin subfamily 2 member A2 isoform 1 precursor",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276544",
            "id": "NP_001276544"
        },
        {
            "name": "butyrophilin subfamily 2 member A2 isoform 2 precursor",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276543",
            "id": "NP_001276543"
        }
    ],
    "function": [
        {
            "annotation": "Btn2a2(-/-) mice exhibited enhanced effector CD4(+) and CD8(+) T cell responses, impaired CD4(+) regulatory T cell induction, potentiated antitumor responses, and exacerbated experimental autoimmune encephalomyelitis.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001276543",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276543"
                },
                {
                    "database": "PubMed",
                    "id": "26809444",
                    "url": "https://glygen.org/publication/PubMed/26809444"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001276544",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276544"
                }
            ]
        },
        {
            "annotation": "Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A4QPC6",
                    "url": "https://www.uniprot.org/uniprot/A4QPC6#function"
                },
                {
                    "database": "PubMed",
                    "id": "20208008",
                    "url": "https://glygen.org/publication/PubMed/20208008"
                }
            ]
        },
        {
            "annotation": "RANKL-Induced Btn2a2 - A T Cell Immunomodulatory Molecule - During Osteoclast Differentiation Fine-Tunes Bone Resorption. Publication Status: Online-Only",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001276543",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276543"
                },
                {
                    "database": "PubMed",
                    "id": "34421818",
                    "url": "https://glygen.org/publication/PubMed/34421818"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001276544",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276544"
                }
            ]
        },
        {
            "annotation": "These data are consistent with a coinhibitory role for mouse Butyrophilins",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001276543",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276543"
                },
                {
                    "database": "PubMed",
                    "id": "20208008",
                    "url": "https://glygen.org/publication/PubMed/20208008"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001276544",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276544"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A4QPC6",
                    "url": "https://www.uniprot.org/uniprot/A4QPC6"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Btn2a2",
            "url": "https://www.uniprot.org/uniprot/A4QPC6",
            "locus": {
                "chromosome": "13",
                "start_pos": 23488857,
                "end_pos": 23477676,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000053216",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000053216"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000053216",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000053216",
            "database": "Bgee"
        },
        {
            "id": "cd15819",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15819",
            "database": "CDD"
        },
        {
            "id": "238555",
            "url": "https://www.ncbi.nlm.nih.gov/gene/238555",
            "database": "GeneID"
        },
        {
            "id": "IPR001870",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001870",
            "database": "InterPro"
        },
        {
            "id": "IPR003599",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599",
            "database": "InterPro"
        },
        {
            "id": "IPR003877",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR003877",
            "database": "InterPro"
        },
        {
            "id": "IPR003879",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR003879",
            "database": "InterPro"
        },
        {
            "id": "IPR006574",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR006574",
            "database": "InterPro"
        },
        {
            "id": "IPR007110",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110",
            "database": "InterPro"
        },
        {
            "id": "IPR013106",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106",
            "database": "InterPro"
        },
        {
            "id": "IPR013320",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320",
            "database": "InterPro"
        },
        {
            "id": "IPR013783",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783",
            "database": "InterPro"
        },
        {
            "id": "IPR036179",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179",
            "database": "InterPro"
        },
        {
            "id": "IPR037958",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR037958",
            "database": "InterPro"
        },
        {
            "id": "IPR043136",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR043136",
            "database": "InterPro"
        },
        {
            "id": "mmu:238555",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:238555",
            "database": "KEGG Pathway"
        },
        {
            "id": "3606486",
            "url": "http://www.informatics.jax.org/marker/MGI:3606486",
            "database": "MGI"
        },
        {
            "id": "FWVIELF",
            "url": "https://omabrowser.org/oma/group/FWVIELF/",
            "database": "OMA"
        },
        {
            "id": "522383at2759",
            "url": "http://www.orthodb.org/?query=522383at2759",
            "database": "OrthoDB"
        },
        {
            "id": "PF00622",
            "url": "http://pfam.xfam.org/family/PF00622",
            "database": "Pfam"
        },
        {
            "id": "PF07686",
            "url": "http://pfam.xfam.org/family/PF07686",
            "database": "Pfam"
        },
        {
            "id": "PF13765",
            "url": "http://pfam.xfam.org/family/PF13765",
            "database": "Pfam"
        },
        {
            "id": "PR_A4QPC6",
            "url": "http://purl.obolibrary.org/obo/PR_A4QPC6",
            "database": "PRO"
        },
        {
            "id": "R-MMU-8851680",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8851680",
            "database": "Reactome"
        },
        {
            "id": "NP_001276543",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276543",
            "database": "RefSeq"
        },
        {
            "id": "NP_001276544",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276544",
            "database": "RefSeq"
        },
        {
            "id": "A4QPC6",
            "url": "https://www.uniprot.org/uniprot/A4QPC6",
            "database": "UniProtKB"
        },
        {
            "id": "A4QPC6-1",
            "url": "https://www.uniprot.org/uniprot/A4QPC6-1",
            "database": "UniProtKB"
        },
        {
            "id": "A4QPC6-2",
            "url": "https://www.uniprot.org/uniprot/A4QPC6-2",
            "database": "UniProtKB"
        },
        {
            "id": "B9EJ60",
            "url": "https://www.uniprot.org/uniprot/B9EJ60",
            "database": "UniProtKB"
        },
        {
            "id": "B9EJ60-1",
            "url": "https://www.uniprot.org/uniprot/B9EJ60-1",
            "database": "UniProtKB"
        },
        {
            "id": "I7HIQ7",
            "url": "https://www.uniprot.org/uniprot/I7HIQ7",
            "database": "UniProtKB"
        },
        {
            "id": "I7HIQ7-1",
            "url": "https://www.uniprot.org/uniprot/I7HIQ7-1",
            "database": "UniProtKB"
        }
    ],
    "sequence": {
        "sequence": "MEPTTSLRSCPIASLLFFLVLSLFVLVSAQFTVIGPAEPILAMVGENTTLHCHLSPERNAEEMEVRWFRWRFFPAVLVYRGHQERPEEQMVAYRGRTTFMRTDISKGRVALIIHNVTAYDNGIYCCYFQEGRSYDQATMKLMVASLGSEPLIKMKTLEDGSILLECTSEGWYPEPRAVWRDPYDEVVPALEEEYTADREGLFTVTMTIIIRDCSVRNMTCSVNNTLLSQEVESVILIPESFVPSLPLWMVAVAVTLPVVMLILLTSGSICLVKKHRRKKSILSAEKEAEYEEKEAARQLQEELRWRRTLLHAADVVLDPDTAHPELFLSDDQRSVIRGSSRQSVPDNPERFDCRPCVLGRESFSSGKHYWEVEVENVMVWAIGVCRDSVERKGEALLVPQNGFWTLEMFGSQYRALSSPEKIIPLKERLHRIAVFLDCEGGDISFYNMRDRSHIYTCPPVTFTGPLRPFFRLGSDDSPLFICPAFTGAQGVTIPEGGLFLYKTRPISQSLVRKP",
        "length": 514,
        "header": "sp|A4QPC6-1|BT2A2_MOUSE Isoform 1 of Butyrophilin subfamily 2 member A2  OS=Mus musculus OX=10090 GN=Btn2a2 PE=1 SV=1 CANONICAL=A4QPC6-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A4QPC6-1",
            "url": "https://www.uniprot.org/uniprot/A4QPC6#A4QPC6-1",
            "sequence": {
                "sequence": "MEPTTSLRSCPIASLLFFLVLSLFVLVSAQFTVIGPAEPILAMVGENTTLHCHLSPERNAEEMEVRWFRWRFFPAVLVYRGHQERPEEQMVAYRGRTTFMRTDISKGRVALIIHNVTAYDNGIYCCYFQEGRSYDQATMKLMVASLGSEPLIKMKTLEDGSILLECTSEGWYPEPRAVWRDPYDEVVPALEEEYTADREGLFTVTMTIIIRDCSVRNMTCSVNNTLLSQEVESVILIPESFVPSLPLWMVAVAVTLPVVMLILLTSGSICLVKKHRRKKSILSAEKEAEYEEKEAARQLQEELRWRRTLLHAADVVLDPDTAHPELFLSDDQRSVIRGSSRQSVPDNPERFDCRPCVLGRESFSSGKHYWEVEVENVMVWAIGVCRDSVERKGEALLVPQNGFWTLEMFGSQYRALSSPEKIIPLKERLHRIAVFLDCEGGDISFYNMRDRSHIYTCPPVTFTGPLRPFFRLGSDDSPLFICPAFTGAQGVTIPEGGLFLYKTRPISQSLVRKP",
                "length": 514,
                "header": "sp|A4QPC6-1|BT2A2_MOUSE Isoform 1 of Butyrophilin subfamily 2 member A2  OS=Mus musculus OX=10090 GN=Btn2a2 PE=1 SV=1 CANONICAL=A4QPC6-1"
            },
            "locus": {
                "chromosome": "13",
                "start_pos": 23672087,
                "end_pos": 23662407,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000110432",
                        "url": "https://www.ensembl.org/id/ENSMUST00000110432"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000106062",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000106062"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A4QPC6-2",
            "url": "https://www.uniprot.org/uniprot/A4QPC6#A4QPC6-2",
            "sequence": {
                "sequence": "MEPTTSLRSCPIASLLFFLVLSLFVLVSAQFTVIGPAEPILAMVGENTTLHCHLSPERNAEEMEVRWFRWRFFPAVLVYRGHQERPEEQMVAYRGRTTFMRTDISKGRVALIIHNVTAYDNGIYCCYFQEGRSYDQATMKLMVASLGSEPLIKMKTLEDGSILLECTSEGWYPEPRAVWRDPYDEVVPALEEEYTADREGLFTVTMTIIIRDCSVRNMTCSVNNTLLSQEVESVILIPESFVPSLPLWMVAVAVTLPVVMLILLTSGSICLVKKHRRKKSILSAEKEAEYEEKEAARQLQEELRWRRTLLHAADVVLDPDTAHPELFLSDDQRSVIRGSSRQSVPDNPERFDCRPCVLGRESFSSGKHYWENGFWTLEMFGSQYRALSSPEKDHTSERASSPYSCLPGLSHIYTCPPVTFTGPLRPFFRLGSDDSPLFICPAFTGAQGVTIPEGGLFLYKTRPISQSLVRKP",
                "length": 472,
                "header": "sp|A4QPC6-2|BT2A2_MOUSE Isoform 2 of Butyrophilin subfamily 2 member A2  OS=Mus musculus OX=10090 GN=Btn2a2 PE=1 SV=1 CANONICAL=A4QPC6-1"
            },
            "locus": {}
        },
        {
            "isoform_ac": "B9EJ60-1",
            "url": "https://www.uniprot.org/uniprot/A4QPC6#B9EJ60-1",
            "sequence": {
                "sequence": "MEPTTSLRSCPIASLLFFLVLSLFVLVSAQFTVIGPAEPILAMVGENTTLHCHLSPERNAEEMEVRWFRWRFFPAVLVYRGHQERPEEQMVAYRGRTTFMRTDISKGRVALIIHNVTAYDNGIYCCYFQEGRSYDQATMKLMVASLGSEPLIKMKTLEDGSILLECTSEGWYPEPRAVWRDPYDEVVPALEEEYTADREGLFTVTMTIIIRDCSVRNMTCSVNNTLLSQEVESVILIPESFVPSLPLWMVAVAVTLPVVMLILLTSGSICLVKKHRRKKSILSAEKEAEYEEKEAARQLQEELPDVVLDPDTAHPELFLSDDQRSVIRGSSRQSVPDNPERFDCRPCVLGRESFSSGKHYWEVEVENVMVWAIGVCRDSVERKGEALLVPQNGFWTLEMFGSQYRALSSPEKIIPLKERLHRIAVFLDCEGGDISFYNMRDRSHIYTCPPVTFTGPLRPFFRLGSDDSPLFICPAFTGAQGVTIPEGGLFLYKTRPISQSLVRKP",
                "length": 505,
                "header": "tr|B9EJ60-1|BT2A2_MOUSE Computationally mapped isoform of Butyrophilin subfamily 2 member A2  OS=Mus musculus OX=10090 GN=Btn2a2 PE=1 SV=1 CANONICAL=A4QPC6-1"
            },
            "locus": {
                "chromosome": "13",
                "start_pos": 23672087,
                "end_pos": 23662407,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000223877",
                        "url": "https://www.ensembl.org/id/ENSMUST00000223877"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000153680",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000153680"
                    }
                ]
            }
        },
        {
            "isoform_ac": "I7HIQ7-1",
            "url": "https://www.uniprot.org/uniprot/A4QPC6#I7HIQ7-1",
            "sequence": {
                "sequence": "MEPTTSLRSCPIASLLFFLVLSLFVLVSAQFTVIGPAEPILAMVGENTTLHCHLSPERNAEEMEVRWFRWRFFPAVLVYRGHQERPEEQMVAYRGRTTFMRTDISKGRVALIIHNVTAYDNGIYCCYFQEGRSYDQATMKLMVASLGSEPLIKMKTLEDGSILLECTSEGWYPEPRAVWRDPYDEVVPALEEEYTADREGLFTVTMTIIIRDCSVRNMTCSVNNTLLSQEVESVILIPESFVPSLPLWMVAVAVTLPVVMLILLTSGSICLVKKHRRKKSILSAEKEAEYEEKEAARQLQEELRWRRTLLHAADVVLDPDTAHPELFLSDDQRSVIRGSSRQSVPDNPERFDCRPCVLGRESFSSGKHYWENGFWTLEMFGSQYRALSSPEKIIPLKERLHRIAVFLDYHTFTHVLL",
                "length": 417,
                "header": "tr|I7HIQ7-1|BT2A2_MOUSE Computationally mapped isoform of Butyrophilin subfamily 2 member A2  OS=Mus musculus OX=10090 GN=Btn2a2 PE=1 SV=1 CANONICAL=A4QPC6-1"
            },
            "locus": {
                "chromosome": "13",
                "start_pos": 23672087,
                "end_pos": 23662571,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000041541",
                        "url": "https://www.ensembl.org/id/ENSMUST00000041541"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000048251",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000048251"
                    }
                ]
            }
        }
    ],
    "glycosylation": [
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 115,
            "start_aa": "Asn",
            "end_pos": 115,
            "end_aa": "Asn",
            "residue": "Asn",
            "evidence": [
                {
                    "id": "A4QPC6",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/A4QPC6#ptm_processing"
                }
            ]
        },
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 47,
            "start_aa": "Asn",
            "end_pos": 47,
            "end_aa": "Asn",
            "residue": "Asn",
            "evidence": [
                {
                    "id": "A4QPC6",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/A4QPC6#ptm_processing"
                }
            ]
        }
    ],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [
        "glycoprotein",
        "glycoprotein_predicted"
    ],
    "publication": [
        {
            "title": "BTN1A1, the mammary gland butyrophilin, and BTN2A2 are both inhibitors of T cell activation.",
            "journal": "J. Immunol.",
            "date": "2010",
            "authors": "Trowsdale J., Mather I.H., Rhodes D.A., Palmer D.B., Ammann J.U., Aw D., Knezevic B.R., Smith I.A.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A4QPC6",
                    "url": "https://www.uniprot.org/uniprot/A4QPC6"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001276544",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276544"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001276543",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276543"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "20208008",
                    "url": "https://glygen.org/publication/PubMed/20208008"
                }
            ]
        },
        {
            "title": "Btn2a2, a T cell immunomodulatory molecule coregulated with MHC class II genes.",
            "journal": "The Journal of experimental medicine",
            "date": "2016",
            "authors": "Sarter K, Leimgruber E, Gobet F, Agrawal V, Dunand-Sauthier I, Barras E, Mastelic-Gavillet B, Kamath A, Fontannaz P, Guery L, Duraes Fdo V, Lippens C, Ravn U, Santiago-Raber ML, Magistrelli G, Fischer N, Siegrist CA, Hugues S, Reith W",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001276544",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276544"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001276543",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276543"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "26809444",
                    "url": "https://glygen.org/publication/PubMed/26809444"
                }
            ]
        },
        {
            "title": "RANKL-Induced Btn2a2 - A T Cell Immunomodulatory Molecule - During Osteoclast Differentiation Fine-Tunes Bone Resorption.",
            "journal": "Frontiers in endocrinology",
            "date": "2021",
            "authors": "Frech M, Schuster G, Andes FT, Schett G, Zaiss MM, Sarter K",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001276544",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276544"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001276543",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276543"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "34421818",
                    "url": "https://glygen.org/publication/PubMed/34421818"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:238555",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:238555",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-MMU-8851680",
            "name": "Butyrophilin (BTN) family interactions",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8851680",
            "resource": "Reactome",
            "description": "Butyrophilin (BTN) family interactions"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "D4A076-1",
            "protein_name": "Butyrophilin, subfamily 2, member A2",
            "gene_name": "Btn2a2",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MEPATSLHSCPLASLLFFLVLSLLALLSAQFTVIGPAEPILAMVGENITLHCHLTPERNAEDMEVRWFRWRFSPAVLVYRGHQERPEEQMVPYQGRTTFMSTDISKGRVALIIHNVTTYDNGIYYCYFQEGRSYDQATIRLRVASLGSEPLIQMKTLEDGSILLKCTSGGWYPEPRAVWRDPYDEVVPALEEEYTADREGLFRVTMTIIIRDCCVRNMTCSINNTLLSQETASVILIPEPFVRSLALWMVATAVILPIVMVILLTSGSICLVKKHHRKKSILSAEKEAKYEEKETARQLQEELQWRQTLLHAADVVLDPDTAHPELFLSADQRSVRRGPSRQSVSDNPERFDCRPCVLGRDSFSSGKHYWEVEVENVMVWAIGVCKDSVERKGEALLVPQNGFWTLEMFGSQYRALSSPEKIIPLKERLHRVAVFLDCEGGDISFYNMRDRSHIYTCPPVTFTGPLRPFFRLGSDDSPLFICPAFTGAQGVTIPEGGLFLYRTRPISQSLVRKPESSAQHYLV",
                "length": 523
            },
            "evidence": [
                {
                    "id": "56012",
                    "url": "http://www.informatics.jax.org/homology/56012",
                    "database": "MGI"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "Q8WVV5-1",
            "protein_name": "Butyrophilin subfamily 2 member A2",
            "gene_name": "BTN2A2",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MEPAAALHFSLPASLLLLLLLLLLSLCALVSAQFTVVGPANPILAMVGENTTLRCHLSPEKNAEDMEVRWFRSQFSPAVFVYKGGRERTEEQMEEYRGRITFVSKDINRGSVALVIHNVTAQENGIYRCYFQEGRSYDEAILRLVVAGLGSKPLIEIKAQEDGSIWLECISGGWYPEPLTVWRDPYGEVVPALKEVSIADADGLFMVTTAVIIRDKYVRNVSCSVNNTLLGQEKETVIFIPESFMPSASPWMVALAVILTASPWMVSMTVILAVFIIFMAVSICCIKKLQREKKILSGEKKVEQEEKEIAQQLQEELRWRRTFLHAADVVLDPDTAHPELFLSEDRRSVRRGPYRQRVPDNPERFDSQPCVLGWESFASGKHYWEVEVENVMVWTVGVCRHSVERKGEVLLIPQNGFWTLEMFGNQYRALSSPERILPLKESLCRVGVFLDYEAGDVSFYNMRDRSHIYTCPRSAFTVPVRPFFRLGSDDSPIFICPALTGASGVMVPEEGLKLHRVGTHQSL",
                "length": 523
            },
            "evidence": [
                {
                    "id": "56012",
                    "url": "http://www.informatics.jax.org/homology/56012",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 3,
                "go_terms": [
                    {
                        "name": "integral component of membrane",
                        "id": "GO:0016021",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A4QPC6",
                                "url": "https://www.uniprot.org/uniprot/A4QPC6"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cell surface",
                        "id": "GO:0009986",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A4QPC6",
                                "url": "https://www.uniprot.org/uniprot/A4QPC6"
                            }
                        ],
                        "pmid": "23589618"
                    },
                    {
                        "name": "external side of plasma membrane",
                        "id": "GO:0009897",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A4QPC6",
                                "url": "https://www.uniprot.org/uniprot/A4QPC6"
                            }
                        ],
                        "pmid": "21873635"
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 11,
                "go_terms": [
                    {
                        "name": "negative regulation of phosphatidylinositol 3-kinase signaling",
                        "id": "GO:0014067",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014067",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A4QPC6",
                                "url": "https://www.uniprot.org/uniprot/A4QPC6"
                            }
                        ],
                        "pmid": "23589618"
                    },
                    {
                        "name": "T cell receptor signaling pathway",
                        "id": "GO:0050852",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050852",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A4QPC6",
                                "url": "https://www.uniprot.org/uniprot/A4QPC6"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "negative regulation of ERK1 and ERK2 cascade",
                        "id": "GO:0070373",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070373",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A4QPC6",
                                "url": "https://www.uniprot.org/uniprot/A4QPC6"
                            }
                        ],
                        "pmid": "23589618"
                    },
                    {
                        "name": "regulation of cytokine production",
                        "id": "GO:0001817",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001817",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A4QPC6",
                                "url": "https://www.uniprot.org/uniprot/A4QPC6"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "negative regulation of G1/S transition of mitotic cell cycle",
                        "id": "GO:2000134",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000134",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A4QPC6",
                                "url": "https://www.uniprot.org/uniprot/A4QPC6"
                            }
                        ],
                        "pmid": "23589618"
                    },
                    {
                        "name": "negative regulation of protein kinase B signaling",
                        "id": "GO:0051898",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051898",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A4QPC6",
                                "url": "https://www.uniprot.org/uniprot/A4QPC6"
                            }
                        ],
                        "pmid": "23589618"
                    },
                    {
                        "name": "negative regulation of activated T cell proliferation",
                        "id": "GO:0046007",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046007",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A4QPC6",
                                "url": "https://www.uniprot.org/uniprot/A4QPC6"
                            }
                        ],
                        "pmid": "20208008"
                    },
                    {
                        "name": "negative regulation of T cell receptor signaling pathway",
                        "id": "GO:0050860",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050860",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A4QPC6",
                                "url": "https://www.uniprot.org/uniprot/A4QPC6"
                            }
                        ],
                        "pmid": "23589618"
                    },
                    {
                        "name": "positive regulation of regulatory T cell differentiation",
                        "id": "GO:0045591",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045591",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A4QPC6",
                                "url": "https://www.uniprot.org/uniprot/A4QPC6"
                            }
                        ],
                        "pmid": "23589618"
                    },
                    {
                        "name": "negative regulation of cytokine production",
                        "id": "GO:0001818",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001818",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A4QPC6",
                                "url": "https://www.uniprot.org/uniprot/A4QPC6"
                            }
                        ],
                        "pmid": "20208008"
                    },
                    {
                        "name": "negative regulation of cellular metabolic process",
                        "id": "GO:0031324",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031324",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A4QPC6",
                                "url": "https://www.uniprot.org/uniprot/A4QPC6"
                            }
                        ],
                        "pmid": "20208008"
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 1,
                "go_terms": [
                    {
                        "name": "signaling receptor binding",
                        "id": "GO:0005102",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005102",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A4QPC6",
                                "url": "https://www.uniprot.org/uniprot/A4QPC6"
                            }
                        ],
                        "pmid": "21873635"
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 115,
            "end_pos": 117,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 217,
            "end_pos": 219,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 223,
            "end_pos": 225,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 47,
            "end_pos": 49,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [
        {
            "annotation": "N-glycosylated.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A4QPC6",
                    "url": "https://www.uniprot.org/uniprot/A4QPC6"
                },
                {
                    "database": "PubMed",
                    "id": "20208008",
                    "url": "https://glygen.org/publication/PubMed/20208008"
                }
            ]
        }
    ],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        }
    ]
}