{ "uniprot_canonical_ac": "A4L9P8-1", "uniprot_ac": "A4L9P8", "uniprot_id": "CE295_RAT", "mass": { "chemical_mass": 269982.0, "monoisotopic_mass": 269982.0 }, "refseq": {}, "gene_names": [ { "name": "Cep295", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A4L9P8", "id": "A4L9P8" } ], "protein_names": [ { "name": "Centrosomal protein of 295 kDa", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A4L9P8#names_and_taxonomy", "id": "A4L9P8" } ], "function": [ { "annotation": "Centriole-enriched microtubule-binding protein involved in centriole biogenesis. Essential for the generation of the distal portion of new-born centrioles in a CENPJ- and CEP120-mediated elongation dependent manner during the cell cycle S/G2 phase after formation of the initiating cartwheel structure. Required for the recruitment of centriolar proteins, such as POC1B, POC5 and CEP135, into the distal portion of centrioles. Also required for centriole-to-centrosome conversion during mitotic progression, but is dispensable for cartwheel removal or centriole disengagement. Binds to and stabilizes centriolar microtubule.", "evidence": [ { "database": "UniProtKB", "id": "A4L9P8", "url": "https://www.uniprot.org/uniprot/A4L9P8#function" }, { "database": "PubMed", "id": "Q9C0D2", "url": "https://glygen.org/publication/PubMed/Q9C0D2" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A4L9P8", "url": "https://www.uniprot.org/uniprot/A4L9P8" } ], "common_name": "Rat" } ], "gene": [ { "name": "Cep295", "url": "https://www.uniprot.org/uniprot/A4L9P8", "locus": { "chromosome": "8", "start_pos": 13909188, "end_pos": 13871213, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000010999", "url": "https://www.ensembl.org/id/ENSRNOG00000010999" } ] } } ], "crossref": [ { "id": "ENSRNOG00000010999", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000010999", "database": "Bgee" }, { "id": "IPR029560", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029560", "database": "InterPro" }, { "id": "FVNREMD", "url": "https://omabrowser.org/oma/group/FVNREMD/", "database": "OMA" }, { "id": "PTHR21553:SF25", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21553:SF25", "database": "PANTHER" }, { "id": "PR_A4L9P8", "url": "http://purl.obolibrary.org/obo/PR_A4L9P8", "database": "PRO" }, { "id": "1311723", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1311723", "database": "RGD" }, { "id": "A0A0G2K417", "url": "https://www.uniprot.org/uniprot/A0A0G2K417", "database": "UniProtKB" }, { "id": "A0A0G2K417-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K417-1", "database": "UniProtKB" }, { "id": "A0A0G2K773", "url": "https://www.uniprot.org/uniprot/A0A0G2K773", "database": "UniProtKB" }, { "id": "A0A0G2K773-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K773-1", "database": "UniProtKB" }, { "id": "A4L9P8", "url": "https://www.uniprot.org/uniprot/A4L9P8", "database": "UniProtKB" }, { "id": "A4L9P8-1", "url": "https://www.uniprot.org/uniprot/A4L9P8-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MKRKVMNGKLRLSPNEEAFILKEDYERRRKLRLLQVREQERGIAFQIREDIKQRRNQQVSHLAEELRAEWEEAQSQKIQNLEKLYLASLRHMGDGHQQAKENEPDLDALSRRAAERKTKAEARHKEALKAQKKQKEMLMKQKTRHIKARKEAVLVEKERSAKMARLPPPVPSPFENIDINRIPSLKTNRSTYHHISAFVSRQMGTKQPDAHLAAEEEARRVERLRKQAAQERMEQSERAHARGSQAMKKIHLAQNQERLMEELKQLQREDLACKRQTAAQMPSQLLELPYRRSEMKEDWQRELEFAFEDVYSADRKVKGNLILHLKPEPLPTMSDQLQDEELDLSMEQENEVPLATKTQQIPSRILLKRLLNKIRNQKSLWTIKSFSEDDNQVTASIISEIERKVPSTDSGTITTGETAVSFEQEQVMGSDRLMIESGPPSSEDKPLCYKSVTGKEQAMGVSPPATTVAQSSVLLHPQEEAARLRMSARHKQIMEIEEQKQKQLELLEQIEQQKLRLETDCFQAQLEETRKQADHLEVRPAPVSHAMISDEERHRQMIRNYQYQLLQQNRLHKQTVETARKRLLEYQTVLKERCPSMSARSLIPDSVVSEPPQQAQKPAVASDYWDPSQRPKLSPSKYQPVQPSQIPALDQNHIQVPRQGHIPQRQGETARAKQSVESQERQWQFSQVETQQRDYEFIFKDSHSLSRTSSYVRPQTLQAAGEVSKPLRAIICQTSDSQQISSEDSENISSKPTEPSSSLPLMPECSSSSLSVKLESETIQKAFTTVNRSVISQMHGQPLSSSETGTTQQGDIRFLQGQLELQKKVLQERQEAQEKLLSCTQKELEEQTGIPVFFPSPVGNMFSSLPSASAESGNIQTSSTKSDATVSSDSMDNPYSQPISLRQTNLEFLQEQFSVEKDNLQARREAQEVSFTHTQSKLDKIVRSEQTGSSWPQLVALESFSSLTSADTQSRKIQKPPLPTNKKGLLPSQSEILSSQDGSSGFLQQTLPLQNTLKLLQEQLTIQRGMIQPRLNAQETLLLHKERCSVDSKAGPVNSLSSAVAQHSEAGPQSLQELYSSKKENTVLSSHLITPEVQEESHGSPQHSLPRQEHFASLQEQAHIQRVILGARKQIQEFAHKQNEFKKGLYSQQTGALSSPSQGTGWEISQESLSVRSDSTDPLSHFKIPGFQERLVRALQPTFPLRDNLQEHQEWVDPEKESFQFSPQTQENRSSQQTGFSSFTPSLRQPSCVSLPSVDSGITQHPLSTERDSKVTSSHLQIPELQHRLLKISQLIQPQQDSLKALQEQLATSRTIIHSRQEALEETLREWKEKIFPEQVGPFSPLMTQHSFASFPVSDIERAQELCSTNSEGAISSGYSEMLELPDRALGLSCTALPQQGNLTVHPGHLHAQTNSFHSTEKAQEKLVFPRPCKLEEISAEHSIQPPHDDLQALQQQLDVHREAIRSCQDIQEELLLQRLNKLEQRVSSKQISSSPLLSQVALPIANSEGTLQSSPAKNDDTEMLRSHSEYLNFSQPLQDNVTEQLDLEVVFHKELLLHKQKSQTKSESPEHAAPFNDAVIPRLQDRLLSYFQPALTQQDSMSPQKQLNLQREALYSRQKAQEELLVQRQTALQQQVQKHRETLKGFSNVSQTRAASGENDLEMQKTEQLTGWFPHIQGWPWGDSSQGSSSGDQPGAAAVHAEHSGESLGKELSGRASKPPVSKVKCVFDLNQHELSTIQEVESPTSGRTSMPGKAEFYRDRDPLRVSVSREQSYLGSPVAHDPFGCHQPSVQENSKSHDTAKAVKVKKSDIEDHALLSHAISEEEEEEEACTNLSPLMKPDDEVETQEISQELLSSMTVSTGSFLSYEITDLSLTDPESFSEQTEHQEQESSSKEEETGSLSCAVPSTQVTYQQQHSLGAHNSLLPTEEENASDQTHVHQIIDKDINEANLIPDKRDFQVPAVDLDFPELEHLFPHLHRQLFKPLEPHLDLDLSSPGTSQEDRDFYQQNSESSSEKHVKALSTSTLCFTALTAGSHSPNSRLNQQLDVNLAHATTEGSEQSFQQLLPEFSSQESQHTDLPSIYSIEARGTSQSMENQNYSEILQNKKKSIYFQPSTENLSPACSSSDTTLFDQLHPQHSTPCGSVSSEGSVKQLEGREEMLGFEELSRRAVPMSQRLTEDENVVLPINPYVGTVEMETSIQGSNSLSIQNEKPIQNVIKTETTKAVRNVCQLAQEEHMLKSESCPFRRPIPVWETETGYGIMEEPDLTLLSTSDISITDTDLANLTIEDNEAQCSQAGAVQPSSSVETTFCGAASEPWADQPTVASSAIPGSLGEAFMKRKKTFMERSYQRQREIWNKTPLPQAKVSKEKLSTSSSLSHLKEAVSGDETAKRNRSQCI", "length": 2395, "header": "sp|A4L9P8-1|CE295_RAT Isoform 1 of Centrosomal protein of 295 kDa OS=Rattus norvegicus OX=10116 GN=Cep295 PE=2 SV=2 CANONICAL=A4L9P8-1" }, "isoforms": [ { "isoform_ac": "A0A0G2K417-1", "url": "https://www.uniprot.org/uniprot/A4L9P8#A0A0G2K417-1", "sequence": { "sequence": "MKRKVMNGKLRLSPNEEAFILKEDYERRRKLRLLQVREQERGIAFQIREDIKQRRNQQVSHLAEELRAEWEEAQSQKIQNLEKLYLASLRHMGDGHQQAKENEPDLDALSRRAAERKTKAEARHKEALKAQKKQKEMLMKQKTRHIKARKEAVLVEKERSAKMARLPPPVPSPFENIDINRIPSLKTNRSTYHHISAFVSRQMGTKQPDAHLAAEEEARRVERLRKQAAQERMEQSERAHARGSQAMKKIHLAQNQERLMEELKQLQREDLACKRQTAAQMPSQLLELPYRRSEMKEDWQRELEFAFEDVYSADRKVKGNLILHLKPEPLPTMSDQLQDEELDLSMEQENEVPLATKTQQIPSRILLKRLLNKIRNQKSLWTIKSFSEDDNQVTASIISEIERKVPSTDSGTITTGETAVSFEQEQVMGSDRLMIESGPPSSEDKPLCYKSVTGKEQAMGVSPPATTVAQSSVLLHPQEEAARLRMSARHKQIMEIEEQKQKQLELLEQIEQQKLRLETDCFQAQLEETRKQADHLEVRPAPVSHAMISDEERHRQMIRNYQYQLLQQNRLHKQTVETARKRLLEYQTVLKERCPSMSARSLIPDSVVSEPPQQAQKPAVASDYWDPSQRPKLSPSKYQPVQPSQIPALDQNHIQVPRQGHIPQRQGETARAKQSVESQERQWQFSQVETQQRDYEFIFKDSHSLSRTSSYVRPQTLQAAGEVSKPLRAIICQTSDSQQISSEDSENISSKPTEPSSSLPLMPECSSSSLSVKLESETIQKAFTTVNRSVISQMHGQPLSSSETGTTQQGDIRFLQGQLELQKKVLQERQEAQEKLLSCTQKELEEQTGIPVFFPSPVGNMFSSLPSASAESGNIQTSSTKSDATVSSDSMDNPYSQPISLRQTNLEFLQEQFSVEKDNLQARREAQEVSFTHTQSKLDKIVRSEQTGSSWPQLVALESFSSLTSADTQSRKIQKPPLPTNKKGLLPSQSEILSSQDGSSGFLQQTLPLQNTLKLLQEQLTIQRGMIQPRLNAQETLLLHKERCSVDSKAGPVNSLSSAVAQHSEAGPQSLQELYSSKKENTVLSSHLITPEVQEESHGSPQHSLPRQEHFASLQEQAHIQRVILGARKQIQEFAHKQNEFKKGLYSQQTGALSSPSQGTGWEISQESLSVRSDSTDPLSHFKIPGFQERLVRALQPTFPLRDNLQEHQEWVDPEKESFQFSPQTQENRSSQQTGFSSFTPSLRQPSCVSLPSVDSGITQHPLSTERDSKVTSSHLQIPELQHRLLKISQLIQPQQDSLKALQEQLATSRTIIHSRQEALEETLREWKEKIFPEQVGPFSPLMTQHSFASFPVSDIERAQELCSTNSEGAISSGYSEMLELPDRALGLSCTALPQQGNLTVHPGHLHAQTNSFHSTEKAQEKLVFPRPCKLEEISAEHSIQPPHDDLQALQQQLDVHREAIRSCQDIQEELLLQRLNKLEQRVSSKQISSSPLLSQVALPIANSEGTLQSSPAKNDDTEMLRSHSEYLNFSQPLQDNVTEQLDLEVVFHKELLLHKQKSQTKSESPEHSLPALFLPKEIEHPFIPLPFAETKSKSICESYLSEKEHAAPFNDAVIPRLQDRLLSYFQPALTQQDSMSPQKQLNLQREALYSRQKAQEELLVQRQTALQQQVQKHRETLKGFSNVSQTRAASGENDLEMQKTEQLTGWFPHIQGWPWGDSSQGSSSGDQPGAAAVHAEHSGESLGKELSGRASKPPVSKVKCVFDLNQHELSTIQEVESPTSGRTSMPGKAEFYRDRDPLRVSVSREQSYLGSPVAHDPFGCHQPSVQENSKSHDTAKAVKVKKSDIEDHALLSHAISEEEEEEEACTNLSPLMKPDDEVETQEISQELLSSMTVSTGSFLSYEITDLSLTDPVPAVDLDFPELEHLFPHLHRQLFKPLEPHLDLDLSSPGTSQEDRDFYQNSESSSEKHVKALSTSTLCFTALTAGSHSPNSRLNQQLDVNLAHATTEGSEQSFQQLLPEFSSQESQHTDLPSIYSIEARGTSQSMENQNYSEILQNKKKSIYFQPSTENLSPACSSSDTTLFDQLHPQHSTPCGSVSSEGSVKQLEGREEMLGFEELSRRAVPMSQRLTEDENVVLPINPYVGTVEMETSIQGSNSLSIQNEKPIQNVIKTETTKAVRNVCQLAQEEHMLKSESCPFRRPIPVWETETGYGIMEEPDLTLLSTSDISITDTDLANLTIEDNEAQCSQAGAVQPSSSVETTFCGAASEPWADQPTVASSAIPGSLGEAFMKRKKTFMERSYQRQREIWNKTPLPQAKVSKEKLSTKAVSGDETAKRNRSQCI", "length": 2342, "header": "tr|A0A0G2K417-1|A0A0G2K417_RAT Computationally mapped isoform of Centrosomal protein of 295 kDa OS=Rattus norvegicus OX=10116 GN=Cep295 PE=4 SV=1 CANONICAL=A4L9P8-1" }, "locus": { "chromosome": "8", "start_pos": 13906355, "end_pos": 13871415, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000078372", "url": "https://www.ensembl.org/id/ENSRNOT00000078372" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000072866", "url": "https://www.ensembl.org/id/ENSRNOP00000072866" } ] } }, { "isoform_ac": "A0A0G2K773-1", "url": "https://www.uniprot.org/uniprot/A4L9P8#A0A0G2K773-1", "sequence": { "sequence": "MTEVTRSGPWLSSRYPNGCWVTGRVQIPVCCEVRPHTLSDPLYLKYSEMKRKVMNGKLRLSPNEEAFILKEDYERRRKLRLLQVREQERGIAFQIREDIKQRRNQQVSHLAEELRAEWEEAQSQKIQNLEKLYLASLRHMGDGHQQAKENEPDLDALSRRAAERKTKAEARHKEALKAQKKQKEMLMKQKTRHIKARKEAVLVEKERSAKMARLPPPVPSPFENIDINRIPSLKTNRSTYHHISAFVSRQMGTKQPDAHLAAEEEARRVERLRKQAAQERMEQSERAHARGSQAMKKIHLAQNQERLMEELKQLQREDLACKRQTAAQMPSQLLELPYRRSEMKEDWQRELEFAFEDVYSADRKVKGNLILHLKPEPLPTMSDQLQDEELDLSMEQENEVPLATKTQQIPSRILLKRLLNKIRNQKSLWTIKSFSEDDNQVTASIISEIERKVPSTDSGTITTGETAVSFEQEQVMGSDRLMIESGPPSSEDKPLCYKSVTGKEQAMGVSPPATTVAQSSVLLHPQEEAARLRMSARHKQIMEIEEQKQKQLELLEQIEQQKLRLETDCFQAQLEETRKQADHLEVRPAPVSHAMISDEERHRQMIRNYQYQLLQQNRLHKQTVETARKRLLEYQTVLKERCPSMSARSLIPDSVVSEPPQQAQKPAVASDYWDPSQRPKLSPSKYQPVQPSQIPALDQNHIQVPRQGHIPQRQGETARAKQSVESQERQWQFSQVETQQRDYEFIFKDSHSLSRTSSYVRPQTLQAAGEVSKPLRAIICQTSDSQQISSEDSENISSKPTEPSSSLPLMPECSSSSLSVKLESETIQKAFTTVNRSVISQMHGQPLSSSETGTTQQGDIRFLQGQLELQKKVLQERQEAQEKLLSCTQKELEEQTGIPVFFPSPVGNMFSSLPSASAESGNIQTSSTKSDATVSSDSMDNPYSQPISLRQTNLEFLQEQFSVEKDNLQARREAQEVSFTHTQSKLDKIVRSEQTGSSWPQLVALESFSSLTSADTQSRKIQKPPLPTNKKGLLPSQSEILSSQDGSSGFLQQTLPLQNTLKLLQEQLTIQRGMIQPRLNAQETLLLHKERCSVDSKAGPVNSLSSAVAQHSEAGPQSLQELYSSKKENTVLSSHLITPEVQEESHGSPQHSLPRQEHFASLQEQAHIQRVILGARKQIQEFAHKQNEFKKGLYSQQTGALSSPSQGTGWEISQESLSVRSDSTDPLSHFKIPGFQERLVRALQPTFPLRDNLQEHQEWVDPEKESFQFSPQTQENRSSQQTGFSSFTPSLRQPSCVSLPSVDSGITQHPLSTERDSKVTSSHLQIPELQHRLLKISQLIQPQQDSLKALQEQLATSRTIIHSRQEALEETLREWKEKIFPEQVGPFSPLMTQHSFASFPVSDIERAQELCSTNSEGAISSGYSEMLELPDRALGLSCTALPQQGNLTVHPGHLHAQTNSFHSTEKAQEKLVFPRPCKLEEISAEHSIQPPHDDLQALQQQLDVHREAIRSCQDIQEELLLQRLNKLEQRVSSKQISSSPLLSQVALPIANSEGTLQSSPAKNDDTEMLRSHSEYLNFSQPLQDNVTEQLDLEVVFHKELLLHKQKSQTKSESPEHSLPALFLPKEIEHPFIPLPFAETKSKSICESYLSEKEHAAPFNDAVIPRLQDRLLSYFQPALTQQDSMSPQKQLNLQREALYSRQKAQEELLVQRQTALQQQVQKHRETLKGFSNVSQTRAASGENDLEMQKTEQLTGWFPHIQGWPWGDSSQGSSSGDQPGAAAVHAEHSGESLGKELSGRASKPPVSKVKCVFDLNQHELSTIQEVESPTSGRTSMPGKAEFYRDRDPLRVSVSREQSYLGSPVAHDPFGCHQPSVQENSKSHDTAKAVKVKKSDIEDHALLSHAISEEEEEEEACTNLSPLMKPDDEVETQEISQELLSSMTVSTGSFLSYEITDLSLTDPESFSEQTEHQEQESSSKEEETGSLSCAVPSTQVTYQQQHSLGAHNSLLPTEEENASDQTHVHQIIDKDINEANLIPDKRDFQVPAVDLDFPELEHLFPHLHRQLFKPLEPHLDLDLSSPGTSQEDRDFYQQNSESSSEKHVKALSTSTLCFTALTAGSHSPNSRLNQQLDVNLAHATTEGSEQSFQQLLPEFSSQESQHTDLPSIYSIEARGTSQSMENQNYSEILQNKKKSIYFQPSTENLSPACSSSDTTLFDQLHPQHSTPCGSVSSEGSVKQLEGREEMLGFEELSRRAVPMSQRLTEDENVVLPINPYVGTVEMETSIQGSNSLSIQNEKPIQNVIKTETTKAVRNVCQLAQEEHMLKSESCPFRRPIPVWETETGYGIMEEPDLTLLSTSDISITDTDLANLTIEDNEAQCSQAGAVQPSSSVETTFCGAASEPWADQPTVASSAIPGSLGEAFMKRKKTFMERSYQRQREIWNKTPLPQAKVSKEKLSTKAVSGDETAKRNRSQCI", "length": 2473, "header": "tr|A0A0G2K773-1|CE295_RAT Computationally mapped isoform of Centrosomal protein of 295 kDa OS=Rattus norvegicus OX=10116 GN=Cep295 PE=2 SV=1 CANONICAL=A4L9P8-1" }, "locus": { "chromosome": "8", "start_pos": 13909154, "end_pos": 13871415, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000083011", "url": "https://www.ensembl.org/id/ENSRNOT00000083011" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000074090", "url": "https://www.ensembl.org/id/ENSRNOP00000074090" } ] } }, { "isoform_ac": "A4L9P8-1", "url": "https://www.uniprot.org/uniprot/A4L9P8#A4L9P8-1", "sequence": { "sequence": "MKRKVMNGKLRLSPNEEAFILKEDYERRRKLRLLQVREQERGIAFQIREDIKQRRNQQVSHLAEELRAEWEEAQSQKIQNLEKLYLASLRHMGDGHQQAKENEPDLDALSRRAAERKTKAEARHKEALKAQKKQKEMLMKQKTRHIKARKEAVLVEKERSAKMARLPPPVPSPFENIDINRIPSLKTNRSTYHHISAFVSRQMGTKQPDAHLAAEEEARRVERLRKQAAQERMEQSERAHARGSQAMKKIHLAQNQERLMEELKQLQREDLACKRQTAAQMPSQLLELPYRRSEMKEDWQRELEFAFEDVYSADRKVKGNLILHLKPEPLPTMSDQLQDEELDLSMEQENEVPLATKTQQIPSRILLKRLLNKIRNQKSLWTIKSFSEDDNQVTASIISEIERKVPSTDSGTITTGETAVSFEQEQVMGSDRLMIESGPPSSEDKPLCYKSVTGKEQAMGVSPPATTVAQSSVLLHPQEEAARLRMSARHKQIMEIEEQKQKQLELLEQIEQQKLRLETDCFQAQLEETRKQADHLEVRPAPVSHAMISDEERHRQMIRNYQYQLLQQNRLHKQTVETARKRLLEYQTVLKERCPSMSARSLIPDSVVSEPPQQAQKPAVASDYWDPSQRPKLSPSKYQPVQPSQIPALDQNHIQVPRQGHIPQRQGETARAKQSVESQERQWQFSQVETQQRDYEFIFKDSHSLSRTSSYVRPQTLQAAGEVSKPLRAIICQTSDSQQISSEDSENISSKPTEPSSSLPLMPECSSSSLSVKLESETIQKAFTTVNRSVISQMHGQPLSSSETGTTQQGDIRFLQGQLELQKKVLQERQEAQEKLLSCTQKELEEQTGIPVFFPSPVGNMFSSLPSASAESGNIQTSSTKSDATVSSDSMDNPYSQPISLRQTNLEFLQEQFSVEKDNLQARREAQEVSFTHTQSKLDKIVRSEQTGSSWPQLVALESFSSLTSADTQSRKIQKPPLPTNKKGLLPSQSEILSSQDGSSGFLQQTLPLQNTLKLLQEQLTIQRGMIQPRLNAQETLLLHKERCSVDSKAGPVNSLSSAVAQHSEAGPQSLQELYSSKKENTVLSSHLITPEVQEESHGSPQHSLPRQEHFASLQEQAHIQRVILGARKQIQEFAHKQNEFKKGLYSQQTGALSSPSQGTGWEISQESLSVRSDSTDPLSHFKIPGFQERLVRALQPTFPLRDNLQEHQEWVDPEKESFQFSPQTQENRSSQQTGFSSFTPSLRQPSCVSLPSVDSGITQHPLSTERDSKVTSSHLQIPELQHRLLKISQLIQPQQDSLKALQEQLATSRTIIHSRQEALEETLREWKEKIFPEQVGPFSPLMTQHSFASFPVSDIERAQELCSTNSEGAISSGYSEMLELPDRALGLSCTALPQQGNLTVHPGHLHAQTNSFHSTEKAQEKLVFPRPCKLEEISAEHSIQPPHDDLQALQQQLDVHREAIRSCQDIQEELLLQRLNKLEQRVSSKQISSSPLLSQVALPIANSEGTLQSSPAKNDDTEMLRSHSEYLNFSQPLQDNVTEQLDLEVVFHKELLLHKQKSQTKSESPEHAAPFNDAVIPRLQDRLLSYFQPALTQQDSMSPQKQLNLQREALYSRQKAQEELLVQRQTALQQQVQKHRETLKGFSNVSQTRAASGENDLEMQKTEQLTGWFPHIQGWPWGDSSQGSSSGDQPGAAAVHAEHSGESLGKELSGRASKPPVSKVKCVFDLNQHELSTIQEVESPTSGRTSMPGKAEFYRDRDPLRVSVSREQSYLGSPVAHDPFGCHQPSVQENSKSHDTAKAVKVKKSDIEDHALLSHAISEEEEEEEACTNLSPLMKPDDEVETQEISQELLSSMTVSTGSFLSYEITDLSLTDPESFSEQTEHQEQESSSKEEETGSLSCAVPSTQVTYQQQHSLGAHNSLLPTEEENASDQTHVHQIIDKDINEANLIPDKRDFQVPAVDLDFPELEHLFPHLHRQLFKPLEPHLDLDLSSPGTSQEDRDFYQQNSESSSEKHVKALSTSTLCFTALTAGSHSPNSRLNQQLDVNLAHATTEGSEQSFQQLLPEFSSQESQHTDLPSIYSIEARGTSQSMENQNYSEILQNKKKSIYFQPSTENLSPACSSSDTTLFDQLHPQHSTPCGSVSSEGSVKQLEGREEMLGFEELSRRAVPMSQRLTEDENVVLPINPYVGTVEMETSIQGSNSLSIQNEKPIQNVIKTETTKAVRNVCQLAQEEHMLKSESCPFRRPIPVWETETGYGIMEEPDLTLLSTSDISITDTDLANLTIEDNEAQCSQAGAVQPSSSVETTFCGAASEPWADQPTVASSAIPGSLGEAFMKRKKTFMERSYQRQREIWNKTPLPQAKVSKEKLSTSSSLSHLKEAVSGDETAKRNRSQCI", "length": 2395, "header": "sp|A4L9P8-1|CE295_RAT Isoform 1 of Centrosomal protein of 295 kDa OS=Rattus norvegicus OX=10116 GN=Cep295 PE=2 SV=2 CANONICAL=A4L9P8-1" }, "locus": { "chromosome": "8", "start_pos": 13906355, "end_pos": 13871415, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000029634", "url": "https://www.ensembl.org/id/ENSRNOT00000029634" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000029431", "url": "https://www.ensembl.org/id/ENSRNOP00000029431" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 13, "end_pos": 13, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A4L9P8", "url": "https://www.uniprot.org/uniprot/A4L9P8" } ] }, { "start_pos": 1565, "end_pos": 1565, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A4L9P8", "url": "https://www.uniprot.org/uniprot/A4L9P8" } ] }, { "start_pos": 634, "end_pos": 634, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A4L9P8", "url": "https://www.uniprot.org/uniprot/A4L9P8" } ] } ], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "positive regulation of protein acetylation", "id": "GO:1901985", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901985", "evidence": [ { "database": "UniProtKB", "id": "A4L9P8", "url": "https://www.uniprot.org/uniprot/A4L9P8" } ], "pmid": "" }, { "name": "positive regulation of establishment of protein localization", "id": "GO:1904951", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904951", "evidence": [ { "database": "UniProtKB", "id": "A4L9P8", "url": "https://www.uniprot.org/uniprot/A4L9P8" } ], "pmid": "" }, { "name": "positive regulation of centriole elongation", "id": "GO:1903724", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903724", "evidence": [ { "database": "UniProtKB", "id": "A4L9P8", "url": "https://www.uniprot.org/uniprot/A4L9P8" } ], "pmid": "" }, { "name": "centriole replication", "id": "GO:0007099", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007099", "evidence": [ { "database": "UniProtKB", "id": "A4L9P8", "url": "https://www.uniprot.org/uniprot/A4L9P8" } ], "pmid": "" }, { "name": "positive regulation of centrosome duplication", "id": "GO:0010825", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010825", "evidence": [ { "database": "UniProtKB", "id": "A4L9P8", "url": "https://www.uniprot.org/uniprot/A4L9P8" } ], "pmid": "" }, { "name": "regulation of centriole replication", "id": "GO:0046599", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046599", "evidence": [ { "database": "UniProtKB", "id": "A4L9P8", "url": "https://www.uniprot.org/uniprot/A4L9P8" } ], "pmid": "21873635" } ] }, { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "A4L9P8", "url": "https://www.uniprot.org/uniprot/A4L9P8" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A4L9P8", "url": "https://www.uniprot.org/uniprot/A4L9P8" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A4L9P8", "url": "https://www.uniprot.org/uniprot/A4L9P8" } ], "pmid": "" }, { "name": "centriole", "id": "GO:0005814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "evidence": [ { "database": "UniProtKB", "id": "A4L9P8", "url": "https://www.uniprot.org/uniprot/A4L9P8" } ], "pmid": "" }, { "name": "mitotic spindle microtubule", "id": "GO:1990498", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990498", "evidence": [ { "database": "UniProtKB", "id": "A4L9P8", "url": "https://www.uniprot.org/uniprot/A4L9P8" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A4L9P8", "url": "https://www.uniprot.org/uniprot/A4L9P8" } ], "pmid": "" }, { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "A4L9P8", "url": "https://www.uniprot.org/uniprot/A4L9P8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "A4L9P8", "url": "https://www.uniprot.org/uniprot/A4L9P8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1228, "end_pos": 1230, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1398, "end_pos": 1400, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1529, "end_pos": 1531, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1537, "end_pos": 1539, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1645, "end_pos": 1647, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1830, "end_pos": 1832, "annotation": "n_glycosylation_sequon" }, { "start_pos": 188, "end_pos": 190, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1928, "end_pos": 1930, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2095, "end_pos": 2097, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2115, "end_pos": 2117, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2281, "end_pos": 2283, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2354, "end_pos": 2356, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2390, "end_pos": 2392, "annotation": "n_glycosylation_sequon" }, { "start_pos": 747, "end_pos": 749, "annotation": "n_glycosylation_sequon" }, { "start_pos": 787, "end_pos": 789, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ] }