{ "uniprot_canonical_ac": "A4L9P7-1", "uniprot_ac": "A4L9P7", "uniprot_id": "PDS5A_RAT", "mass": { "chemical_mass": 150286.0, "monoisotopic_mass": 150286.0 }, "refseq": { "ac": "NP_001077093", "name": "sister chromatid cohesion protein PDS5 homolog A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077093" }, "gene_names": [ { "name": "Pds5a", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A4L9P7", "id": "A4L9P7" }, { "name": "Pds5a", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077093", "id": "NP_001077093" }, { "name": "RGD1307094; Scc-112", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077093", "id": "NP_001077093" } ], "protein_names": [ { "name": "Sister chromatid cohesion protein PDS5 homolog A", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A4L9P7#names_and_taxonomy", "id": "A4L9P7" }, { "name": "PDS5, regulator of cohesion maintenance, homolog A", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077093", "id": "NP_001077093" }, { "name": "sister chromatid cohesion protein PDS5 homolog A", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077093", "id": "NP_001077093" } ], "function": [ { "annotation": "Data show that the siRNA-mediated knockdown of Pds5A affects sister chromatid cohesion but does not influence mitotic checkpoint function or the proliferation and survival of glioblastoma multiforme cells.", "evidence": [ { "database": "RefSeq", "id": "NP_001077093", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077093" }, { "database": "PubMed", "id": "21069257", "url": "https://glygen.org/publication/PubMed/21069257" } ] }, { "annotation": "Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "A4L9P7", "url": "https://www.uniprot.org/uniprot/A4L9P7#function" } ] } ], "disease": [ { "disease_id": "DOID:11725", "recommended_name": { "id": "DOID:11725", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11725", "name": "Cornelia de Lange syndrome", "description": "A syndrome that is characterized by slow growth before and after birth, intellectual disability that is usually severe to profound, skeletal abnormalities involving the arms and hands, and distinctive facial features." }, "synonyms": [ { "id": "DOID:11725", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11725", "name": "Brachmann de Lange syndrome", "description": "" }, { "id": "DOID:11725", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11725", "name": "De Lange syndrome", "description": "" }, { "id": "MONDO:0007387", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007387", "name": "Cornelia de Lange syndrome 1", "description": "Any Cornelia de Lange syndrome in which the cause of the disease is a mutation in the NIPBL gene." }, { "id": "MONDO:0007387", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007387", "name": "Cdl", "description": "" }, { "id": "MONDO:0007387", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007387", "name": "De Lange syndrome", "description": "" }, { "id": "MONDO:0007387", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007387", "name": "Brachmann-De Lange syndrome", "description": "" }, { "id": "MONDO:0007387", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007387", "name": "CDLS1", "description": "" }, { "id": "MONDO:0007387", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007387", "name": "NIPBL Cornelia de Lange syndrome", "description": "" }, { "id": "MONDO:0007387", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007387", "name": "Cornelia De Lange syndrome type 1", "description": "" }, { "id": "MONDO:0007387", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007387", "name": "Cornelia DE Lange syndrome 1; CDLS1", "description": "" }, { "id": "MONDO:0007387", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007387", "name": "typus Degenerativus Amstelodamensis", "description": "" }, { "id": "MONDO:0007387", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007387", "name": "Cornelia de Lange syndrome 1", "description": "" }, { "id": "MONDO:0007387", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007387", "name": "Cornelia de Lange syndrome caused by mutation in NIPBL", "description": "" }, { "id": "MIM:122470", "resource": "MIM", "url": "https://www.omim.org/entry/122470", "name": "Cornelia de Lange syndrome 1", "description": "Cornelia de Lange syndrome 1" } ], "evidence": [ { "id": "11725", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:11725" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A4L9P7", "url": "https://www.uniprot.org/uniprot/A4L9P7" } ], "common_name": "Rat" } ], "gene": [ { "name": "Pds5a", "url": "https://www.uniprot.org/uniprot/A4L9P7", "locus": { "chromosome": "14", "start_pos": 44185446, "end_pos": 44280079, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000002541", "url": "https://www.ensembl.org/id/ENSRNOG00000002541" } ] } } ], "crossref": [ { "id": "ENSRNOG00000002541", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000002541", "database": "Bgee" }, { "id": "305343", "url": "https://www.ncbi.nlm.nih.gov/gene/305343", "database": "GeneID" }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro" }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro" }, { "id": "IPR039776", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039776", "database": "InterPro" }, { "id": "rno:305343", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:305343", "database": "KEGG Pathway" }, { "id": "VVACDIM", "url": "https://omabrowser.org/oma/group/VVACDIM/", "database": "OMA" }, { "id": "69768at2759", "url": "http://www.orthodb.org/?query=69768at2759", "database": "OrthoDB" }, { "id": "PTHR12663", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12663", "database": "PANTHER" }, { "id": "PR_A4L9P7", "url": "http://purl.obolibrary.org/obo/PR_A4L9P7", "database": "PRO" }, { "id": "R-RNO-2467813", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2467813", "database": "Reactome" }, { "id": "R-RNO-2468052", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2468052", "database": "Reactome" }, { "id": "R-RNO-2470946", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2470946", "database": "Reactome" }, { "id": "R-RNO-2500257", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2500257", "database": "Reactome" }, { "id": "NP_001077093", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077093", "database": "RefSeq" }, { "id": "1307094", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1307094", "database": "RGD" }, { "id": "A4L9P7", "url": "https://www.uniprot.org/uniprot/A4L9P7", "database": "UniProtKB" }, { "id": "A4L9P7-1", "url": "https://www.uniprot.org/uniprot/A4L9P7-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MDFTQPKPATALCGVVSADGKIAYPPGVKEITDKITTDEMIKRLKMVVKTFMDMDQDSEDEKQQYLPLALHLASEFFLRNPNKDVRLLVACCLADIFRIYAPEAPYTSHDKLKDIFLFITRQLKGLEDTKSPQFNRYFYLLENLAWVKSYNICFELEDCNEIFIQLFRTLFSVINNSHNKKVQMHMLDLMSSIIMEGDGVTQELLDSILINLIPAHKNLNKQSFDLAKVLLKRTVQTIEACIANFFNQVLVLGRSSVSDLSEHVFDLIQELFAIDPHLLLSVMPQLEFKLKSNDGEERLAVVRLLAKLFGSKDSDLATQNRPLWQCFLGRFNDIHVPVRLESVKFASHCLMNHPDLAKDLTEYLKVRSHDPEEAIRHDVIVTIITAAKRDLALVNDQLLGFVRERTLDKRWRVRKEAMMGLAQLYKKYCLHGEAGKEAAEKVSWIKDKLLHIYYQNSIDDKLLVEKIFAQYLVPHNLETEERMKCLYYLYASLDPNAVKALNEMWKCQNMLRSHVRELLDLHKQPTSEANCSAMFGKLMTIAKNLPDPGKAQDFVKKFNQVLGDDEKLRSQLELLISPTCSCKQADICVREIARKLANPKQPTNPFLEMVKFLLERIAPVHIDSEAISALVKLMNKSIEGTADDEEEGVSPDSAIRSGLELLKVLSFTHPTSFHSAETYESLLQCLRMEDDKVAEAAIQIFRNTGHKIETDLPQIRSTLIPILHQKAKRGTPHQAKQAVHCIHAIFSNKEVQLAQIFEPLSRSLNADVPEQLITPLVSLGHISMLAPDQFASPMKSVVANFIVKDLLMNDRSTGEKNGKLWSPDEEVSPEVLAKVQAIKLLVRWLLGMKNNQSKSANSTLRLLSAMLVSEGDLTEQKRISKSDMSRLRLAAGSAIMKLAQEPCYHEIITPEQFQLCALVINDECYQVRQIFAQKLHKALVKLLLPLEYMAIFALCAKDPVKERRAHARQCLLKNISIRREYIKQNPMATEKLLSLLPEYVVPYMIHLLAHDPDFTRSQDVDQLRDIKECLWFMLEVLMTKNENNSHAFMKKMAENIKLTRDAQSPDEAKTNEKLYTVCDVALCVINSKSALCNADSPKDPVLPMKFFTQPEKDFSNDKSYISEETRVLLLTGKPKPTGVLGTVNKPLSATGRKPYVRSAGTETGSNINASSELSPSAGNRSREQSSEASETGVSENEENPVRIISVTPVKSIDTVKNKEINSDQSTQGNISSDRGKKRIVTAAGAENIQQKPDEKADESGPPAPSKPRRGRRPKSESQGNATKNDDLSKPVSKGRKRAAGSQESLEAGNAKAPKLQDGAKKAVPAERQIDLQR", "length": 1333, "header": "sp|A4L9P7-1|PDS5A_RAT Isoform 1 of Sister chromatid cohesion protein PDS5 homolog A OS=Rattus norvegicus OX=10116 GN=Pds5a PE=1 SV=1 CANONICAL=A4L9P7-1" }, "isoforms": [ { "isoform_ac": "A4L9P7-1", "url": "https://www.uniprot.org/uniprot/A4L9P7#A4L9P7-1", "sequence": { "sequence": "MDFTQPKPATALCGVVSADGKIAYPPGVKEITDKITTDEMIKRLKMVVKTFMDMDQDSEDEKQQYLPLALHLASEFFLRNPNKDVRLLVACCLADIFRIYAPEAPYTSHDKLKDIFLFITRQLKGLEDTKSPQFNRYFYLLENLAWVKSYNICFELEDCNEIFIQLFRTLFSVINNSHNKKVQMHMLDLMSSIIMEGDGVTQELLDSILINLIPAHKNLNKQSFDLAKVLLKRTVQTIEACIANFFNQVLVLGRSSVSDLSEHVFDLIQELFAIDPHLLLSVMPQLEFKLKSNDGEERLAVVRLLAKLFGSKDSDLATQNRPLWQCFLGRFNDIHVPVRLESVKFASHCLMNHPDLAKDLTEYLKVRSHDPEEAIRHDVIVTIITAAKRDLALVNDQLLGFVRERTLDKRWRVRKEAMMGLAQLYKKYCLHGEAGKEAAEKVSWIKDKLLHIYYQNSIDDKLLVEKIFAQYLVPHNLETEERMKCLYYLYASLDPNAVKALNEMWKCQNMLRSHVRELLDLHKQPTSEANCSAMFGKLMTIAKNLPDPGKAQDFVKKFNQVLGDDEKLRSQLELLISPTCSCKQADICVREIARKLANPKQPTNPFLEMVKFLLERIAPVHIDSEAISALVKLMNKSIEGTADDEEEGVSPDSAIRSGLELLKVLSFTHPTSFHSAETYESLLQCLRMEDDKVAEAAIQIFRNTGHKIETDLPQIRSTLIPILHQKAKRGTPHQAKQAVHCIHAIFSNKEVQLAQIFEPLSRSLNADVPEQLITPLVSLGHISMLAPDQFASPMKSVVANFIVKDLLMNDRSTGEKNGKLWSPDEEVSPEVLAKVQAIKLLVRWLLGMKNNQSKSANSTLRLLSAMLVSEGDLTEQKRISKSDMSRLRLAAGSAIMKLAQEPCYHEIITPEQFQLCALVINDECYQVRQIFAQKLHKALVKLLLPLEYMAIFALCAKDPVKERRAHARQCLLKNISIRREYIKQNPMATEKLLSLLPEYVVPYMIHLLAHDPDFTRSQDVDQLRDIKECLWFMLEVLMTKNENNSHAFMKKMAENIKLTRDAQSPDEAKTNEKLYTVCDVALCVINSKSALCNADSPKDPVLPMKFFTQPEKDFSNDKSYISEETRVLLLTGKPKPTGVLGTVNKPLSATGRKPYVRSAGTETGSNINASSELSPSAGNRSREQSSEASETGVSENEENPVRIISVTPVKSIDTVKNKEINSDQSTQGNISSDRGKKRIVTAAGAENIQQKPDEKADESGPPAPSKPRRGRRPKSESQGNATKNDDLSKPVSKGRKRAAGSQESLEAGNAKAPKLQDGAKKAVPAERQIDLQR", "length": 1333, "header": "sp|A4L9P7-1|PDS5A_RAT Isoform 1 of Sister chromatid cohesion protein PDS5 homolog A OS=Rattus norvegicus OX=10116 GN=Pds5a PE=1 SV=1 CANONICAL=A4L9P7-1" }, "locus": { "chromosome": "14", "start_pos": 44279878, "end_pos": 44185485, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000003437", "url": "https://www.ensembl.org/id/ENSRNOT00000003437" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000003437", "url": "https://www.ensembl.org/id/ENSRNOP00000003437" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 1096, "end_pos": 1096, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A4L9P7", "url": "https://www.uniprot.org/uniprot/A4L9P7" } ] }, { "start_pos": 1174, "end_pos": 1174, "kinase_uniprot_canonical_ac": "Q703I1-1", "kinase_gene_name": "Oser1", "residue": "Ser", "comment": "", "evidence": [ { "database": "UniProtKB", "id": "A4L9P7", "url": "https://www.uniprot.org/uniprot/A4L9P7" }, { "database": "iPTMnet", "id": "A4L9P7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A4L9P7" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" } ] }, { "start_pos": 1174, "end_pos": 1174, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A4L9P7", "url": "https://www.uniprot.org/uniprot/A4L9P7" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" } ] }, { "start_pos": 1194, "end_pos": 1194, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A4L9P7", "url": "https://www.uniprot.org/uniprot/A4L9P7" } ] }, { "start_pos": 1207, "end_pos": 1207, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "A4L9P7", "url": "https://www.uniprot.org/uniprot/A4L9P7" } ] }, { "start_pos": 1304, "end_pos": 1304, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A4L9P7", "url": "https://www.uniprot.org/uniprot/A4L9P7" } ] } ], "glycation": [], "keywords": [], "publication": [ { "title": "The cohesin-interacting protein, precocious dissociation of sisters 5A/sister chromatid cohesion protein 112, is up-regulated in human astrocytic tumors.", "journal": "International journal of molecular medicine", "date": "2011", "authors": "Hagemann C, Weigelin B, Schommer S, Schulze M, Al-Jomah N, Anacker J, Gerngras S, Kuhnel S, Kessler AF, Polat B, Ernestus RI, Patel R, Vince GH", "evidence": [ { "database": "RefSeq", "id": "NP_001077093", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077093" } ], "reference": [ { "type": "PubMed", "id": "21069257", "url": "https://glygen.org/publication/PubMed/21069257" } ] }, { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nature communications", "date": "2012", "authors": "Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV", "evidence": [ { "database": "UniProtKB", "id": "A4L9P7", "url": "https://www.uniprot.org/uniprot/A4L9P7" }, { "database": "iPTMnet", "id": "A4L9P7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A4L9P7" } ], "reference": [ { "type": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" } ] } ], "pathway": [ { "id": "rno:305343", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:305343", "resource": "KEGG Pathway" }, { "id": "R-RNO-2467813", "name": "Separation of Sister Chromatids", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2467813", "resource": "Reactome", "description": "Separation of Sister Chromatids" }, { "id": "R-RNO-2468052", "name": "Establishment of Sister Chromatid Cohesion", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2468052", "resource": "Reactome", "description": "Establishment of Sister Chromatid Cohesion" }, { "id": "R-RNO-2470946", "name": "Cohesin Loading onto Chromatin", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2470946", "resource": "Reactome", "description": "Cohesin Loading onto Chromatin" }, { "id": "R-RNO-2500257", "name": "Resolution of Sister Chromatid Cohesion", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2500257", "resource": "Reactome", "description": "Resolution of Sister Chromatid Cohesion" } ], "orthologs": [ { "uniprot_canonical_ac": "Q29RF7-1", "protein_name": "Sister chromatid cohesion protein PDS5 homolog A", "gene_name": "PDS5A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDFTAQPKPATALCGVVSADGKIAYPPGVKEITDKITTDEMIKRLKMVVKTFMDMDQDSEDEKQQYLPLALHLASEFFLRNPNKDVRLLVACCLADIFRIYAPEAPYTSHDKLKDIFLFITRQLKGLEDTKSPQFNRYFYLLENLAWVKSYNICFELEDCNEIFIQLFRTLFSVINNSHNKKVQMHMLDLMSSIIMEGDGVTQELLDSILINLIPAHKNLNKQSFDLAKVLLKRTVQTIEACIANFFNQVLVLGRSSVSDLSEHVFDLIQELFAIDPHLLLSVMPQLEFKLKSNDGEERLAVVRLLAKLFGSKDSDLATQNRPLWQCFLGRFNDIHVPVRLESVKFASHCLMNHPDLAKDLTEYLKVRSHDPEEAIRHDVIVTIITAAKRDLALVNDQLLGFVRERTLDKRWRVRKEAMMGLAQLYKKYCLHGEAGKEAAEKVSWIKDKLLHIYYQNSIDDKLLVEKIFAQYLVPHNLETEERMKCLYYLYASLDPNAVKALNEMWKCQNMLRSHVRELLDLHKQPTSEANCSAMFGKLMTIAKNLPDPGKAQDFVKKFNQVLGDDEKLRSQLELLISPTCSCKQADICVREIARKLANPKQPTNPFLEMVKFLLERIAPVHIDSEAISALVKLMNKSIEGTADDEEEGVSPDTAIRSGLELLKVLSFTHPTSFHSAETYESLLQCLRMEDDKVAEAAIQIFRNTGHKIETDLPQIRSTLIPILHQKAKRGTPHQAKQAVHCIHAIFTNKEVQLAQIFEPLSRSLNADVPEQLITPLVSLGHISMLAPDQFASPMKSVVANFIVKDLLMNDRSTGEKNGKLWSPDEEVSPEVLAKVQAIKLLVRWLLGMKNNQSKSANSTLRLLSAMLVSEGDLTEQKRISKSDMSRLRLAAGSAIMKLAQEPCYHEIITPEQFQLCALVINDECYQVRQIFAQKLHKALVKLLLPLEYMAIFALCAKDPVKERRAHARQCLLKNISIRREYIKQNPMATEKLLSLLPEYVVPYMIHLLAHDPDFTRSQDVDQLRDIKECLWFMLEVLMTKNENNSHAFMKKMAENIKLTRDAQSPDESKTNEKLYTVCDVALCVINSKSALCNADSPKDPVLPMKFFTQPEKDFCNDKSYISEETRVLLLTGKPKPAGVLGAVNKPLSATGRKPYVRSTGTETGSNINVNSELNPSTGNRSREQSSEAAETGVSENEENPVRIISVTPVKNIDPVKNKEINSDQATQGNISSDRGKKRTVTAAGAENIQQKTDEKVDESGPPAPSKPRRGRRPKSESQGNATKNDDLNKPINKGRKRAAVGQESPGGLEAGNAKAPKLQDLAKKAAPAERQIDLQR", "length": 1337 }, "evidence": [ { "id": "22877", "url": "http://www.informatics.jax.org/homology/22877", "database": "MGI" }, { "id": "A4L9P7", "url": "https://omabrowser.org/oma/group/A4L9P7/", "database": "OMA" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q6A026-1", "protein_name": "Sister chromatid cohesion protein PDS5 homolog A", "gene_name": "Pds5a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDFTQPKPATALCGVVSADGKIAYPPGVKEITDKITTDEMIKRLKMVVKTFMDMDQDSEDEKQQYLPLALHLASEFFLRNPNKDVRLLVACCLADIFRIYAPEAPYTSHDKLKDIFLFITRQLKGLEDTKSPQFNRYFYLLENLAWVKSYNICFELEDCNEIFIQLFRTLFSVINNSHNTKVQMHMLDLMSSIIMEGDGVTQELLDSILINLIPAHKNLNKQSFDLAKVLLKRTVQTIEACIANFFNQVLVLGRSSVSDLSEHVFDLIQELFAIDPQLLLSVMPQLEFKLKSNDGEERLAVVRLLAKLFGSKDSDLATQNRPLWQCFLGRFNDIHVPVRLESVKFASHCLMNHPDLAKDLTEYLKVRSHDPEEAIRHDVIVTIITAAKRDLALVNDQLLGFVRERTLDKRWRVRKEAMMGLAQLYKKYCLHGEAGKEAAEKVSWIKDKLLHIYYQNSIDDKLLVEKIFAQYLVPHNLETEERMKCLYYLYASLDPNAVKALNEMWKCQNMLRSHVRELLDLHKQPTSEANCSAMFGKLMTIAKNLPDPGKAQDFVKKFNQVLGDDEKLRSQLELLISPTCSCKQADVCVREIARKLANPKQPTNPFLEMVKFLLERIAPVHIDSEAISALVKLMNKSIEGTADDEEEGVSPDSAIRSGLELLKVLSFTHPTSFHSAETYESLLQCLRMEDDKVAEAAIQIFRNTGHKIETDLPQIRSTLIPILHQKAKRGTPHQAKQAVHCIHAIFSNKEVQLAQIFEPLSRSLNADVPEQLITPLVSLGHISMLAPDQFASPMKSVVANFIVKDLLMNDRSTGEKNGKLWSPDEEVSPEVLAKVYLLRLLVRWLLGMKNNQSKSANSTLRLLSAMLVSEGDLTEQKRISKSDMSRLRLAAGSAIMKLAQEPCYHEIITPEQFQLCALVINDECYQVRQIFAQKLHKALVKLLLPLEYMAIFALCAKDPVKERRAHARQCLLKNISIRREYIKQNPMATEKLLSLLPEYVVPYMIHLLAHDPDFTRSQDVDQLRDIKECLWFMLEVLMTKNENNSHAFMKKMAENIKLTRDAQSPDESKTNEKLYTVCDVALCVINSKSALCNADSPKDPVLPMKFFTQPEKDFCNDKSYISEETRVLLLTGKPKPTGVLGTVNKPLSATGRKPYVRSAGTETGSNINANSELSPSAGSRSREQSSEASETGVSENEENPVRIISVTPVKNIDTVKNKEINSDQSTQGNISSDRGKKRIVTAAGAENIQKPDEKVDESGPPAPSKPRRGRRPKSESQGNATKNDDLNKPVSKGRKRAAGSQESLEAGNAKAPKLQDGAKKAVPAERQIDLQR", "length": 1332 }, "evidence": [ { "id": "22877", "url": "http://www.informatics.jax.org/homology/22877", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A4L9P7", "url": "https://www.uniprot.org/uniprot/A4L9P7" } ], "pmid": "21873635" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A4L9P7", "url": "https://www.uniprot.org/uniprot/A4L9P7" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A4L9P7", "url": "https://www.uniprot.org/uniprot/A4L9P7" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "A4L9P7", "url": "https://www.uniprot.org/uniprot/A4L9P7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 10, "go_terms": [ { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "A4L9P7", "url": "https://www.uniprot.org/uniprot/A4L9P7" } ], "pmid": "21873635" }, { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "A4L9P7", "url": "https://www.uniprot.org/uniprot/A4L9P7" } ], "pmid": "" }, { "name": "heart morphogenesis", "id": "GO:0003007", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003007", "evidence": [ { "database": "UniProtKB", "id": "A4L9P7", "url": "https://www.uniprot.org/uniprot/A4L9P7" } ], "pmid": "" }, { "name": "anterior/posterior pattern specification", "id": "GO:0009952", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009952", "evidence": [ { "database": "UniProtKB", "id": "A4L9P7", "url": "https://www.uniprot.org/uniprot/A4L9P7" } ], "pmid": "" }, { "name": "roof of mouth development", "id": "GO:0060021", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060021", "evidence": [ { "database": "UniProtKB", "id": "A4L9P7", "url": "https://www.uniprot.org/uniprot/A4L9P7" } ], "pmid": "" }, { "name": "metanephros development", "id": "GO:0001656", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001656", "evidence": [ { "database": "UniProtKB", "id": "A4L9P7", "url": "https://www.uniprot.org/uniprot/A4L9P7" } ], "pmid": "" }, { "name": "neuroblast migration", "id": "GO:0097402", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097402", "evidence": [ { "database": "UniProtKB", "id": "A4L9P7", "url": "https://www.uniprot.org/uniprot/A4L9P7" } ], "pmid": "" }, { "name": "mitotic sister chromatid cohesion", "id": "GO:0007064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007064", "evidence": [ { "database": "UniProtKB", "id": "A4L9P7", "url": "https://www.uniprot.org/uniprot/A4L9P7" } ], "pmid": "" }, { "name": "lens development in camera-type eye", "id": "GO:0002088", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002088", "evidence": [ { "database": "UniProtKB", "id": "A4L9P7", "url": "https://www.uniprot.org/uniprot/A4L9P7" } ], "pmid": "" }, { "name": "negative regulation of DNA replication", "id": "GO:0008156", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008156", "evidence": [ { "database": "UniProtKB", "id": "A4L9P7", "url": "https://www.uniprot.org/uniprot/A4L9P7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1043, "end_pos": 1045, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1168, "end_pos": 1170, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1179, "end_pos": 1181, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1229, "end_pos": 1231, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1280, "end_pos": 1282, "annotation": "n_glycosylation_sequon" }, { "start_pos": 175, "end_pos": 177, "annotation": "n_glycosylation_sequon" }, { "start_pos": 530, "end_pos": 532, "annotation": "n_glycosylation_sequon" }, { "start_pos": 635, "end_pos": 637, "annotation": "n_glycosylation_sequon" }, { "start_pos": 851, "end_pos": 853, "annotation": "n_glycosylation_sequon" }, { "start_pos": 857, "end_pos": 859, "annotation": "n_glycosylation_sequon" }, { "start_pos": 974, "end_pos": 976, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "synthesized_glycans": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ] }