{ "uniprot_canonical_ac": "A4KWA5-1", "uniprot_ac": "A4KWA5", "uniprot_id": "CL2D2_RAT", "mass": { "chemical_mass": 25559.0, "monoisotopic_mass": 25559.0 }, "refseq": { "ac": "NP_001078871", "name": "C-type lectin domain family 2 member D2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078871" }, "gene_names": [ { "name": "Clec2d2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A4KWA5", "id": "A4KWA5" }, { "name": "Clec2d2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078871", "id": "NP_001078871" }, { "name": "Clr2; RGD1562831", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078871", "id": "NP_001078871" } ], "protein_names": [ { "name": "C-type lectin domain family 2 member D2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A4KWA5#names_and_taxonomy", "id": "A4KWA5" }, { "name": "C-type lectin domain family 2 member D2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078871", "id": "NP_001078871" }, { "name": "C-type lectin-related protein 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078871", "id": "NP_001078871" } ], "function": [ { "annotation": "Lectin-type cell surface receptor.", "evidence": [ { "database": "UniProtKB", "id": "A4KWA5", "url": "https://www.uniprot.org/uniprot/A4KWA5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A4KWA5", "url": "https://www.uniprot.org/uniprot/A4KWA5" } ], "common_name": "Rat" } ], "gene": [ { "name": "Clec2d2", "url": "https://www.uniprot.org/uniprot/A4KWA5", "locus": { "chromosome": "4", "start_pos": 162437089, "end_pos": 162448422, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000059890", "url": "https://www.ensembl.org/id/ENSRNOG00000059890" } ] } } ], "crossref": [ { "id": "ENSRNOG00000059890", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000059890", "database": "Bgee" }, { "id": "cd03593", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03593", "database": "CDD" }, { "id": "362445", "url": "https://www.ncbi.nlm.nih.gov/gene/362445", "database": "GeneID" }, { "id": "IPR001304", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001304", "database": "InterPro" }, { "id": "IPR016186", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016186", "database": "InterPro" }, { "id": "IPR016187", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016187", "database": "InterPro" }, { "id": "IPR033992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033992", "database": "InterPro" }, { "id": "rno:362445", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:362445", "database": "KEGG Pathway" }, { "id": "CRREKWN", "url": "https://omabrowser.org/oma/group/CRREKWN/", "database": "OMA" }, { "id": "945977at2759", "url": "http://www.orthodb.org/?query=945977at2759", "database": "OrthoDB" }, { "id": "PF00059", "url": "http://pfam.xfam.org/family/PF00059", "database": "Pfam" }, { "id": "PR_A4KWA5", "url": "http://purl.obolibrary.org/obo/PR_A4KWA5", "database": "PRO" }, { "id": "NP_001078871", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078871", "database": "RefSeq" }, { "id": "1562831", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1562831", "database": "RGD" }, { "id": "A4KWA5", "url": "https://www.uniprot.org/uniprot/A4KWA5", "database": "UniProtKB" }, { "id": "A4KWA5-1", "url": "https://www.uniprot.org/uniprot/A4KWA5-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MPSSAHLQDAPPLLSRTLTQDEEQTSLRQSSSCGLSAASASESLSGSTKSRIPHSKMLQGNLPRIISPESPAKLPCCYGVIMVLSVAVVALSVALSVKKTPQILTVKTYAACPRNWIGVGNKCYYFNETPSNWTFSQTLCKAQEAELARFDTEEELNFLKRHKGSSGYWIGLHRESSSQPWKWTDNTAYNNLVPIGGDEKHGFLSDNGFSSGRGYIVRKSICSKPNSYTSQCQ", "length": 233, "header": "sp|A4KWA5-1|CL2D2_RAT Isoform 1 of C-type lectin domain family 2 member D2 OS=Rattus norvegicus OX=10116 GN=Clec2d2 PE=2 SV=1 CANONICAL=A4KWA5-1" }, "isoforms": [ { "isoform_ac": "A4KWA5-1", "url": "https://www.uniprot.org/uniprot/A4KWA5#A4KWA5-1", "sequence": { "sequence": "MPSSAHLQDAPPLLSRTLTQDEEQTSLRQSSSCGLSAASASESLSGSTKSRIPHSKMLQGNLPRIISPESPAKLPCCYGVIMVLSVAVVALSVALSVKKTPQILTVKTYAACPRNWIGVGNKCYYFNETPSNWTFSQTLCKAQEAELARFDTEEELNFLKRHKGSSGYWIGLHRESSSQPWKWTDNTAYNNLVPIGGDEKHGFLSDNGFSSGRGYIVRKSICSKPNSYTSQCQ", "length": 233, "header": "sp|A4KWA5-1|CL2D2_RAT Isoform 1 of C-type lectin domain family 2 member D2 OS=Rattus norvegicus OX=10116 GN=Clec2d2 PE=2 SV=1 CANONICAL=A4KWA5-1" }, "locus": { "chromosome": "4", "start_pos": 162445282, "end_pos": 162437099, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000038801", "url": "https://www.ensembl.org/id/ENSRNOT00000038801" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000035114", "url": "https://www.ensembl.org/id/ENSRNOP00000035114" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 132, "start_aa": "Asn", "end_pos": 132, "end_aa": "Asn", "residue": "Asn", "evidence": [ { "id": "A4KWA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A4KWA5#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Cytomegalovirus evasion of innate immunity by subversion of the NKR-P1B:Ocil/Clr-b missing-self axis.", "journal": "Immunity", "date": "2007", "authors": "Chen P., Voigt S., Carlyle J.R., Chou W., Mesci A., Ettinger J., Fine J.H.", "evidence": [ { "database": "UniProtKB", "id": "A4KWA5", "url": "https://www.uniprot.org/uniprot/A4KWA5" } ], "reference": [ { "type": "PubMed", "id": "17462921", "url": "https://glygen.org/publication/PubMed/17462921" } ] } ], "pathway": [ { "id": "rno:362445", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:362445", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A4KWA6-1", "protein_name": "C-type lectin domain family 2 member D3", "gene_name": "Clec2d3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSSSAHLQDAPPLLSGTLTQNEGQTSLRQSSSCGPSAASASESLSGYTESRIPHSKVRQGKGLRSIFPESRVKRYCCYGGVITVVAIAIVVPLSVTLSVKQMEQTSINNTSAASINNTSAASINNTSAACPSNWTEYGNKCFYFSEYTSNWTFSKDFCAAQGAELARFDTEEELNFLKRYKGSSGYWIGLHRESSEHPWKWTDNTQYNNLIPIRGDGQCGFLSDQLNISSSRVYVERPWICSKPKKYISQSQ", "length": 252 }, "evidence": [ { "id": "134308", "url": "http://www.informatics.jax.org/homology/134308", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "A4KWA8-1", "protein_name": "C-type lectin domain family 2 member D6", "gene_name": "Clec2d6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPSSAHLQDSPPLLSRTLTQNEGQTSLRQSSSCGPSATSASESLSGYTESRIPHSEMLQEKFHGIILPESPAKLLCCCAVIVVLSVAVVALSVALSVKKTPQISTVKTYAACPRNWIGVGNKCYYFNETARNWTFSQTLCKEQEAELARFDTEEELNFLRRYKGSPGCWIGLHRESSAHNWTWTDNTAYNKLLPIRGVEKHGFLSDNGISSSRDYIKRNSICSKLNSYTSQCQ", "length": 233 }, "evidence": [ { "id": "134308", "url": "http://www.informatics.jax.org/homology/134308", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5M9I1-1", "protein_name": "C-type lectin domain family 2 member D-related protein", "gene_name": "", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPSSAHLQDPPPHLSRTLTQDEEQTSLRQSSSCGPSTTSASASESLSGSTKSRISQKKLLEGMLPKIIPTESAAKLLCCYAVFMALTVVVIALSIALSVKKTPQISAVNTYAACQRNWIGFGNKCYYFNETARNWTFSQTLCKEQEAELARFDNEEELNFLKRYKGSSGYWIGLHRESSADPWKWTDNTAYNNLVPIKGEEKHGFLSDNGLSSGKDYIKRKSICSKLNSYTSQCP", "length": 235 }, "evidence": [ { "id": "134308", "url": "http://www.informatics.jax.org/homology/134308", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q925N7-1", "protein_name": "C-type lectin domain family 2 member D5", "gene_name": "Ocil", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPSSAHLQDPPPLLSRTLTQNEGQTSLRQSSSCGPSAASASESLSGSTESRIPHSKMLQGKLPRNIPLEYPAGLYCCYVVIIVLSVAVVALSVALSVKKTAQISTINTYAACPRNWIGVGNKCFYFNEIPSNWTLSQTLCKEQGAELARFDTEEELNFLRRYKGSSGYWFGLHRESSAHPWKWTDNTEYNNSVSIGGDEKHGFLSDNGFSSGRGYIVRKSICRKPNSYTSQCL", "length": 233 }, "evidence": [ { "id": "134308", "url": "http://www.informatics.jax.org/homology/134308", "database": "MGI" } ], "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "natural killer cell lectin-like receptor binding", "id": "GO:0046703", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046703", "evidence": [ { "database": "UniProtKB", "id": "A4KWA5", "url": "https://www.uniprot.org/uniprot/A4KWA5" } ], "pmid": "21873635" }, { "name": "carbohydrate binding", "id": "GO:0030246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030246", "evidence": [ { "database": "UniProtKB", "id": "A4KWA5", "url": "https://www.uniprot.org/uniprot/A4KWA5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "integral component of membrane", "id": "GO:0016021", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "evidence": [ { "database": "UniProtKB", "id": "A4KWA5", "url": "https://www.uniprot.org/uniprot/A4KWA5" } ], "pmid": "" }, { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "A4KWA5", "url": "https://www.uniprot.org/uniprot/A4KWA5" } ], "pmid": "21873635" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 127, "end_pos": 129, "annotation": "n_glycosylation_sequon" }, { "start_pos": 132, "end_pos": 134, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "synthesized_glycans": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" } ] }