{
    "uniprot_canonical_ac": "A4GG66-1",
    "uniprot_ac": "A4GG66",
    "uniprot_id": "CXG1_RAT",
    "mass": {
        "chemical_mass": 45666.0,
        "monoisotopic_mass": 45666.0
    },
    "refseq": {
        "ac": "NP_001078850",
        "name": "gap junction gamma-1 protein",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078850"
    },
    "gene_names": [
        {
            "name": "Gjc1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A4GG66",
            "id": "A4GG66"
        },
        {
            "name": "Cx45; Cxnq; Gja7",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078850",
            "id": "NP_001078850"
        },
        {
            "name": "Gja7",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A4GG66",
            "id": "A4GG66"
        },
        {
            "name": "Gjc1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078850",
            "id": "NP_001078850"
        }
    ],
    "protein_names": [
        {
            "name": "Gap junction gamma-1 protein",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A4GG66#names_and_taxonomy",
            "id": "A4GG66"
        },
        {
            "name": "Connexin-45",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A4GG66#names_and_taxonomy",
            "id": "A4GG66"
        },
        {
            "name": "Cx45",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A4GG66#names_and_taxonomy",
            "id": "A4GG66"
        },
        {
            "name": "Gap junction alpha-7 protein",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A4GG66#names_and_taxonomy",
            "id": "A4GG66"
        },
        {
            "name": "gap junction channel protein connexin 45; connexin-45; gap junction alpha-7 protein; gap junction membrane channel protein alpha 7; connexin q",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078850",
            "id": "NP_001078850"
        },
        {
            "name": "gap junction gamma-1 protein",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078850",
            "id": "NP_001078850"
        }
    ],
    "function": [
        {
            "annotation": "Changes in connexins, including Cx36, Cx43, and Cx45, may contribute to the damage process. Publication Status: Online-Only",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001078850",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078850"
                },
                {
                    "database": "PubMed",
                    "id": "24883012",
                    "url": "https://glygen.org/publication/PubMed/24883012"
                }
            ]
        },
        {
            "annotation": "Cx45-puncta in the cerebellar molecular layer were co-localized with Cx36-puncta and additionally occurred along Bergmann glial processes adjacent to Cx43-puncta. Expression of both Cx43 and Cx45 in Bergmann glia of rat may contribute to the complex properties of junctional coupling between these cells and perhaps to their reported coupling with Purkinje cells.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001078850",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078850"
                },
                {
                    "database": "PubMed",
                    "id": "28561933",
                    "url": "https://glygen.org/publication/PubMed/28561933"
                }
            ]
        },
        {
            "annotation": "Data suggests that connexin 45 and ZO-1 directly interact in osteoblastic cells (ROS/Cx45) [ZO-1]",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001078850",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078850"
                },
                {
                    "database": "PubMed",
                    "id": "12064590",
                    "url": "https://glygen.org/publication/PubMed/12064590"
                }
            ]
        },
        {
            "annotation": "One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A4GG66",
                    "url": "https://www.uniprot.org/uniprot/A4GG66#function"
                }
            ]
        },
        {
            "annotation": "The absence of Cx43/Cx45 hemichannels in skeltal muscles cells greatly attenuates the inflammasome activation and muscle atrophy.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001078850",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078850"
                },
                {
                    "database": "PubMed",
                    "id": "24043768",
                    "url": "https://glygen.org/publication/PubMed/24043768"
                }
            ]
        },
        {
            "annotation": "The results of the present study revealed that during memory consolidation in a passive avoidance paradigm, a rapid upregulation of Cx45 mRNAs level occurs in the hippocampus, which declines to the control level by 24 h after training.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001078850",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078850"
                },
                {
                    "database": "PubMed",
                    "id": "27913256",
                    "url": "https://glygen.org/publication/PubMed/27913256"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A4GG66",
                    "url": "https://www.uniprot.org/uniprot/A4GG66"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Gjc1",
            "url": "https://www.uniprot.org/uniprot/A4GG66",
            "locus": {
                "chromosome": "10",
                "start_pos": 90912287,
                "end_pos": 90781402,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000048838",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000048838"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000048838",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000048838",
            "database": "Bgee"
        },
        {
            "id": "266706",
            "url": "https://www.ncbi.nlm.nih.gov/gene/266706",
            "database": "GeneID"
        },
        {
            "id": "IPR000500",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000500",
            "database": "InterPro"
        },
        {
            "id": "IPR002265",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR002265",
            "database": "InterPro"
        },
        {
            "id": "IPR013092",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013092",
            "database": "InterPro"
        },
        {
            "id": "IPR017990",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR017990",
            "database": "InterPro"
        },
        {
            "id": "IPR019570",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR019570",
            "database": "InterPro"
        },
        {
            "id": "IPR038359",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR038359",
            "database": "InterPro"
        },
        {
            "id": "rno:266706",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:266706",
            "database": "KEGG Pathway"
        },
        {
            "id": "VRWKQHR",
            "url": "https://omabrowser.org/oma/group/VRWKQHR/",
            "database": "OMA"
        },
        {
            "id": "692491at2759",
            "url": "http://www.orthodb.org/?query=692491at2759",
            "database": "OrthoDB"
        },
        {
            "id": "PTHR11984",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11984",
            "database": "PANTHER"
        },
        {
            "id": "PF00029",
            "url": "http://pfam.xfam.org/family/PF00029",
            "database": "Pfam"
        },
        {
            "id": "PR_A4GG66",
            "url": "http://purl.obolibrary.org/obo/PR_A4GG66",
            "database": "PRO"
        },
        {
            "id": "R-RNO-112303",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-112303",
            "database": "Reactome"
        },
        {
            "id": "R-RNO-190861",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-190861",
            "database": "Reactome"
        },
        {
            "id": "NP_001078850",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078850",
            "database": "RefSeq"
        },
        {
            "id": "628889",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=628889",
            "database": "RGD"
        },
        {
            "id": "A4GG66",
            "url": "https://www.uniprot.org/uniprot/A4GG66",
            "database": "UniProtKB"
        },
        {
            "id": "A4GG66-1",
            "url": "https://www.uniprot.org/uniprot/A4GG66-1",
            "database": "UniProtKB"
        }
    ],
    "sequence": {
        "sequence": "MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWKQHRALEETEEDHEEDPMMYPEMELESEKENKEQSQPKPKHDGRRRIREDGLMKIYVLQLLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGLCLLLNIWEMLHLGFGTIRDSLNSKRRELDDPGAYNYPFTWNTPSAPPGYNIAVKPDQIQYTELSNAKIAYKQNKANIAQEQQYGSHEEHLPADLETLQREIRMAQERLDLAIQAYHHQNNPHGPREKKAKVGSKSGSNKSSISSKSGDGKTSVWI",
        "length": 396,
        "header": "sp|A4GG66-1|CXG1_RAT Isoform 1 of Gap junction gamma-1 protein  OS=Rattus norvegicus OX=10116 GN=Gjc1 PE=2 SV=1 CANONICAL=A4GG66-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A4GG66-1",
            "url": "https://www.uniprot.org/uniprot/A4GG66#A4GG66-1",
            "sequence": {
                "sequence": "MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWKQHRALEETEEDHEEDPMMYPEMELESEKENKEQSQPKPKHDGRRRIREDGLMKIYVLQLLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGLCLLLNIWEMLHLGFGTIRDSLNSKRRELDDPGAYNYPFTWNTPSAPPGYNIAVKPDQIQYTELSNAKIAYKQNKANIAQEQQYGSHEEHLPADLETLQREIRMAQERLDLAIQAYHHQNNPHGPREKKAKVGSKSGSNKSSISSKSGDGKTSVWI",
                "length": 396,
                "header": "sp|A4GG66-1|CXG1_RAT Isoform 1 of Gap junction gamma-1 protein  OS=Rattus norvegicus OX=10116 GN=Gjc1 PE=2 SV=1 CANONICAL=A4GG66-1"
            },
            "locus": {
                "chromosome": "10",
                "start_pos": 90782864,
                "end_pos": 90781677,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000073372",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000073372"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000066371",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000066371"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Connexin45 interacts with zonula occludens-1 in osteoblastic cells.",
            "journal": "Cell communication & adhesion",
            "date": "2001",
            "authors": "Laing JG, Manley-Markowski RN, Koval M, Civitelli R, Steinberg TH",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001078850",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078850"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "12064590",
                    "url": "https://glygen.org/publication/PubMed/12064590"
                }
            ]
        },
        {
            "title": "Primary structure, organization, and expression of the rat connexin45 gene.",
            "journal": "DNA Cell Biol.",
            "date": "2007",
            "authors": "Vos M.A., Bierhuizen M.F., Jansen A.T., Mutsaers N.A., Teunissen B.E., Vuerhard M.J.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A4GG66",
                    "url": "https://www.uniprot.org/uniprot/A4GG66"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "17328669",
                    "url": "https://glygen.org/publication/PubMed/17328669"
                }
            ]
        },
        {
            "title": "De novo expression of connexin hemichannels in denervated fast skeletal muscles leads to atrophy.",
            "journal": "Proceedings of the National Academy of Sciences of the United States of America",
            "date": "2013",
            "authors": "Cea LA, Cisterna BA, Puebla C, Frank M, Figueroa XF, Cardozo C, Willecke K, Latorre R, Saez JC",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001078850",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078850"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "24043768",
                    "url": "https://glygen.org/publication/PubMed/24043768"
                }
            ]
        },
        {
            "title": "Gap junction proteins in the light-damaged albino rat.",
            "journal": "Molecular vision",
            "date": "2014",
            "authors": "Guo CX, Tran H, Green CR, Danesh-Meyer HV, Acosta ML",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001078850",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078850"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "24883012",
                    "url": "https://glygen.org/publication/PubMed/24883012"
                }
            ]
        },
        {
            "title": "Rapid upregulation of the hippocampal connexins 36 and 45 mRNA levels during memory consolidation.",
            "journal": "Behavioural brain research",
            "date": "2017",
            "authors": "Beheshti S, Zeinali R, Esmaeili A",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001078850",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078850"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "27913256",
                    "url": "https://glygen.org/publication/PubMed/27913256"
                }
            ]
        },
        {
            "title": "Cx36, Cx43 and Cx45 in mouse and rat cerebellar cortex: species-specific expression, compensation in Cx36 null mice and co-localization in neurons vs. glia.",
            "journal": "The European journal of neuroscience",
            "date": "2017",
            "authors": "Nagy JI, Rash JE",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001078850",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078850"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "28561933",
                    "url": "https://glygen.org/publication/PubMed/28561933"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "rno:266706",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:266706",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-RNO-112303",
            "name": "Electric Transmission Across Gap Junctions",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-112303",
            "resource": "Reactome",
            "description": "Electric Transmission Across Gap Junctions"
        },
        {
            "id": "R-RNO-190861",
            "name": "Gap junction assembly",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-190861",
            "resource": "Reactome",
            "description": "Gap junction assembly"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "P28229-1",
            "protein_name": "Gap junction gamma-1 protein",
            "gene_name": "Gjc1",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWKQHRALEETEEDHEEDPMMYPEMELESEKENKEQSQPKPKHDGRRRIREDGLMKIYVLQLLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGLCLLLNIWEMLHLGFGTIRDSLNSKRRELDDPGAYNYPFTWNTPSAPPGYNIAVKPDQIQYTELSNAKIAYKQNKANIAQEQQYGSHEEHLPADLETLQREIRMAQERLDLAIQAYHHQNNPHGPREKKAKVGSKSGSNKSSISSKSGDGKTSVWI",
                "length": 396
            },
            "evidence": [
                {
                    "id": "4016",
                    "url": "http://www.informatics.jax.org/homology/4016",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "P36383-1",
            "protein_name": "Gap junction gamma-1 protein",
            "gene_name": "GJC1",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWKQHRALEETEEDNEEDPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQLLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGLCLLLNIWEMLHLGFGTIRDSLNSKRRELEDPGAYNYPFTWNTPSAPPGYNIAVKPDQIQYTELSNAKIAYKQNKANTAQEQQYGSHEENLPADLEALQREIRMAQERLDLAVQAYSHQNNPHGPREKKAKVGSKAGSNKSTASSKSGDGKTSVWI",
                "length": 396
            },
            "evidence": [
                {
                    "id": "4016",
                    "url": "http://www.informatics.jax.org/homology/4016",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 9,
                "go_terms": [
                    {
                        "name": "vasculogenesis",
                        "id": "GO:0001570",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001570",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A4GG66",
                                "url": "https://www.uniprot.org/uniprot/A4GG66"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cell-cell signaling",
                        "id": "GO:0007267",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007267",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A4GG66",
                                "url": "https://www.uniprot.org/uniprot/A4GG66"
                            }
                        ],
                        "pmid": "11668048"
                    },
                    {
                        "name": "heart development",
                        "id": "GO:0007507",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007507",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A4GG66",
                                "url": "https://www.uniprot.org/uniprot/A4GG66"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "chemical synaptic transmission",
                        "id": "GO:0007268",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007268",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A4GG66",
                                "url": "https://www.uniprot.org/uniprot/A4GG66"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "visual perception",
                        "id": "GO:0007601",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007601",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A4GG66",
                                "url": "https://www.uniprot.org/uniprot/A4GG66"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cardiac muscle tissue development",
                        "id": "GO:0048738",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048738",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A4GG66",
                                "url": "https://www.uniprot.org/uniprot/A4GG66"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cell development",
                        "id": "GO:0048468",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048468",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A4GG66",
                                "url": "https://www.uniprot.org/uniprot/A4GG66"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "AV node cell to bundle of His cell communication by electrical coupling",
                        "id": "GO:0086053",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0086053",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A4GG66",
                                "url": "https://www.uniprot.org/uniprot/A4GG66"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "gap junction assembly",
                        "id": "GO:0016264",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016264",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A4GG66",
                                "url": "https://www.uniprot.org/uniprot/A4GG66"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 3,
                "go_terms": [
                    {
                        "name": "ion channel activity",
                        "id": "GO:0005216",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005216",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A4GG66",
                                "url": "https://www.uniprot.org/uniprot/A4GG66"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling",
                        "id": "GO:0086077",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0086077",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A4GG66",
                                "url": "https://www.uniprot.org/uniprot/A4GG66"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "gap junction channel activity",
                        "id": "GO:0005243",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005243",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A4GG66",
                                "url": "https://www.uniprot.org/uniprot/A4GG66"
                            }
                        ],
                        "pmid": "11668048"
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 4,
                "go_terms": [
                    {
                        "name": "integral component of membrane",
                        "id": "GO:0016021",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A4GG66",
                                "url": "https://www.uniprot.org/uniprot/A4GG66"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "synapse",
                        "id": "GO:0045202",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A4GG66",
                                "url": "https://www.uniprot.org/uniprot/A4GG66"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "gap junction",
                        "id": "GO:0005921",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005921",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A4GG66",
                                "url": "https://www.uniprot.org/uniprot/A4GG66"
                            }
                        ],
                        "pmid": "11668048"
                    },
                    {
                        "name": "connexin complex",
                        "id": "GO:0005922",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005922",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A4GG66",
                                "url": "https://www.uniprot.org/uniprot/A4GG66"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 15,
            "end_pos": 17,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 379,
            "end_pos": 381,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        }
    ]
}