{ "uniprot_canonical_ac": "A3QPB9-1", "uniprot_ac": "A3QPB9", "uniprot_id": "IL21_RAT", "mass": { "chemical_mass": 17065.0, "monoisotopic_mass": 17065.0 }, "refseq": { "ac": "NP_001102413", "name": "interleukin-21 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102413" }, "gene_names": [ { "name": "Il21", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A3QPB9", "id": "A3QPB9" }, { "name": "IL-21", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102413", "id": "NP_001102413" }, { "name": "Il21", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102413", "id": "NP_001102413" } ], "protein_names": [ { "name": "Interleukin-21", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A3QPB9#names_and_taxonomy", "id": "A3QPB9" }, { "name": "IL-21", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A3QPB9#names_and_taxonomy", "id": "A3QPB9" }, { "name": "interleukin-21 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102413", "id": "NP_001102413" } ], "function": [ { "annotation": "Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "A3QPB9", "url": "https://www.uniprot.org/uniprot/A3QPB9#function" }, { "database": "PubMed", "id": "Q9HBE4", "url": "https://glygen.org/publication/PubMed/Q9HBE4" }, { "database": "PubMed", "id": "Q9ES17", "url": "https://glygen.org/publication/PubMed/Q9ES17" } ] } ], "disease": [ { "disease_id": "DOID:12177", "recommended_name": { "id": "DOID:12177", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:12177", "name": "common variable immunodeficiency", "description": "An agammaglobulinemia that is results in insufficient production of antibodies needed to respond to exposure of pathogens and is characterized by low Ig levels with phenotypically normal B cells that can proliferate but do not develop into Ig-producing cells." }, "synonyms": [ { "id": "DOID:12177", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:12177", "name": "CVID", "description": "" }, { "id": "DOID:12177", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:12177", "name": "acquired agammaglobulinemia", "description": "" }, { "id": "DOID:12177", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:12177", "name": "acquired hypogammaglobulinemia", "description": "" }, { "id": "DOID:12177", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:12177", "name": "common variable agammaglobulinemia", "description": "" }, { "id": "DOID:12177", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:12177", "name": "sporadic hypogammaglobulinemia", "description": "" }, { "id": "MONDO:0014260", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014260", "name": "immunodeficiency, common variable, 10", "description": "Any common variable immunodeficiency in which the cause of the disease is a mutation in the NFKB2 gene." }, { "id": "MONDO:0014260", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014260", "name": "NFKB2 common variable immunodeficiency", "description": "" }, { "id": "MONDO:0014260", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014260", "name": "immunodeficiency, common variable, type 10", "description": "" }, { "id": "MONDO:0014260", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014260", "name": "immunodeficiency, common variable, with central adrenal insufficiency", "description": "" }, { "id": "MONDO:0014260", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014260", "name": "immunodeficiency, common variable, 10; CVID10", "description": "" }, { "id": "MONDO:0014260", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014260", "name": "immunodeficiency, common variable, 10", "description": "" }, { "id": "MONDO:0014260", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014260", "name": "Deficit in anterior pituitary function and variable immunodeficiency", "description": "" }, { "id": "MONDO:0014260", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014260", "name": "CVID10", "description": "" }, { "id": "MONDO:0014260", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014260", "name": "common variable immunodeficiency caused by mutation in NFKB2", "description": "" }, { "id": "MONDO:0014338", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014338", "name": "IL21-related infantile inflammatory bowel disease", "description": "" }, { "id": "MONDO:0014338", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014338", "name": "immunodeficiency, common variable, 11", "description": "" }, { "id": "MONDO:0014338", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014338", "name": "immunodeficiency, common variable, type 11", "description": "" }, { "id": "MONDO:0014338", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014338", "name": "IL21-related infantile IBD", "description": "" }, { "id": "MONDO:0014338", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014338", "name": "immunodeficiency, common variable, 11; CVID11", "description": "" }, { "id": "MONDO:0014338", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014338", "name": "CVID11", "description": "" }, { "id": "MONDO:0014338", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014338", "name": "IL21 deficiency", "description": "" }, { "id": "MONDO:0013284", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013284", "name": "immunodeficiency, common variable, 4", "description": "" }, { "id": "MONDO:0013284", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013284", "name": "immunodeficiency, common variable, 4; CVID4", "description": "" }, { "id": "MONDO:0013284", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013284", "name": "immunodeficiency, common variable, 4", "description": "" }, { "id": "MONDO:0013284", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013284", "name": "immunodeficiency, common variable, type 4", "description": "" }, { "id": "MONDO:0013284", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013284", "name": "CVID4", "description": "" }, { "id": "MONDO:0013284", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013284", "name": "antibody deficiency due to Baffr defect", "description": "" }, { "id": "MONDO:0009413", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009413", "name": "immunodeficiency, common variable, 2", "description": "" }, { "id": "MONDO:0009413", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009413", "name": "hypogammaglobulinemia due to TACI deficiency", "description": "" }, { "id": "MONDO:0009413", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009413", "name": "antibody deficiency due to TACI defect", "description": "" }, { "id": "MONDO:0009413", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009413", "name": "immunodeficiency, common variable, type 2", "description": "" }, { "id": "MONDO:0009413", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009413", "name": "CVID2", "description": "" }, { "id": "MONDO:0009413", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009413", "name": "immunodeficiency, common variable, 2; CVID2", "description": "" }, { "id": "MONDO:0009413", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009413", "name": "immunodeficiency, common variable, 2", "description": "" }, { "id": "MONDO:0011864", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011864", "name": "immunodeficiency, common variable, 1", "description": "" }, { "id": "MONDO:0011864", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011864", "name": "immunodeficiency, common variable, 1; CVID1", "description": "" }, { "id": "MONDO:0011864", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011864", "name": "immunodeficiency, common variable", "description": "" }, { "id": "MONDO:0011864", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011864", "name": "immunodeficiency, common variable, 1", "description": "" }, { "id": "MONDO:0011864", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011864", "name": "antibody deficiency due to Icos defect", "description": "" }, { "id": "MONDO:0011864", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011864", "name": "immunodeficiency, common variable, type 1", "description": "" }, { "id": "MONDO:0011864", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011864", "name": "CVID1", "description": "" }, { "id": "MONDO:0013862", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013862", "name": "immunodeficiency, common variable, 7", "description": "" }, { "id": "MONDO:0013862", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013862", "name": "immunodeficiency, common variable, 7", "description": "" }, { "id": "MONDO:0013862", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013862", "name": "immunodeficiency, common variable, 7; CVID7", "description": "" }, { "id": "MONDO:0013862", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013862", "name": "CVID7", "description": "" }, { "id": "MONDO:0013862", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013862", "name": "immunodeficiency, common variable, type 7", "description": "" }, { "id": "MONDO:0013863", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013863", "name": "combined immunodeficiency due to LRBA deficiency", "description": "" }, { "id": "MONDO:0013863", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013863", "name": "immunodeficiency, common variable, 8, with autoimmunity", "description": "" }, { "id": "MONDO:0013863", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013863", "name": "CVID8", "description": "" }, { "id": "MONDO:0013863", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013863", "name": "Cid due to LRBA deficiency", "description": "" }, { "id": "MONDO:0013863", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013863", "name": "immunodeficiency, common variable, 8, with autoimmunity; CVID8", "description": "" }, { "id": "MONDO:0013283", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013283", "name": "immunodeficiency, common variable, 3", "description": "" }, { "id": "MONDO:0013283", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013283", "name": "immunodeficiency, common variable, type 3", "description": "" }, { "id": "MONDO:0013283", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013283", "name": "CVID3", "description": "" }, { "id": "MONDO:0013283", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013283", "name": "antibody deficiency due to CD19 defect", "description": "" }, { "id": "MONDO:0013283", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013283", "name": "immunodeficiency, common variable, 3; CVID3", "description": "" }, { "id": "MONDO:0013283", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013283", "name": "immunodeficiency, common variable, 3", "description": "" }, { "id": "MONDO:0013286", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013286", "name": "immunodeficiency, common variable, 6", "description": "Any common variable immunodeficiency in which the cause of the disease is a mutation in the CD81 gene." }, { "id": "MONDO:0013286", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013286", "name": "CD81 common variable immunodeficiency", "description": "" }, { "id": "MONDO:0013286", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013286", "name": "immunodeficiency, common variable, 6", "description": "" }, { "id": "MONDO:0013286", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013286", "name": "antibody deficiency due to CD81 defect", "description": "" }, { "id": "MONDO:0013286", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013286", "name": "immunodeficiency, common variable, 6; CVID6", "description": "" }, { "id": "MONDO:0013286", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013286", "name": "immunodeficiency, common variable, type 6", "description": "" }, { "id": "MONDO:0013286", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013286", "name": "CVID6", "description": "" }, { "id": "MONDO:0013286", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013286", "name": "common variable immunodeficiency caused by mutation in CD81", "description": "" }, { "id": "MONDO:0013285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013285", "name": "immunodeficiency, common variable, 5", "description": "Any common variable immunodeficiency in which the cause of the disease is a mutation in the MS4A1 gene." }, { "id": "MONDO:0013285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013285", "name": "immunodeficiency, common variable, 5", "description": "" }, { "id": "MONDO:0013285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013285", "name": "immunodeficiency, common variable, 5; CVID5", "description": "" }, { "id": "MONDO:0013285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013285", "name": "MS4A1 common variable immunodeficiency", "description": "" }, { "id": "MONDO:0013285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013285", "name": "antibody deficiency due to CD20 defect", "description": "" }, { "id": "MONDO:0013285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013285", "name": "immunodeficiency, common variable, type 5", "description": "" }, { "id": "MONDO:0013285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013285", "name": "CVID5", "description": "" }, { "id": "MONDO:0013285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013285", "name": "common variable immunodeficiency caused by mutation in MS4A1", "description": "" }, { "id": "MIM:615577", "resource": "MIM", "url": "https://www.omim.org/entry/615577", "name": "Immunodeficiency, common variable, 10", "description": "Immunodeficiency, common variable, 10" }, { "id": "MIM:615767", "resource": "MIM", "url": "https://www.omim.org/entry/615767", "name": "Immunodeficiency, common variable, 11", "description": "Immunodeficiency, common variable, 11" }, { "id": "MIM:613494", "resource": "MIM", "url": "https://www.omim.org/entry/613494", "name": "Immunodeficiency, common variable, 4", "description": "Immunodeficiency, common variable, 4" }, { "id": "MIM:240500", "resource": "MIM", "url": "https://www.omim.org/entry/240500", "name": "Immunodeficiency, common variable, 2", "description": "Immunodeficiency, common variable, 2" }, { "id": "MIM:607594", "resource": "MIM", "url": "https://www.omim.org/entry/607594", "name": "Immunodeficiency, common variable, 1", "description": "Immunodeficiency, common variable, 1" }, { "id": "MIM:614699", "resource": "MIM", "url": "https://www.omim.org/entry/614699", "name": "Immunodeficiency, common variable, 7", "description": "Immunodeficiency, common variable, 7" }, { "id": "MIM:614700", "resource": "MIM", "url": "https://www.omim.org/entry/614700", "name": "Immunodeficiency, common variable, 8, with autoimmunity", "description": "Immunodeficiency, common variable, 8, with autoimmunity" }, { "id": "MIM:613493", "resource": "MIM", "url": "https://www.omim.org/entry/613493", "name": "Immunodeficiency, common variable, 3", "description": "Immunodeficiency, common variable, 3" }, { "id": "MIM:613496", "resource": "MIM", "url": "https://www.omim.org/entry/613496", "name": "Immunodeficiency, common variable, 6", "description": "Immunodeficiency, common variable, 6" }, { "id": "MIM:613495", "resource": "MIM", "url": "https://www.omim.org/entry/613495", "name": "Immunodeficiency, common variable, 5", "description": "Immunodeficiency, common variable, 5" } ], "evidence": [ { "id": "12177", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:12177" } ] }, { "disease_id": "DOID:2841", "recommended_name": { "id": "DOID:2841", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2841", "name": "asthma", "description": "A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing." }, "synonyms": [ { "id": "DOID:2841", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2841", "name": "Exercise induced asthma", "description": "" }, { "id": "DOID:2841", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2841", "name": "bronchial hyperreactivity", "description": "" }, { "id": "DOID:2841", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2841", "name": "chronic obstructive asthma", "description": "" }, { "id": "DOID:2841", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2841", "name": "chronic obstructive asthma with acute exacerbation", "description": "" }, { "id": "DOID:2841", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2841", "name": "chronic obstructive asthma with status asthmaticus", "description": "" }, { "id": "DOID:2841", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2841", "name": "exercise-induced asthma", "description": "" }, { "id": "MONDO:0010940", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010940", "name": "inherited susceptibility to asthma", "description": "" }, { "id": "MONDO:0010940", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010940", "name": "asthma-related traits, susceptibility to", "description": "" }, { "id": "MONDO:0010940", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010940", "name": "asthma, diminished response to Antileukotriene treatment 1N", "description": "" }, { "id": "MONDO:0010940", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010940", "name": "asthma, protection against", "description": "" }, { "id": "MONDO:0010940", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010940", "name": "asthma, susceptibility to", "description": "" }, { "id": "MONDO:0010940", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010940", "name": "asthma, bronchial", "description": "" }, { "id": "MIM:600807", "resource": "MIM", "url": "https://www.omim.org/entry/600807", "name": "Asthma", "description": "Asthma" } ], "evidence": [ { "id": "2841", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2841" } ] }, { "disease_id": "DOID:3388", "recommended_name": { "id": "DOID:3388", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3388", "name": "periodontal disease", "description": "A mouth disease that is relating to or affecting the structures surrounding and supporting the teeth." }, "synonyms": [ { "id": "DOID:3388", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3388", "name": "Periodontal disease", "description": "" }, { "id": "DOID:3388", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3388", "name": "disease of supporting structures of teeth", "description": "" }, { "id": "DOID:3388", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3388", "name": "periodontium disorder", "description": "" } ], "evidence": [ { "id": "3388", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3388" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A3QPB9", "url": "https://www.uniprot.org/uniprot/A3QPB9" } ], "common_name": "Rat" } ], "gene": [ { "name": "Il21", "url": "https://www.uniprot.org/uniprot/A3QPB9", "locus": { "chromosome": "2", "start_pos": 123972356, "end_pos": 123965021, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000017376", "url": "https://www.ensembl.org/id/ENSRNOG00000017376" } ] } } ], "crossref": [ { "id": "ENSRNOG00000017376", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000017376", "database": "Bgee" }, { "id": "365769", "url": "https://www.ncbi.nlm.nih.gov/gene/365769", "database": "GeneID" }, { "id": "IPR003443", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003443", "database": "InterPro" }, { "id": "IPR009079", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009079", "database": "InterPro" }, { "id": "rno:365769", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:365769", "database": "KEGG Pathway" }, { "id": "HCEWSAF", "url": "https://omabrowser.org/oma/group/HCEWSAF/", "database": "OMA" }, { "id": "1439856at2759", "url": "http://www.orthodb.org/?query=1439856at2759", "database": "OrthoDB" }, { "id": "PTHR14356", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14356", "database": "PANTHER" }, { "id": "PF02372", "url": "http://pfam.xfam.org/family/PF02372", "database": "Pfam" }, { "id": "PR_A3QPB9", "url": "http://purl.obolibrary.org/obo/PR_A3QPB9", "database": "PRO" }, { "id": "R-RNO-9020958", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9020958", "database": "Reactome" }, { "id": "NP_001102413", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102413", "database": "RefSeq" }, { "id": "1307384", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1307384", "database": "RGD" }, { "id": "A3QPB9", "url": "https://www.uniprot.org/uniprot/A3QPB9", "database": "UniProtKB" }, { "id": "A3QPB9-1", "url": "https://www.uniprot.org/uniprot/A3QPB9-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MERTLVCLILIFLGTVAHKSSPQRPDHLLIRLRHLMDIVEQLKIYENDLDPELLTAPQDVKGQCEHEAFACFQKAKLKPSNTGNNKTFINDLLAQLRRRLPAKRTGNKQRHMAKCPSCDLYEKKTPKEFLERLKWLLQKMIHQHLS", "length": 146, "header": "sp|A3QPB9-1|IL21_RAT Isoform 1 of Interleukin-21 OS=Rattus norvegicus OX=10116 GN=Il21 PE=2 SV=1 CANONICAL=A3QPB9-1" }, "isoforms": [ { "isoform_ac": "A3QPB9-1", "url": "https://www.uniprot.org/uniprot/A3QPB9#A3QPB9-1", "sequence": { "sequence": "MERTLVCLILIFLGTVAHKSSPQRPDHLLIRLRHLMDIVEQLKIYENDLDPELLTAPQDVKGQCEHEAFACFQKAKLKPSNTGNNKTFINDLLAQLRRRLPAKRTGNKQRHMAKCPSCDLYEKKTPKEFLERLKWLLQKMIHQHLS", "length": 146, "header": "sp|A3QPB9-1|IL21_RAT Isoform 1 of Interleukin-21 OS=Rattus norvegicus OX=10116 GN=Il21 PE=2 SV=1 CANONICAL=A3QPB9-1" }, "locus": { "chromosome": "2", "start_pos": 123972356, "end_pos": 123965024, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000023348", "url": "https://www.ensembl.org/id/ENSRNOT00000023348" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000023348", "url": "https://www.ensembl.org/id/ENSRNOP00000023348" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 85, "start_aa": "Asn", "end_pos": 85, "end_aa": "Asn", "residue": "Asn", "evidence": [ { "id": "A3QPB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A3QPB9#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "rno:365769", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:365769", "resource": "KEGG Pathway" }, { "id": "R-RNO-9020958", "name": "Interleukin-21 signaling", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9020958", "resource": "Reactome", "description": "Interleukin-21 signaling" } ], "orthologs": [ { "uniprot_canonical_ac": "Q9ES17-1", "protein_name": "Interleukin-21", "gene_name": "Il21", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MERTLVCLVVIFLGTVAHKSSPQGPDRLLIRLRHLIDIVEQLKIYENDLDPELLSAPQDVKGHCEHAAFACFQKAKLKPSNPGNNKTFIIDLVAQLRRRLPARRGGKKQKHIAKCPSCDSYEKRTPKEFLERLKWLLQKMIHQHLS", "length": 146 }, "evidence": [ { "id": "11032", "url": "http://www.informatics.jax.org/homology/11032", "database": "MGI" }, { "id": "A3QPB9", "url": "https://omabrowser.org/oma/group/A3QPB9/", "database": "OMA" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9HBE4-1", "protein_name": "Interleukin-21", "gene_name": "IL21", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRSSPGNMERIVICLMVIFLGTLVHKSSSQGQDRHMIRMRQLIDIVDQLKNYVNDLVPEFLPAPEDVETNCEWSAFSCFQKAQLKSANTGNNERIINVSIKKLKRKPPSTNAGRRQKHRLTCPSCDSYEKKPPKEFLERFKSLLQKMIHQHLSSRTHGSEDS", "length": 162 }, "evidence": [ { "id": "11032", "url": "http://www.informatics.jax.org/homology/11032", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 17, "go_terms": [ { "name": "positive regulation of interleukin-17 production", "id": "GO:0032740", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032740", "evidence": [ { "database": "UniProtKB", "id": "A3QPB9", "url": "https://www.uniprot.org/uniprot/A3QPB9" } ], "pmid": "" }, { "name": "positive regulation of cell population proliferation", "id": "GO:0008284", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008284", "evidence": [ { "database": "UniProtKB", "id": "A3QPB9", "url": "https://www.uniprot.org/uniprot/A3QPB9" } ], "pmid": "" }, { "name": "positive regulation of cytokine production", "id": "GO:0001819", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001819", "evidence": [ { "database": "UniProtKB", "id": "A3QPB9", "url": "https://www.uniprot.org/uniprot/A3QPB9" } ], "pmid": "" }, { "name": "germinal center B cell differentiation", "id": "GO:0002314", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002314", "evidence": [ { "database": "UniProtKB", "id": "A3QPB9", "url": "https://www.uniprot.org/uniprot/A3QPB9" } ], "pmid": "" }, { "name": "positive regulation of B cell proliferation", "id": "GO:0030890", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030890", "evidence": [ { "database": "UniProtKB", "id": "A3QPB9", "url": "https://www.uniprot.org/uniprot/A3QPB9" } ], "pmid": "" }, { "name": "positive regulation of interferon-gamma production", "id": "GO:0032729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032729", "evidence": [ { "database": "UniProtKB", "id": "A3QPB9", "url": "https://www.uniprot.org/uniprot/A3QPB9" } ], "pmid": "" }, { "name": "positive regulation of T cell proliferation", "id": "GO:0042102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042102", "evidence": [ { "database": "UniProtKB", "id": "A3QPB9", "url": "https://www.uniprot.org/uniprot/A3QPB9" } ], "pmid": "" }, { "name": "cell maturation", "id": "GO:0048469", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048469", "evidence": [ { "database": "UniProtKB", "id": "A3QPB9", "url": "https://www.uniprot.org/uniprot/A3QPB9" } ], "pmid": "" }, { "name": "cellular response to virus", "id": "GO:0098586", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098586", "evidence": [ { "database": "UniProtKB", "id": "A3QPB9", "url": "https://www.uniprot.org/uniprot/A3QPB9" } ], "pmid": "" }, { "name": "positive regulation of natural killer cell mediated cytotoxicity", "id": "GO:0045954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045954", "evidence": [ { "database": "UniProtKB", "id": "A3QPB9", "url": "https://www.uniprot.org/uniprot/A3QPB9" } ], "pmid": "" }, { "name": "positive regulation of tyrosine phosphorylation of STAT protein", "id": "GO:0042531", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042531", "evidence": [ { "database": "UniProtKB", "id": "A3QPB9", "url": "https://www.uniprot.org/uniprot/A3QPB9" } ], "pmid": "" }, { "name": "positive regulation of interleukin-10 production", "id": "GO:0032733", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032733", "evidence": [ { "database": "UniProtKB", "id": "A3QPB9", "url": "https://www.uniprot.org/uniprot/A3QPB9" } ], "pmid": "" }, { "name": "tyrosine phosphorylation of STAT protein", "id": "GO:0007260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007260", "evidence": [ { "database": "UniProtKB", "id": "A3QPB9", "url": "https://www.uniprot.org/uniprot/A3QPB9" } ], "pmid": "" }, { "name": "positive regulation of natural killer cell cytokine production", "id": "GO:0002729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002729", "evidence": [ { "database": "UniProtKB", "id": "A3QPB9", "url": "https://www.uniprot.org/uniprot/A3QPB9" } ], "pmid": "" }, { "name": "positive regulation of natural killer cell differentiation", "id": "GO:0032825", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032825", "evidence": [ { "database": "UniProtKB", "id": "A3QPB9", "url": "https://www.uniprot.org/uniprot/A3QPB9" } ], "pmid": "" }, { "name": "positive regulation of immunoglobulin production", "id": "GO:0002639", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002639", "evidence": [ { "database": "UniProtKB", "id": "A3QPB9", "url": "https://www.uniprot.org/uniprot/A3QPB9" } ], "pmid": "" }, { "name": "T follicular helper cell differentiation", "id": "GO:0061470", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061470", "evidence": [ { "database": "UniProtKB", "id": "A3QPB9", "url": "https://www.uniprot.org/uniprot/A3QPB9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A3QPB9", "url": "https://www.uniprot.org/uniprot/A3QPB9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "cytokine activity", "id": "GO:0005125", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005125", "evidence": [ { "database": "UniProtKB", "id": "A3QPB9", "url": "https://www.uniprot.org/uniprot/A3QPB9" } ], "pmid": "" }, { "name": "interleukin-2 receptor binding", "id": "GO:0005134", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005134", "evidence": [ { "database": "UniProtKB", "id": "A3QPB9", "url": "https://www.uniprot.org/uniprot/A3QPB9" } ], "pmid": "" }, { "name": "cytokine receptor binding", "id": "GO:0005126", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005126", "evidence": [ { "database": "UniProtKB", "id": "A3QPB9", "url": "https://www.uniprot.org/uniprot/A3QPB9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 85, "end_pos": 87, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "synthesized_glycans": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ] }