{
    "uniprot_canonical_ac": "A3KMN5-1",
    "uniprot_ac": "A3KMN5",
    "uniprot_id": "LARGN_MOUSE",
    "mass": {
        "chemical_mass": 32836.0,
        "monoisotopic_mass": 32836.0
    },
    "refseq": {
        "ac": "NP_001074693",
        "name": "protein Largen",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074693"
    },
    "gene_names": [
        {
            "name": "Prr16",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A3KMN5",
            "id": "A3KMN5"
        },
        {
            "name": "5430406M13Rik; AI607429",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074693",
            "id": "NP_001074693"
        },
        {
            "name": "Prr16",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074693",
            "id": "NP_001074693"
        }
    ],
    "protein_names": [
        {
            "name": "Protein Largen",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A3KMN5#names_and_taxonomy",
            "id": "A3KMN5"
        },
        {
            "name": "Proline-rich protein 16",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A3KMN5#names_and_taxonomy",
            "id": "A3KMN5"
        },
        {
            "name": "proline-rich protein 16",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074693",
            "id": "NP_001074693"
        },
        {
            "name": "protein Largen",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074693",
            "id": "NP_001074693"
        }
    ],
    "function": [
        {
            "annotation": "Regulator of cell size that promotes cell size increase independently of mTOR and Hippo signaling pathways. Acts by stimulating the translation of specific mRNAs, including those encoding proteins affecting mitochondrial functions. Increases mitochondrial mass and respiration (Probable).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A3KMN5",
                    "url": "https://www.uniprot.org/uniprot/A3KMN5#function"
                },
                {
                    "database": "PubMed",
                    "id": "24656129",
                    "url": "https://glygen.org/publication/PubMed/24656129"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A3KMN5",
                    "url": "https://www.uniprot.org/uniprot/A3KMN5"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Prr16",
            "url": "https://www.uniprot.org/uniprot/A3KMN5",
            "locus": {
                "chromosome": "18",
                "start_pos": 51117898,
                "end_pos": 51304641,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000073565",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000073565"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000073565",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000073565",
            "database": "Bgee"
        },
        {
            "id": "71373",
            "url": "https://www.ncbi.nlm.nih.gov/gene/71373",
            "database": "GeneID"
        },
        {
            "id": "IPR027997",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR027997",
            "database": "InterPro"
        },
        {
            "id": "mmu:71373",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:71373",
            "database": "KEGG Pathway"
        },
        {
            "id": "1918623",
            "url": "http://www.informatics.jax.org/marker/MGI:1918623",
            "database": "MGI"
        },
        {
            "id": "STPCFIS",
            "url": "https://omabrowser.org/oma/group/STPCFIS/",
            "database": "OMA"
        },
        {
            "id": "1282387at2759",
            "url": "http://www.orthodb.org/?query=1282387at2759",
            "database": "OrthoDB"
        },
        {
            "id": "PTHR15917",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15917",
            "database": "PANTHER"
        },
        {
            "id": "PF15252",
            "url": "http://pfam.xfam.org/family/PF15252",
            "database": "Pfam"
        },
        {
            "id": "PR_A3KMN5",
            "url": "http://purl.obolibrary.org/obo/PR_A3KMN5",
            "database": "PRO"
        },
        {
            "id": "NP_001074693",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074693",
            "database": "RefSeq"
        },
        {
            "id": "A3KMN5",
            "url": "https://www.uniprot.org/uniprot/A3KMN5",
            "database": "UniProtKB"
        },
        {
            "id": "A3KMN5-1",
            "url": "https://www.uniprot.org/uniprot/A3KMN5-1",
            "database": "UniProtKB"
        },
        {
            "id": "A3KMN5-2",
            "url": "https://www.uniprot.org/uniprot/A3KMN5-2",
            "database": "UniProtKB"
        }
    ],
    "sequence": {
        "sequence": "MSAKSKGNPSSSSAAEGPPAASKTKVKEQIKIIVEDLELVLGDLKDVAKELKEVVDQIDTLTSDLQLEDEMTDSSKTDTLNSSSSGTTASSIEKIKEQANAPLIKPPAHPSAILTVLRKPNPPPPPPRLTPVRCEEPQRVVPTANPVKTNGTLLRNGGLAGRPNKIPNGDICCIPNSNLDKAPLQSLMHRPEKDRSPQAGPRERVRFNEKVQYHGYCPDCESRYNIKNREVHLHSEPVHPPGKIPHQGPLLHPPPHLPNFPLENGGLGISHSNSFPPPTPATVPPPAAPKPQKTILRKSTTTTV",
        "length": 304,
        "header": "sp|A3KMN5-1|LARGN_MOUSE Isoform 1 of Protein Largen  OS=Mus musculus OX=10090 GN=Prr16 PE=2 SV=1 CANONICAL=A3KMN5-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A3KMN5-1",
            "url": "https://www.uniprot.org/uniprot/A3KMN5#A3KMN5-1",
            "sequence": {
                "sequence": "MSAKSKGNPSSSSAAEGPPAASKTKVKEQIKIIVEDLELVLGDLKDVAKELKEVVDQIDTLTSDLQLEDEMTDSSKTDTLNSSSSGTTASSIEKIKEQANAPLIKPPAHPSAILTVLRKPNPPPPPPRLTPVRCEEPQRVVPTANPVKTNGTLLRNGGLAGRPNKIPNGDICCIPNSNLDKAPLQSLMHRPEKDRSPQAGPRERVRFNEKVQYHGYCPDCESRYNIKNREVHLHSEPVHPPGKIPHQGPLLHPPPHLPNFPLENGGLGISHSNSFPPPTPATVPPPAAPKPQKTILRKSTTTTV",
                "length": 304,
                "header": "sp|A3KMN5-1|LARGN_MOUSE Isoform 1 of Protein Largen  OS=Mus musculus OX=10090 GN=Prr16 PE=2 SV=1 CANONICAL=A3KMN5-1"
            },
            "locus": {
                "chromosome": "18",
                "start_pos": 51436434,
                "end_pos": 51251003,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000116639",
                        "url": "https://www.ensembl.org/id/ENSMUST00000116639"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000112338",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000112338"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A3KMN5-2",
            "url": "https://www.uniprot.org/uniprot/A3KMN5#A3KMN5-2",
            "sequence": {
                "sequence": "MTDSSKTDTLNSSSSGTTASSIEKIKEQANAPLIKPPAHPSAILTVLRKPNPPPPPPRLTPVRCEEPQRVVPTANPVKTNGTLLRNGGLAGRPNKIPNGDICCIPNSNLDKAPLQSLMHRPEKDRSPQAGPRERVRFNEKVQYHGYCPDCESRYNIKNREVHLHSEPVHPPGKIPHQGPLLHPPPHLPNFPLENGGLGISHSNSFPPPTPATVPPPAAPKPQKTILRKSTTTTV",
                "length": 234,
                "header": "sp|A3KMN5-2|LARGN_MOUSE Isoform 2 of Protein Largen  OS=Mus musculus OX=10090 GN=Prr16 PE=2 SV=1 CANONICAL=A3KMN5-1"
            },
            "locus": {}
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Largen: a molecular regulator of mammalian cell size control.",
            "journal": "Mol. Cell",
            "date": "2014",
            "authors": "Sasaki M., Wakutani Y., Wang F., Inoue S., Li W., Yamamoto K., Sonenberg N., Ikura M., Mak T.W., McCracken S., Wakeham A., Topisirovic I., Alexandrova R., Elia A.J., Gandin V., Haight J., Itsumi M., Lapin V., Mullen P.J., Oo Y.D., Shahinian A., Silvester J.L.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A3KMN5",
                    "url": "https://www.uniprot.org/uniprot/A3KMN5"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "24656129",
                    "url": "https://glygen.org/publication/PubMed/24656129"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:71373",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:71373",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "D4A107-1",
            "protein_name": "Uncharacterized protein",
            "gene_name": "",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "QVVDQIDTLTSDLQLEDEMTDSSKTDTLNSSSSGTTASSIEKIKEQANAPLIKPPAHPSAILTVLRKPNPPPPPPRLTPVRCEEPQKAAPTANPLKTNGTLLRNGGLPGRPNKIPNGDICCVPNSNLDKAPLQSLMHRPEKDRSPQAGPRERVRFNEKVQYHGYCPDCETRYNIKNREVHLHSEPVHPPGKLPHYGPVLPPPPHLPTFPLENGGLGISHSNSFPPHTPATVPPPPTAPKPQKTILRKSTTTTV",
                "length": 253
            },
            "evidence": [
                {
                    "id": "A3KMN5",
                    "url": "https://omabrowser.org/oma/group/A3KMN5/",
                    "database": "OMA"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "Q569H4-1",
            "protein_name": "Protein Largen",
            "gene_name": "PRR16",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MSAKSKGNPSSSCPAEGPPAASKTKVKEQIKIIVEDLELVLGDLKDVAKELKEVVDQIDTLTSDLQLEDEMTDSSKTDTLNSSSSGTTASSLEKIKVQANAPLIKPPAHPSAILTVLRKPNPPPPPPRLTPVKCEDPKRVVPTANPVKTNGTLLRNGGLPGGPNKIPNGDICCIPNSNLDKAPVQLLMHRPEKDRCPQAGPRERVRFNEKVQYHGYCPDCDTRYNIKNREVHLHSEPVHPPGKIPHQGPPLPPTPHLPPFPLENGGMGISHSNSFPPIRPATVPPPTAPKPQKTILRKSTTTTV",
                "length": 304
            },
            "evidence": [
                {
                    "id": "41152",
                    "url": "http://www.informatics.jax.org/homology/41152",
                    "database": "MGI"
                },
                {
                    "id": "A3KMN5",
                    "url": "https://omabrowser.org/oma/group/A3KMN5/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 2,
                "go_terms": [
                    {
                        "name": "positive regulation of cell size",
                        "id": "GO:0045793",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045793",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A3KMN5",
                                "url": "https://www.uniprot.org/uniprot/A3KMN5"
                            }
                        ],
                        "pmid": "24656129"
                    },
                    {
                        "name": "positive regulation of translation",
                        "id": "GO:0045727",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045727",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A3KMN5",
                                "url": "https://www.uniprot.org/uniprot/A3KMN5"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 150,
            "end_pos": 152,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 81,
            "end_pos": 83,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        }
    ]
}