{ "uniprot_canonical_ac": "A3KGF7-1", "uniprot_ac": "A3KGF7", "uniprot_id": "PLCB2_MOUSE", "mass": { "chemical_mass": 134546.0, "monoisotopic_mass": 134546.0 }, "refseq": { "ac": "NP_001277719", "name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform b", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277719" }, "gene_names": [ { "name": "Plcb2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A3KGF7", "id": "A3KGF7" }, { "name": "AI550384; B230205M18Rik; B230399N12", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277719", "id": "NP_001277719" }, { "name": "Plcb2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277719", "id": "NP_001277719" } ], "protein_names": [ { "name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A3KGF7#names_and_taxonomy", "id": "A3KGF7" }, { "name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform b", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277719", "id": "NP_001277719" }, { "name": "3.1.4.11", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A3KGF7#names_and_taxonomy", "id": "A3KGF7" }, { "name": "PLC-beta-2; phosphoinositide phospholipase C-beta-2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277719", "id": "NP_001277719" }, { "name": "PLC-beta-2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A3KGF7#names_and_taxonomy", "id": "A3KGF7" }, { "name": "Phosphoinositide phospholipase C-beta-2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A3KGF7#names_and_taxonomy", "id": "A3KGF7" }, { "name": "Phospholipase C-beta-2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A3KGF7#names_and_taxonomy", "id": "A3KGF7" } ], "function": [ { "annotation": "Mash1-expressing cells may be relevant to type III cells and a subset of PLCbeta2-positive cell differentiation in adult mouse taste buds.", "evidence": [ { "database": "RefSeq", "id": "NP_001277719", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277719" }, { "database": "PubMed", "id": "32960355", "url": "https://glygen.org/publication/PubMed/32960355" } ] }, { "annotation": "The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.", "evidence": [ { "database": "UniProtKB", "id": "A3KGF7", "url": "https://www.uniprot.org/uniprot/A3KGF7#function" }, { "database": "PubMed", "id": "Q00722", "url": "https://glygen.org/publication/PubMed/Q00722" }, { "database": "UniProtKB", "id": "E9PYI3", "url": "https://www.uniprot.org/uniprot/E9PYI3#function" }, { "database": "PubMed", "id": "PIRNR000956", "url": "https://glygen.org/publication/PubMed/PIRNR000956" } ] } ], "disease": [ { "disease_id": "DOID:9970", "recommended_name": { "id": "DOID:9970", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9970", "name": "obesity", "description": "An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness." }, "synonyms": [ { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "monogenic obesity", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "genetic obesity (disease)", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "genetic obesity", "description": "" }, { "id": "MIM:601665", "resource": "MIM", "url": "https://www.omim.org/entry/601665", "name": "Obesity", "description": "Obesity" } ], "evidence": [ { "id": "9970", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9970" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A3KGF7", "url": "https://www.uniprot.org/uniprot/A3KGF7" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Plcb2", "url": "https://www.uniprot.org/uniprot/A3KGF7", "locus": { "chromosome": "2", "start_pos": 118728438, "end_pos": 118707517, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000040061", "url": "https://www.ensembl.org/id/ENSMUSG00000040061" } ] } } ], "crossref": [ { "id": "ENSMUSG00000040061", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000040061", "database": "Bgee" }, { "id": "cd13361", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13361", "database": "CDD" }, { "id": "18796", "url": "https://www.ncbi.nlm.nih.gov/gene/18796", "database": "GeneID" }, { "id": "A3KGF7", "url": "https://www.ebi.ac.uk/intact/interactors/id:A3KGF7*", "database": "IntAct" }, { "id": "IPR000008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000008", "database": "InterPro" }, { "id": "IPR000909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000909", "database": "InterPro" }, { "id": "IPR001192", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001192", "database": "InterPro" }, { "id": "IPR001711", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001711", "database": "InterPro" }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro" }, { "id": "IPR014815", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014815", "database": "InterPro" }, { "id": "IPR015359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015359", "database": "InterPro" }, { "id": "IPR016280", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016280", "database": "InterPro" }, { "id": "IPR017946", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017946", "database": "InterPro" }, { "id": "IPR028403", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028403", "database": "InterPro" }, { "id": "IPR035892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035892", "database": "InterPro" }, { "id": "IPR037862", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037862", "database": "InterPro" }, { "id": "mmu:18796", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:18796", "database": "KEGG Pathway" }, { "id": "107465", "url": "http://www.informatics.jax.org/marker/MGI:107465", "database": "MGI" }, { "id": "TQNWAND", "url": "https://omabrowser.org/oma/group/TQNWAND/", "database": "OMA" }, { "id": "368239at2759", "url": "http://www.orthodb.org/?query=368239at2759", "database": "OrthoDB" }, { "id": "PTHR10336", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10336", "database": "PANTHER" }, { "id": "PTHR10336:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10336:SF10", "database": "PANTHER" }, { "id": "PF00168", "url": "http://pfam.xfam.org/family/PF00168", "database": "Pfam" }, { "id": "PF00387", "url": "http://pfam.xfam.org/family/PF00387", "database": "Pfam" }, { "id": "PF00388", "url": "http://pfam.xfam.org/family/PF00388", "database": "Pfam" }, { "id": "PF08703", "url": "http://pfam.xfam.org/family/PF08703", "database": "Pfam" }, { "id": "PF09279", "url": "http://pfam.xfam.org/family/PF09279", "database": "Pfam" }, { "id": "PF17787", "url": "http://pfam.xfam.org/family/PF17787", "database": "Pfam" }, { "id": "PR_A3KGF7", "url": "http://purl.obolibrary.org/obo/PR_A3KGF7", "database": "PRO" }, { "id": "R-MMU-112043", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-112043", "database": "Reactome" }, { "id": "R-MMU-1855204", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1855204", "database": "Reactome" }, { "id": "R-MMU-399997", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-399997", "database": "Reactome" }, { "id": "R-MMU-4086398", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-4086398", "database": "Reactome" }, { "id": "R-MMU-416476", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-416476", "database": "Reactome" }, { "id": "R-MMU-418217", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-418217", "database": "Reactome" }, { "id": "R-MMU-434316", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-434316", "database": "Reactome" }, { "id": "R-MMU-500657", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-500657", "database": "Reactome" }, { "id": "NP_001277719", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277719", "database": "RefSeq" }, { "id": "33179", "url": "https://www.rhea-db.org/rhea/33179", "database": "Rhea" }, { "id": "43484", "url": "https://www.rhea-db.org/rhea/43484", "database": "Rhea" }, { "id": "A3KGF7", "url": "https://www.uniprot.org/uniprot/A3KGF7", "database": "UniProtKB" }, { "id": "A3KGF7-1", "url": "https://www.uniprot.org/uniprot/A3KGF7-1", "database": "UniProtKB" }, { "id": "A3KGF7-2", "url": "https://www.uniprot.org/uniprot/A3KGF7-2", "database": "UniProtKB" }, { "id": "A3KGF7-3", "url": "https://www.uniprot.org/uniprot/A3KGF7-3", "database": "UniProtKB" }, { "id": "A3KGF7-4", "url": "https://www.uniprot.org/uniprot/A3KGF7-4", "database": "UniProtKB" }, { "id": "E9PYI3", "url": "https://www.uniprot.org/uniprot/E9PYI3", "database": "UniProtKB" }, { "id": "E9PYI3-1", "url": "https://www.uniprot.org/uniprot/E9PYI3-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MSLLNPVLLPPNVKAYLSQGERFIKWDDETSIASPVILRVDPKGYYLYWTYQNQEMEFLDVTSIRDTRFGKFAKIPKSQKLREVFNMDFPDNHFLLKTLTVVSGPDMVDLTFYNFVSYKENVGKDWAEDVLALAKHPMTVNAPRSTFLDKILVKLKMQLNPEGKIPVKNFFQMFPADRKRVEAALGACHLAKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHSKAKPYMTKEHLTKFINQKQRDPRLNSLLFPPARPEQVQVLIDKYEPSGINVQRGQLSPEGMVWFLCGPENSVLAHDTLLIHQDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDILFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKMAEYCRSMFGETLLTDPLENFPLKPGIPLPSPEDLRGKILIKNKKNQFSGPASPSKKPGGVAEGSLPSSVPVEEDTGWTAEDRTEVEEEEVVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFISFEFSAQKNRSYVVSSFTELKAYELLSKASMQFVDYNKRQMSRVYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEFMRRLDKQFNPFSVDRIDVVVATTLSITIISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKLSPTANSINPVWKEEPFIFEKILMPELASLRIAVMEEGSKFLGHRIIPINALHSGYHHLCLRSESNMALTMPALFVFLEMKDYIPDTWADLTVALANPIKYFNAQDKKSVKLKGVTGSLPEKLFSGTPVASQSNGAPVSAGNGSTAPGTKATGEEATKEVTEPQTASLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLAELQTQAAGCKLRPGKGSRKKRTLPCEETVVAPSEPHDRADPRVQELKDRLEQELQQQGEEQYRSVLKRKEQHVTEQIAKMMELAREKQAAELKTFKETSETDTKEMKKKLEAKRLERIQAMTKVTTDKVAQERLKREINNSHIQEVVQAVKQMTETLERHQEKLEERQTACLEQIQAMEKQFQEKALAEYEAKMKGLEAEVKESVRAYFKDCFPTEAEDKPERSCEASEESCPQEPLVSKADTQESRL", "length": 1181, "header": "sp|A3KGF7-1|PLCB2_MOUSE Isoform 1 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 OS=Mus musculus OX=10090 GN=Plcb2 PE=1 SV=1 CANONICAL=A3KGF7-1" }, "isoforms": [ { "isoform_ac": "A3KGF7-1", "url": "https://www.uniprot.org/uniprot/A3KGF7#A3KGF7-1", "sequence": { "sequence": "MSLLNPVLLPPNVKAYLSQGERFIKWDDETSIASPVILRVDPKGYYLYWTYQNQEMEFLDVTSIRDTRFGKFAKIPKSQKLREVFNMDFPDNHFLLKTLTVVSGPDMVDLTFYNFVSYKENVGKDWAEDVLALAKHPMTVNAPRSTFLDKILVKLKMQLNPEGKIPVKNFFQMFPADRKRVEAALGACHLAKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHSKAKPYMTKEHLTKFINQKQRDPRLNSLLFPPARPEQVQVLIDKYEPSGINVQRGQLSPEGMVWFLCGPENSVLAHDTLLIHQDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDILFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKMAEYCRSMFGETLLTDPLENFPLKPGIPLPSPEDLRGKILIKNKKNQFSGPASPSKKPGGVAEGSLPSSVPVEEDTGWTAEDRTEVEEEEVVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFISFEFSAQKNRSYVVSSFTELKAYELLSKASMQFVDYNKRQMSRVYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEFMRRLDKQFNPFSVDRIDVVVATTLSITIISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKLSPTANSINPVWKEEPFIFEKILMPELASLRIAVMEEGSKFLGHRIIPINALHSGYHHLCLRSESNMALTMPALFVFLEMKDYIPDTWADLTVALANPIKYFNAQDKKSVKLKGVTGSLPEKLFSGTPVASQSNGAPVSAGNGSTAPGTKATGEEATKEVTEPQTASLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLAELQTQAAGCKLRPGKGSRKKRTLPCEETVVAPSEPHDRADPRVQELKDRLEQELQQQGEEQYRSVLKRKEQHVTEQIAKMMELAREKQAAELKTFKETSETDTKEMKKKLEAKRLERIQAMTKVTTDKVAQERLKREINNSHIQEVVQAVKQMTETLERHQEKLEERQTACLEQIQAMEKQFQEKALAEYEAKMKGLEAEVKESVRAYFKDCFPTEAEDKPERSCEASEESCPQEPLVSKADTQESRL", "length": 1181, "header": "sp|A3KGF7-1|PLCB2_MOUSE Isoform 1 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 OS=Mus musculus OX=10090 GN=Plcb2 PE=1 SV=1 CANONICAL=A3KGF7-1" }, "locus": { "chromosome": "2", "start_pos": 118558802, "end_pos": 118539483, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000102524", "url": "https://www.ensembl.org/id/ENSMUST00000102524" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000099583", "url": "https://www.ensembl.org/id/ENSMUSP00000099583" } ] } }, { "isoform_ac": "A3KGF7-2", "url": "https://www.uniprot.org/uniprot/A3KGF7#A3KGF7-2", "sequence": { "sequence": "MSLLNPVLLPPNVKAYLSQGERFIKWDDETSIASPVILRVDPKGYYLYWTYQNQSQKLREVFNMDFPDNHFLLKTLTVVSGPDMVDLTFYNFVSYKENVGKDWAEDVLALAKHPMTVNAPRSTFLDKILVKLKMQLNPEGKIPVKNFFQMFPADRKRVEAALGACHLAKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHSKAKPYMTKEHLTKFINQKQRDPRLNSLLFPPARPEQVQVLIDKYEPSGINVQRGQLSPEGMVWFLCGPENSVLAHDTLLIHQDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDILFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKMAEYCRSMFGETLLTDPLENFPLKPGIPLPSPEDLRGKILIKNKKNQFSGPASPSKKPGGVAEGSLPSSVPVEEDTGWTAEDRTEVEEEEVVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFISFEFSAQKNRSYVVSSFTELKAYELLSKASMQFVDYNKRQMSRVYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEFMRRLDKQFNPFSVDRIDVVVATTLSITARPRADKWLGGLGS", "length": 679, "header": "sp|A3KGF7-2|PLCB2_MOUSE Isoform 2 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 OS=Mus musculus OX=10090 GN=Plcb2 PE=1 SV=1 CANONICAL=A3KGF7-1" }, "locus": {} }, { "isoform_ac": "A3KGF7-3", "url": "https://www.uniprot.org/uniprot/A3KGF7#A3KGF7-3", "sequence": { "sequence": "MSLLNPVLLPPNVKAYLSQGERFIKWDDETSIASPVILRVDPKGYYLYWTYQNQEMEFLDVTSIRDTRFGKFAKIPKSQKLREVFNMDFPDNHFLLKTLTVVSGPDMVDLTFYNFVSYKENVGKDWAEDVLALAKHPMTVNAPRSTFLDKILVKLKMQLNPEGKIPVKNFFQMFPADRKRVEAALGACHLAKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHSKAKPYMTKEHLTKFINQKQRDPRLNSLLFPPARPEQVQVLIDKYEPSGINVQRGQLSPEGMVWFLCGPENSVLAHDTLLIHQDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDILFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKMAEYCRSMFGETLLTDPLENFPLKPGIPLPSPEDLRGKILIKNKKNQFSGPASPSKKPGGVAEGSLPSSVPVEEDTGWTAEDRTEVEEEEVVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFISFEFSAQKNRSYVVSSFTELKAYELLSKASMQFVDYNKRQMSRVYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEFMRRLDKQFNPFSVDRIDVVVATTLSITARPRADKWLGGLGS", "length": 702, "header": "sp|A3KGF7-3|PLCB2_MOUSE Isoform 3 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 OS=Mus musculus OX=10090 GN=Plcb2 PE=1 SV=1 CANONICAL=A3KGF7-1" }, "locus": {} }, { "isoform_ac": "A3KGF7-4", "url": "https://www.uniprot.org/uniprot/A3KGF7#A3KGF7-4", "sequence": { "sequence": "MEFLDVTSIRDTRFGKFAKIPKSQKLREVFNMDFPDNHFLLKTLTVVSGPDMVDLTFYNFVSYKENVGKDWAEDVLALAKHPMTVNAPRSTFLDKILVKLKMQLNPEGKIPVKNFFQMFPADRKRVEAALGACHLAKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHSKAKPYMTKEHLTKFINQKQRDPRLNSLLFPPARPEQVQVLIDKYEPSGINVQRGQLSPEGMVWFLCGPENSVLAHDTLLIHQDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDILFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKMAEYCRSMFGETLLTDPLENFPLKPGIPLPSPEDLRGKILIKNKKNQFSGPASPSKKPGGVAEGSLPSSVPVEEDTGWTAEDRTEVEEEEVVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFISFEFSAQKNRSYVVSSFTELKAYELLSKASMQFVDYNKRQMSRVYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMGKNTSKTREPSPGPLTTSPEPSPGPCIPRCPPSEPSSGPCLSDPYSSLDKEL", "length": 633, "header": "sp|A3KGF7-4|PLCB2_MOUSE Isoform 4 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 OS=Mus musculus OX=10090 GN=Plcb2 PE=1 SV=1 CANONICAL=A3KGF7-1" }, "locus": {} }, { "isoform_ac": "E9PYI3-1", "url": "https://www.uniprot.org/uniprot/A3KGF7#E9PYI3-1", "sequence": { "sequence": "MSLLNPVLLPPNVKAYLSQGERFIKWDDETSIASPVILRVDPKGYYLYWTYQNQSQKLREVFNMDFPDNHFLLKTLTVVSGPDMVDLTFYNFVSYKENVGKDWAEDVLALAKHPMTVNAPRSTFLDKILVKLKMQLNPEGKIPVKNFFQMFPADRKRVEAALGACHLAKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHSKAKPYMTKEHLTKFINQKQRDPRLNSLLFPPARPEQVQVLIDKYEPSGINVQRGQLSPEGMVWFLCGPENSVLAHDTLLIHQDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDILFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKMAEYCRSMFGETLLTDPLENFPLKPGIPLPSPEDLRGKILIKNKKNQFSGPASPSKKPGGVAEGSLPSSVPVEEDTGWTAEDRTEVEEEEVVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFISFEFSAQKNRSYVVSSFTELKAYELLSKASMQFVDYNKRQMSRVYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEFMRRLDKQFNPFSVDRIDVVVATTLSITIISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKLSPTANSINPVWKEEPFIFEKILMPELASLRIAVMEEGSKFLGHRIIPINALHSGYHHLCLRSESNMALTMPALFVFLEMKDYIPDTWADLTVALANPIKYFNAQDKKSVKLKGVTGSLPEKLFSGTPVASQSNGAPVSAGNGSTAPGTKATGEEATKEVTEPQTASLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLAELQTQAAGCKLRPGKGSRKKRTLPCEETVVAPSEPHDRADPRVQELKDRLEQELQQQGEEQYRSVLKRKEQHVTEQIAKMMELAREKQAAELKTFKETSETDTKEMKKKLEAKRLERIQAMTKVTTDKVAQERLKREINNSHIQEVVQAVKQMTETLERHQEKLEERQTACLEQIQAMEKQFQEKALAEYEAKMKGLEAEVKESVRAYFKDCFPTEAEDKPERSCEASEESCPQEPLVSKADTQESRL", "length": 1158, "header": "tr|E9PYI3-1|E9PYI3_MOUSE Computationally mapped isoform of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase OS=Mus musculus OX=10090 GN=Plcb2 PE=1 SV=1 CANONICAL=A3KGF7-1" }, "locus": { "chromosome": "2", "start_pos": 118558802, "end_pos": 118539483, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000159756", "url": "https://www.ensembl.org/id/ENSMUST00000159756" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000124364", "url": "https://www.ensembl.org/id/ENSMUSP00000124364" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 950, "end_pos": 950, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A3KGF7", "url": "https://www.uniprot.org/uniprot/A3KGF7" } ] } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Mash1-expressing cells may be relevant to type III cells and a subset of PLCbeta2-positive cell differentiation in adult mouse taste buds.", "journal": "Cell and tissue research", "date": "2021", "authors": "Hsu CC, Seta Y, Matsuyama K, Kataoka S, Nakatomi M, Toyono T, Gunjigake KK, Kuroishi KN, Kawamoto T", "evidence": [ { "database": "RefSeq", "id": "NP_001277719", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277719" } ], "reference": [ { "type": "PubMed", "id": "32960355", "url": "https://glygen.org/publication/PubMed/32960355" } ] } ], "pathway": [ { "id": "mmu:18796", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:18796", "resource": "KEGG Pathway" }, { "id": "R-MMU-112043", "name": "PLC beta mediated events", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-112043", "resource": "Reactome", "description": "PLC beta mediated events" }, { "id": "R-MMU-1855204", "name": "Synthesis of IP3 and IP4 in the cytosol", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1855204", "resource": "Reactome", "description": "Synthesis of IP3 and IP4 in the cytosol" }, { "id": "R-MMU-399997", "name": "Acetylcholine regulates insulin secretion", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-399997", "resource": "Reactome", "description": "Acetylcholine regulates insulin secretion" }, { "id": "R-MMU-4086398", "name": "Ca2+ pathway", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-4086398", "resource": "Reactome", "description": "Ca2+ pathway" }, { "id": "R-MMU-416476", "name": "G alpha (q) signalling events", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-416476", "resource": "Reactome", "description": "G alpha (q) signalling events" }, { "id": "R-MMU-418217", "name": "G beta:gamma signalling through PLC beta", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-418217", "resource": "Reactome", "description": "G beta:gamma signalling through PLC beta" }, { "id": "R-MMU-434316", "name": "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-434316", "resource": "Reactome", "description": "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion" }, { "id": "R-MMU-500657", "name": "Presynaptic function of Kainate receptors", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-500657", "resource": "Reactome", "description": "Presynaptic function of Kainate receptors" } ], "orthologs": [ { "uniprot_canonical_ac": "O89040-1", "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2", "gene_name": "Plcb2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSLLNPVLLPPKVKAYLSQGERFIKWDDETSIASPVILRVDPKGYYLYWTHQSKEMEFLDVTSIRDTRFGKFAKIPKSQKLREVFNMDFPDNHFLLKTFTVVSGPDMVGLTFHNFVSYKENVGKDWAEDVLALAKHPMTANASRSTFLDKILVKLKMQLSPEGKIPVKNFFQMFPADRKRVEAALSACHLAKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQKQRDPRLNSLLFPPARPEQVQALIDKYEPSGINVQRGQLSPEGMVWFLCGPENSVLAHDTLRIHQDMTQPLNHYFINSSHNTYLTAGQFSGPSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDILFKEAVEAIAESAFKTSPYPVILSFENHVDSPRQQAKMAEYCRTMFGETLLTEPLENFPLKPGMPLPSPEDLRGKILIKNKKNQFSGPASPNKKPDGVSEGGFPSSVPVEEDTGWTAEDRTEVEEGEEEEEVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFISFEFSAQKNRSYLVSSFTELKAYELLSKASMQFVDYNKRQMSRVYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEFMRRQDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKLSPTANSINPVWKEEPFIFEKILVPELASLRIAVMEEGGKFIGHRIIPINALHSGYHHLCLRSESNMPLTMPALFVFLEMKDYVPDTWADLTVALANPIKYFSAHDKKSVKLKEVTGSLPEKLFSGIPVASQSNGAPVSAGNGSTAPGTKAKEEATKEVAEPQTTSLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLAELQDPAASCKLRPGKGSRKKRIVPCEETIVVPREVLEGPDPRVQDLKDRLEQELQQQGEEQYRSVLKRKEQHVTEQIAKMMELAREKQAAELKSFKETSETDTKEMKKKLEAKRLERIQAMTKVTTDKVAQERLKREINNSHIQEVVQAVKQMTETLERHQEKLEEKQTACLEQIQAMEKQFQEKALAEYEAKMKGLEAEVKESMRACFKACFPTEAEEKPERPCEASEESCPQEPLVNKTDTQESRL", 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"MSLLNPVLLPPKVKAYLSQGERFIKWDDETTVASPVILRVDPKGYYLYWTYQSKEMEFLDITSIRDTRFGKFAKMPKSQKLRDVFNMDFPDNSFLLKTLTVVSGPDMVDLTFHNFVSYKENVGKAWAEDVLALVKHPLTANASRSTFLDKILVKLKMQLNSEGKIPVKNFFQMFPADRKRVEAALSACHLPKGKNDAINPEDFPEPVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQKQRDSRLNSLLFPPARPDQVQGLIDKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTIFGDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNKKNQFSGPTSSSKDTGGEAEGSSPPSAPAGEGTVWAGEEGTELEEEEVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFVSFEFSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQMSRIYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKLSPSTNSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHLCLHSESNMPLTMPALFIFLEMKDYIPGAWADLTVALANPIKFFSAHDTKSVKLKEAMGGLPEKPFPLASPVASQVNGALAPTSNGSPAARAGAREEAMKEAAEPRTASLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLAELGPPGVGGVGACKLGPGKGSRKKRSLPREESAGAAPGEGPEGVDGRVRELKDRLELELLRQGEEQYECVLKRKEQHVAEQISKMMELAREKQAAELKALKETSENDTKEMKKKLETKRLERIQGMTKVTTDKMAQERLKREINNSHIQEVVQVIKQMTENLERHQEKLEEKQAACLEQIREMEKQFQKEALAEYEARMKGLEAEVKESVRACLRTCFPSEAKDKPERACECPPELCEQDPLIAKADAQESRL", "length": 1185 }, "evidence": [ { "id": "20957", "url": "http://www.informatics.jax.org/homology/20957", "database": "MGI" }, { "id": "A3KGF7", "url": "https://omabrowser.org/oma/group/A3KGF7/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "G-protein beta/gamma-subunit complex", "id": "GO:0031680", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031680", "evidence": [ { "database": "UniProtKB", "id": "A3KGF7", "url": "https://www.uniprot.org/uniprot/A3KGF7" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A3KGF7", "url": "https://www.uniprot.org/uniprot/A3KGF7" } ], "pmid": "21606356" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A3KGF7", "url": "https://www.uniprot.org/uniprot/A3KGF7" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A3KGF7", "url": "https://www.uniprot.org/uniprot/A3KGF7" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A3KGF7", "url": "https://www.uniprot.org/uniprot/A3KGF7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "phosphatidylinositol phospholipase C activity", "id": "GO:0004435", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004435", "evidence": [ { "database": "UniProtKB", "id": "A3KGF7", "url": "https://www.uniprot.org/uniprot/A3KGF7" } ], "pmid": "" }, { "name": "phospholipid binding", "id": "GO:0005543", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005543", "evidence": [ { "database": "UniProtKB", "id": "A3KGF7", "url": "https://www.uniprot.org/uniprot/A3KGF7" } ], "pmid": "" }, { "name": "phospholipase C activity", "id": "GO:0004629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004629", "evidence": [ { "database": "UniProtKB", "id": "A3KGF7", "url": "https://www.uniprot.org/uniprot/A3KGF7" } ], "pmid": "" }, { "name": "G-protein beta/gamma-subunit complex binding", "id": "GO:0031683", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031683", "evidence": [ { "database": "UniProtKB", "id": "A3KGF7", "url": "https://www.uniprot.org/uniprot/A3KGF7" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A3KGF7", "url": "https://www.uniprot.org/uniprot/A3KGF7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "lipid catabolic process", "id": "GO:0016042", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016042", "evidence": [ { "database": "UniProtKB", "id": "A3KGF7", "url": "https://www.uniprot.org/uniprot/A3KGF7" } ], "pmid": "" }, { "name": "phospholipase C-activating G protein-coupled receptor signaling pathway", "id": "GO:0007200", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007200", "evidence": [ { "database": "UniProtKB", "id": "A3KGF7", "url": "https://www.uniprot.org/uniprot/A3KGF7" } ], "pmid": "" }, { "name": "phosphatidylinositol-mediated signaling", "id": "GO:0048015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048015", "evidence": [ { "database": "UniProtKB", "id": "A3KGF7", "url": "https://www.uniprot.org/uniprot/A3KGF7" } ], "pmid": "21873635" }, { "name": "phosphatidylinositol metabolic process", "id": "GO:0046488", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046488", "evidence": [ { "database": "UniProtKB", "id": "A3KGF7", "url": "https://www.uniprot.org/uniprot/A3KGF7" } ], "pmid": "" }, { "name": "detection of chemical stimulus involved in sensory perception of bitter taste", "id": "GO:0001580", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001580", "evidence": [ { "database": "UniProtKB", "id": "A3KGF7", "url": "https://www.uniprot.org/uniprot/A3KGF7" } ], "pmid": "" }, { "name": "sensory perception of bitter taste", "id": "GO:0050913", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050913", "evidence": [ { "database": "UniProtKB", "id": "A3KGF7", "url": "https://www.uniprot.org/uniprot/A3KGF7" } ], "pmid": "15759003" }, { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "A3KGF7", "url": "https://www.uniprot.org/uniprot/A3KGF7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1072, "end_pos": 1074, "annotation": "n_glycosylation_sequon" }, { "start_pos": 324, "end_pos": 326, "annotation": "n_glycosylation_sequon" }, { "start_pos": 569, "end_pos": 571, "annotation": "n_glycosylation_sequon" }, { "start_pos": 864, "end_pos": 866, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "33179", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P10687-1", "A0A096MJW8-1", "D4AAX6-1", "P24135-1", "O89040-1", "Q62688-1", "Q9QW07-1", "Q62711-1", "D4A978-1", "F1M324-1", "Q99JE6-1", "P10686-1", "P10688-1", "Q99P84-1", "Q5FX52-1", "Q8WTR4-1", "Q8N3E9-1", "O75038-1", "P19174-1", "Q86YW0-1", "Q9NQ66-1", "P16885-1", "Q9UPR0-1", "Q9BRC7-1", "Q15111-1", "Q4KWH8-1", "Q9P212-1", "Q01970-1", "P51178-1", "Q15147-1", "Q00722-1", "Q91UZ1-1", "Q8K2J0-1", "P51432-1", "Q8K4D7-1", "Q4KWH5-1", "A2AP18-1", "Q62077-1", "Q640M6-1", "Q8K4S1-1", "A3KGF7-1", "Q8R3B1-1", "Q9Z1B3-1", "Q8K3R3-1", "Q8CIH5-1", "P13217-1", "P25455-3", "Q9VXH3-1" ], "evidence": [ { "id": "33179", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/33179" } ] }, { "id": "43484", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P10687-1", "Q99JE6-1", "Q9QW07-1", "Q62711-1", "O89040-1", "P10688-1", "P10686-1", "Q9BRC7-1", "Q9NQ66-1", "P19174-1", "P51178-1", "Q15147-1", "Q01970-1", "Q00722-1", "P51432-1", "Q91UZ1-1", "Q9Z1B3-1", "Q62077-1", "A3KGF7-1", "Q8K3R3-1", "Q8R3B1-1" ], "evidence": [ { "id": "43484", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/43484" } ] }, { "id": "R-MMU-111879", "name": "PIP2 hydrolysis", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9Z1B3-1", "A3KGF7-1", "P51432-1", "Q91UZ1-1" ], "evidence": [ { "id": "R-MMU-111879", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-111879" } ] }, { "id": "R-MMU-112037", "name": "Inactivation of PLC beta", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9Z1B3-1", "A3KGF7-1", "P51432-1", "Q91UZ1-1" ], "evidence": [ { "id": "R-MMU-112037", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-112037" } ] }, { "id": "R-MMU-114688", "name": "PLC-beta hydrolyses PIP2 to DAG and IP3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9Z1B3-1", "A3KGF7-1", "P51432-1", "Q91UZ1-1" ], "evidence": [ { "id": "R-MMU-114688", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-114688" } ] }, { "id": "R-MMU-1855177", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9Z1B3-1", "A3KGF7-1", "Q8K4D7-1", "P51432-1", "Q91UZ1-1" ], "evidence": [ { "id": "R-MMU-1855177", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1855177" } ] }, { "id": "R-MMU-398040", "name": "Gbeta:gamma activation of PLC beta", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9Z1B3-1", "A3KGF7-1", "P51432-1" ], "evidence": [ { "id": "R-MMU-398040", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-398040" } ] }, { "id": "R-MMU-398193", "name": "PLC beta-mediated PIP2 hydrolysis", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9Z1B3-1", "A3KGF7-1", "P51432-1" ], "evidence": [ { "id": "R-MMU-398193", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-398193" } ] }, { "id": "R-MMU-399998", "name": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9Z1B3-1", "A3KGF7-1", "P51432-1" ], "evidence": [ { "id": "R-MMU-399998", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-399998" } ] }, { "id": "R-MMU-500717", "name": "Activation of GRIK3 homomer", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9Z1B3-1", "A3KGF7-1", "P51432-1" ], "evidence": [ { "id": "R-MMU-500717", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-500717" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A096MJW8", "gene_name": "Plch1", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "A0A096MJW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A096MJW8" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "A0A096MJW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A096MJW8" } ] } ] }, { "uniprot_ac": "A2AP18", "gene_name": "Plch2", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "A2AP18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AP18" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "A2AP18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AP18" } ] } ] }, { "uniprot_ac": "A3KGF7", "gene_name": "Plcb2", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "A3KGF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A3KGF7" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "A3KGF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A3KGF7" } ] } ] }, { "uniprot_ac": "D4A978", "gene_name": "Plcd3", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "D4A978", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A978" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "D4A978", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A978" } ] } ] }, { "uniprot_ac": "D4AAX6", "gene_name": "Plch2", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "D4AAX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4AAX6" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "D4AAX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4AAX6" } ] } ] }, { "uniprot_ac": "F1M324", "gene_name": "Plcl2", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "F1M324", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M324" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "F1M324", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M324" } ] } ] }, { "uniprot_ac": "O75038", "gene_name": "PLCH2", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "O75038", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75038" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "O75038", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75038" } ] } ] }, { "uniprot_ac": "O89040", "gene_name": "Plcb2", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "O89040", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O89040" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "O89040", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O89040" } ] } ] }, { "uniprot_ac": "P10686", "gene_name": "Plcg1", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "P10686", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10686" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P10686", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10686" } ] } ] }, { "uniprot_ac": "P10687", "gene_name": "Plcb1", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "P10687", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10687" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P10687", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10687" } ] } ] }, { "uniprot_ac": "P10688", "gene_name": "Plcd1", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "P10688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10688" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P10688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10688" } ] } ] }, { "uniprot_ac": "P13217", "gene_name": "norpA", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "P13217", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13217" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P13217", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13217" } ] } ] }, { "uniprot_ac": "P16885", "gene_name": "PLCG2", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "P16885", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16885" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P16885", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16885" } ] } ] }, { "uniprot_ac": "P19174", "gene_name": "PLCG1", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "P19174", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19174" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P19174", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19174" } ] } ] }, { "uniprot_ac": "P24135", "gene_name": "Plcg2", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "P24135", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24135" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P24135", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24135" } ] } ] }, { "uniprot_ac": "P25455", "gene_name": "Plc21C", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "P25455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25455" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P25455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25455" } ] } ] }, { "uniprot_ac": "P51178", "gene_name": "PLCD1", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "P51178", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51178" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P51178", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51178" } ] } ] }, { "uniprot_ac": "P51432", "gene_name": "Plcb3", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "P51432", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51432" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P51432", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51432" } ] } ] }, { "uniprot_ac": "Q00722", "gene_name": "PLCB2", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "Q00722", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00722" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "Q00722", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00722" } ] } ] }, { "uniprot_ac": "Q01970", "gene_name": "PLCB3", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "Q01970", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01970" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "Q01970", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01970" } ] } ] }, { "uniprot_ac": "Q15111", "gene_name": "PLCL1", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "Q15111", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15111" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "Q15111", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15111" } ] } ] }, { "uniprot_ac": "Q15147", "gene_name": "PLCB4", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "Q15147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15147" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "Q15147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15147" } ] } ] }, { "uniprot_ac": "Q4KWH5", "gene_name": "Plch1", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "Q4KWH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KWH5" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "Q4KWH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KWH5" } ] } ] }, { "uniprot_ac": "Q4KWH8", "gene_name": "PLCH1", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "Q4KWH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KWH8" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "Q4KWH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KWH8" } ] } ] }, { "uniprot_ac": "Q5FX52", "gene_name": "Plcz1", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "Q5FX52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5FX52" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "Q5FX52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5FX52" } ] } ] }, { "uniprot_ac": "Q62077", "gene_name": "Plcg1", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "Q62077", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62077" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "Q62077", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62077" } ] } ] }, { "uniprot_ac": "Q62688", "gene_name": "Plcl1", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "Q62688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62688" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "Q62688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62688" } ] } ] }, { "uniprot_ac": "Q62711", "gene_name": "Plcd4", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "Q62711", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62711" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "Q62711", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62711" } ] } ] }, { "uniprot_ac": "Q640M6", "gene_name": "Gdpd5", "activity": [ { "ec_number": "3.1.4.2", "activity": "sn-glycero-3-phosphocholine + H(2)O = choline + sn-glycerol 3-phosphate.", "evidence": [ { "id": "Q640M6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q640M6" } ] }, { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "Q640M6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q640M6" } ] } ] }, { "uniprot_ac": "Q86YW0", "gene_name": "PLCZ1", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "Q86YW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86YW0" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "Q86YW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86YW0" } ] } ] }, { "uniprot_ac": "Q8CIH5", "gene_name": "Plcg2", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "Q8CIH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CIH5" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "Q8CIH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CIH5" } ] } ] }, { "uniprot_ac": "Q8K2J0", "gene_name": "Plcd3", "activity": [ { 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