{ "uniprot_canonical_ac": "A3KFX0-1", "uniprot_ac": "A3KFX0", "uniprot_id": "5NT1A_MOUSE", "mass": { "chemical_mass": 40678.0, "monoisotopic_mass": 40678.0 }, "refseq": { "ac": "NP_001078971", "name": "cytosolic 5'-nucleotidase 1A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078971" }, "gene_names": [ { "name": "Nt5c1a", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A3KFX0", "id": "A3KFX0" }, { "name": "Cn1a; Gm49", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078971", "id": "NP_001078971" }, { "name": "Nt5c1a", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078971", "id": "NP_001078971" } ], "protein_names": [ { "name": "Cytosolic 5'-nucleotidase 1A", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A3KFX0#names_and_taxonomy", "id": "A3KFX0" }, { "name": "3.1.3.5", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A3KFX0#names_and_taxonomy", "id": "A3KFX0" }, { "name": "Cytosolic 5'-nucleotidase IA", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A3KFX0#names_and_taxonomy", "id": "A3KFX0" }, { "name": "cN-IA", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A3KFX0#names_and_taxonomy", "id": "A3KFX0" }, { "name": "cN1A", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A3KFX0#names_and_taxonomy", "id": "A3KFX0" }, { "name": "cytosolic 5' nucleotidase, type 1A; cN-IA; cytosolic 5'-nucleotidase IA", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078971", "id": "NP_001078971" }, { "name": "cytosolic 5'-nucleotidase 1A", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078971", "id": "NP_001078971" } ], "function": [ { "annotation": "Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "A3KFX0", "url": "https://www.uniprot.org/uniprot/A3KFX0#function" } ] }, { "annotation": "NT5C1A suppression promotes AMP-activated protein kinase (AMPK) phosphorylation and metabolism in human and mouse skeletal muscle", "evidence": [ { "database": "RefSeq", "id": "NP_001078971", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078971" }, { "database": "PubMed", "id": "21873433", "url": "https://glygen.org/publication/PubMed/21873433" } ] }, { "annotation": "The results on muscles from the NT5C knockout mice contradict previous findings where AMP levels and AMPK activity were shown to be modulated by NT5C enzymes.", "evidence": [ { "database": "RefSeq", "id": "NP_001078971", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078971" }, { "database": "PubMed", "id": "28325731", "url": "https://glygen.org/publication/PubMed/28325731" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A3KFX0", "url": "https://www.uniprot.org/uniprot/A3KFX0" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Nt5c1a", "url": "https://www.uniprot.org/uniprot/A3KFX0", "locus": { "chromosome": "4", "start_pos": 123201504, "end_pos": 123216275, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000054958", "url": "https://www.ensembl.org/id/ENSMUSG00000054958" } ] } } ], "crossref": [ { "id": "ENSMUSG00000054958", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000054958", "database": "Bgee" }, { "id": "230718", "url": "https://www.ncbi.nlm.nih.gov/gene/230718", "database": "GeneID" }, { "id": "IPR010394", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010394", "database": "InterPro" }, { "id": "mmu:230718", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:230718", "database": "KEGG Pathway" }, { "id": "2155700", "url": "http://www.informatics.jax.org/marker/MGI:2155700", "database": "MGI" }, { "id": "IRTLMAW", "url": "https://omabrowser.org/oma/group/IRTLMAW/", "database": "OMA" }, { "id": "694318at2759", "url": "http://www.orthodb.org/?query=694318at2759", "database": "OrthoDB" }, { "id": "PTHR31367", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31367", "database": "PANTHER" }, { "id": "PF06189", "url": "http://pfam.xfam.org/family/PF06189", "database": "Pfam" }, { "id": "PR_A3KFX0", "url": "http://purl.obolibrary.org/obo/PR_A3KFX0", "database": "PRO" }, { "id": "R-MMU-73621", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-73621", "database": "Reactome" }, { "id": "R-MMU-74259", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-74259", "database": "Reactome" }, { "id": "NP_001078971", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078971", "database": "RefSeq" }, { "id": "12484", "url": "https://www.rhea-db.org/rhea/12484", "database": "Rhea" }, { "id": "A3KFX0", "url": "https://www.uniprot.org/uniprot/A3KFX0", "database": "UniProtKB" }, { "id": "A3KFX0-1", "url": "https://www.uniprot.org/uniprot/A3KFX0-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MEPGQPREAREPGPGAETAAVPRWEEAKTFYDNLSSKKKPKSPKPQNAVTIAVSSRALFRMDEEQRIYTEQGVEEYVRYQLEHENEPFSPGPAFPFVKALEAVNKRLRELYPDSEDIFDIVLMTNNHAQVGVRLINSINHYDLFIERFCMTGGNSPICYLKAYHTNLYLSADADKVREAIDEGIAAATIFSPSRDVVVSQSQLRVAFDGDAVLFSDESERIVKAHGLDRFFEHEKAHENKPLAQGPLKGFLEALGRLQKKFYSKGLRLECPIRTYLVTARSAASSGARALKTLRSWGLETDEALFLAGAPKGPLLEKIRPHIFFDDQMFHVAGAQEMGTVAAHVPYGVAQNPRRAAAAKQSLGAQ", "length": 365, "header": "sp|A3KFX0-1|5NT1A_MOUSE Isoform 1 of Cytosolic 5'-nucleotidase 1A OS=Mus musculus OX=10090 GN=Nt5c1a PE=1 SV=1 CANONICAL=A3KFX0-1" }, "isoforms": [ { "isoform_ac": "A3KFX0-1", "url": "https://www.uniprot.org/uniprot/A3KFX0#A3KFX0-1", "sequence": { "sequence": "MEPGQPREAREPGPGAETAAVPRWEEAKTFYDNLSSKKKPKSPKPQNAVTIAVSSRALFRMDEEQRIYTEQGVEEYVRYQLEHENEPFSPGPAFPFVKALEAVNKRLRELYPDSEDIFDIVLMTNNHAQVGVRLINSINHYDLFIERFCMTGGNSPICYLKAYHTNLYLSADADKVREAIDEGIAAATIFSPSRDVVVSQSQLRVAFDGDAVLFSDESERIVKAHGLDRFFEHEKAHENKPLAQGPLKGFLEALGRLQKKFYSKGLRLECPIRTYLVTARSAASSGARALKTLRSWGLETDEALFLAGAPKGPLLEKIRPHIFFDDQMFHVAGAQEMGTVAAHVPYGVAQNPRRAAAAKQSLGAQ", "length": 365, "header": "sp|A3KFX0-1|5NT1A_MOUSE Isoform 1 of Cytosolic 5'-nucleotidase 1A OS=Mus musculus OX=10090 GN=Nt5c1a PE=1 SV=1 CANONICAL=A3KFX0-1" }, "locus": { "chromosome": "4", "start_pos": 123109997, "end_pos": 123095351, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000068262", "url": "https://www.ensembl.org/id/ENSMUST00000068262" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000069422", "url": "https://www.ensembl.org/id/ENSMUSP00000069422" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Suppression of 5'-nucleotidase enzymes promotes AMP-activated protein kinase (AMPK) phosphorylation and metabolism in human and mouse skeletal muscle.", "journal": "The Journal of biological chemistry", "date": "2011", "authors": "Kulkarni SS, Karlsson HK, Szekeres F, Chibalin AV, Krook A, Zierath JR", "evidence": [ { "database": "RefSeq", "id": "NP_001078971", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078971" } ], "reference": [ { "type": "PubMed", "id": "21873433", "url": "https://glygen.org/publication/PubMed/21873433" } ] }, { "title": "Effects of genetic deletion of soluble 5'-nucleotidases NT5C1A and NT5C2 on AMPK activation and nucleotide levels in contracting mouse skeletal muscles.", "journal": "American journal of physiology. Endocrinology and metabolism", "date": "2017", "authors": "Kviklyte S, Vertommen D, Yerna X, Andersen H, Xu X, Gailly P, Bohlooly-Y M, Oscarsson J, Rider MH", "evidence": [ { "database": "RefSeq", "id": "NP_001078971", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078971" } ], "reference": [ { "type": "PubMed", "id": "28325731", "url": "https://glygen.org/publication/PubMed/28325731" } ] } ], "pathway": [ { "id": "mmu:230718", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:230718", "resource": "KEGG Pathway" }, { "id": "R-MMU-73621", "name": "Pyrimidine catabolism", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-73621", "resource": "Reactome", "description": "Pyrimidine catabolism" }, { "id": "R-MMU-74259", "name": "Purine catabolism", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-74259", "resource": "Reactome", "description": "Purine catabolism" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZVD3-1", "protein_name": "5'-nucleotidase, cytosolic IA (Predicted)", "gene_name": "Nt5c1a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEPRQPPEAREPGPGAETAAVPRWEEAKTFYDNLSPKKKPKSPKPQNAVTIAVSSRALFRMDEEQRIYTEQGVEEYVRYQLEHENEPFSPGPAFPFVKALEAVNKQLRELYPDSEDIFDIVLMTNNHAQVGVRLINSINHYDLFIERFCMTGGNSPICYLKAYHTNLYLSADAEKVREAIDEGIAAATIFSPSKDVVVSQSQLRVAFDGDAVLFSDESERIVKAHGLDRFFEHEKAHENKPLAQGPLKGFLEALGRLQKKFYSKGLRLECPIRTYLVTARSAASSGARALKTLRSWGLETDEALFLAGAPKGPLLEKIRPHIFFDDQMFHVAGAQEMGTVAAHVPYGVAQNPRREKQSLGAQ", "length": 362 }, "evidence": [ { "id": "57173", "url": "http://www.informatics.jax.org/homology/57173", "database": "MGI" }, { "id": "A3KFX0", "url": "https://omabrowser.org/oma/group/A3KFX0/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9BXI3-1", "protein_name": "Cytosolic 5'-nucleotidase 1A", "gene_name": "NT5C1A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEPGQPREPQEPREPGPGAETAAAPVWEEAKIFYDNLAPKKKPKSPKPQNAVTIAVSSRALFRMDEEQQIYTEQGVEEYVRYQLEHENEPFSPGPAFPFVKALEAVNRRLRELYPDSEDVFDIVLMTNNHAQVGVRLINSINHYDLFIERFCMTGGNSPICYLKAYHTNLYLSADAEKVREAIDEGIAAATIFSPSRDVVVSQSQLRVAFDGDAVLFSDESERIVKAHGLDRFFEHEKAHENKPLAQGPLKGFLEALGRLQKKFYSKGLRLECPIRTYLVTARSAASSGARALKTLRSWGLETDEALFLAGAPKGPLLEKIRPHIFFDDQMFHVAGAQEMGTVAAHVPYGVAQTPRRTAPAKQAPSAQ", "length": 368 }, "evidence": [ { "id": "57173", "url": "http://www.informatics.jax.org/homology/57173", "database": "MGI" }, { "id": "A3KFX0", "url": "https://omabrowser.org/oma/group/A3KFX0/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "allantoin biosynthetic process", "id": "GO:0019428", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019428", "evidence": [ { "database": "UniProtKB", "id": "A3KFX0", "url": "https://www.uniprot.org/uniprot/A3KFX0" } ], "pmid": "" }, { "name": "adenosine metabolic process", "id": "GO:0046085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046085", "evidence": [ { "database": "UniProtKB", "id": "A3KFX0", "url": "https://www.uniprot.org/uniprot/A3KFX0" } ], "pmid": "" }, { "name": "AMP catabolic process", "id": "GO:0006196", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006196", "evidence": [ { "database": "UniProtKB", "id": "A3KFX0", "url": "https://www.uniprot.org/uniprot/A3KFX0" } ], "pmid": "11133996" }, { "name": "purine nucleoside monophosphate catabolic process", "id": "GO:0009128", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009128", "evidence": [ { "database": "UniProtKB", "id": "A3KFX0", "url": "https://www.uniprot.org/uniprot/A3KFX0" } ], "pmid": "21873433" }, { "name": "allantoin metabolic process", "id": "GO:0000255", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000255", "evidence": [ { "database": "UniProtKB", "id": "A3KFX0", "url": "https://www.uniprot.org/uniprot/A3KFX0" } ], "pmid": "11133996" }, { "name": "dAMP catabolic process", "id": "GO:0046059", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046059", "evidence": [ { "database": "UniProtKB", "id": "A3KFX0", "url": "https://www.uniprot.org/uniprot/A3KFX0" } ], "pmid": "11133996" }, { "name": "IMP catabolic process", "id": "GO:0006204", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006204", "evidence": [ { "database": "UniProtKB", "id": "A3KFX0", "url": "https://www.uniprot.org/uniprot/A3KFX0" } ], "pmid": "11133996" }, { "name": "dGMP catabolic process", "id": "GO:0046055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046055", "evidence": [ { "database": "UniProtKB", "id": "A3KFX0", "url": "https://www.uniprot.org/uniprot/A3KFX0" } ], "pmid": "11133996" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "A3KFX0", "url": "https://www.uniprot.org/uniprot/A3KFX0" } ], "pmid": "" }, { "name": "nucleotide binding", "id": "GO:0000166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000166", "evidence": [ { "database": "UniProtKB", "id": "A3KFX0", "url": "https://www.uniprot.org/uniprot/A3KFX0" } ], "pmid": "" }, { "name": "5'-nucleotidase activity", "id": "GO:0008253", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008253", "evidence": [ { "database": "UniProtKB", "id": "A3KFX0", "url": "https://www.uniprot.org/uniprot/A3KFX0" } ], "pmid": "11133996" }, { "name": "IMP 5'-nucleotidase activity", "id": "GO:0050483", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050483", "evidence": [ { "database": "UniProtKB", "id": "A3KFX0", "url": "https://www.uniprot.org/uniprot/A3KFX0" } ], "pmid": "11133996" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A3KFX0", "url": "https://www.uniprot.org/uniprot/A3KFX0" } ], "pmid": "11133996" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 33, "end_pos": 35, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "12484", "name": "", "equation": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6AYP7-1", "P21588-1", "P20646-1", "B2GUX5-1", "P21589-1", "Q969T7-1", "Q96P26-1", "Q9BXI3-1", "Q9H0P0-4", "P49902-1", "P15309-1", "Q3UFY7-1", "Q9JM14-1", "A3KFX0-1", "Q61503-1", "Q91YE9-1", "Q3V1L4-1", "Q9D020-3", "Q8CE08-1", "Q9W197-1" ], "evidence": [ { "id": "12484", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/12484" } ] }, { "id": "R-MMU-109380", "name": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A3KFX0-1" ], "evidence": [ { "id": "R-MMU-109380", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-109380" } ] }, { "id": "R-MMU-109387", "name": "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A3KFX0-1" ], "evidence": [ { "id": "R-MMU-109387", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-109387" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A3KFX0", "gene_name": "Nt5c1a", "activity": [ { "ec_number": "3.1.3.5", "activity": "A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.", "evidence": [ { "id": "A3KFX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A3KFX0" } ] }, { "ec_number": "3.1.3.5", "activity": "", "evidence": [ { "id": "A3KFX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A3KFX0" } ] } ] }, { "uniprot_ac": "B2GUX5", "gene_name": "Nt5c3a", "activity": [ { "ec_number": "3.1.3.5", "activity": "A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.", "evidence": [ { "id": "B2GUX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2GUX5" } ] }, { "ec_number": "3.1.3.5", "activity": "", "evidence": [ { "id": "B2GUX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2GUX5" } ] } ] }, { "uniprot_ac": "P15309", "gene_name": "ACP3", "activity": [ { "ec_number": "3.1.3.5", "activity": "A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.", "evidence": [ { "id": "P15309", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15309" } ] }, { "ec_number": "3.1.3.2", "activity": "A phosphate monoester + H(2)O = an alcohol + phosphate.", "evidence": [ { "id": "P15309", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15309" } ] }, { "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.", "evidence": [ { "id": "P15309", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15309" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "P15309", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15309" } ] } ] }, { "uniprot_ac": "P20646", "gene_name": "Acp3", "activity": [ { "ec_number": "3.1.3.5", "activity": "A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.", "evidence": [ { "id": "P20646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20646" } ] }, { "ec_number": "3.1.3.2", "activity": "A phosphate monoester + H(2)O = an alcohol + phosphate.", "evidence": [ { "id": "P20646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20646" } ] }, { "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.", "evidence": [ { "id": "P20646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20646" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "P20646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20646" } ] } ] }, { "uniprot_ac": 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