{ "uniprot_canonical_ac": "A2VDH3-1", "uniprot_ac": "A2VDH3", "uniprot_id": "LRC38_MOUSE", "mass": { "chemical_mass": 32343.0, "monoisotopic_mass": 32343.0 }, "refseq": { "ac": "NP_001156455", "name": "leucine-rich repeat-containing protein 38 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156455" }, "gene_names": [ { "name": "Lrrc38", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2VDH3", "id": "A2VDH3" }, { "name": "A230053A07Rik", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156455", "id": "NP_001156455" }, { "name": "Lrrc38", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156455", "id": "NP_001156455" } ], "protein_names": [ { "name": "Leucine-rich repeat-containing protein 38", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2VDH3#names_and_taxonomy", "id": "A2VDH3" }, { "name": "BK channel auxiliary gamma subunit LRRC38", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2VDH3#names_and_taxonomy", "id": "A2VDH3" }, { "name": "leucine-rich repeat-containing protein 38 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156455", "id": "NP_001156455" }, { "name": "leucine-rich repeat-containing protein 38; BK channel auxilliary gamma subunit LRRC38; BK channel auxiliary gamma subunit LRRC38", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156455", "id": "NP_001156455" } ], "function": [ { "annotation": "Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "A2VDH3", "url": "https://www.uniprot.org/uniprot/A2VDH3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A2VDH3", "url": "https://www.uniprot.org/uniprot/A2VDH3" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Lrrc38", "url": "https://www.uniprot.org/uniprot/A2VDH3", "locus": { "chromosome": "4", "start_pos": 143349757, "end_pos": 143371032, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000028584", "url": "https://www.ensembl.org/id/ENSMUSG00000028584" } ] } } ], "crossref": [ { "id": "ENSMUSG00000028584", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000028584", "database": "Bgee" }, { "id": "242735", "url": "https://www.ncbi.nlm.nih.gov/gene/242735", "database": "GeneID" }, { "id": "IPR000372", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000372", "database": "InterPro" }, { "id": "IPR000483", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000483", "database": "InterPro" }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro" }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro" }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro" }, { "id": "mmu:242735", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:242735", "database": "KEGG Pathway" }, { "id": "2442845", "url": "http://www.informatics.jax.org/marker/MGI:2442845", "database": "MGI" }, { "id": "HCFQRCA", "url": "https://omabrowser.org/oma/group/HCFQRCA/", "database": "OMA" }, { "id": "826997at2759", "url": "http://www.orthodb.org/?query=826997at2759", "database": "OrthoDB" }, { "id": "PF13855", "url": "http://pfam.xfam.org/family/PF13855", "database": "Pfam" }, { "id": "PR_A2VDH3", "url": "http://purl.obolibrary.org/obo/PR_A2VDH3", "database": "PRO" }, { "id": "NP_001156455", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156455", "database": "RefSeq" }, { "id": "A2VDH3", "url": "https://www.uniprot.org/uniprot/A2VDH3", "database": "UniProtKB" }, { "id": "A2VDH3-1", "url": "https://www.uniprot.org/uniprot/A2VDH3-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MSLCVAPRHPTGAAAALGLGSLLVLLGPGRACPAGCACTDPHTVDCRDRGLPSVPDPFPLDVRKLLVAGNRIQQIPEDFFIFHGDLVYLDFRNNSLRSLEEGTFSGSGKLAFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNHLAGVHEAAFESLESLQVLELNDNNLRSLNVAALDALPALRTVRLDGNPWLCDCDFAHLFSWIQENTSKLPKGLDAIQCSLPMEDRRVALRELSEASFSECKFSLSLTDLFIIIFSGVAVSIAAIISSFFLATVVQCFQRCAPNKDTEDEDDDEDD", "length": 298, "header": "sp|A2VDH3-1|LRC38_MOUSE Isoform 1 of Leucine-rich repeat-containing protein 38 OS=Mus musculus OX=10090 GN=Lrrc38 PE=2 SV=2 CANONICAL=A2VDH3-1" }, "isoforms": [ { "isoform_ac": "A2VDH3-1", "url": "https://www.uniprot.org/uniprot/A2VDH3#A2VDH3-1", "sequence": { "sequence": "MSLCVAPRHPTGAAAALGLGSLLVLLGPGRACPAGCACTDPHTVDCRDRGLPSVPDPFPLDVRKLLVAGNRIQQIPEDFFIFHGDLVYLDFRNNSLRSLEEGTFSGSGKLAFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNHLAGVHEAAFESLESLQVLELNDNNLRSLNVAALDALPALRTVRLDGNPWLCDCDFAHLFSWIQENTSKLPKGLDAIQCSLPMEDRRVALRELSEASFSECKFSLSLTDLFIIIFSGVAVSIAAIISSFFLATVVQCFQRCAPNKDTEDEDDDEDD", "length": 298, "header": "sp|A2VDH3-1|LRC38_MOUSE Isoform 1 of Leucine-rich repeat-containing protein 38 OS=Mus musculus OX=10090 GN=Lrrc38 PE=2 SV=2 CANONICAL=A2VDH3-1" }, "locus": { "chromosome": "4", "start_pos": 143096584, "end_pos": 143076739, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000052458", "url": "https://www.ensembl.org/id/ENSMUST00000052458" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000053597", "url": "https://www.ensembl.org/id/ENSMUSP00000053597" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 119, "start_aa": "Asn", "end_pos": 119, "end_aa": "Asn", "residue": "Asn", "evidence": [ { "id": "A2VDH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2VDH3#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "mmu:242735", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:242735", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZYA6-1", "protein_name": "Leucine rich repeat containing 38 (Predicted)", "gene_name": "Lrrc38", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSLYAVPRRPTGAFAALGLGSLLVLLGPGRACPTGCACTDPHTVDCRDRGLPSVPDPFPLDVRKLLVAGNRIQQIPEDFFIFHGDLVYLDFRNNSLRSLEEGTFSGSAKLAFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLAGVHEAAFESLESLQVLELNGNNLRSLNVAALDALPALRTVRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDAIQCSLPMEERRVALRELSEASFSECKFSLSLTDLFIIIFSGVAVSVAAIISSFFLATVVQCFQRCAPNKDTEDEDDDEDD", "length": 298 }, "evidence": [ { "id": "A2VDH3", "url": "https://omabrowser.org/oma/group/A2VDH3/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5VT99-1", "protein_name": "Leucine-rich repeat-containing protein 38", "gene_name": "LRRC38", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRPRAPACAAAALGLCSLLLLLAPGHACPAGCACTDPHTVDCRDRGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLPMESRRISLRELSEASFSECRFSLSLTDLCIIIFSGVAVSIAAIISSFFLATVVQCLQRCAPNKDAEDEDEDKDD", "length": 294 }, "evidence": [ { "id": "77949", "url": "http://www.informatics.jax.org/homology/77949", "database": "MGI" }, { "id": "A2VDH3", "url": "https://omabrowser.org/oma/group/A2VDH3/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "transmembrane transporter binding", "id": "GO:0044325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044325", "evidence": [ { "database": "UniProtKB", "id": "A2VDH3", "url": "https://www.uniprot.org/uniprot/A2VDH3" } ], "pmid": "" }, { "name": "voltage-gated potassium channel activity", "id": "GO:0005249", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005249", "evidence": [ { "database": "UniProtKB", "id": "A2VDH3", "url": "https://www.uniprot.org/uniprot/A2VDH3" } ], "pmid": "21873635" }, { "name": "potassium channel activator activity", "id": "GO:0099104", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099104", "evidence": [ { "database": "UniProtKB", "id": "A2VDH3", "url": "https://www.uniprot.org/uniprot/A2VDH3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "voltage-gated potassium channel complex", "id": "GO:0008076", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008076", "evidence": [ { "database": "UniProtKB", "id": "A2VDH3", "url": "https://www.uniprot.org/uniprot/A2VDH3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "positive regulation of voltage-gated potassium channel activity", "id": "GO:1903818", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903818", "evidence": [ { "database": "UniProtKB", "id": "A2VDH3", "url": "https://www.uniprot.org/uniprot/A2VDH3" } ], "pmid": "" }, { "name": "potassium ion transmembrane transport", "id": "GO:0071805", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071805", "evidence": [ { "database": "UniProtKB", "id": "A2VDH3", "url": "https://www.uniprot.org/uniprot/A2VDH3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 119, "end_pos": 121, "annotation": "n_glycosylation_sequon" }, { "start_pos": 208, "end_pos": 210, "annotation": "n_glycosylation_sequon" }, { "start_pos": 93, "end_pos": 95, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "synthesized_glycans": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ] }