{ "uniprot_canonical_ac": "A2VD11-1", "uniprot_ac": "A2VD11", "uniprot_id": "A2VD11_RAT", "mass": { "chemical_mass": 36082.0, "monoisotopic_mass": 36082.0 }, "refseq": { "ac": "NP_001103143", "name": "splicing factor YJU2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103143" }, "gene_names": [ { "name": "Yju2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2VD11", "id": "A2VD11" }, { "name": "Ccdc94", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103143", "id": "NP_001103143" }, { "name": "Ccdc94", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2VD11", "id": "A2VD11" }, { "name": "YJU2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2VD11", "id": "A2VD11" }, { "name": "Yju2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103143", "id": "NP_001103143" } ], "protein_names": [ { "name": "Splicing factor YJU2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2VD11#names_and_taxonomy", "id": "A2VD11" }, { "name": "coiled-coil domain-containing protein 94; coiled-coil domain containing 94", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103143", "id": "NP_001103143" }, { "name": "splicing factor YJU2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103143", "id": "NP_001103143" } ], "function": [ { "annotation": "Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex.", "evidence": [ { "database": "UniProtKB", "id": "A2VD11", "url": "https://www.uniprot.org/uniprot/A2VD11#function" }, { "database": "PubMed", "id": "MF_03226", "url": "https://glygen.org/publication/PubMed/MF_03226" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A2VD11", "url": "https://www.uniprot.org/uniprot/A2VD11" } ], "common_name": "Rat" } ], "gene": [ { "name": "Yju2", "url": "https://www.uniprot.org/uniprot/A2VD11", "locus": { "chromosome": "9", "start_pos": 11108741, "end_pos": 11098924, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000047456", "url": "https://www.ensembl.org/id/ENSRNOG00000047456" } ] } } ], "crossref": [ { "id": "ENSRNOG00000047456", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000047456", "database": "Bgee" }, { "id": "501285", "url": "https://www.ncbi.nlm.nih.gov/gene/501285", "database": "GeneID" }, { "id": "IPR007590", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007590", "database": "InterPro" }, { "id": "IPR043701", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043701", "database": "InterPro" }, { "id": "rno:501285", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:501285", "database": "KEGG Pathway" }, { "id": "SCADKPT", "url": "https://omabrowser.org/oma/group/SCADKPT/", "database": "OMA" }, { "id": "1583452at2759", "url": "http://www.orthodb.org/?query=1583452at2759", "database": "OrthoDB" }, { "id": "PTHR12111", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12111", "database": "PANTHER" }, { "id": "PF04502", "url": "http://pfam.xfam.org/family/PF04502", "database": "Pfam" }, { "id": "NP_001103143", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103143", "database": "RefSeq" }, { "id": "1589601", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1589601", "database": "RGD" }, { "id": "A2VD11", "url": "https://www.uniprot.org/uniprot/A2VD11", "database": "UniProtKB" }, { "id": "A2VD11-1", "url": "https://www.uniprot.org/uniprot/A2VD11-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MSERKVLNKYYPPDFDPSKIPKLKLPKDRQYVVRLMAPFNMRCKTCGEYIYKGKKFNARKETVQNEAYLGLPIFRFYIKCTRCLAEITFKTDPENTDYTMEHGATRNFQAEKLLEEEEKRMQKEREDEELNNPMKVLENRTKDSKLEMEVLENLQELKDLNQRQAHVDFEAMLLQHRLSQEQWQQQQEEEDERETVALLEEARYRRLLDDSDSEDEAPPSQPQAAARPNPTAILDEVPKTKRKAEGLCRKAQLAGLVIPKKAKTEANRVSEQVRVPTTGAPESRKVANPAPQTPGASSLSQLGAYGDSEDSDS", "length": 313, "header": "tr|A2VD11-1|A2VD11_RAT Isoform 1 of Splicing factor YJU2 OS=Rattus norvegicus OX=10116 GN=Yju2 PE=1 SV=1 CANONICAL=A2VD11-1" }, "isoforms": [ { "isoform_ac": "A2VD11-1", "url": "https://www.uniprot.org/uniprot/A2VD11#A2VD11-1", "sequence": { "sequence": "MSERKVLNKYYPPDFDPSKIPKLKLPKDRQYVVRLMAPFNMRCKTCGEYIYKGKKFNARKETVQNEAYLGLPIFRFYIKCTRCLAEITFKTDPENTDYTMEHGATRNFQAEKLLEEEEKRMQKEREDEELNNPMKVLENRTKDSKLEMEVLENLQELKDLNQRQAHVDFEAMLLQHRLSQEQWQQQQEEEDERETVALLEEARYRRLLDDSDSEDEAPPSQPQAAARPNPTAILDEVPKTKRKAEGLCRKAQLAGLVIPKKAKTEANRVSEQVRVPTTGAPESRKVANPAPQTPGASSLSQLGAYGDSEDSDS", "length": 313, "header": "tr|A2VD11-1|A2VD11_RAT Isoform 1 of Splicing factor YJU2 OS=Rattus norvegicus OX=10116 GN=Yju2 PE=1 SV=1 CANONICAL=A2VD11-1" }, "locus": { "chromosome": "9", "start_pos": 11108707, "end_pos": 11100018, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000072357", "url": "https://www.ensembl.org/id/ENSRNOT00000072357" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000067468", "url": "https://www.ensembl.org/id/ENSRNOP00000067468" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nat. Commun.", "date": "2012", "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "evidence": [ { "database": "UniProtKB", "id": "A2VD11", "url": "https://www.uniprot.org/uniprot/A2VD11" } ], "reference": [ { "type": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" } ] } ], "pathway": [ { "id": "rno:501285", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:501285", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q9BW85-1", "protein_name": "Splicing factor YJU2", "gene_name": "YJU2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSERKVLNKYYPPDFDPSKIPKLKLPKDRQYVVRLMAPFNMRCKTCGEYIYKGKKFNARKETVQNEVYLGLPIFRFYIKCTRCLAEITFKTDPENTDYTMEHGATRNFQAEKLLEEEEKRVQKEREDEELNNPMKVLENRTKDSKLEMEVLENLQELKDLNQRQAHVDFEAMLRQHRLSEEERRRQQQEEDEQETAALLEEARKRRLLEDSDSEDEAAPSPLQPALRPNPTAILDEAPKPKRKVEVWEQSVGSLGSRPPLSRLVVVKKAKADPDCSNGQPQAAPTPGAPQNRKEANPTPLTPGASSLSQLGAYLDSDDSNGSN", "length": 323 }, "evidence": [ { "id": "6350", "url": "http://www.informatics.jax.org/homology/6350", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D6J3-1", "protein_name": "Splicing factor YJU2", "gene_name": "Yju2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSERKVLNKYYPPDFDPSKIPKLKLPKDRQYVVRLMAPFNMRCKTCGEYIYKGKKFNARKETVQNEAYLGLPIFRFYIKCTRCLAEITFKTDPENTDYTMEHGATRNFQAEKLLEEEEKRVQKEREDEELNNPMKVLENRTKDSKLEMEVLENLQELKDLNQRQAHVDFEAMLRQHRMSQEQWQQQQEEEDERETAALLEEARHRRLLEDSESEDEAPPSRPRAAARPNPTAILNEVPQTKRKAEALCSKAQLAGLVVPKKVKTEANGASEQVGVPTAAGAPKSRKADNPTPQTPGTSSLSQLGAYGDSEDSDS", "length": 314 }, "evidence": [ { "id": "6350", "url": "http://www.informatics.jax.org/homology/6350", "database": "MGI" }, { "id": "A2VD11", "url": "https://omabrowser.org/oma/group/A2VD11/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "generation of catalytic spliceosome for first transesterification step", "id": "GO:0000349", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000349", "evidence": [ { "database": "UniProtKB", "id": "A2VD11", "url": "https://www.uniprot.org/uniprot/A2VD11" } ], "pmid": "" }, { "name": "RNA splicing", "id": "GO:0008380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008380", "evidence": [ { "database": "UniProtKB", "id": "A2VD11", "url": "https://www.uniprot.org/uniprot/A2VD11" } ], "pmid": "21873635" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A2VD11", "url": "https://www.uniprot.org/uniprot/A2VD11" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "U2-type catalytic step 1 spliceosome", "id": "GO:0071006", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071006", "evidence": [ { "database": "UniProtKB", "id": "A2VD11", "url": "https://www.uniprot.org/uniprot/A2VD11" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 139, "end_pos": 141, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "synthesized_glycans": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ] }