{ "uniprot_canonical_ac": "A2VCW9-1", "uniprot_ac": "A2VCW9", "uniprot_id": "AASS_RAT", "mass": { "chemical_mass": 102908.0, "monoisotopic_mass": 102908.0 }, "refseq": { "ac": "NP_001094433", "name": "alpha-aminoadipic semialdehyde synthase, mitochondrial precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094433" }, "gene_names": [ { "name": "Aass", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2VCW9", "id": "A2VCW9" }, { "name": "Aass", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094433", "id": "NP_001094433" } ], "protein_names": [ { "name": "Alpha-aminoadipic semialdehyde synthase, mitochondrial", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2VCW9#names_and_taxonomy", "id": "A2VCW9" }, { "name": "LKR/SDH", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2VCW9#names_and_taxonomy", "id": "A2VCW9" }, { "name": "alpha-aminoadipic semialdehyde synthase, mitochondrial precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094433", "id": "NP_001094433" }, { "name": "alpha-aminoadipic semialdehyde synthase, mitochondrial; LKR/SDH", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094433", "id": "NP_001094433" } ], "function": [ { "annotation": "Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-oxoglutarate reductase and saccharopine dehydrogenase activity, respectively (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "A2VCW9", "url": "https://www.uniprot.org/uniprot/A2VCW9#function" }, { "database": "PubMed", "id": "Q9UDR5", "url": "https://glygen.org/publication/PubMed/Q9UDR5" } ] } ], "disease": [ { "disease_id": "DOID:9274", "recommended_name": { "id": "DOID:9274", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9274", "name": "hyperlysinemia", "description": "An amino acid metabolic disorder that involves an abnormal increase of lysine in the blood." }, "synonyms": [ { "id": "MONDO:0009388", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009388", "name": "hyperlysinemia (disease)", "description": "Hyperlysinaemia is a lysine metabolism disorder characterised by elevated levels of lysine in the cerebrospinal fluid and blood. Variable degrees of saccharopinuria are also present." }, { "id": "MONDO:0009388", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009388", "name": "hyperlysinemia type I", "description": "" }, { "id": "MONDO:0009388", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009388", "name": "Alpha-aminoadipic semialdehyde synthase deficiency", "description": "" }, { "id": "MONDO:0009388", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009388", "name": "L-lysine:NAD-oxido-reductase deficiency", "description": "" }, { "id": "MONDO:0009388", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009388", "name": "L-lysine NAD-oxido-reductase deficiency", "description": "" }, { "id": "MONDO:0009388", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009388", "name": "hyperlysinemia, type I", "description": "" }, { "id": "MONDO:0009388", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009388", "name": "hyperlysinemia", "description": "" }, { "id": "MONDO:0009388", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009388", "name": "lysine:Alpha-ketoglutarate reductase deficiency", "description": "" }, { "id": "MONDO:0009388", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009388", "name": "lysine intolerance", "description": "" }, { "id": "MONDO:0009388", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009388", "name": "lysine alpha-ketoglutarate reductase deficiency", "description": "" }, { "id": "MONDO:0009388", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009388", "name": "hyperlysinemia, type 1", "description": "" }, { "id": "MONDO:0009389", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009389", "name": "hyperlysinemia due to defect in lysine transport into mitochondria", "description": "" }, { "id": "MONDO:0009389", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009389", "name": "hyperlysinemia due to defect in lysine TRANSPORT into mitochondria", "description": "" }, { "id": "MIM:238700", "resource": "MIM", "url": "https://www.omim.org/entry/238700", "name": "Hyperlysinemia, 1", "description": "Hyperlysinemia, 1" } ], "evidence": [ { "id": "9274", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9274" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A2VCW9", "url": "https://www.uniprot.org/uniprot/A2VCW9" } ], "common_name": "Rat" } ], "gene": [ { "name": "Aass", "url": "https://www.uniprot.org/uniprot/A2VCW9", "locus": { "chromosome": "4", "start_pos": 50200328, "end_pos": 50152452, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000039494", "url": "https://www.ensembl.org/id/ENSRNOG00000039494" } ] } } ], "crossref": [ { "id": "ENSRNOG00000039494", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000039494", "database": "Bgee" }, { "id": "296925", "url": "https://www.ncbi.nlm.nih.gov/gene/296925", "database": "GeneID" }, { "id": "IPR005097", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005097", "database": "InterPro" }, { "id": "IPR007698", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007698", "database": "InterPro" }, { "id": "IPR007886", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007886", "database": "InterPro" }, { "id": "IPR032095", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032095", "database": "InterPro" }, { "id": "IPR036291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036291", "database": "InterPro" }, { "id": "rno:296925", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:296925", "database": "KEGG Pathway" }, { "id": "KMEGRSE", "url": "https://omabrowser.org/oma/group/KMEGRSE/", "database": "OMA" }, { "id": "498994at2759", "url": "http://www.orthodb.org/?query=498994at2759", "database": "OrthoDB" }, { "id": "PF03435", "url": "http://pfam.xfam.org/family/PF03435", "database": "Pfam" }, { "id": "PF05222", "url": "http://pfam.xfam.org/family/PF05222", "database": "Pfam" }, { "id": "PF16653", "url": "http://pfam.xfam.org/family/PF16653", "database": "Pfam" }, { "id": "PR_A2VCW9", "url": "http://purl.obolibrary.org/obo/PR_A2VCW9", "database": "PRO" }, { "id": "R-RNO-71064", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-71064", "database": "Reactome" }, { "id": "NP_001094433", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094433", "database": "RefSeq" }, { "id": "1310811", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1310811", "database": "RGD" }, { "id": "19373", "url": "https://www.rhea-db.org/rhea/19373", "database": "Rhea" }, { "id": "24520", "url": "https://www.rhea-db.org/rhea/24520", "database": "Rhea" }, { "id": "A2VCW9", "url": "https://www.uniprot.org/uniprot/A2VCW9", "database": "UniProtKB" }, { "id": "A2VCW9-1", "url": "https://www.uniprot.org/uniprot/A2VCW9-1", "database": "UniProtKB" }, { "id": "D4ACE9", "url": "https://www.uniprot.org/uniprot/D4ACE9", "database": "UniProtKB" }, { "id": "D4ACE9-1", "url": "https://www.uniprot.org/uniprot/D4ACE9-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MLRAQRLRLARLRACVSRGLHHKPVMALRREDVNAWERRAPLAPKHIKGITKLGYKVLIQPSNRRAIHDKEYVRAGGILQEDITEACLILGVKRPPEEKLMSKKTYAFFSHTIKAQEANMSLLDEVLKQEIRLIDYEKMVDHRGSRIVAFGHWAGVAGMINILHGMGLRLLALGHHTPFMHLGMAHNYRNSSQAVQAVRDAGYEISLGLMPKSIGPLTFVFTGTGNVSKGAQEVFNELPCEYVEPHELKEVSKTGDLRKVYGTVLSRHHHLVRKTDGVYDPVEYEKYPERYISRFNADIAPYTTCLINGIYWEQNTPRLLTRQDAQSLLVPVKSSVVPVEGCPELPHKLVAICDISADTGGSIDFMTECTTIERPFCMYDADQHIIHDSVEGSGILMCSIDNLPAQLPIEATEYFGDMLYPYVEEMLLSDASQPLESQNFSPVVRDAVITSNGLLTDKYKYIQKLRESRERIQFLSMSTKKKVLVLGSGYVSGPVLEYLSRGNNIEITLGSDMTNQMQQLSKKYDINTVNVTVGKQEDKLQSLVESQDLVISLLPYVLHPVVAKACIDSKVNMVTASYITPAMKELEKSVDDAGITVIGELGLDPGLDHMLAMETIDKAKDLGATIESYVSYCGGLPAPEHSDNPLRYKFSWSPVGVLMNIMQPASYLLNGKVVNVTGGVSFLNSVTPMDYFPGLNLEGYPNRDSTKYAEIYGISSAHTLLRGTLRYKGYSKALNGFVKLGLINRETYPALRPEANPLTWKQLLCDLVGISRSSSCEKLKEVVFTKLGGDSTQLEAAEWLGLLGDEQVPQAESIVDAFSKHLVSKLSYGPEEKDMIVMRDSFGIRHPSGHLENKTIDLVVYGDFNGFSAMAKTVGLPTAMAAKMLLDGEIETKGLMGPFSKEIYGPILERIKAEGIVFNTQSTIKL", "length": 926, "header": "sp|A2VCW9-1|AASS_RAT Isoform 1 of Alpha-aminoadipic semialdehyde synthase, mitochondrial OS=Rattus norvegicus OX=10116 GN=Aass PE=2 SV=1 CANONICAL=A2VCW9-1" }, "isoforms": [ { "isoform_ac": "A2VCW9-1", "url": "https://www.uniprot.org/uniprot/A2VCW9#A2VCW9-1", "sequence": { "sequence": "MLRAQRLRLARLRACVSRGLHHKPVMALRREDVNAWERRAPLAPKHIKGITKLGYKVLIQPSNRRAIHDKEYVRAGGILQEDITEACLILGVKRPPEEKLMSKKTYAFFSHTIKAQEANMSLLDEVLKQEIRLIDYEKMVDHRGSRIVAFGHWAGVAGMINILHGMGLRLLALGHHTPFMHLGMAHNYRNSSQAVQAVRDAGYEISLGLMPKSIGPLTFVFTGTGNVSKGAQEVFNELPCEYVEPHELKEVSKTGDLRKVYGTVLSRHHHLVRKTDGVYDPVEYEKYPERYISRFNADIAPYTTCLINGIYWEQNTPRLLTRQDAQSLLVPVKSSVVPVEGCPELPHKLVAICDISADTGGSIDFMTECTTIERPFCMYDADQHIIHDSVEGSGILMCSIDNLPAQLPIEATEYFGDMLYPYVEEMLLSDASQPLESQNFSPVVRDAVITSNGLLTDKYKYIQKLRESRERIQFLSMSTKKKVLVLGSGYVSGPVLEYLSRGNNIEITLGSDMTNQMQQLSKKYDINTVNVTVGKQEDKLQSLVESQDLVISLLPYVLHPVVAKACIDSKVNMVTASYITPAMKELEKSVDDAGITVIGELGLDPGLDHMLAMETIDKAKDLGATIESYVSYCGGLPAPEHSDNPLRYKFSWSPVGVLMNIMQPASYLLNGKVVNVTGGVSFLNSVTPMDYFPGLNLEGYPNRDSTKYAEIYGISSAHTLLRGTLRYKGYSKALNGFVKLGLINRETYPALRPEANPLTWKQLLCDLVGISRSSSCEKLKEVVFTKLGGDSTQLEAAEWLGLLGDEQVPQAESIVDAFSKHLVSKLSYGPEEKDMIVMRDSFGIRHPSGHLENKTIDLVVYGDFNGFSAMAKTVGLPTAMAAKMLLDGEIETKGLMGPFSKEIYGPILERIKAEGIVFNTQSTIKL", "length": 926, "header": "sp|A2VCW9-1|AASS_RAT Isoform 1 of Alpha-aminoadipic semialdehyde synthase, mitochondrial OS=Rattus norvegicus OX=10116 GN=Aass PE=2 SV=1 CANONICAL=A2VCW9-1" }, "locus": {} }, { "isoform_ac": "D4ACE9-1", "url": "https://www.uniprot.org/uniprot/A2VCW9#D4ACE9-1", "sequence": { "sequence": "MLRAQRLRLARLRACVSRGLHHKPVMALRREDVNAWERRAPLAPKHIKGITKLGYKVLIQPSNRRAIHDKEYVRAGGILQEDITEACLILGVKRPPEEKLMSKKTYAFFSHTIKAQEANMSLLDEVLKQEIRLIDYEKMVDHRGSRIVAFGQWAGVAGMINILHGMGLRLLALGHHTPFMHLGMAHNYRNSSQAVQAVRDAGYEISLGLMPKSIGPLTFVFTGTGNVSKGAQEVFNELPCEYVEPHELKEVSKTGDLRKVYGTVLSRHHHLVRKTDGVYDPVEYEKYPERYISRFNADIAPYTTFRICGIGWHCGSRRISISIQDCYLIKVKIKLICRVDTCYVAVIFRLVAICDISADTGGSIDFMTECTTIERPFCMYDADQHIIHDSVEGSGILMCSIDNLPAQLPIEATEYFGDMLYPYVEEMLLSDASQPLESQNFSPVVRDAVITSNGLLTDKYKYIQKLRESRERIQFLSMSTKKKVLVLGSGYVSGPVLEYLSRGNNIEITLGSDMTNQMQQLSKKYDINTVNVTVGKQEDKLQSLVESQDLVISLLPYVLHPVVAKACIDSKVNMVTASYITPAMKELEKSVDDAGITVIGELGLDPGLDHMLAMETIDKAKDLGATIESYVSYCGGLPAPEHSDNPLRYKFSWSPVGVLMNIMQPASYLLNGKVVNVTGGVSFLNSVPMDYFPGLNLEGYPNRDSTKYAEIYGISSAHTLLRGTLRYKGYSKALNGFVKLGLINRETYPALRPEANPLTWKQLLCDLVGISRSSSCEKLKEVVFTKLGGDSTQLEAAEWLGLLGDEQVPQAESIVDAFSKHLVSKLSYGPEEKDMIVMRDSFGIRHPSGHLENKTIDLVVYGDFNGFSAMAKTVGLPTAMAAKMLLDGEIETKGLMGPFSKEIYGPILERIKAEGIVFNTQSTIKL", "length": 926, "header": "tr|D4ACE9-1|AASS_RAT Computationally mapped isoform of Alpha-aminoadipic semialdehyde synthase, mitochondrial OS=Rattus norvegicus OX=10116 GN=Aass PE=2 SV=3 CANONICAL=A2VCW9-1" }, "locus": { "chromosome": "4", "start_pos": 50200328, "end_pos": 50152455, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000060530", "url": "https://www.ensembl.org/id/ENSRNOT00000060530" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000057271", "url": "https://www.ensembl.org/id/ENSRNOP00000057271" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "rno:296925", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:296925", "resource": "KEGG Pathway" }, { "id": "R-RNO-71064", "name": "Lysine catabolism", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-71064", "resource": "Reactome", "description": "Lysine catabolism" } ], "orthologs": [ { "uniprot_canonical_ac": "Q99K67-1", "protein_name": "Alpha-aminoadipic semialdehyde synthase, mitochondrial", "gene_name": "Aass", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLRAQRPRLARLRACLSRGLHHKPVMALRREDVNAWERRAPLAPKHIKGITKLGYKVLIQPSNRRAIHDKEYVRAGGILQEDITEACLILGVKRPPEEKLMSKKTYAFFSHTIKAQEANMNLLDEVLKQEIRLIDYEKMVDHRGSRIVAFGQWAGVAGMINILHGMGLRLLALGHHTPFMHLGMAHNYRNSSQAVQAVRDAGYEISLGLMPKSIGPLTFVFTGTGNVSKGAQEVFNELPCEYVEPHELREVSKTGDLRKVYGTVLSRHHHLVRKTDGVYDPVEYEKYPERYTSRFNTDIAPYTTCLINGIYWEQNTPRLLTRQDAQSLLVPVKSSVVPVEGCPELPHKLVAICDISADTGGSIDFMTECTTIERPFCMYDADQQIIHDSVEGSGILMCSIDNLPAQLPIEATEYFGDMLYPYVEEMLLSDASQPLESQNFSPVVRDAVITSNGLLTDKYKYIQKLRESRERIQFLSMSTKKKVLVLGSGYVSGPVLEYLSRDNNIEITLGSDMTNQMQQLSKKYNINPVSLTVGKQEAKLQSLVESQDLVISLLPYVLHPVVAKACIESRVNMVTASYITPAMKELEKSVDDAGITVIGELGLDPGLDHMLAMETIDTAKELGATVESYVSYCGGLPAPEHSDNPLRYKFSWSPVGVLMNIMQPASYLLNGKVVNVTGGVSFLNSVTPMDYFPGLNLEGYPNRDSIKYAEIYGISSAHTLLRGTLRYKGYSKALNGFVKLGLINREAYPALRPEANPLTWKQLLCDLVGISRSSPCEKLKEVVFTKLGGDNTQLEAAEWLGLLGDEQVPQAESIVDAFSKHLVSKLSYGPEEKDMIVMRDSFGIRHPSGHLENKTIDLVVYGDFNGFSAMAKTVGLPTAMAAKMLLDGEIEAKGLMGPFTKEIYGPILERIKAEGIVFNTQSTIKL", "length": 926 }, "evidence": [ { "id": "4212", "url": "http://www.informatics.jax.org/homology/4212", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UDR5-1", "protein_name": "Alpha-aminoadipic semialdehyde synthase, mitochondrial", "gene_name": "AASS", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLQVHRTGLGRLGVSLSKGLHHKAVLAVRREDVNAWERRAPLAPKHIKGITNLGYKVLIQPSNRRAIHDKDYVKAGGILQEDISEACLILGVKRPPEEKLMSRKTYAFFSHTIKAQEANMGLLDEILKQEIRLIDYEKMVDHRGVRVVAFGQWAGVAGMINILHGMGLRLLALGHHTPFMHIGMAHNYRNSSQAVQAVRDAGYEISLGLMPKSIGPLTFVFTGTGNVSKGAQAIFNELPCEYVEPHELKEVSQTGDLRKVYGTVLSRHHHLVRKTDAVYDPAEYDKHPERYISRFNTDIAPYTTCLINGIYWEQNTPRLLTRQDAQSLLAPGKFSPAGVEGCPALPHKLVAICDISADTGGSIEFMTECTTIEHPFCMYDADQHIIHDSVEGSGILMCSIDNLPAQLPIEATECFGDMLYPYVEEMILSDATQPLESQNFSPVVRDAVITSNGTLPDKYKYIQTLRESRERAQSLSMGTRRKVLVLGSGYISEPVLEYLSRDGNIEITVGSDMKNQIEQLGKKYNINPVSMDICKQEEKLGFLVAKQDLVISLLPYVLHPLVAKACITNKVNMVTASYITPALKELEKSVEDAGITIIGELGLDPGLDHMLAMETIDKAKEVGATIESYISYCGGLPAPEHSNNPLRYKFSWSPVGVLMNVMQSATYLLDGKVVNVAGGISFLDAVTSMDFFPGLNLEGYPNRDSTKYAEIYGISSAHTLLRGTLRYKGYMKALNGFVKLGLINREALPAFRPEANPLTWKQLLCDLVGISPSSEHDVLKEAVLKKLGGDNTQLEAAEWLGLLGDEQVPQAESILDALSKHLVMKLSYGPEEKDMIVMRDSFGIRHPSGHLEHKTIDLVAYGDINGFSAMAKTVGLPTAMAAKMLLDGEIGAKGLMGPFSKEIYGPILERIKAEGIIYTTQSTIKP", "length": 926 }, "evidence": [ { "id": "4212", "url": "http://www.informatics.jax.org/homology/4212", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A2VCW9", "url": "https://www.uniprot.org/uniprot/A2VCW9" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A2VCW9", "url": "https://www.uniprot.org/uniprot/A2VCW9" } ], "pmid": "21873635" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "L-lysine catabolic process to acetyl-CoA via saccharopine", "id": "GO:0033512", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033512", "evidence": [ { "database": "UniProtKB", "id": "A2VCW9", "url": "https://www.uniprot.org/uniprot/A2VCW9" } ], "pmid": "" }, { "name": "lysine biosynthetic process via aminoadipic acid", "id": "GO:0019878", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019878", "evidence": [ { "database": "UniProtKB", "id": "A2VCW9", "url": "https://www.uniprot.org/uniprot/A2VCW9" } ], "pmid": "21873635" }, { "name": "L-lysine catabolic process", "id": "GO:0019477", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019477", "evidence": [ { "database": "UniProtKB", "id": "A2VCW9", "url": "https://www.uniprot.org/uniprot/A2VCW9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity", "id": "GO:0047131", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047131", "evidence": [ { "database": "UniProtKB", "id": "A2VCW9", "url": "https://www.uniprot.org/uniprot/A2VCW9" } ], "pmid": "" }, { "name": "saccharopine dehydrogenase (NADP+, L-lysine-forming) activity", "id": "GO:0047130", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047130", "evidence": [ { "database": "UniProtKB", "id": "A2VCW9", "url": "https://www.uniprot.org/uniprot/A2VCW9" } ], "pmid": "" }, { "name": "saccharopine dehydrogenase activity", "id": "GO:0004753", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004753", "evidence": [ { "database": "UniProtKB", "id": "A2VCW9", "url": "https://www.uniprot.org/uniprot/A2VCW9" } ], "pmid": "21873635" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 119, "end_pos": 121, "annotation": "n_glycosylation_sequon" }, { "start_pos": 190, "end_pos": 192, "annotation": "n_glycosylation_sequon" }, { "start_pos": 226, "end_pos": 228, "annotation": "n_glycosylation_sequon" }, { "start_pos": 439, "end_pos": 441, "annotation": "n_glycosylation_sequon" }, { "start_pos": 530, "end_pos": 532, "annotation": "n_glycosylation_sequon" }, { "start_pos": 675, "end_pos": 677, "annotation": "n_glycosylation_sequon" }, { "start_pos": 853, "end_pos": 855, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "19373", "name": "", "equation": "H2O + L-saccharopine + NADP(+) = 2-oxoglutarate + H(+) + L-lysine + NADPH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A2VCW9-1", "Q9UDR5-1", "Q99K67-1", "Q9VLX0-1" ], "evidence": [ { "id": "19373", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19373" } ] }, { "id": "24520", "name": "", "equation": "H2O + L-saccharopine + NAD(+) = (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A2VCW9-1", "Q9UDR5-1", "Q99K67-1", "Q9VLX0-1" ], "evidence": [ { "id": "24520", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/24520" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A2VCW9", "gene_name": "Aass", "activity": [ { "ec_number": "1.5.1.8", "activity": 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"Q99K67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99K67" } ] }, { "ec_number": "1.5.1.9", "activity": "N(6)-(L-1,3-dicarboxypropyl)-L-lysine + NAD(+) + H(2)O = L-glutamate + (S)-2-amino-6-oxohexanoate + NADH.", "evidence": [ { "id": "Q99K67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99K67" } ] } ] }, { "uniprot_ac": "Q9UDR5", "gene_name": "AASS", "activity": [ { "ec_number": "1.5.1.8", "activity": "N(6)-(L-1,3-dicarboxypropyl)-L-lysine + NADP(+) + H(2)O = L-lysine + 2-oxoglutarate + NADPH.", "evidence": [ { "id": "Q9UDR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UDR5" } ] }, { "ec_number": "1.5.1.9", "activity": "N(6)-(L-1,3-dicarboxypropyl)-L-lysine + NAD(+) + H(2)O = L-glutamate + (S)-2-amino-6-oxohexanoate + NADH.", "evidence": [ { "id": "Q9UDR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UDR5" } ] }, { "ec_number": "1.5.1.9", "activity": "", "evidence": [ { "id": "Q9UDR5", 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