{
    "uniprot_canonical_ac": "A2VCV8-1",
    "uniprot_ac": "A2VCV8",
    "uniprot_id": "A2VCV8_RAT",
    "mass": {
        "chemical_mass": 33420.0,
        "monoisotopic_mass": 33420.0
    },
    "refseq": {
        "ac": "NP_001029284",
        "name": "max-like protein X",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029284"
    },
    "gene_names": [
        {
            "name": "Mlx",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2VCV8",
            "id": "A2VCV8"
        },
        {
            "name": "Mlx",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029284",
            "id": "NP_001029284"
        },
        {
            "name": "Tcfl4",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029284",
            "id": "NP_001029284"
        },
        {
            "name": "rCG_32676",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2VCV8",
            "id": "A2VCV8"
        }
    ],
    "protein_names": [
        {
            "name": "MAX dimerization protein MLX",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2VCV8#names_and_taxonomy",
            "id": "A2VCV8"
        },
        {
            "name": "MAX-like protein X, isoform CRA_a",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2VCV8#names_and_taxonomy",
            "id": "A2VCV8"
        },
        {
            "name": "MAX-like protein X",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2VCV8#names_and_taxonomy",
            "id": "A2VCV8"
        },
        {
            "name": "max-like factor protein; transcription factor-like 4; MLX, MAX dimerization protein",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029284",
            "id": "NP_001029284"
        },
        {
            "name": "max-like protein X",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029284",
            "id": "NP_001029284"
        }
    ],
    "function": [
        {
            "annotation": "ChREBP.Mlx is the principal transcription factor regulating glucose-responsive genes in the liver and coordinately regulates a family of genes required for glucose utilization and energy storage",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001029284",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029284"
                },
                {
                    "database": "PubMed",
                    "id": "16885160",
                    "url": "https://glygen.org/publication/PubMed/16885160"
                }
            ]
        },
        {
            "annotation": "Involved in control of hepatic L-type pyruvate kinase gene transcription",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001029284",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029284"
                },
                {
                    "database": "PubMed",
                    "id": "16644726",
                    "url": "https://glygen.org/publication/PubMed/16644726"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2VCV8",
                    "url": "https://www.uniprot.org/uniprot/A2VCV8"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Mlx",
            "url": "https://www.uniprot.org/uniprot/A2VCV8",
            "locus": {
                "chromosome": "10",
                "start_pos": 88997399,
                "end_pos": 89002152,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000019983",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000019983"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000019983",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000019983",
            "database": "Bgee"
        },
        {
            "id": "360631",
            "url": "https://www.ncbi.nlm.nih.gov/gene/360631",
            "database": "GeneID"
        },
        {
            "id": "IPR011598",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011598",
            "database": "InterPro"
        },
        {
            "id": "IPR032647",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR032647",
            "database": "InterPro"
        },
        {
            "id": "IPR036638",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036638",
            "database": "InterPro"
        },
        {
            "id": "rno:360631",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:360631",
            "database": "KEGG Pathway"
        },
        {
            "id": "AHNTEDE",
            "url": "https://omabrowser.org/oma/group/AHNTEDE/",
            "database": "OMA"
        },
        {
            "id": "1234389at2759",
            "url": "http://www.orthodb.org/?query=1234389at2759",
            "database": "OrthoDB"
        },
        {
            "id": "PTHR15741:SF25",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15741:SF25",
            "database": "PANTHER"
        },
        {
            "id": "PF00010",
            "url": "http://pfam.xfam.org/family/PF00010",
            "database": "Pfam"
        },
        {
            "id": "R-RNO-163765",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-163765",
            "database": "Reactome"
        },
        {
            "id": "NP_001029284",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029284",
            "database": "RefSeq"
        },
        {
            "id": "1308590",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1308590",
            "database": "RGD"
        },
        {
            "id": "A2VCV8",
            "url": "https://www.uniprot.org/uniprot/A2VCV8",
            "database": "UniProtKB"
        },
        {
            "id": "A2VCV8-1",
            "url": "https://www.uniprot.org/uniprot/A2VCV8-1",
            "database": "UniProtKB"
        }
    ],
    "sequence": {
        "sequence": "MTEPGASPEDPWVKASSADAHAGEGRAGRARARRGSGRRGAPQLSPESPLLSRPRGCREDSSHPACAKVEYAYSDNSLDPGLFVESTHKGSVVSRANSIGSTSASSVPNTDDEDSDYQQESYKESYKDRRRRAHTQAEQKRRDAIKRGYDDLQTIVPTCQQQDFSIGSQKLSKAIVLQKTIDYIQFLHKEKKKQEEEVSTLRKDVTALKIMKVNYEQIVKAHQDNPHEGEDQVSDQVKFNVFQGIMDSLFQSFNASISVASFQELSACVFSWIEEHCEPQTLREIVIGVLHQLKNQLY",
        "length": 298,
        "header": "tr|A2VCV8-1|A2VCV8_RAT Isoform 1 of MAX-like protein X, isoform CRA_a  OS=Rattus norvegicus OX=10116 GN=Mlx PE=1 SV=1 CANONICAL=A2VCV8-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A2VCV8-1",
            "url": "https://www.uniprot.org/uniprot/A2VCV8#A2VCV8-1",
            "sequence": {
                "sequence": "MTEPGASPEDPWVKASSADAHAGEGRAGRARARRGSGRRGAPQLSPESPLLSRPRGCREDSSHPACAKVEYAYSDNSLDPGLFVESTHKGSVVSRANSIGSTSASSVPNTDDEDSDYQQESYKESYKDRRRRAHTQAEQKRRDAIKRGYDDLQTIVPTCQQQDFSIGSQKLSKAIVLQKTIDYIQFLHKEKKKQEEEVSTLRKDVTALKIMKVNYEQIVKAHQDNPHEGEDQVSDQVKFNVFQGIMDSLFQSFNASISVASFQELSACVFSWIEEHCEPQTLREIVIGVLHQLKNQLY",
                "length": 298,
                "header": "tr|A2VCV8-1|A2VCV8_RAT Isoform 1 of MAX-like protein X, isoform CRA_a  OS=Rattus norvegicus OX=10116 GN=Mlx PE=1 SV=1 CANONICAL=A2VCV8-1"
            },
            "locus": {
                "chromosome": "10",
                "start_pos": 89001157,
                "end_pos": 88997439,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000027116",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000027116"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000027116",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000027116"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Regulation of rat hepatic L-pyruvate kinase promoter composition and activity by glucose, n-3 polyunsaturated fatty acids, and peroxisome proliferator-activated receptor-alpha agonist.",
            "journal": "The Journal of biological chemistry",
            "date": "2006",
            "authors": "Xu J, Christian B, Jump DB",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001029284",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029284"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "16644726",
                    "url": "https://glygen.org/publication/PubMed/16644726"
                }
            ]
        },
        {
            "title": "ChREBP*Mlx is the principal mediator of glucose-induced gene expression in the liver.",
            "journal": "The Journal of biological chemistry",
            "date": "2006",
            "authors": "Ma L, Robinson LN, Towle HC",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001029284",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029284"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "16885160",
                    "url": "https://glygen.org/publication/PubMed/16885160"
                }
            ]
        },
        {
            "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.",
            "journal": "Nat. Commun.",
            "date": "2012",
            "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2VCV8",
                    "url": "https://www.uniprot.org/uniprot/A2VCV8"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "22673903",
                    "url": "https://glygen.org/publication/PubMed/22673903"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "rno:360631",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:360631",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-RNO-163765",
            "name": "ChREBP activates metabolic gene expression",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-163765",
            "resource": "Reactome",
            "description": "ChREBP activates metabolic gene expression"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "O08609-1",
            "protein_name": "Max-like protein X",
            "gene_name": "Mlx",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MTEPGASPEDPWVKASFADAHAGEGRAGRARARRGSGRRGAPQLSPESPLLSGARGCREDSSHPACAKVEYAYSDNSLDPGLFVESTHKGSVVSRANSIGSTSASSVPNTDDEDSDYQQEAYKESYKDRRRRAHTQAEQKRRDAIKRGYDDLQTIVPTCQQQDFSIGSQKLSKAIVLQKTIDYIQFLHKEKKKQEEEVSTLRKDVTALKIMKVNYEQIVKAHQDNPHEGEDQVSDQVKFNVFQGIMDSLFQSFNASISVASFQELSACVFSWIEEHCEPQTLREIVIGVLHQLKNQLY",
                "length": 298
            },
            "evidence": [
                {
                    "id": "7969",
                    "url": "http://www.informatics.jax.org/homology/7969",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "Q9UH92-1",
            "protein_name": "Max-like protein X",
            "gene_name": "MLX",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MTEPGASPEDPWVKASPVGAHAGEGRAGRARARRGAGRRGASLLSPKSPTLSVPRGCREDSSHPACAKVEYAYSDNSLDPGLFVESTRKGSVVSRANSIGSTSASSVPNTDDEDSDYHQEAYKESYKDRRRRAHTQAEQKRRDAIKRGYDDLQTIVPTCQQQDFSIGSQKLSKAIVLQKTIDYIQFLHKEKKKQEEEVSTLRKDVTALKIMKVNYEQIVKAHQDNPHEGEDQVSDQVKFNVFQGIMDSLFQSFNASISVASFQELSACVFSWIEEHCKPQTLREIVIGVLHQLKNQLY",
                "length": 298
            },
            "evidence": [
                {
                    "id": "7969",
                    "url": "http://www.informatics.jax.org/homology/7969",
                    "database": "MGI"
                },
                {
                    "id": "A2VCV8",
                    "url": "https://omabrowser.org/oma/group/A2VCV8/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 5,
                "go_terms": [
                    {
                        "name": "negative regulation of transcription by RNA polymerase II",
                        "id": "GO:0000122",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2VCV8",
                                "url": "https://www.uniprot.org/uniprot/A2VCV8"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of transcription by RNA polymerase II",
                        "id": "GO:0006357",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2VCV8",
                                "url": "https://www.uniprot.org/uniprot/A2VCV8"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "nucleocytoplasmic transport",
                        "id": "GO:0006913",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006913",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2VCV8",
                                "url": "https://www.uniprot.org/uniprot/A2VCV8"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of transcription by RNA polymerase II",
                        "id": "GO:0045944",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2VCV8",
                                "url": "https://www.uniprot.org/uniprot/A2VCV8"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of transcription, DNA-templated",
                        "id": "GO:0045892",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2VCV8",
                                "url": "https://www.uniprot.org/uniprot/A2VCV8"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 8,
                "go_terms": [
                    {
                        "name": "DNA binding",
                        "id": "GO:0003677",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2VCV8",
                                "url": "https://www.uniprot.org/uniprot/A2VCV8"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein homodimerization activity",
                        "id": "GO:0042803",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2VCV8",
                                "url": "https://www.uniprot.org/uniprot/A2VCV8"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein heterodimerization activity",
                        "id": "GO:0046982",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2VCV8",
                                "url": "https://www.uniprot.org/uniprot/A2VCV8"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding",
                        "id": "GO:0000977",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2VCV8",
                                "url": "https://www.uniprot.org/uniprot/A2VCV8"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific",
                        "id": "GO:0001227",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2VCV8",
                                "url": "https://www.uniprot.org/uniprot/A2VCV8"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding",
                        "id": "GO:0000978",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2VCV8",
                                "url": "https://www.uniprot.org/uniprot/A2VCV8"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "DNA-binding transcription factor activity, RNA polymerase II-specific",
                        "id": "GO:0000981",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2VCV8",
                                "url": "https://www.uniprot.org/uniprot/A2VCV8"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "sequence-specific double-stranded DNA binding",
                        "id": "GO:1990837",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990837",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2VCV8",
                                "url": "https://www.uniprot.org/uniprot/A2VCV8"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 5,
                "go_terms": [
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2VCV8",
                                "url": "https://www.uniprot.org/uniprot/A2VCV8"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nucleoplasm",
                        "id": "GO:0005654",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2VCV8",
                                "url": "https://www.uniprot.org/uniprot/A2VCV8"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytoplasm",
                        "id": "GO:0005737",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2VCV8",
                                "url": "https://www.uniprot.org/uniprot/A2VCV8"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytosol",
                        "id": "GO:0005829",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2VCV8",
                                "url": "https://www.uniprot.org/uniprot/A2VCV8"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nuclear membrane",
                        "id": "GO:0031965",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2VCV8",
                                "url": "https://www.uniprot.org/uniprot/A2VCV8"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 254,
            "end_pos": 256,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        },
        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
        }
    ]
}