{ "uniprot_canonical_ac": "A2TGX5-1", "uniprot_ac": "A2TGX5", "uniprot_id": "CLM8_RAT", "mass": { "chemical_mass": 34495.0, "monoisotopic_mass": 34495.0 }, "refseq": {}, "gene_names": [ { "name": "Cd300a", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2TGX5", "id": "A2TGX5" } ], "protein_names": [ { "name": "CMRF35-like molecule 8", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2TGX5#names_and_taxonomy", "id": "A2TGX5" }, { "name": "CD300 antigen-like family member A", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2TGX5#names_and_taxonomy", "id": "A2TGX5" }, { "name": "CLM-8", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2TGX5#names_and_taxonomy", "id": "A2TGX5" } ], "function": [ { "annotation": "Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6.", "evidence": [ { "database": "UniProtKB", "id": "A2TGX5", "url": "https://www.uniprot.org/uniprot/A2TGX5#function" }, { "database": "PubMed", "id": "Q9UGN4", "url": "https://glygen.org/publication/PubMed/Q9UGN4" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A2TGX5", "url": "https://www.uniprot.org/uniprot/A2TGX5" } ], "common_name": "Rat" } ], "gene": [ { "name": "Cd300a", "url": "https://www.uniprot.org/uniprot/A2TGX5", "locus": { "chromosome": "10", "start_pos": 103438303, "end_pos": 103450947, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000057058", "url": "https://www.ensembl.org/id/ENSRNOG00000057058" } ] } } ], "crossref": [ { "id": "ENSRNOG00000057058", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000057058", "database": "Bgee" }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro" }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro" }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro" }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro" }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro" }, { "id": "WRMIRRH", "url": "https://omabrowser.org/oma/group/WRMIRRH/", "database": "OMA" }, { "id": "PF07686", "url": "http://pfam.xfam.org/family/PF07686", "database": "Pfam" }, { "id": "PR_A2TGX5", "url": "http://purl.obolibrary.org/obo/PR_A2TGX5", "database": "PRO" }, { "id": "R-RNO-198933", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-198933", "database": "Reactome" }, { "id": "R-RNO-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6798695", "database": "Reactome" }, { "id": "1583719", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1583719", "database": "RGD" }, { "id": "A0A0G2K2W8", "url": "https://www.uniprot.org/uniprot/A0A0G2K2W8", "database": "UniProtKB" }, { "id": "A0A0G2K2W8-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K2W8-1", "database": "UniProtKB" }, { "id": "A0A0G2K697", "url": "https://www.uniprot.org/uniprot/A0A0G2K697", "database": "UniProtKB" }, { "id": "A0A0G2K697-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K697-1", "database": "UniProtKB" }, { "id": "A2TGX5", "url": "https://www.uniprot.org/uniprot/A2TGX5", "database": "UniProtKB" }, { "id": "A2TGX5-1", "url": "https://www.uniprot.org/uniprot/A2TGX5-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MTQLASAVWPPTLLLLLLFWVPGCVPLRGPSSVTGTVGESLNVTCQYEERFKMNKKYWCRGSLVLLCKDIVRTGGSEEARNGRVSIRDDRDNLTFTVTLQNLTLEDAGTYMCAVDIPLIDHSFKVELSVVPGNIPVSSPGTTRETTVVPTSFSTKGPTQGSIPEGHHEHYEPQGLSLPVLLSVLALLLLLLVGTSLLAWRMFQKRSVKADKHPEMSQNLRQAEEQSESQYVNLQLHTLPLREEPVPPSQVEVEYSTLALPQEELHYTSVVFDSQRQNSHANGDPPCQSPDQKTEYSEIRKPREGLSDPHP", "length": 310, "header": "sp|A2TGX5-1|CLM8_RAT Isoform 1 of CMRF35-like molecule 8 OS=Rattus norvegicus OX=10116 GN=Cd300a PE=2 SV=1 CANONICAL=A2TGX5-1" }, "isoforms": [ { "isoform_ac": "A0A0G2K2W8-1", "url": "https://www.uniprot.org/uniprot/A2TGX5#A0A0G2K2W8-1", "sequence": { "sequence": "MTQLASAVWLPTLLLLLLFWVPGCVPLRGPAVKETVGESLEVELVSMKERFKMNKKWCREVTCLLCKIIVIPGGSEEARNGRVSIRNRDNLAFTSGTYLTLEDAGTYMCAVDIPLIDHSFKVELSVVPGNIPVSSPGTTRETTVVPTSFSTKGPTQGSIPEGHHEHYEPQGLSLPVLLSVLALLLLLLVGTSLLAWRMFQKRSVKADKHPEMSQNLRQAEEQSESQYVNLQLHTLPLREEPVPPSQVEVEYSTLALPQEELHYTSVVFDSQRQNSHANGDPPCQSPDQKTEYSEIRKPREGLSDPHP", "length": 307, "header": "tr|A0A0G2K2W8-1|CLM8_RAT Computationally mapped isoform of CMRF35-like molecule 8 OS=Rattus norvegicus OX=10116 GN=Cd300a PE=2 SV=1 CANONICAL=A2TGX5-1" }, "locus": { "chromosome": "10", "start_pos": 103450911, "end_pos": 103438303, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000085262", "url": "https://www.ensembl.org/id/ENSRNOT00000085262" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000072406", "url": "https://www.ensembl.org/id/ENSRNOP00000072406" } ] } }, { "isoform_ac": "A0A0G2K697-1", "url": "https://www.uniprot.org/uniprot/A2TGX5#A0A0G2K697-1", "sequence": { "sequence": "LCFPGCVPLRGPSVTETVGESLEVACQYEERFKMNKKYCRESLVLCKIIVIPGGSEEARNGRVSIRNDRDNLAFTSGTYLTLEDAGTYMCAVDIPLIDHSFKVELSVVPGNIPVSSPGTTRETTVVPTSFSTKGPTQGSIPEGHHEHYEPQGLSLPVLLSVLALLLLLLVGTSLLAWRMFQKRSVKADKHPEMSQNLRQAEEQSESQYVNLQLHTLPLREEPVPPSQVEVEYSTLALPQEELHYTSVVFDSQRQNSHANGDPPCQSPDQKTEYSEIRKPREGLSDPHP", "length": 288, "header": "tr|A0A0G2K697-1|CLM8_RAT Computationally mapped isoform of CMRF35-like molecule 8 OS=Rattus norvegicus OX=10116 GN=Cd300a PE=2 SV=1 CANONICAL=A2TGX5-1" }, "locus": { "chromosome": "10", "start_pos": 103450911, "end_pos": 103441549, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000079545", "url": "https://www.ensembl.org/id/ENSRNOT00000079545" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000073730", "url": "https://www.ensembl.org/id/ENSRNOP00000073730" } ] } }, { "isoform_ac": "A2TGX5-1", "url": "https://www.uniprot.org/uniprot/A2TGX5#A2TGX5-1", "sequence": { "sequence": "MTQLASAVWPPTLLLLLLFWVPGCVPLRGPSSVTGTVGESLNVTCQYEERFKMNKKYWCRGSLVLLCKDIVRTGGSEEARNGRVSIRDDRDNLTFTVTLQNLTLEDAGTYMCAVDIPLIDHSFKVELSVVPGNIPVSSPGTTRETTVVPTSFSTKGPTQGSIPEGHHEHYEPQGLSLPVLLSVLALLLLLLVGTSLLAWRMFQKRSVKADKHPEMSQNLRQAEEQSESQYVNLQLHTLPLREEPVPPSQVEVEYSTLALPQEELHYTSVVFDSQRQNSHANGDPPCQSPDQKTEYSEIRKPREGLSDPHP", "length": 310, "header": "sp|A2TGX5-1|CLM8_RAT Isoform 1 of CMRF35-like molecule 8 OS=Rattus norvegicus OX=10116 GN=Cd300a PE=2 SV=1 CANONICAL=A2TGX5-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 101, "start_aa": "Asn", "end_pos": 101, "end_aa": "Asn", "residue": "Asn", "evidence": [ { "id": "A2TGX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2TGX5#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 42, "start_aa": "Asn", "end_pos": 42, "end_aa": "Asn", "residue": "Asn", "evidence": [ { "id": "A2TGX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2TGX5#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 92, "start_aa": "Asn", "end_pos": 92, "end_aa": "Asn", "residue": "Asn", "evidence": [ { "id": "A2TGX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2TGX5#ptm_processing" } ] } ], "phosphorylation": [ { "start_pos": 295, "end_pos": 295, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "A2TGX5", "url": "https://www.uniprot.org/uniprot/A2TGX5" } ] } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-RNO-198933", "name": "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-198933", "resource": "Reactome", "description": "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell" }, { "id": "R-RNO-6798695", "name": "Neutrophil degranulation", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "integral component of membrane", "id": "GO:0016021", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "evidence": [ { "database": "UniProtKB", "id": "A2TGX5", "url": "https://www.uniprot.org/uniprot/A2TGX5" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A2TGX5", "url": "https://www.uniprot.org/uniprot/A2TGX5" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A2TGX5", "url": "https://www.uniprot.org/uniprot/A2TGX5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "transmembrane signaling receptor activity", "id": "GO:0004888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004888", "evidence": [ { "database": "UniProtKB", "id": "A2TGX5", "url": "https://www.uniprot.org/uniprot/A2TGX5" } ], "pmid": "21873635" }, { "name": "phosphatidylethanolamine binding", "id": "GO:0008429", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008429", "evidence": [ { "database": "UniProtKB", "id": "A2TGX5", "url": "https://www.uniprot.org/uniprot/A2TGX5" } ], "pmid": "" }, { "name": "phosphatidylserine binding", "id": "GO:0001786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001786", "evidence": [ { "database": "UniProtKB", "id": "A2TGX5", "url": "https://www.uniprot.org/uniprot/A2TGX5" } ], "pmid": "" }, { "name": "phosphatase binding", "id": "GO:0019902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019902", "evidence": [ { "database": "UniProtKB", "id": "A2TGX5", "url": "https://www.uniprot.org/uniprot/A2TGX5" } ], "pmid": "" }, { "name": "signaling receptor activity", "id": "GO:0038023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038023", "evidence": [ { "database": "UniProtKB", "id": "A2TGX5", "url": "https://www.uniprot.org/uniprot/A2TGX5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 18, "go_terms": [ { "name": "negative regulation of serotonin secretion", "id": "GO:0014063", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014063", "evidence": [ { "database": "UniProtKB", "id": "A2TGX5", "url": "https://www.uniprot.org/uniprot/A2TGX5" } ], "pmid": "" }, { "name": "positive regulation of phosphoprotein phosphatase activity", "id": "GO:0032516", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032516", "evidence": [ { "database": "UniProtKB", "id": "A2TGX5", "url": "https://www.uniprot.org/uniprot/A2TGX5" } ], "pmid": "" }, { "name": "negative regulation of fibroblast proliferation", "id": "GO:0048147", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048147", "evidence": [ { "database": "UniProtKB", "id": "A2TGX5", "url": "https://www.uniprot.org/uniprot/A2TGX5" } ], "pmid": "" }, { "name": "receptor-mediated endocytosis", "id": "GO:0006898", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006898", "evidence": [ { "database": "UniProtKB", "id": "A2TGX5", "url": "https://www.uniprot.org/uniprot/A2TGX5" } ], "pmid": "" }, { "name": "negative regulation of MAP kinase activity", "id": "GO:0043407", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043407", "evidence": [ { "database": "UniProtKB", "id": "A2TGX5", "url": "https://www.uniprot.org/uniprot/A2TGX5" } ], "pmid": "" }, { "name": "negative regulation of B cell proliferation", "id": "GO:0030889", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030889", "evidence": [ { "database": "UniProtKB", "id": "A2TGX5", "url": "https://www.uniprot.org/uniprot/A2TGX5" } ], "pmid": "" }, { "name": "negative regulation of MyD88-dependent toll-like receptor signaling pathway", "id": "GO:0034125", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034125", "evidence": [ { "database": "UniProtKB", "id": "A2TGX5", "url": "https://www.uniprot.org/uniprot/A2TGX5" } ], "pmid": "" }, { "name": "regulation of T cell receptor signaling pathway", "id": "GO:0050856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050856", "evidence": [ { "database": "UniProtKB", "id": "A2TGX5", "url": "https://www.uniprot.org/uniprot/A2TGX5" } ], "pmid": "" }, { "name": "negative regulation of mast cell activation involved in immune response", "id": "GO:0033007", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033007", "evidence": [ { "database": "UniProtKB", "id": "A2TGX5", "url": "https://www.uniprot.org/uniprot/A2TGX5" } ], "pmid": "" }, { "name": "negative regulation of mast cell degranulation", "id": "GO:0043305", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043305", "evidence": [ { "database": "UniProtKB", "id": "A2TGX5", "url": "https://www.uniprot.org/uniprot/A2TGX5" } ], "pmid": "" }, { "name": "negative regulation of B cell receptor signaling pathway", "id": "GO:0050859", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050859", "evidence": [ { "database": "UniProtKB", "id": "A2TGX5", "url": "https://www.uniprot.org/uniprot/A2TGX5" } ], "pmid": "" }, { "name": "negative regulation of NK T cell activation", "id": "GO:0051134", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051134", "evidence": [ { "database": "UniProtKB", "id": "A2TGX5", "url": "https://www.uniprot.org/uniprot/A2TGX5" } ], "pmid": "" }, { "name": "negative regulation of phagocytosis, engulfment", "id": "GO:0060101", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060101", "evidence": [ { "database": "UniProtKB", "id": "A2TGX5", "url": "https://www.uniprot.org/uniprot/A2TGX5" } ], "pmid": "" }, { "name": "negative regulation of neutrophil activation", "id": "GO:1902564", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902564", "evidence": [ { "database": "UniProtKB", "id": "A2TGX5", "url": "https://www.uniprot.org/uniprot/A2TGX5" } ], "pmid": "" }, { "name": "negative regulation of eosinophil activation", "id": "GO:1902567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902567", "evidence": [ { "database": "UniProtKB", "id": "A2TGX5", "url": "https://www.uniprot.org/uniprot/A2TGX5" } ], "pmid": "" }, { "name": "negative regulation of activation of Janus kinase activity", "id": "GO:1902569", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902569", "evidence": [ { "database": "UniProtKB", "id": "A2TGX5", "url": "https://www.uniprot.org/uniprot/A2TGX5" } ], "pmid": "" }, { "name": "negative regulation of eosinophil migration", "id": "GO:2000417", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000417", "evidence": [ { "database": "UniProtKB", "id": "A2TGX5", "url": "https://www.uniprot.org/uniprot/A2TGX5" } ], "pmid": "" }, { "name": "serotonin secretion by mast cell", "id": "GO:0002552", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002552", "evidence": [ { "database": "UniProtKB", "id": "A2TGX5", "url": "https://www.uniprot.org/uniprot/A2TGX5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 101, "end_pos": 103, "annotation": "n_glycosylation_sequon" }, { "start_pos": 42, "end_pos": 44, "annotation": "n_glycosylation_sequon" }, { "start_pos": 92, "end_pos": 94, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "N-glycosylated.", "evidence": [ { "database": "UniProtKB", "id": "A2TGX5", "url": "https://www.uniprot.org/uniprot/A2TGX5" }, { "database": "PubMed", "id": "Q6SJQ0", "url": "https://glygen.org/publication/PubMed/Q6SJQ0" } ] }, { "annotation": "Phosphorylated on tyrosine.", "evidence": [ { "database": "UniProtKB", "id": "A2TGX5", "url": "https://www.uniprot.org/uniprot/A2TGX5" }, { "database": "PubMed", "id": "Q6SJQ0", "url": "https://glygen.org/publication/PubMed/Q6SJQ0" } ] } ], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ] }