{ "uniprot_canonical_ac": "A2RT62-1", "uniprot_ac": "A2RT62", "uniprot_id": "FXL16_MOUSE", "mass": { "chemical_mass": 51878.0, "monoisotopic_mass": 51878.0 }, "refseq": { "ac": "NP_001157697", "name": "F-box/LRR-repeat protein 16 isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157697" }, "gene_names": [ { "name": "Fbxl16", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2RT62", "id": "A2RT62" }, { "name": "BC042620; Scirr1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157697", "id": "NP_001157697" }, { "name": "Fbxl16", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157697", "id": "NP_001157697" } ], "protein_names": [ { "name": "F-box/LRR-repeat protein 16", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2RT62#names_and_taxonomy", "id": "A2RT62" }, { "name": "F-box and leucine-rich repeat protein 16", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2RT62#names_and_taxonomy", "id": "A2RT62" }, { "name": "F-box/LRR-repeat protein 16 isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157697", "id": "NP_001157697" }, { "name": "F-box/LRR-repeat protein 16", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157697", "id": "NP_001157697" } ], "function": [ { "annotation": "FBXL16 negatively regulates the activity of B55alpha-PP2A to modulate the genesis of FLK1+ progenitor cells.", "evidence": [ { "database": "RefSeq", "id": "NP_001157697", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157697" }, { "database": "PubMed", "id": "24390425", "url": "https://glygen.org/publication/PubMed/24390425" } ] }, { "annotation": "SCIRR1 ise involved in the succeeding injury and/or repair processes of the injured spinal cord.", "evidence": [ { "database": "RefSeq", "id": "NP_001157697", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157697" }, { "database": "PubMed", "id": "17603280", "url": "https://glygen.org/publication/PubMed/17603280" } ] }, { "annotation": "Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.", "evidence": [ { "database": "UniProtKB", "id": "A2RT62", "url": "https://www.uniprot.org/uniprot/A2RT62#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A2RT62", "url": "https://www.uniprot.org/uniprot/A2RT62" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Fbxl16", "url": "https://www.uniprot.org/uniprot/A2RT62", "locus": { "chromosome": "17", "start_pos": 25809085, "end_pos": 25821244, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000025738", "url": "https://www.ensembl.org/id/ENSMUSG00000025738" } ] } } ], "crossref": [ { "id": "ENSMUSG00000025738", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000025738", "database": "Bgee" }, { "id": "214931", "url": "https://www.ncbi.nlm.nih.gov/gene/214931", "database": "GeneID" }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro" }, { "id": "IPR006553", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006553", "database": "InterPro" }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro" }, { "id": "IPR036047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036047", "database": "InterPro" }, { "id": "mmu:214931", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:214931", "database": "KEGG Pathway" }, { "id": "2448488", "url": "http://www.informatics.jax.org/marker/MGI:2448488", "database": "MGI" }, { "id": "FWAGLMP", "url": "https://omabrowser.org/oma/group/FWAGLMP/", "database": "OMA" }, { "id": "1282076at2759", "url": "http://www.orthodb.org/?query=1282076at2759", "database": "OrthoDB" }, { "id": "PF13516", "url": "http://pfam.xfam.org/family/PF13516", "database": "Pfam" }, { "id": "PR_A2RT62", "url": "http://purl.obolibrary.org/obo/PR_A2RT62", "database": "PRO" }, { "id": "R-MMU-8951664", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8951664", "database": "Reactome" }, { "id": "R-MMU-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983168", "database": "Reactome" }, { "id": "NP_001157697", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157697", "database": "RefSeq" }, { "id": "A0A494B9I8", "url": "https://www.uniprot.org/uniprot/A0A494B9I8", "database": "UniProtKB" }, { "id": "A0A494B9I8-1", "url": "https://www.uniprot.org/uniprot/A0A494B9I8-1", "database": "UniProtKB" }, { "id": "A2RT62", "url": "https://www.uniprot.org/uniprot/A2RT62", "database": "UniProtKB" }, { "id": "A2RT62-1", "url": "https://www.uniprot.org/uniprot/A2RT62-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MSSPGIDGDPKPPCLPRNGLVKLPGQPNGLGAASITKGTPAAKNRPCQPPPPPTLPPPSLATPLSRVALAGGPCPPASGPASGPVSGPPVERPPLATDEKILNGLFWYFSACEKCILAQVCKAWRRVLYQPKFWAGLTPVLHAKELYNVLPGGEKEFVNLQGFAARGFEGFCLVGVSDLDICEFIDNYSLSKKGVKAMSLKRSTITDAGLEVMLEQMQGVVRLELSGCNDFTEAGLWSSLSARITSLSVSDCINVADDAIAAISQLLPNLAELSLQAYHVTDTALAYFTARQGHSTHTLRLLSCWEITNHGVVNVVHSLPNLTSLSLSGCSKVTDDGVELVAENLRKLRSLDLSWCPRITDMALEYVACDLHRLEELVLDRCVRITDTGLSYLSTMSSLRSLYLRWCCQVQDFGLKHLLAMRNLRLLSLAGCPLLTTTGLSGLVQLQELEELELTNCPGATPELFKYFSQHLPRCLVIE", "length": 479, "header": "sp|A2RT62-1|FXL16_MOUSE Isoform 1 of F-box/LRR-repeat protein 16 OS=Mus musculus OX=10090 GN=Fbxl16 PE=1 SV=1 CANONICAL=A2RT62-1" }, "isoforms": [ { "isoform_ac": "A0A494B9I8-1", "url": "https://www.uniprot.org/uniprot/A2RT62#A0A494B9I8-1", "sequence": { "sequence": "XELVAENLRKLRSLDLSWCPRITDMALEYVACDLHRLEELVLDSLYLRWCCQVQDFGLKHLLAMRNLRLLSLAGCPLLTTTGLSGLVQLQELEELELTNCPGATPELFKYFSQHLPRCLVIE", "length": 122, "header": "tr|A0A494B9I8-1|A0A494B9I8_MOUSE Computationally mapped isoform of F-box/LRR-repeat protein 16 OS=Mus musculus OX=10090 GN=Fbxl16 PE=1 SV=1 CANONICAL=A2RT62-1" }, "locus": { "chromosome": "17", "start_pos": 26038494, "end_pos": 26037033, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000235694", "url": "https://www.ensembl.org/id/ENSMUST00000235694" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000157669", "url": "https://www.ensembl.org/id/ENSMUSP00000157669" } ] } }, { "isoform_ac": "A2RT62-1", "url": "https://www.uniprot.org/uniprot/A2RT62#A2RT62-1", "sequence": { "sequence": "MSSPGIDGDPKPPCLPRNGLVKLPGQPNGLGAASITKGTPAAKNRPCQPPPPPTLPPPSLATPLSRVALAGGPCPPASGPASGPVSGPPVERPPLATDEKILNGLFWYFSACEKCILAQVCKAWRRVLYQPKFWAGLTPVLHAKELYNVLPGGEKEFVNLQGFAARGFEGFCLVGVSDLDICEFIDNYSLSKKGVKAMSLKRSTITDAGLEVMLEQMQGVVRLELSGCNDFTEAGLWSSLSARITSLSVSDCINVADDAIAAISQLLPNLAELSLQAYHVTDTALAYFTARQGHSTHTLRLLSCWEITNHGVVNVVHSLPNLTSLSLSGCSKVTDDGVELVAENLRKLRSLDLSWCPRITDMALEYVACDLHRLEELVLDRCVRITDTGLSYLSTMSSLRSLYLRWCCQVQDFGLKHLLAMRNLRLLSLAGCPLLTTTGLSGLVQLQELEELELTNCPGATPELFKYFSQHLPRCLVIE", "length": 479, "header": "sp|A2RT62-1|FXL16_MOUSE Isoform 1 of F-box/LRR-repeat protein 16 OS=Mus musculus OX=10090 GN=Fbxl16 PE=1 SV=1 CANONICAL=A2RT62-1" }, "locus": { "chromosome": "17", "start_pos": 26038493, "end_pos": 26035405, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000045692", "url": "https://www.ensembl.org/id/ENSMUST00000045692" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000048562", "url": "https://www.ensembl.org/id/ENSMUSP00000048562" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Identification and characterization of scirr1, a novel gene up-regulated after spinal cord injury.", "journal": "Experimental & molecular medicine", "date": "2007", "authors": "Liu T, Ma Z, Que H, Li X, Ni Y, Jing S, Liu S", "evidence": [ { "database": "RefSeq", "id": "NP_001157697", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157697" } ], "reference": [ { "type": "PubMed", "id": "17603280", "url": "https://glygen.org/publication/PubMed/17603280" } ] }, { "title": "Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.", "journal": "Mol. Cell. Proteomics", "date": "2014", "authors": "Beausoleil S.A., Wang Y., Zhou J., Comb M.J., Guo A., Lee K.A., Aguiar M., Bedford M.T., Gu H., Jia X., Kornhauser J., Mulhern D., Ren J., Silva J.C., Vemulapalli V., Yang V.", "evidence": [ { "database": "UniProtKB", "id": "A2RT62", "url": "https://www.uniprot.org/uniprot/A2RT62" } ], "reference": [ { "type": "PubMed", "id": "24129315", "url": "https://glygen.org/publication/PubMed/24129315" } ] }, { "title": "F-box protein FBXL16 binds PP2A-B55alpha and regulates differentiation of embryonic stem cells along the FLK1+ lineage.", "journal": "Molecular & cellular proteomics : MCP", "date": "2014", "authors": "Honarpour N, Rose CM, Brumbaugh J, Anderson J, Graham RL, Sweredoski MJ, Hess S, Coon JJ, Deshaies RJ", "evidence": [ { "database": "RefSeq", "id": "NP_001157697", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157697" } ], "reference": [ { "type": "PubMed", "id": "24390425", "url": "https://glygen.org/publication/PubMed/24390425" } ] } ], "pathway": [ { "id": "mmu:214931", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:214931", "resource": "KEGG Pathway" }, { "id": "R-MMU-8951664", "name": "Neddylation", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8951664", "resource": "Reactome", "description": "Neddylation" }, { "id": "R-MMU-983168", "name": "Antigen processing: Ubiquitination & Proteasome degradation", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "Q5MJ12-1", "protein_name": "F-box/LRR-repeat protein 16", "gene_name": "Fbxl16", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSSPGIDGDPKPSCLPRNGLVKLPGQPNGLGAASITKGTPAAKNRPCQPPPPPTLPPPSLATPLSRVALAGGPCPPASGPASGPVPGPPVERPPLATDEKILNGLFWYFSACEKCILAQVCKAWRRVLYQPKFWAGLTPVLHAKELYNVLPGGEKEFVNLQGFAARGFEGFCLVGVSDLDICEFIDNYSLSKKGVKAMSLKRSTITDAGLEVMLEQMQGVVRLELSGCNDFTEAGLWSSLSARITSLSVSDCINVADDAIAAISQLLPNLAELSLQAYHVTDTALAYFTARQGHSTHTLRLLSCWEITNHGVVNVVHSLPNLTSLSLSGCSKVTDDGVELVAENLRKLRSLDLSWCPRITDMALEYVACDLHRLEELVLDRCVRITDTGLSYLSTMSSLRSLYLRWCCQVQDFGLKHLLAMRSLRLLSLAGCPLLTTTGLSGLVQLQELEELELTNCPGATPELFKYFSQHLPRCLVIE", "length": 479 }, "evidence": [ { "id": "17732", "url": "http://www.informatics.jax.org/homology/17732", "database": "MGI" }, { "id": "A2RT62", "url": "https://omabrowser.org/oma/group/A2RT62/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8N461-1", "protein_name": "F-box/LRR-repeat protein 16", "gene_name": "FBXL16", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSSPGIDGDPKPPCLPRNGLVKLPGQPNGLGAASITKGTPATKNRPCQPPPPPTLPPPSLAAPLSRAALAGGPCTPAGGPASALAPGHPAERPPLATDEKILNGLFWYFSACEKCVLAQVCKAWRRVLYQPKFWAGLTPVLHAKELYNVLPGGEKEFVNLQGFAARGFEGFCLVGVSDLDICEFIDNYALSKKGVKAMSLKRSTITDAGLEVMLEQMQGVVRLELSGCNDFTEAGLWSSLSARITSLSVSDCINVADDAIAAISQLLPNLAELSLQAYHVTDTALAYFTARQGHSTHTLRLLSCWEITNHGVVNVVHSLPNLTALSLSGCSKVTDDGVELVAENLRKLRSLDLSWCPRITDMALEYVACDLHRLEELVLDRCVRITDTGLSYLSTMSSLRSLYLRWCCQVQDFGLKHLLALGSLRLLSLAGCPLLTTTGLSGLVQLQELEELELTNCPGATPELFKYFSQHLPRCLVIE", "length": 479 }, "evidence": [ { "id": "17732", "url": "http://www.informatics.jax.org/homology/17732", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A2RT62", "url": "https://www.uniprot.org/uniprot/A2RT62" } ], "pmid": "" }, { "name": "SCF ubiquitin ligase complex", "id": "GO:0019005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019005", "evidence": [ { "database": "UniProtKB", "id": "A2RT62", "url": "https://www.uniprot.org/uniprot/A2RT62" } ], "pmid": "21873635" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "id": "GO:0031146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031146", "evidence": [ { "database": "UniProtKB", "id": "A2RT62", "url": "https://www.uniprot.org/uniprot/A2RT62" } ], "pmid": "21873635" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 187, "end_pos": 189, "annotation": "n_glycosylation_sequon" }, { "start_pos": 321, "end_pos": 323, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ] }