{
    "uniprot_canonical_ac": "A2RT60-1",
    "uniprot_ac": "A2RT60",
    "uniprot_id": "HTRA4_MOUSE",
    "mass": {
        "chemical_mass": 51988.0,
        "monoisotopic_mass": 51988.0
    },
    "refseq": {
        "ac": "NP_001074656",
        "name": "serine protease HTRA4 precursor",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074656"
    },
    "gene_names": [
        {
            "name": "Htra4",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2RT60",
            "id": "A2RT60"
        },
        {
            "name": "B430206E18Rik",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074656",
            "id": "NP_001074656"
        },
        {
            "name": "Htra4",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074656",
            "id": "NP_001074656"
        }
    ],
    "protein_names": [
        {
            "name": "Serine protease HTRA4",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2RT60#names_and_taxonomy",
            "id": "A2RT60"
        },
        {
            "name": "3.4.21.-",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2RT60#names_and_taxonomy",
            "id": "A2RT60"
        },
        {
            "name": "High-temperature requirement factor A4",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2RT60#names_and_taxonomy",
            "id": "A2RT60"
        },
        {
            "name": "high-temperature requirement factor A4; serine protease HTRA4",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074656",
            "id": "NP_001074656"
        },
        {
            "name": "serine protease HTRA4 precursor",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074656",
            "id": "NP_001074656"
        }
    ],
    "function": [
        {
            "annotation": "Mice, featuring a conditional null allele of HtrA4, may provide a valuable tool to investigate the role of HtrA4 in development and pathogenesis of coronary heart disease and preeclampsia.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001074656",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074656"
                },
                {
                    "database": "PubMed",
                    "id": "26353049",
                    "url": "https://glygen.org/publication/PubMed/26353049"
                }
            ]
        },
        {
            "annotation": "Serine protease.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2RT60",
                    "url": "https://www.uniprot.org/uniprot/A2RT60#function"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2RT60",
                    "url": "https://www.uniprot.org/uniprot/A2RT60"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Htra4",
            "url": "https://www.uniprot.org/uniprot/A2RT60",
            "locus": {
                "chromosome": "8",
                "start_pos": 25038962,
                "end_pos": 25024929,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000037406",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000037406"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000037406",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000037406",
            "database": "Bgee"
        },
        {
            "id": "330723",
            "url": "https://www.ncbi.nlm.nih.gov/gene/330723",
            "database": "GeneID"
        },
        {
            "id": "IPR000867",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000867",
            "database": "InterPro"
        },
        {
            "id": "IPR001478",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001478",
            "database": "InterPro"
        },
        {
            "id": "IPR001940",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001940",
            "database": "InterPro"
        },
        {
            "id": "IPR002350",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR002350",
            "database": "InterPro"
        },
        {
            "id": "IPR009003",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR009003",
            "database": "InterPro"
        },
        {
            "id": "IPR009030",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR009030",
            "database": "InterPro"
        },
        {
            "id": "IPR036034",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036034",
            "database": "InterPro"
        },
        {
            "id": "IPR036058",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036058",
            "database": "InterPro"
        },
        {
            "id": "IPR041489",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR041489",
            "database": "InterPro"
        },
        {
            "id": "mmu:330723",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:330723",
            "database": "KEGG Pathway"
        },
        {
            "id": "3036260",
            "url": "http://www.informatics.jax.org/marker/MGI:3036260",
            "database": "MGI"
        },
        {
            "id": "NQQWIEV",
            "url": "https://omabrowser.org/oma/group/NQQWIEV/",
            "database": "OMA"
        },
        {
            "id": "630723at2759",
            "url": "http://www.orthodb.org/?query=630723at2759",
            "database": "OrthoDB"
        },
        {
            "id": "PF00219",
            "url": "http://pfam.xfam.org/family/PF00219",
            "database": "Pfam"
        },
        {
            "id": "PF07648",
            "url": "http://pfam.xfam.org/family/PF07648",
            "database": "Pfam"
        },
        {
            "id": "PF17820",
            "url": "http://pfam.xfam.org/family/PF17820",
            "database": "Pfam"
        },
        {
            "id": "PR_A2RT60",
            "url": "http://purl.obolibrary.org/obo/PR_A2RT60",
            "database": "PRO"
        },
        {
            "id": "NP_001074656",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074656",
            "database": "RefSeq"
        },
        {
            "id": "A2RT60",
            "url": "https://www.uniprot.org/uniprot/A2RT60",
            "database": "UniProtKB"
        },
        {
            "id": "A2RT60-1",
            "url": "https://www.uniprot.org/uniprot/A2RT60-1",
            "database": "UniProtKB"
        }
    ],
    "sequence": {
        "sequence": "MSFQRLWAVRTQFLLLWLLLPAVPVPWAEARRSRVSLPCPDACDPTRCPTLPTCSAGLAPVPDRCGCCRVCAAAEGQECGGARGRPCAPRLRCGAPFSRDPSGGAWLGTCGCAEGAEDAVVCGSDGRTYPSLCALRKENRAARQRGALPAVPVQKGACEEAGTTRAGRLRRKYNFIAAVVEKVAPSVVHLQLFRRSPLTNQEIPSSSGSGFIVSEDGLIVTNAHVLTNQQKIQVELQSGARYEATVKDIDHKLDLALIKIEPDTELPVLLLGRSSDLRAGEFVVALGSPFSLQNTVTAGIVSTTQRGGRELGLKNSDIDYIQTDAIINHGNSGGPLVNLDGDVIGINTLKVTAGISFAIPSDRIRQFLEDYHERQLKGKAPLQKKYLGLRMLPLTLNLLQEMKRQDPEFPDVSSGVFVYEVIQGSAAASSGLRDHDVIVSINGQPVTTTTDVIEAVKDNDFLSIIVLRGSQTLFLTVTPEIIN",
        "length": 483,
        "header": "sp|A2RT60-1|HTRA4_MOUSE Isoform 1 of Serine protease HTRA4  OS=Mus musculus OX=10090 GN=Htra4 PE=2 SV=1 CANONICAL=A2RT60-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A2RT60-1",
            "url": "https://www.uniprot.org/uniprot/A2RT60#A2RT60-1",
            "sequence": {
                "sequence": "MSFQRLWAVRTQFLLLWLLLPAVPVPWAEARRSRVSLPCPDACDPTRCPTLPTCSAGLAPVPDRCGCCRVCAAAEGQECGGARGRPCAPRLRCGAPFSRDPSGGAWLGTCGCAEGAEDAVVCGSDGRTYPSLCALRKENRAARQRGALPAVPVQKGACEEAGTTRAGRLRRKYNFIAAVVEKVAPSVVHLQLFRRSPLTNQEIPSSSGSGFIVSEDGLIVTNAHVLTNQQKIQVELQSGARYEATVKDIDHKLDLALIKIEPDTELPVLLLGRSSDLRAGEFVVALGSPFSLQNTVTAGIVSTTQRGGRELGLKNSDIDYIQTDAIINHGNSGGPLVNLDGDVIGINTLKVTAGISFAIPSDRIRQFLEDYHERQLKGKAPLQKKYLGLRMLPLTLNLLQEMKRQDPEFPDVSSGVFVYEVIQGSAAASSGLRDHDVIVSINGQPVTTTTDVIEAVKDNDFLSIIVLRGSQTLFLTVTPEIIN",
                "length": 483,
                "header": "sp|A2RT60-1|HTRA4_MOUSE Isoform 1 of Serine protease HTRA4  OS=Mus musculus OX=10090 GN=Htra4 PE=2 SV=1 CANONICAL=A2RT60-1"
            },
            "locus": {
                "chromosome": "8",
                "start_pos": 25528890,
                "end_pos": 25515588,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000084031",
                        "url": "https://www.ensembl.org/id/ENSMUST00000084031"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000081044",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000081044"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [
        "enzyme"
    ],
    "publication": [
        {
            "title": "Generation and characterization of mice with a conditional null allele of the HtrA4 gene.",
            "journal": "Molecular medicine reports",
            "date": "2015",
            "authors": "Liu J, Li Y, Hoh J",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001074656",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074656"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "26353049",
                    "url": "https://glygen.org/publication/PubMed/26353049"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:330723",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:330723",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "D3ZKF5-1",
            "protein_name": "Serine protease HTR4",
            "gene_name": "Htra4",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MSRSKMSSQRLWAVRAQFLLLWLLLWAAPVPWAEARRSRVSLPCPDACDPTRCPPLPSCSAGSALVPDRCGCCQVCAAVEGQECGGARGRPCVPGLRCGAPFSREPSGRAWLGTCGCAEGAEGAAVCGSDGRTYPSLCALRKENRAARQRGALPAVPVQKGACGDSGTTRAGRLRTKYNFIAAVVEKVAPSVVHLQLFRRSPLTNQEIPSSSGSGFIVSEDGLIVTNAHVLTNQQKIQVELQNGAQYEATVKDIDHKLDLALIKIEPDTDLPVLLLGRSSDLRAGEFVVALGSPFSLQNTVTAGIVSTTQRGGKELGLKDSDIDYIQTDAIINHGNSGGPLVNLDGDVIGINTLKVTAGISFAIPSDRIRQFLADYHERQLKGKAPLQKKYLGLRMLPLTLNLLQEMKRQDPDFPDVSSGVFVYEVIQGSAAASSGLRDHDVIVSINGQPVTTTTDVIEAVKDNAFLSIIVLRGSQTLFLTVTPEIIN",
                "length": 488
            },
            "evidence": [
                {
                    "id": "17801",
                    "url": "http://www.informatics.jax.org/homology/17801",
                    "database": "MGI"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "P83105-1",
            "protein_name": "Serine protease HTRA4",
            "gene_name": "HTRA4",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MIRPQLRTAGLGRCLLPGLLLLLVPVLWAGAEKLHTQPSCPAVCQPTRCPALPTCALGTTPVFDLCRCCRVCPAAEREVCGGAQGQPCAPGLQCLQPLRPGFPSTCGCPTLGGAVCGSDRRTYPSMCALRAENRAARRLGKVPAVPVQWGNCGDTGTRSAGPLRRNYNFIAAVVEKVAPSVVHVQLWGRLLHGSRLVPVYSGSGFIVSEDGLIITNAHVVRNQQWIEVVLQNGARYEAVVKDIDLKLDLAVIKIESNAELPVLMLGRSSDLRAGEFVVALGSPFSLQNTATAGIVSTKQRGGKELGMKDSDMDYVQIDATINYGNSGGPLVNLDGDVIGVNSLRVTDGISFAIPSDRVRQFLAEYHEHQMKGKAFSNKKYLGLQMLSLTVPLSEELKMHYPDFPDVSSGVYVCKVVEGTAAQSSGLRDHDVIVNINGKPITTTTDVVKALDSDSLSMAVLRGKDNLLLTVIPETIN",
                "length": 476
            },
            "evidence": [
                {
                    "id": "17801",
                    "url": "http://www.informatics.jax.org/homology/17801",
                    "database": "MGI"
                },
                {
                    "id": "A2RT60",
                    "url": "https://omabrowser.org/oma/group/A2RT60/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Molecular Function",
                "total": 4,
                "go_terms": [
                    {
                        "name": "endopeptidase activity",
                        "id": "GO:0004175",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004175",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2RT60",
                                "url": "https://www.uniprot.org/uniprot/A2RT60"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "serine-type endopeptidase activity",
                        "id": "GO:0004252",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2RT60",
                                "url": "https://www.uniprot.org/uniprot/A2RT60"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "identical protein binding",
                        "id": "GO:0042802",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2RT60",
                                "url": "https://www.uniprot.org/uniprot/A2RT60"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "insulin-like growth factor binding",
                        "id": "GO:0005520",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005520",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2RT60",
                                "url": "https://www.uniprot.org/uniprot/A2RT60"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 1,
                "go_terms": [
                    {
                        "name": "extracellular region",
                        "id": "GO:0005576",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2RT60",
                                "url": "https://www.uniprot.org/uniprot/A2RT60"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 1,
                "go_terms": [
                    {
                        "name": "proteolysis",
                        "id": "GO:0006508",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2RT60",
                                "url": "https://www.uniprot.org/uniprot/A2RT60"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        },
        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
        }
    ]
}