{
    "uniprot_canonical_ac": "A2RSX7-1",
    "uniprot_ac": "A2RSX7",
    "uniprot_id": "TYW5_MOUSE",
    "mass": {
        "chemical_mass": 36633.0,
        "monoisotopic_mass": 36633.0
    },
    "refseq": {
        "ac": "NP_001032831",
        "name": "tRNA wybutosine-synthesizing protein 5 isoform 1",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032831"
    },
    "gene_names": [
        {
            "name": "Tyw5",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2RSX7",
            "id": "A2RSX7"
        },
        {
            "name": "1110034B05Rik",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032831",
            "id": "NP_001032831"
        },
        {
            "name": "1110034B05Rik",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2RSX7",
            "id": "A2RSX7"
        },
        {
            "name": "Tyw5",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032831",
            "id": "NP_001032831"
        }
    ],
    "protein_names": [
        {
            "name": "tRNA wybutosine-synthesizing protein 5",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2RSX7#names_and_taxonomy",
            "id": "A2RSX7"
        },
        {
            "name": "1.14.11.42",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2RSX7#names_and_taxonomy",
            "id": "A2RSX7"
        },
        {
            "name": "jmjC domain-containing protein C2orf60 homolog; tRNA yW-synthesizing enzyme 5; tRNA wybutosine-synthesizing protein 5; tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032831",
            "id": "NP_001032831"
        },
        {
            "name": "tRNA wybutosine-synthesizing protein 5 isoform 1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032831",
            "id": "NP_001032831"
        },
        {
            "name": "tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2RSX7#names_and_taxonomy",
            "id": "A2RSX7"
        }
    ],
    "function": [
        {
            "annotation": "tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2RSX7",
                    "url": "https://www.uniprot.org/uniprot/A2RSX7#function"
                },
                {
                    "database": "PubMed",
                    "id": "A2RUC4",
                    "url": "https://glygen.org/publication/PubMed/A2RUC4"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2RSX7",
                    "url": "https://www.uniprot.org/uniprot/A2RSX7"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Tyw5",
            "url": "https://www.uniprot.org/uniprot/A2RSX7",
            "locus": {
                "chromosome": "1",
                "start_pos": 57407101,
                "end_pos": 57388237,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000048495",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000048495"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000048495",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000048495",
            "database": "Bgee"
        },
        {
            "id": "68736",
            "url": "https://www.ncbi.nlm.nih.gov/gene/68736",
            "database": "GeneID"
        },
        {
            "id": "IPR003347",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR003347",
            "database": "InterPro"
        },
        {
            "id": "IPR029612",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR029612",
            "database": "InterPro"
        },
        {
            "id": "IPR041667",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR041667",
            "database": "InterPro"
        },
        {
            "id": "mmu:68736",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:68736",
            "database": "KEGG Pathway"
        },
        {
            "id": "1915986",
            "url": "http://www.informatics.jax.org/marker/MGI:1915986",
            "database": "MGI"
        },
        {
            "id": "PLYDDRP",
            "url": "https://omabrowser.org/oma/group/PLYDDRP/",
            "database": "OMA"
        },
        {
            "id": "1385616at2759",
            "url": "http://www.orthodb.org/?query=1385616at2759",
            "database": "OrthoDB"
        },
        {
            "id": "PTHR12461:SF50",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12461:SF50",
            "database": "PANTHER"
        },
        {
            "id": "PF13621",
            "url": "http://pfam.xfam.org/family/PF13621",
            "database": "Pfam"
        },
        {
            "id": "PR_A2RSX7",
            "url": "http://purl.obolibrary.org/obo/PR_A2RSX7",
            "database": "PRO"
        },
        {
            "id": "NP_001032831",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032831",
            "database": "RefSeq"
        },
        {
            "id": "37899",
            "url": "https://www.rhea-db.org/rhea/37899",
            "database": "Rhea"
        },
        {
            "id": "A2RSX7",
            "url": "https://www.uniprot.org/uniprot/A2RSX7",
            "database": "UniProtKB"
        },
        {
            "id": "A2RSX7-1",
            "url": "https://www.uniprot.org/uniprot/A2RSX7-1",
            "database": "UniProtKB"
        },
        {
            "id": "A2RSX7-2",
            "url": "https://www.uniprot.org/uniprot/A2RSX7-2",
            "database": "UniProtKB"
        },
        {
            "id": "E0CZH0",
            "url": "https://www.uniprot.org/uniprot/E0CZH0",
            "database": "UniProtKB"
        },
        {
            "id": "E0CZH0-1",
            "url": "https://www.uniprot.org/uniprot/E0CZH0-1",
            "database": "UniProtKB"
        },
        {
            "id": "G3UW53",
            "url": "https://www.uniprot.org/uniprot/G3UW53",
            "database": "UniProtKB"
        },
        {
            "id": "G3UW53-1",
            "url": "https://www.uniprot.org/uniprot/G3UW53-1",
            "database": "UniProtKB"
        }
    ],
    "sequence": {
        "sequence": "MAEQRLPVPRLRGVSREQFMEHLYPQRKPLVLEGLDLGSCTSKWTVDYLSQVGGTKEVKIHVAAVPQMDFISKNFVYRTLPFNKLVQRAAEETHKEFFISEDEKYYLRSLGEDPRKDVADIRQQFPSLGGDITFPMFFREEQFFSSVFRISSPGLQLWTHYDVMDNFLIQVTGKKRITLFNPRDAQYLYLSGSKSEVLNIDSPDLDKYPLFPKARRYECSLEAGDVLFIPALWFHNVVSEEFGVGVNIFWKHLPSECYDTTDTYGNKDPVAASRAVQILDRALKTLAELPEEYRDFYARQMVLRIQDKAYSKNFE",
        "length": 315,
        "header": "sp|A2RSX7-1|TYW5_MOUSE Isoform 1 of tRNA wybutosine-synthesizing protein 5  OS=Mus musculus OX=10090 GN=Tyw5 PE=2 SV=2 CANONICAL=A2RSX7-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A2RSX7-1",
            "url": "https://www.uniprot.org/uniprot/A2RSX7#A2RSX7-1",
            "sequence": {
                "sequence": "MAEQRLPVPRLRGVSREQFMEHLYPQRKPLVLEGLDLGSCTSKWTVDYLSQVGGTKEVKIHVAAVPQMDFISKNFVYRTLPFNKLVQRAAEETHKEFFISEDEKYYLRSLGEDPRKDVADIRQQFPSLGGDITFPMFFREEQFFSSVFRISSPGLQLWTHYDVMDNFLIQVTGKKRITLFNPRDAQYLYLSGSKSEVLNIDSPDLDKYPLFPKARRYECSLEAGDVLFIPALWFHNVVSEEFGVGVNIFWKHLPSECYDTTDTYGNKDPVAASRAVQILDRALKTLAELPEEYRDFYARQMVLRIQDKAYSKNFE",
                "length": 315,
                "header": "sp|A2RSX7-1|TYW5_MOUSE Isoform 1 of tRNA wybutosine-synthesizing protein 5  OS=Mus musculus OX=10090 GN=Tyw5 PE=2 SV=2 CANONICAL=A2RSX7-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 57445620,
                "end_pos": 57427658,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000162686",
                        "url": "https://www.ensembl.org/id/ENSMUST00000162686"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000125427",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000125427"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A2RSX7-2",
            "url": "https://www.uniprot.org/uniprot/A2RSX7#A2RSX7-2",
            "sequence": {
                "sequence": "MAEQRLPVPRLRGVSREQFMEHLYPQRKPLVLEGLDLGSCTSKWTVDYLSQVGGTKEVKIHVAAVPQMDFIKLYLLTSWSREQPKKHIKNSSFQRMRNTTYGHLEKTQGRMLQTSDSSSHH",
                "length": 121,
                "header": "sp|A2RSX7-2|TYW5_MOUSE Isoform 2 of tRNA wybutosine-synthesizing protein 5  OS=Mus musculus OX=10090 GN=Tyw5 PE=2 SV=2 CANONICAL=A2RSX7-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 57445620,
                "end_pos": 57432613,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000079998",
                        "url": "https://www.ensembl.org/id/ENSMUST00000079998"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000078912",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000078912"
                    }
                ]
            }
        },
        {
            "isoform_ac": "E0CZH0-1",
            "url": "https://www.uniprot.org/uniprot/A2RSX7#E0CZH0-1",
            "sequence": {
                "sequence": "MAEQRLPVPRLRGVSREQFMEHLYPQRKPLVLEGLDLGSCTSKWTVDYLSQVGGTKEVKIHVAAVPQMDFIKLYLLTSWSREQPKKHIKNSSFQRMRNTTYGHLEKTQGSRKNSFTGKVGCCCWAFPIIGL",
                "length": 131,
                "header": "tr|E0CZH0-1|E0CZH0_MOUSE Computationally mapped isoform of tRNA wybutosine-synthesizing protein 5  OS=Mus musculus OX=10090 GN=Tyw5 PE=1 SV=1 CANONICAL=A2RSX7-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 57445620,
                "end_pos": 57432790,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000160118",
                        "url": "https://www.ensembl.org/id/ENSMUST00000160118"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000125386",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000125386"
                    }
                ]
            }
        },
        {
            "isoform_ac": "G3UW53-1",
            "url": "https://www.uniprot.org/uniprot/A2RSX7#G3UW53-1",
            "sequence": {
                "sequence": "PVPRLRGVSREQFMEHLYPQRKPLVLEGLDLGSCTSKWTVDYLSQVGGTKEVKIHVAAVPQMDFIKLYLLTSWSREQPKKHIKNSSFQRMRNTTYGHLEKTQGSRKNSFTGKDVADIRQQFPSLGGDITFPMFFREEQFFSSVFRISSPGLQLWTHYDVMDNFLIQVTGKKRITLFNPRDAQYLYLSGSKSEVLNIDSPDLDKYPLFPKARRYECSLEAGDVLFIPALWFHNVVSEEFGVGVNIFWKHLPSECYD",
                "length": 255,
                "header": "tr|G3UW53-1|TYW5_MOUSE Computationally mapped isoform of tRNA wybutosine-synthesizing protein 5  OS=Mus musculus OX=10090 GN=Tyw5 PE=2 SV=1 CANONICAL=A2RSX7-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 57445602,
                "end_pos": 57427826,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000160837",
                        "url": "https://www.ensembl.org/id/ENSMUST00000160837"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000128576",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000128576"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [
        "enzyme"
    ],
    "publication": [],
    "pathway": [
        {
            "id": "mmu:68736",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:68736",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "A2RUC4-1",
            "protein_name": "tRNA wybutosine-synthesizing protein 5",
            "gene_name": "TYW5",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MAGQHLPVPRLEGVSREQFMQHLYPQRKPLVLEGIDLGPCTSKWTVDYLSQVGGKKEVKIHVAAVAQMDFISKNFVYRTLPFDQLVQRAAEEKHKEFFVSEDEKYYLRSLGEDPRKDVADIRKQFPLLKGDIKFPEFFKEEQFFSSVFRISSPGLQLWTHYDVMDNLLIQVTGKKRVVLFSPRDAQYLYLKGTKSEVLNIDNPDLAKYPLFSKARRYECSLEAGDVLFIPALWFHNVISEEFGVGVNIFWKHLPSECYDKTDTYGNKDPTAASRAAQILDRALKTLAELPEEYRDFYARRMVLHIQDKAYSKNSE",
                "length": 315
            },
            "evidence": [
                {
                    "id": "72085",
                    "url": "http://www.informatics.jax.org/homology/72085",
                    "database": "MGI"
                },
                {
                    "id": "A2RSX7",
                    "url": "https://omabrowser.org/oma/group/A2RSX7/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        },
        {
            "uniprot_canonical_ac": "D3ZY75-1",
            "protein_name": "tRNA-yW synthesizing protein 5",
            "gene_name": "Tyw5",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MAEQRLPVPRLRGVSREQFMEHLYPQRKPLVLEGLDLGSCTSKWTVDYLSQVGGTKEVKIHVAAVAQMDFISKNFVYRTLPFNKLVQRAAEETHKEFFISQDERYYLRSLGEDPRKDIADIRQQFPSLGEDITFPMFFREEQFFSSVFRISSPGLQLWTHYDVMDNFLIQVTGKKRITLFSPRDAQYLYLSGSKSEVLNIDSPDLDKYPLFPKARRYECSLEAGDVLFIPALWFHNVVSEEFGVGVNVFLKHLPSECYDTTDTYGNKDPVAASRAMQILDRALKTLAELPEEYRDFYARQMVLRIQDKAYSKNSE",
                "length": 315
            },
            "evidence": [
                {
                    "id": "72085",
                    "url": "http://www.informatics.jax.org/homology/72085",
                    "database": "MGI"
                },
                {
                    "id": "A2RSX7",
                    "url": "https://omabrowser.org/oma/group/A2RSX7/",
                    "database": "OMA"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Molecular Function",
                "total": 5,
                "go_terms": [
                    {
                        "name": "iron ion binding",
                        "id": "GO:0005506",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005506",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2RSX7",
                                "url": "https://www.uniprot.org/uniprot/A2RSX7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein homodimerization activity",
                        "id": "GO:0042803",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2RSX7",
                                "url": "https://www.uniprot.org/uniprot/A2RSX7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "tRNA binding",
                        "id": "GO:0000049",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000049",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2RSX7",
                                "url": "https://www.uniprot.org/uniprot/A2RSX7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "2-oxoglutarate-dependent dioxygenase activity",
                        "id": "GO:0016706",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016706",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2RSX7",
                                "url": "https://www.uniprot.org/uniprot/A2RSX7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity",
                        "id": "GO:0102524",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0102524",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2RSX7",
                                "url": "https://www.uniprot.org/uniprot/A2RSX7"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 1,
                "go_terms": [
                    {
                        "name": "wybutosine biosynthetic process",
                        "id": "GO:0031591",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031591",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2RSX7",
                                "url": "https://www.uniprot.org/uniprot/A2RSX7"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [
        {
            "id": "37899",
            "name": "",
            "equation": "2-oxoglutarate + 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + O2 = 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + CO2 + succinate",
            "summary": "",
            "cellular_location": "",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "A2RUC4-1",
                "A2RSX7-1"
            ],
            "evidence": [
                {
                    "id": "37899",
                    "database": "Rhea",
                    "url": "https://www.rhea-db.org/rhea/37899"
                }
            ]
        }
    ],
    "reaction_participants": [],
    "reaction_enzymes": [
        {
            "uniprot_ac": "A2RSX7",
            "gene_name": "Tyw5",
            "activity": [
                {
                    "ec_number": "1.14.11.42",
                    "activity": "7-(3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + 2-oxoglutarate + O(2) = 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + succinate + CO(2).",
                    "evidence": [
                        {
                            "id": "A2RSX7",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A2RSX7"
                        }
                    ]
                },
                {
                    "ec_number": "1.14.11.42",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "A2RSX7",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A2RSX7"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "A2RUC4",
            "gene_name": "TYW5",
            "activity": [
                {
                    "ec_number": "1.14.11.42",
                    "activity": "7-(3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + 2-oxoglutarate + O(2) = 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + succinate + CO(2).",
                    "evidence": [
                        {
                            "id": "A2RUC4",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A2RUC4"
                        }
                    ]
                },
                {
                    "ec_number": "1.14.11.42",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "A2RUC4",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A2RUC4"
                        }
                    ]
                }
            ]
        }
    ],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        },
        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
        }
    ]
}