{ "uniprot_canonical_ac": "A2RRU4-1", "uniprot_ac": "A2RRU4", "uniprot_id": "SCAP_RAT", "mass": { "chemical_mass": 139499.0, "monoisotopic_mass": 139499.0 }, "refseq": { "ac": "NP_001094436", "name": "sterol regulatory element-binding protein cleavage-activating protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094436" }, "gene_names": [ { "name": "Scap", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4" }, { "name": "Scap", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094436", "id": "NP_001094436" } ], "protein_names": [ { "name": "Sterol regulatory element-binding protein cleavage-activating protein", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2RRU4#names_and_taxonomy", "id": "A2RRU4" }, { "name": "SCAP", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2RRU4#names_and_taxonomy", "id": "A2RRU4" }, { "name": "SREBP cleavage activating protein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094436", "id": "NP_001094436" }, { "name": "SREBP cleavage-activating protein", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2RRU4#names_and_taxonomy", "id": "A2RRU4" }, { "name": "sterol regulatory element-binding protein cleavage-activating protein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094436", "id": "NP_001094436" } ], "function": [ { "annotation": "Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum. Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway. Binds cholesterol via its SSD domain.", "evidence": [ { "database": "UniProtKB", "id": "A2RRU4", "url": "https://www.uniprot.org/uniprot/A2RRU4#function" }, { "database": "PubMed", "id": "P97260", "url": "https://glygen.org/publication/PubMed/P97260" } ] }, { "annotation": "Insulin selectively stimulates the processing of SREBP-1c in rat hepatocytes by enhancing the association between the SCAP-SREBP-1c complex and COPII proteins and subsequent ER to Golgi transport and proteolytic cleavage.", "evidence": [ { "database": "RefSeq", "id": "NP_001094436", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094436" }, { "database": "PubMed", "id": "19158095", "url": "https://glygen.org/publication/PubMed/19158095" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A2RRU4", "url": "https://www.uniprot.org/uniprot/A2RRU4" } ], "common_name": "Rat" } ], "gene": [ { "name": "Scap", "url": "https://www.uniprot.org/uniprot/A2RRU4", "locus": { "chromosome": "8", "start_pos": 118570503, "end_pos": 118628651, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000020853", "url": "https://www.ensembl.org/id/ENSRNOG00000020853" } ] } } ], "crossref": [ { "id": "ENSRNOG00000020853", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000020853", "database": "Bgee" }, { "id": "301024", "url": "https://www.ncbi.nlm.nih.gov/gene/301024", "database": "GeneID" }, { "id": "IPR000731", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000731", "database": "InterPro" }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro" }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro" }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro" }, { "id": "IPR030225", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030225", "database": "InterPro" }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro" }, { "id": "rno:301024", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:301024", "database": "KEGG Pathway" }, { "id": "IMKQYNV", "url": "https://omabrowser.org/oma/group/IMKQYNV/", "database": "OMA" }, { "id": "523786at2759", "url": "http://www.orthodb.org/?query=523786at2759", "database": "OrthoDB" }, { "id": "PTHR46378", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46378", "database": "PANTHER" }, { "id": "PF00400", "url": "http://pfam.xfam.org/family/PF00400", "database": "Pfam" }, { "id": "PF12349", "url": "http://pfam.xfam.org/family/PF12349", "database": "Pfam" }, { "id": "PR_A2RRU4", "url": "http://purl.obolibrary.org/obo/PR_A2RRU4", "database": "PRO" }, { "id": "R-RNO-1655829", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1655829", "database": "Reactome" }, { "id": "NP_001094436", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094436", "database": "RefSeq" }, { "id": "1309378", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1309378", "database": "RGD" }, { "id": "A2RRU4", "url": "https://www.uniprot.org/uniprot/A2RRU4", "database": "UniProtKB" }, { "id": "A2RRU4-1", "url": "https://www.uniprot.org/uniprot/A2RRU4-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MTLTERLREKISQAFYNHGLLCASYPIPIILFTGLCILACCYPLLKLPLPGTGPVEFSTPVKGYSPPPADSDHKQGEPSEQPEWYVGAPVAYIQQIFVKSSVSPWHRNLLAVDVFRSPLSRAFQLVEEIRNHVLRDSSGTKSLEEVCLQVTDLLPGLRKLRSLLPEHGCLLLSPGNFWQNDWERFHADPDIIGTIHQHEPKTLQTSATLKDLLFGVPGKYSGVSLYTRKRMVSYTITLVFQRYHAKFLSSLRARLMLLHPSPNCSLRAENLVHVHFKEEIGIAELIPLVTTYIILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSSESWSIMKNVATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADLNKRLPPESCLPSAKPVGRPARYERQLAVRPSTPHTITLQPSSFRNLRLPKRLRVIYFLARTRLAQRLIMAGTVVWIGILVYTDPAGLRTYLAAQVTEQSPLGEGSLGPMPVPSGVLPASHPDPAFSIFPPDAPKLPENQTLPGELPEHAVPAEGVQDSRAPEVTWGPEDEELWRKLSFRHWPTLFNYYNITLAKRYISLLPVIPVTLHLNPREALEGRHPQDGRTAWAPPEPLPAGLWETGPKGPGGTQTHGDITLYKVAALGLAAGIVLVLLLLCLYRVLCPRNYGQPGGGAGRRRRGELPCDDYGYAPPETEIVPLVLRGHLMDIECLASDGMLLVSCCLAGQVCVWDAQTGDCLTRIPRPGPRRDSCGGGAFEAQENWERLSDGGKASPEEPGDSPPLRRRPRGPPPPSLFGDQPDLTCLIDTNFSVQLPPEPTQPEPRHRAGCGRSRDSGYDFSRLVQRVYQEEGLAAVHMSALRPPSPGPPLPQASQEEGTAPEKGSPPLAWAPSTAGSIWSLELQGSLIVVGRSSGRLEVWDAIEGVLCCSNEEISSGITALVFLDRRIVAARLNGSLDFFSLETHTSLSPLQFRGTPGRGSSPSSPVYSSSNTVACHLTHTVPCAHQKPITALRAAAGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQTMVLASGGQDGAICLWDVLTGSRVSHTFAHRGDVTSLTCTTSCVISSGLDDFINIWDRSTGIKLYSIQQDLGCGASLGVISDNLLVTGGQGCVSFWDLNYGDLLQTVYLGKNSEAQPARQILVLDNAAIVCNFGSELSLVYVPSVLEKLD", "length": 1276, "header": "sp|A2RRU4-1|SCAP_RAT Isoform 1 of Sterol regulatory element-binding protein cleavage-activating protein OS=Rattus norvegicus OX=10116 GN=Scap PE=2 SV=1 CANONICAL=A2RRU4-1" }, "isoforms": [ { "isoform_ac": "A2RRU4-1", "url": "https://www.uniprot.org/uniprot/A2RRU4#A2RRU4-1", "sequence": { "sequence": "MTLTERLREKISQAFYNHGLLCASYPIPIILFTGLCILACCYPLLKLPLPGTGPVEFSTPVKGYSPPPADSDHKQGEPSEQPEWYVGAPVAYIQQIFVKSSVSPWHRNLLAVDVFRSPLSRAFQLVEEIRNHVLRDSSGTKSLEEVCLQVTDLLPGLRKLRSLLPEHGCLLLSPGNFWQNDWERFHADPDIIGTIHQHEPKTLQTSATLKDLLFGVPGKYSGVSLYTRKRMVSYTITLVFQRYHAKFLSSLRARLMLLHPSPNCSLRAENLVHVHFKEEIGIAELIPLVTTYIILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSSESWSIMKNVATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADLNKRLPPESCLPSAKPVGRPARYERQLAVRPSTPHTITLQPSSFRNLRLPKRLRVIYFLARTRLAQRLIMAGTVVWIGILVYTDPAGLRTYLAAQVTEQSPLGEGSLGPMPVPSGVLPASHPDPAFSIFPPDAPKLPENQTLPGELPEHAVPAEGVQDSRAPEVTWGPEDEELWRKLSFRHWPTLFNYYNITLAKRYISLLPVIPVTLHLNPREALEGRHPQDGRTAWAPPEPLPAGLWETGPKGPGGTQTHGDITLYKVAALGLAAGIVLVLLLLCLYRVLCPRNYGQPGGGAGRRRRGELPCDDYGYAPPETEIVPLVLRGHLMDIECLASDGMLLVSCCLAGQVCVWDAQTGDCLTRIPRPGPRRDSCGGGAFEAQENWERLSDGGKASPEEPGDSPPLRRRPRGPPPPSLFGDQPDLTCLIDTNFSVQLPPEPTQPEPRHRAGCGRSRDSGYDFSRLVQRVYQEEGLAAVHMSALRPPSPGPPLPQASQEEGTAPEKGSPPLAWAPSTAGSIWSLELQGSLIVVGRSSGRLEVWDAIEGVLCCSNEEISSGITALVFLDRRIVAARLNGSLDFFSLETHTSLSPLQFRGTPGRGSSPSSPVYSSSNTVACHLTHTVPCAHQKPITALRAAAGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQTMVLASGGQDGAICLWDVLTGSRVSHTFAHRGDVTSLTCTTSCVISSGLDDFINIWDRSTGIKLYSIQQDLGCGASLGVISDNLLVTGGQGCVSFWDLNYGDLLQTVYLGKNSEAQPARQILVLDNAAIVCNFGSELSLVYVPSVLEKLD", "length": 1276, "header": "sp|A2RRU4-1|SCAP_RAT Isoform 1 of Sterol regulatory element-binding protein cleavage-activating protein OS=Rattus norvegicus OX=10116 GN=Scap PE=2 SV=1 CANONICAL=A2RRU4-1" }, "locus": { "chromosome": "8", "start_pos": 118628485, "end_pos": 118596844, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000090238", "url": "https://www.ensembl.org/id/ENSRNOT00000090238" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000072003", "url": "https://www.ensembl.org/id/ENSRNOP00000072003" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 263, "start_aa": "Asn", "end_pos": 263, "end_aa": "Asn", "residue": "Asn", "evidence": [ { "id": "A2RRU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2RRU4#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 590, "start_aa": "Asn", "end_pos": 590, "end_aa": "Asn", "residue": "Asn", "evidence": [ { "id": "A2RRU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2RRU4#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 641, "start_aa": "Asn", "end_pos": 641, "end_aa": "Asn", "residue": "Asn", "evidence": [ { "id": "A2RRU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2RRU4#ptm_processing" } ] } ], "phosphorylation": [ { "start_pos": 821, "end_pos": 821, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2RRU4", "url": "https://www.uniprot.org/uniprot/A2RRU4" } ] }, { "start_pos": 837, "end_pos": 837, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2RRU4", "url": "https://www.uniprot.org/uniprot/A2RRU4" } ] }, { "start_pos": 843, "end_pos": 843, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2RRU4", "url": "https://www.uniprot.org/uniprot/A2RRU4" } ] }, { "start_pos": 850, "end_pos": 850, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2RRU4", "url": "https://www.uniprot.org/uniprot/A2RRU4" } ] }, { "start_pos": 905, "end_pos": 905, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2RRU4", "url": "https://www.uniprot.org/uniprot/A2RRU4" } ] }, { "start_pos": 934, "end_pos": 934, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2RRU4", "url": "https://www.uniprot.org/uniprot/A2RRU4" } ] } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Insulin enhances post-translational processing of nascent SREBP-1c by promoting its phosphorylation and association with COPII vesicles.", "journal": "The Journal of biological chemistry", "date": "2009", "authors": "Yellaturu CR, Deng X, Cagen LM, Wilcox HG, Mansbach CM 2nd, Siddiqi SA, Park EA, Raghow R, Elam MB", "evidence": [ { "database": "RefSeq", "id": "NP_001094436", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094436" } ], "reference": [ { "type": "PubMed", "id": "19158095", "url": "https://glygen.org/publication/PubMed/19158095" } ] } ], "pathway": [ { "id": "rno:301024", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:301024", "resource": "KEGG Pathway" }, { "id": "R-RNO-1655829", "name": "Regulation of cholesterol biosynthesis by SREBP (SREBF)", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1655829", "resource": "Reactome", "description": "Regulation of cholesterol biosynthesis by SREBP (SREBF)" } ], "orthologs": [ { "uniprot_canonical_ac": "Q12770-1", "protein_name": "Sterol regulatory element-binding protein cleavage-activating protein", "gene_name": "SCAP", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTLTERLREKISRAFYNHGLLCASYPIPIILFTGFCILACCYPLLKLPLPGTGPVEFTTPVKDYSPPPVDSDRKQGEPTEQPEWYVGAPVAYVQQIFVKSSVFPWHKNLLAVDVFRSPLSRAFQLVEEIRNHVLRDSSGIRSLEELCLQVTDLLPGLRKLRNLLPEHGCLLLSPGNFWQNDWERFHADPDIIGTIHQHEPKTLQTSATLKDLLFGVPGKYSGVSLYTRKRMVSYTITLVFQHYHAKFLGSLRARLMLLHPSPNCSLRAESLVHVHFKEEIGVAELIPLVTTYIILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSSESWSIMKNMATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADLNKRLPPEACLPSAKPVGQPTRYERQLAVRPSTPHTITLQPSSFRNLRLPKRLRVVYFLARTRLAQRLIMAGTVVWIGILVYTDPAGLRNYLAAQVTEQSPLGEGALAPMPVPSGMLPPSHPDPAFSIFPPDAPKLPENQTSPGESPERGGPAEVVHDSPVPEVTWGPEDEELWRKLSFRHWPTLFSYYNITLAKRYISLLPVIPVTLRLNPREALEGRHPQDGRSAWPPPGPIPAGHWEAGPKGPGGVQAHGDVTLYKVAALGLATGIVLVLLLLCLYRVLCPRNYGQLGGGPGRRRRGELPCDDYGYAPPETEIVPLVLRGHLMDIECLASDGMLLVSCCLAGHVCVWDAQTGDCLTRIPRPGRQRRDSGVGSGLEAQESWERLSDGGKAGPEEPGDSPPLRHRPRGPPPPSLFGDQPDLTCLIDTNFSAQPRSSQPTQPEPRHRAVCGRSRDSPGYDFSCLVQRVYQEEGLAAVCTPALRPPSPGPVLSQAPEDEGGSPEKGSPSLAWAPSAEGSIWSLELQGNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFLDKRIVAARLNGSLDFFSLETHTALSPLQFRGTPGRGSSPASPVYSSSDTVACHLTHTVPCAHQKPITALKAAAGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQTMVLASGGQDGAICLWDVLTGSRVSHVFAHRGDVTSLTCTTSCVISSGLDDLISIWDRSTGIKFYSIQQDLGCGASLGVISDNLLVTGGQGCVSFWDLNYGDLLQTVYLGKNSEAQPARQILVLDNAAIVCNFGSELSLVYVPSVLEKLD", "length": 1279 }, "evidence": [ { "id": "8160", "url": "http://www.informatics.jax.org/homology/8160", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q6GQT6-1", "protein_name": "Sterol regulatory element-binding protein cleavage-activating protein", "gene_name": "Scap", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTLTERLREKISQAFYNHGLLCASYPIPIILFTGLCILACCYPLLKLPLPGTGPVEFSTPVKGYSPPPADSDHKQGEPSEQPEWYVGAPVAYIQQIFVKSSVSPWHRNLLAVDVFRSPLSRAFQLVEEIRNHVLRDSSGTKSLEEVCLQVTDLLPGLRKLRSLLPEHGCLLLSPGNFWQNDWERFHADPDIIGTIHQHEPKTLQTSATLKDLLFGVPGKYSGVSLYTRKRMVSYTITLVFQRYHAKFLSSLRARLMLLHPSPNCSLRAENLVHVHFKEEIGIAELIPLVTTYIILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSSESWSIMKNAATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADLNKRLPPESCLPSAKPVGRPARYERQQAVRPSTPHTITLQPSSFRNLRLPKRLRVIYFLARTRLAQRLIMAGTVVWIGILVYTDPAGLRTYLAAQVTEQSPLGEGSLGPMPVPSGVLPASHPDPAFSIFPPDAPKLPENQTLPGELPEHAGPAEGVHDSRAPEVTWGPEDEELWRKLSFRHWPTLFNYYNITLAKRYISLLPVIPVTLHLNPREALEGRHPQDGRSAWAPQEPLPAGLWESGPKGPGGTQTHGDITLYKVAALGLAAGIVLVLLLLCLYRVLCPRNYGQPGGGPGRRRRGELPCDDYGYAPPETEIVPLVLRGHLMDIECLASDGMLLVSCCLAGQVCVWDAQTGDCLTRIPRPGPRRDSCGGGAFETQENWERLSDGGKASPEEPGDSPPLRRRPRGPPPPSLFGDQPDLTCLIDTNFSVQLPPEPTQPEPRHRVGCGRSRDSGYDFSRLVQRVYQEEGLAAMRMPALRPPSPGPPLPQASQEEGTAPEKGSPPLAWTPSTAGSIWSLELQGNLIVVGRSSGRLEVWDAIEGVLCCSNEEISSGITALVFLDRRIVAARLNGSLDFFSLETHTSLSPLQFRGTPGRGSSPSSSVYSSSNTVTCHRTHTVPCAHQKPITALRAAAGRLVTGSQDHTLRVFRLDDSCCLFTLKGHSGAITAVYIDQTMVLASGGQDGAICLWDVLTGSRVSQTFAHRGDVTSLTCTASCVISSGLDDFISIWDRSTGIKLYSIQQDLGCGASLGVISDNLLVTGGQGCVSFWDLNYGDLLQTVYLGKNSEAQPARQILVLDNAAIVCNFGSELSLVYVPSVLEKLD", "length": 1276 }, "evidence": [ { "id": "8160", "url": "http://www.informatics.jax.org/homology/8160", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 12, "go_terms": [ { "name": "COPII-coated vesicle cargo loading", "id": "GO:0090110", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090110", "evidence": [ { "database": "UniProtKB", "id": "A2RRU4", "url": "https://www.uniprot.org/uniprot/A2RRU4" } ], "pmid": "" }, { "name": "immune response", "id": "GO:0006955", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", "evidence": [ { "database": "UniProtKB", "id": "A2RRU4", "url": "https://www.uniprot.org/uniprot/A2RRU4" } ], "pmid": "" }, { "name": "cholesterol metabolic process", "id": "GO:0008203", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008203", "evidence": [ { "database": "UniProtKB", "id": "A2RRU4", "url": "https://www.uniprot.org/uniprot/A2RRU4" } ], "pmid": "" }, { "name": "cellular lipid metabolic process", "id": "GO:0044255", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044255", "evidence": [ { "database": "UniProtKB", "id": "A2RRU4", "url": "https://www.uniprot.org/uniprot/A2RRU4" } ], "pmid": "" }, { "name": "response to hypoxia", "id": "GO:0001666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001666", "evidence": [ { "database": "UniProtKB", "id": "A2RRU4", "url": "https://www.uniprot.org/uniprot/A2RRU4" } ], "pmid": "" }, { "name": "regulation of fatty acid metabolic process", "id": "GO:0019217", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019217", "evidence": [ { "database": "UniProtKB", "id": "A2RRU4", "url": "https://www.uniprot.org/uniprot/A2RRU4" } ], "pmid": "" }, { "name": "regulation of fatty acid biosynthetic process", "id": "GO:0042304", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042304", "evidence": [ { "database": "UniProtKB", "id": "A2RRU4", "url": "https://www.uniprot.org/uniprot/A2RRU4" } ], "pmid": "" }, { "name": "regulation of 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