{ "uniprot_canonical_ac": "A2RRU3-1", "uniprot_ac": "A2RRU3", "uniprot_id": "UTP15_RAT", "mass": { "chemical_mass": 59515.0, "monoisotopic_mass": 59515.0 }, "refseq": { "ac": "NP_001101117", "name": "U3 small nucleolar RNA-associated protein 15 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101117" }, "gene_names": [ { "name": "Utp15", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2RRU3", "id": "A2RRU3" }, { "name": "RGD1310992", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101117", "id": "NP_001101117" }, { "name": "Utp15", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101117", "id": "NP_001101117" } ], "protein_names": [ { "name": "U3 small nucleolar RNA-associated protein 15 homolog", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2RRU3#names_and_taxonomy", "id": "A2RRU3" }, { "name": "U3 small nucleolar RNA-associated protein 15 homolog", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101117", "id": "NP_001101117" }, { "name": "UTP15, U3 small nucleolar ribonucleoprotein, homolog; UTP15 SSU processome component", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101117", "id": "NP_001101117" } ], "function": [ { "annotation": "Involved in nucleolar processing of pre-18S ribosomal RNA.", "evidence": [ { "database": "UniProtKB", "id": "A2RRU3", "url": "https://www.uniprot.org/uniprot/A2RRU3#function" }, { "database": "PubMed", "id": "Q04305", "url": "https://glygen.org/publication/PubMed/Q04305" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A2RRU3", "url": "https://www.uniprot.org/uniprot/A2RRU3" } ], "common_name": "Rat" } ], "gene": [ { "name": "Utp15", "url": "https://www.uniprot.org/uniprot/A2RRU3", "locus": { "chromosome": "2", "start_pos": 28370261, "end_pos": 28353854, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000016591", "url": "https://www.ensembl.org/id/ENSRNOG00000016591" } ] } } ], "crossref": [ { "id": "ENSRNOG00000016591", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000016591", "database": "Bgee" }, { "id": "310019", "url": "https://www.ncbi.nlm.nih.gov/gene/310019", "database": "GeneID" }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro" }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro" }, { "id": "IPR018983", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018983", "database": "InterPro" }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro" }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro" }, { "id": "rno:310019", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:310019", "database": "KEGG Pathway" }, { "id": "WKEHKQP", "url": "https://omabrowser.org/oma/group/WKEHKQP/", "database": "OMA" }, { "id": "621827at2759", "url": "http://www.orthodb.org/?query=621827at2759", "database": "OrthoDB" }, { "id": "PF00400", "url": "http://pfam.xfam.org/family/PF00400", "database": "Pfam" }, { "id": "PF09384", "url": "http://pfam.xfam.org/family/PF09384", "database": "Pfam" }, { "id": "PR_A2RRU3", "url": "http://purl.obolibrary.org/obo/PR_A2RRU3", "database": "PRO" }, { "id": "R-RNO-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6791226", "database": "Reactome" }, { "id": "NP_001101117", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101117", "database": "RefSeq" }, { "id": "1310992", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1310992", "database": "RGD" }, { "id": "A2RRU3", "url": "https://www.uniprot.org/uniprot/A2RRU3", "database": "UniProtKB" }, { "id": "A2RRU3-1", "url": "https://www.uniprot.org/uniprot/A2RRU3-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MAGYKPVVIQTYPVLGEKITQDTLYWNNYKTPVQIKEFGAVSKVDFSPQPPYNYAVTASSRIHIYGRYSQEPVKTFSRFKDTAYCATFRQDGQLLVAGSEDGVVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASKLNPDLFVTGSYDHTVKMFDARTNKNVLCVEHGQPVESVLLFPSGGLLVSAGGRYVKVWDMLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKIYSTTSYKVVHSFDYAASILSLALSHQDETVVVGMTNGILSVKHRKSEAKKESLPRRRRPAYRTFIKGKIYTKQRDDIVVTRPAKKHLEWYDRDLKSFRISKALDRVLEPNCVIKTPEVTVSIIKELNRRGVLANALAGRDEKEITRVLNFLIRNLSQPRFAPVLINAAEIIIDIYLPVIGQSSVVDKKFIVLQGLVEKEIDYQRELLETLGMMDMLFATMTRNGSAPVWEHVPAELPEEKTESPRQPSDTDKNS", "length": 528, "header": "sp|A2RRU3-1|UTP15_RAT Isoform 1 of U3 small nucleolar RNA-associated protein 15 homolog OS=Rattus norvegicus OX=10116 GN=Utp15 PE=2 SV=1 CANONICAL=A2RRU3-1" }, "isoforms": [ { "isoform_ac": "A2RRU3-1", "url": "https://www.uniprot.org/uniprot/A2RRU3#A2RRU3-1", "sequence": { "sequence": "MAGYKPVVIQTYPVLGEKITQDTLYWNNYKTPVQIKEFGAVSKVDFSPQPPYNYAVTASSRIHIYGRYSQEPVKTFSRFKDTAYCATFRQDGQLLVAGSEDGVVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASKLNPDLFVTGSYDHTVKMFDARTNKNVLCVEHGQPVESVLLFPSGGLLVSAGGRYVKVWDMLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKIYSTTSYKVVHSFDYAASILSLALSHQDETVVVGMTNGILSVKHRKSEAKKESLPRRRRPAYRTFIKGKIYTKQRDDIVVTRPAKKHLEWYDRDLKSFRISKALDRVLEPNCVIKTPEVTVSIIKELNRRGVLANALAGRDEKEITRVLNFLIRNLSQPRFAPVLINAAEIIIDIYLPVIGQSSVVDKKFIVLQGLVEKEIDYQRELLETLGMMDMLFATMTRNGSAPVWEHVPAELPEEKTESPRQPSDTDKNS", "length": 528, "header": "sp|A2RRU3-1|UTP15_RAT Isoform 1 of U3 small nucleolar RNA-associated protein 15 homolog OS=Rattus norvegicus OX=10116 GN=Utp15 PE=2 SV=1 CANONICAL=A2RRU3-1" }, "locus": { "chromosome": "2", "start_pos": 28367525, "end_pos": 28354714, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000022259", "url": "https://www.ensembl.org/id/ENSRNOT00000022259" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000022259", "url": "https://www.ensembl.org/id/ENSRNOP00000022259" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "rno:310019", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:310019", "resource": "KEGG Pathway" }, { "id": "R-RNO-6791226", "name": "Major pathway of rRNA processing in the nucleolus and cytosol", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" } ], "orthologs": [ { "uniprot_canonical_ac": "Q8C7V3-1", "protein_name": "U3 small nucleolar RNA-associated protein 15 homolog", "gene_name": "Utp15", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAGYKPVAIQTYPVLGEKITQDTLYWNNYKTPVQIKEFGAVSKVDFSPQLPYNYAVTASSRIHIYGRYSQEPVKTFSRFKDTAYCATFRQDGQLLVAGSEDGVVQLFDINGRAPLRQFEGHTKAVHTVDFTADNYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASKLNPDLFVTGSYDHTVKIFDARTNKNVLCVEHGQPVESVLLFPSGGLLVSAGGRYVKVWDMLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVVHSFDYAASILSLALSHQDETIVVGMTNGILSVKHRKSEAKKTSLPRRRRPAYRTFIKGKNYLKQRDDIMVSRPAKKHLEGYDKDLKSFRVSQALDRVLEPKCVIRTPEVTVSIIKELTRRGVLANALAGRDEKEVTRVLNFLIRNLSQPRFAPVLINAAEIIIDIYLPVIGQSSVVDKKFIVLQELVEKEIDYQRELLETLGMMDMLFATMTRNDSDPVPEHVPAELPEEKTESPTQPSDTDKNS", "length": 528 }, "evidence": [ { "id": "6629", "url": "http://www.informatics.jax.org/homology/6629", "database": "MGI" }, { "id": "A2RRU3", "url": "https://omabrowser.org/oma/group/A2RRU3/", "database": "OMA" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8TED0-1", "protein_name": "U3 small nucleolar RNA-associated protein 15 homolog", "gene_name": "UTP15", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGYKPVAIQTYPILGEKITQDTLYWNNYKTPVQIKEFGAVSKVDFSPQPPYNYAVTASSRIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASKLNPDLFITGSYDHTVKMFDARTSESVLSVEHGQPVESVLLFPSGGLLVSAGGRYVKVWDMLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVVHSFDYAASILSLALAHEDETIVVGMTNGILSVKHRKSEAKKESLPRRRRPAYRTFIKGKNYMKQRDDILINRPAKKHLELYDRDLKHFRISKALDRVLDPTCTIKTPEITVSIIKELNRRGVLANALAGRDEKEISHVLNFLIRNLSQPRFAPVLINAAEIIIDIYLPVIGQSPVVDKKFLLLQGLVEKEIDYQRELLETLGMMDMLFATMRRKEGTSVLEHTSDGFPENKKIES", "length": 518 }, "evidence": [ { "id": "6629", "url": "http://www.informatics.jax.org/homology/6629", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "positive regulation of rRNA processing", "id": "GO:2000234", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000234", "evidence": [ { "database": "UniProtKB", "id": "A2RRU3", "url": "https://www.uniprot.org/uniprot/A2RRU3" } ], "pmid": "" }, { "name": "rRNA processing", "id": "GO:0006364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006364", "evidence": [ { "database": "UniProtKB", "id": "A2RRU3", "url": "https://www.uniprot.org/uniprot/A2RRU3" } ], "pmid": "21873635" }, { "name": "positive regulation of transcription by RNA polymerase I", "id": "GO:0045943", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045943", "evidence": [ { "database": "UniProtKB", "id": "A2RRU3", "url": "https://www.uniprot.org/uniprot/A2RRU3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A2RRU3", "url": "https://www.uniprot.org/uniprot/A2RRU3" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A2RRU3", "url": "https://www.uniprot.org/uniprot/A2RRU3" } ], "pmid": "" }, { "name": "fibrillar center", "id": "GO:0001650", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001650", "evidence": [ { "database": "UniProtKB", "id": "A2RRU3", "url": "https://www.uniprot.org/uniprot/A2RRU3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 428, "end_pos": 430, "annotation": "n_glycosylation_sequon" }, { "start_pos": 497, "end_pos": 499, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "synthesized_glycans": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ] }