{
    "uniprot_canonical_ac": "A2RRU2-1",
    "uniprot_ac": "A2RRU2",
    "uniprot_id": "A2RRU2_RAT",
    "mass": {
        "chemical_mass": 25858.0,
        "monoisotopic_mass": 25858.0
    },
    "refseq": {
        "ac": "NP_001094448",
        "name": "transmembrane protein 127",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094448"
    },
    "gene_names": [
        {
            "name": "Tmem127",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2RRU2",
            "id": "A2RRU2"
        },
        {
            "name": "RGD1309744",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094448",
            "id": "NP_001094448"
        },
        {
            "name": "RGD1309744",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2RRU2",
            "id": "A2RRU2"
        },
        {
            "name": "Tmem127",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094448",
            "id": "NP_001094448"
        },
        {
            "name": "rCG_26229",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2RRU2",
            "id": "A2RRU2"
        }
    ],
    "protein_names": [
        {
            "name": "RCG26229, isoform CRA_a",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2RRU2#names_and_taxonomy",
            "id": "A2RRU2"
        },
        {
            "name": "Transmembrane protein 127",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2RRU2#names_and_taxonomy",
            "id": "A2RRU2"
        },
        {
            "name": "transmembrane protein 127",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094448",
            "id": "NP_001094448"
        }
    ],
    "function": [],
    "disease": [
        {
            "disease_id": "DOID:0050771",
            "recommended_name": {
                "id": "DOID:0050771",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0050771",
                "name": "pheochromocytoma",
                "description": "An endocrine organ benign neoplasm that arises within the adrenal medulla, releasing epinephrines and norepinephrines hormones that cause either episodic or persistent high blood pressure."
            },
            "synonyms": [
                {
                    "id": "DOID:0050771",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0050771",
                    "name": "phaeochromocytoma",
                    "description": ""
                },
                {
                    "id": "MONDO:0008233",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008233",
                    "name": "phaeochromocytoma",
                    "description": ""
                },
                {
                    "id": "MONDO:0008233",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008233",
                    "name": "pheochromocytoma",
                    "description": ""
                },
                {
                    "id": "MONDO:0008233",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008233",
                    "name": "pheochromocytoma, susceptibility to",
                    "description": ""
                },
                {
                    "id": "MIM:171300",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/171300",
                    "name": "Pheochromocytoma",
                    "description": "Pheochromocytoma"
                }
            ],
            "evidence": [
                {
                    "id": "0050771",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050771"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2RRU2",
                    "url": "https://www.uniprot.org/uniprot/A2RRU2"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Tmem127",
            "url": "https://www.uniprot.org/uniprot/A2RRU2",
            "locus": {
                "chromosome": "3",
                "start_pos": 119677575,
                "end_pos": 119690366,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000022727",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000022727"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000022727",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000022727",
            "database": "Bgee"
        },
        {
            "id": "311405",
            "url": "https://www.ncbi.nlm.nih.gov/gene/311405",
            "database": "GeneID"
        },
        {
            "id": "IPR033331",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR033331",
            "database": "InterPro"
        },
        {
            "id": "rno:311405",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:311405",
            "database": "KEGG Pathway"
        },
        {
            "id": "EDYCVNP",
            "url": "https://omabrowser.org/oma/group/EDYCVNP/",
            "database": "OMA"
        },
        {
            "id": "1422066at2759",
            "url": "http://www.orthodb.org/?query=1422066at2759",
            "database": "OrthoDB"
        },
        {
            "id": "PTHR28358",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28358",
            "database": "PANTHER"
        },
        {
            "id": "PR_A2RRU2",
            "url": "http://purl.obolibrary.org/obo/PR_A2RRU2",
            "database": "PRO"
        },
        {
            "id": "NP_001094448",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094448",
            "database": "RefSeq"
        },
        {
            "id": "1309744",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1309744",
            "database": "RGD"
        },
        {
            "id": "A2RRU2",
            "url": "https://www.uniprot.org/uniprot/A2RRU2",
            "database": "UniProtKB"
        },
        {
            "id": "A2RRU2-1",
            "url": "https://www.uniprot.org/uniprot/A2RRU2-1",
            "database": "UniProtKB"
        }
    ],
    "sequence": {
        "sequence": "MYAPGGAGLPGGRRRRSPGSSALPKQPERSLASALPGALSITALCTALAEPAWLHIHGGTCSRQELGVSDVLGYVHPDLLKDFCMNPQTVLLLRVIAAFCFLGILCSLSAFLLDVFGPKHPALKITRRYAFAHILTVLQCATVIGFSYWASELILAQQQQHKKYHGSQVYVTFAVSFYLVAGAGGASILATAANLLRHYPTEEEEQALELLSEMEENDPYPAEYEVINQFQPPPAYTP",
        "length": 238,
        "header": "tr|A2RRU2-1|A2RRU2_RAT Isoform 1 of Transmembrane protein 127  OS=Rattus norvegicus OX=10116 GN=Tmem127 PE=2 SV=1 CANONICAL=A2RRU2-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A2RRU2-1",
            "url": "https://www.uniprot.org/uniprot/A2RRU2#A2RRU2-1",
            "sequence": {
                "sequence": "MYAPGGAGLPGGRRRRSPGSSALPKQPERSLASALPGALSITALCTALAEPAWLHIHGGTCSRQELGVSDVLGYVHPDLLKDFCMNPQTVLLLRVIAAFCFLGILCSLSAFLLDVFGPKHPALKITRRYAFAHILTVLQCATVIGFSYWASELILAQQQQHKKYHGSQVYVTFAVSFYLVAGAGGASILATAANLLRHYPTEEEEQALELLSEMEENDPYPAEYEVINQFQPPPAYTP",
                "length": 238,
                "header": "tr|A2RRU2-1|A2RRU2_RAT Isoform 1 of Transmembrane protein 127  OS=Rattus norvegicus OX=10116 GN=Tmem127 PE=2 SV=1 CANONICAL=A2RRU2-1"
            },
            "locus": {
                "chromosome": "3",
                "start_pos": 119686931,
                "end_pos": 119678179,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000031577",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000031577"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000030631",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000030631"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [],
    "pathway": [
        {
            "id": "rno:311405",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:311405",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "O75204-1",
            "protein_name": "Transmembrane protein 127",
            "gene_name": "TMEM127",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MYAPGGAGLPGGRRRRSPGGSALPKQPERSLASALPGALSITALCTALAEPAWLHIHGGTCSRQELGVSDVLGYVHPDLLKDFCMNPQTVLLLRVIAAFCFLGILCSLSAFLLDVFGPKHPALKITRRYAFAHILTVLQCATVIGFSYWASELILAQQQQHKKYHGSQVYVTFAVSFYLVAGAGGASILATAANLLRHYPTEEEEQALELLSEMEENEPYPAEYEVINQFQPPPAYTP",
                "length": 238
            },
            "evidence": [
                {
                    "id": "9877",
                    "url": "http://www.informatics.jax.org/homology/9877",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q8BGP5-1",
            "protein_name": "Transmembrane protein 127",
            "gene_name": "Tmem127",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MYAPGGAGLPGGRRRRSPGSSALPKQPERSLASALPGALSITALCTALAEPAWLHIHGGTCSRQELGVSDVLGYVNPDLLKDFCMNPQTVLLLRVIAAFCFLGILCSLSAFLLDVFGPKHPALKITRRYAFAHILTVLQCATVIGFSYWASELILAQQQQHKKYHGSQVYVTFAVSFYLVAGAGGASILATAANLLRHYPTEEEEQALELLSEMEENDPYPAEYEVINQFQPPPAYTP",
                "length": 238
            },
            "evidence": [
                {
                    "id": "9877",
                    "url": "http://www.informatics.jax.org/homology/9877",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 5,
                "go_terms": [
                    {
                        "name": "cytoplasm",
                        "id": "GO:0005737",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2RRU2",
                                "url": "https://www.uniprot.org/uniprot/A2RRU2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "early endosome",
                        "id": "GO:0005769",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2RRU2",
                                "url": "https://www.uniprot.org/uniprot/A2RRU2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "plasma membrane",
                        "id": "GO:0005886",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2RRU2",
                                "url": "https://www.uniprot.org/uniprot/A2RRU2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "membrane",
                        "id": "GO:0016020",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2RRU2",
                                "url": "https://www.uniprot.org/uniprot/A2RRU2"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "integral component of membrane",
                        "id": "GO:0016021",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2RRU2",
                                "url": "https://www.uniprot.org/uniprot/A2RRU2"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 4,
                "go_terms": [
                    {
                        "name": "negative regulation of cell population proliferation",
                        "id": "GO:0008285",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2RRU2",
                                "url": "https://www.uniprot.org/uniprot/A2RRU2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "endosome organization",
                        "id": "GO:0007032",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007032",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2RRU2",
                                "url": "https://www.uniprot.org/uniprot/A2RRU2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of TOR signaling",
                        "id": "GO:0032007",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032007",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2RRU2",
                                "url": "https://www.uniprot.org/uniprot/A2RRU2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of TOR signaling",
                        "id": "GO:0032006",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032006",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2RRU2",
                                "url": "https://www.uniprot.org/uniprot/A2RRU2"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 1,
                "go_terms": [
                    {
                        "name": "small GTPase binding",
                        "id": "GO:0031267",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2RRU2",
                                "url": "https://www.uniprot.org/uniprot/A2RRU2"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        }
    ]
}