{
    "uniprot_canonical_ac": "A2IBE0-1",
    "uniprot_ac": "A2IBE0",
    "uniprot_id": "A2IBE0_RAT",
    "mass": {
        "chemical_mass": 37525.0,
        "monoisotopic_mass": 37525.0
    },
    "refseq": {
        "ac": "NP_001103125",
        "name": "carbonic anhydrase 14 precursor",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103125"
    },
    "gene_names": [
        {
            "name": "Ca14",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2IBE0",
            "id": "A2IBE0"
        },
        {
            "name": "Ca14",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103125",
            "id": "NP_001103125"
        },
        {
            "name": "Car14",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103125",
            "id": "NP_001103125"
        },
        {
            "name": "Car14",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2IBE0",
            "id": "A2IBE0"
        },
        {
            "name": "rCG_52058",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2IBE0",
            "id": "A2IBE0"
        }
    ],
    "protein_names": [
        {
            "name": "Carbonic anhydrase 14",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2IBE0#names_and_taxonomy",
            "id": "A2IBE0"
        },
        {
            "name": "Membrane-bound carbonic anhydrase 14",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2IBE0#names_and_taxonomy",
            "id": "A2IBE0"
        },
        {
            "name": "RCG52058, isoform CRA_b",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2IBE0#names_and_taxonomy",
            "id": "A2IBE0"
        },
        {
            "name": "carbonic anhydrase 14 precursor",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103125",
            "id": "NP_001103125"
        },
        {
            "name": "carbonic anhydrase XIV",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103125",
            "id": "NP_001103125"
        }
    ],
    "function": [],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2IBE0",
                    "url": "https://www.uniprot.org/uniprot/A2IBE0"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Ca14",
            "url": "https://www.uniprot.org/uniprot/A2IBE0",
            "locus": {}
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000023162",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000023162",
            "database": "Bgee"
        },
        {
            "id": "791259",
            "url": "https://www.ncbi.nlm.nih.gov/gene/791259",
            "database": "GeneID"
        },
        {
            "id": "IPR001148",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001148",
            "database": "InterPro"
        },
        {
            "id": "IPR018431",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR018431",
            "database": "InterPro"
        },
        {
            "id": "IPR023561",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR023561",
            "database": "InterPro"
        },
        {
            "id": "IPR036398",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036398",
            "database": "InterPro"
        },
        {
            "id": "rno:791259",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:791259",
            "database": "KEGG Pathway"
        },
        {
            "id": "ILAGCLC",
            "url": "https://omabrowser.org/oma/group/ILAGCLC/",
            "database": "OMA"
        },
        {
            "id": "1377476at2759",
            "url": "http://www.orthodb.org/?query=1377476at2759",
            "database": "OrthoDB"
        },
        {
            "id": "PTHR18952",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18952",
            "database": "PANTHER"
        },
        {
            "id": "PTHR18952:SF84",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18952:SF84",
            "database": "PANTHER"
        },
        {
            "id": "PF00194",
            "url": "http://pfam.xfam.org/family/PF00194",
            "database": "Pfam"
        },
        {
            "id": "R-RNO-1475029",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1475029",
            "database": "Reactome"
        },
        {
            "id": "NP_001103125",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103125",
            "database": "RefSeq"
        },
        {
            "id": "1599277",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1599277",
            "database": "RGD"
        },
        {
            "id": "A2IBE0",
            "url": "https://www.uniprot.org/uniprot/A2IBE0",
            "database": "UniProtKB"
        },
        {
            "id": "A2IBE0-1",
            "url": "https://www.uniprot.org/uniprot/A2IBE0-1",
            "database": "UniProtKB"
        }
    ],
    "sequence": {
        "sequence": "MLFFVLLLKVTWILAADGGHHWTYEGPHGQDHWPASYPECGGNAQSPIDIQTDGVIFDPDLPTVQPHGYDQLGTEPLDLHNNGHTVQLSLPPTLHLGGLPRKYTAAQLHLHWGQKGTLKGSEHQINSEATAAELHVVHYDSESYGSLSEAAQKPQGLAVLGILIEVGETENPAYDHILSHLHEVRYKDQKTSVPPFNVRELLPQQLEQFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQETLSSTEEDPSEPLVQNYRVPQPLNQRTIFASFIQVGPLYTTGEMLGLGMGISAGCLCLLLTIYFIAQKIRRKRLGNRKSVVFTSARATTEA",
        "length": 337,
        "header": "tr|A2IBE0-1|A2IBE0_RAT Isoform 1 of Carbonic anhydrase 14  OS=Rattus norvegicus OX=10116 GN=Ca14 PE=1 SV=1 CANONICAL=A2IBE0-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A2IBE0-1",
            "url": "https://www.uniprot.org/uniprot/A2IBE0#A2IBE0-1",
            "sequence": {
                "sequence": "MLFFVLLLKVTWILAADGGHHWTYEGPHGQDHWPASYPECGGNAQSPIDIQTDGVIFDPDLPTVQPHGYDQLGTEPLDLHNNGHTVQLSLPPTLHLGGLPRKYTAAQLHLHWGQKGTLKGSEHQINSEATAAELHVVHYDSESYGSLSEAAQKPQGLAVLGILIEVGETENPAYDHILSHLHEVRYKDQKTSVPPFNVRELLPQQLEQFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQETLSSTEEDPSEPLVQNYRVPQPLNQRTIFASFIQVGPLYTTGEMLGLGMGISAGCLCLLLTIYFIAQKIRRKRLGNRKSVVFTSARATTEA",
                "length": 337,
                "header": "tr|A2IBE0-1|A2IBE0_RAT Isoform 1 of Carbonic anhydrase 14  OS=Rattus norvegicus OX=10116 GN=Ca14 PE=1 SV=1 CANONICAL=A2IBE0-1"
            },
            "locus": {
                "chromosome": "2",
                "start_pos": 198016859,
                "end_pos": 198010549,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000025523",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000025523"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000025523",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000025523"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Carbonic anhydrases and mucosal vanilloid receptors help mediate the hyperemic response to luminal CO2 in rat duodenum.",
            "journal": "Gastroenterology",
            "date": "2006",
            "authors": "Takeuchi T., Akiba Y., Engel E., Ghayouri S., Guth P.H., Kaunitz J.D., Mizumori M., Swenson E.R.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2IBE0",
                    "url": "https://www.uniprot.org/uniprot/A2IBE0"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "16831598",
                    "url": "https://glygen.org/publication/PubMed/16831598"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "rno:791259",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:791259",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-RNO-1475029",
            "name": "Reversible hydration of carbon dioxide",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1475029",
            "resource": "Reactome",
            "description": "Reversible hydration of carbon dioxide"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q9ULX7-1",
            "protein_name": "Carbonic anhydrase 14",
            "gene_name": "CA14",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MLFSALLLEVIWILAADGGQHWTYEGPHGQDHWPASYPECGNNAQSPIDIQTDSVTFDPDLPALQPHGYDQPGTEPLDLHNNGHTVQLSLPSTLYLGGLPRKYVAAQLHLHWGQKGSPGGSEHQINSEATFAELHIVHYDSDSYDSLSEAAERPQGLAVLGILIEVGETKNIAYEHILSHLHEVRHKDQKTSVPPFNLRELLPKQLGQYFRYNGSLTTPPCYQSVLWTVFYRRSQISMEQLEKLQGTLFSTEEEPSKLLVQNYRALQPLNQRMVFASFIQAGSSYTTGEMLSLGVGILVGCLCLLLAVYFIARKIRKKRLENRKSVVFTSAQATTEA",
                "length": 337
            },
            "evidence": [
                {
                    "id": "69105",
                    "url": "http://www.informatics.jax.org/homology/69105",
                    "database": "MGI"
                },
                {
                    "id": "A2IBE0",
                    "url": "https://omabrowser.org/oma/group/A2IBE0/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9WVT6-1",
            "protein_name": "Carbonic anhydrase 14",
            "gene_name": "Ca14",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MLFFALLLKVTWILAADGGHHWTYEGPHGQDHWPTSYPECGGDAQSPINIQTDSVIFDPDLPAVQPHGYDQLGTEPLDLHNNGHTVQLSLPPTLHLGGLPRKYTAAQLHLHWGQRGSLEGSEHQINSEATAAELHVVHYDSQSYSSLSEAAQKPQGLAVLGILIEVGETENPAYDHILSRLHEIRYKDQKTSVPPFSVRELFPQQLEQFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQETLSSTEEDPSEPLVQNYRVPQPLNQRTIFASFIQAGPLYTTGEMLGLGVGILAGCLCLLLAVYFIAQKIRKKRLGNRKSVVFTSARATTEA",
                "length": 337
            },
            "evidence": [
                {
                    "id": "69105",
                    "url": "http://www.informatics.jax.org/homology/69105",
                    "database": "MGI"
                },
                {
                    "id": "A2IBE0",
                    "url": "https://omabrowser.org/oma/group/A2IBE0/",
                    "database": "OMA"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 2,
                "go_terms": [
                    {
                        "name": "plasma membrane",
                        "id": "GO:0005886",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2IBE0",
                                "url": "https://www.uniprot.org/uniprot/A2IBE0"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "integral component of membrane",
                        "id": "GO:0016021",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2IBE0",
                                "url": "https://www.uniprot.org/uniprot/A2IBE0"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 3,
                "go_terms": [
                    {
                        "name": "zinc ion binding",
                        "id": "GO:0008270",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2IBE0",
                                "url": "https://www.uniprot.org/uniprot/A2IBE0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "hydro-lyase activity",
                        "id": "GO:0016836",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016836",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2IBE0",
                                "url": "https://www.uniprot.org/uniprot/A2IBE0"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "carbonate dehydratase activity",
                        "id": "GO:0004089",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004089",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2IBE0",
                                "url": "https://www.uniprot.org/uniprot/A2IBE0"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 1,
                "go_terms": [
                    {
                        "name": "one-carbon metabolic process",
                        "id": "GO:0006730",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006730",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2IBE0",
                                "url": "https://www.uniprot.org/uniprot/A2IBE0"
                            }
                        ],
                        "pmid": "21873635"
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 213,
            "end_pos": 215,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        },
        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
        }
    ]
}