{ "uniprot_canonical_ac": "A2CG63-1", "uniprot_ac": "A2CG63", "uniprot_id": "ARI4B_MOUSE", "mass": { "chemical_mass": 147643.0, "monoisotopic_mass": 147643.0 }, "refseq": { "ac": "NP_919238", "name": "AT-rich interactive domain-containing protein 4B isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919238" }, "gene_names": [ { "name": "Arid4b", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2CG63", "id": "A2CG63" }, { "name": "Arid4b", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919238", "id": "NP_919238" }, { "name": "BCAA; BRCAA1; RBBP1L1; Rbp1l1; SAP180", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919238", "id": "NP_919238" }, { "name": "Sap180", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2CG63", "id": "A2CG63" } ], "protein_names": [ { "name": "AT-rich interactive domain-containing protein 4B", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2CG63#names_and_taxonomy", "id": "A2CG63" }, { "name": "180 kDa Sin3-associated polypeptide", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2CG63#names_and_taxonomy", "id": "A2CG63" }, { "name": "ARID domain-containing protein 4B", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2CG63#names_and_taxonomy", "id": "A2CG63" }, { "name": "AT-rich interactive domain-containing protein 4B isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919238", "id": "NP_919238" }, { "name": "Histone deacetylase complex subunit SAP180", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2CG63#names_and_taxonomy", "id": "A2CG63" }, { "name": "Sin3-associated polypeptide p180", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2CG63#names_and_taxonomy", "id": "A2CG63" }, { "name": "retinoblastoma binding protein 1-like 1; AT-rich interactive domain-containing protein 4B; sin3-associated polypeptide p180; ARID domain-containing protein 4B; 180 kDa Sin3-associated polypeptide; histone deacetylase complex subunit SAP180; breast cancer-associated antigen", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919238", "id": "NP_919238" } ], "function": [ { "annotation": "10 of 12 Arid4a(-/-)Arid4b(+/-) mice progressed to acute myeloid leukemia (AML) and had rapid further increases of leukocyte counts.", "evidence": [ { "database": "RefSeq", "id": "NP_919238", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919238" }, { "database": "PubMed", "id": "18728284", "url": "https://glygen.org/publication/PubMed/18728284" } ] }, { "annotation": "ARID4B is critical for mouse embryonic stem cell differentiation towards mesoderm and endoderm, linking epigenetics to pluripotency exit.", "evidence": [ { "database": "RefSeq", "id": "NP_919238", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919238" }, { "database": "PubMed", "id": "33454011", "url": "https://glygen.org/publication/PubMed/33454011" } ] }, { "annotation": "Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A (PubMed:17043311). Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (PubMed:23487765). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (PubMed:18728284).", "evidence": [ { "database": "UniProtKB", "id": "A2CG63", "url": "https://www.uniprot.org/uniprot/A2CG63#function" }, { "database": "PubMed", "id": "23487765", "url": "https://glygen.org/publication/PubMed/23487765" }, { "database": "PubMed", "id": "17043311", "url": "https://glygen.org/publication/PubMed/17043311" }, { "database": "PubMed", "id": "Q4LE39", "url": "https://glygen.org/publication/PubMed/Q4LE39" }, { "database": "PubMed", "id": "18728284", "url": "https://glygen.org/publication/PubMed/18728284" } ] }, { "annotation": "Differentiation of fetal hematopoietic stem cells requires ARID4B to restrict autocrine KITLG/KIT-Src signaling.", "evidence": [ { "database": "RefSeq", "id": "NP_919238", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919238" }, { "database": "PubMed", "id": "34818550", "url": "https://glygen.org/publication/PubMed/34818550" } ] }, { "annotation": "The study identified ARID4B to be a key regulator of Sertoli cell function important for male germ cell development.", "evidence": [ { "database": "RefSeq", "id": "NP_919238", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919238" }, { "database": "PubMed", "id": "26258622", "url": "https://glygen.org/publication/PubMed/26258622" } ] }, { "annotation": "These results identified ARID4B as a master regulator of a signaling network that governs the establishment of a niche during the critical gonocyte-to-spermatogonial stem cells (SSC) transition phase to control the fate of gonocytes and SSCs.", "evidence": [ { "database": "RefSeq", "id": "NP_919238", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919238" }, { "database": "PubMed", "id": "28207192", "url": "https://glygen.org/publication/PubMed/28207192" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A2CG63", "url": "https://www.uniprot.org/uniprot/A2CG63" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Arid4b", "url": "https://www.uniprot.org/uniprot/A2CG63", "locus": { "chromosome": "13", "start_pos": 14063232, "end_pos": 14199603, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000039219", "url": "https://www.ensembl.org/id/ENSMUSG00000039219" } ] } } ], "crossref": [ { "id": "ENSMUSG00000039219", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000039219", "database": "Bgee" }, { "id": "94246", "url": "https://www.ncbi.nlm.nih.gov/gene/94246", "database": "GeneID" }, { "id": "A2CG63", "url": "https://www.ebi.ac.uk/intact/interactors/id:A2CG63*", "database": "IntAct" }, { "id": "IPR001606", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001606", "database": "InterPro" }, { "id": "IPR002999", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002999", "database": "InterPro" }, { "id": "IPR012603", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012603", "database": "InterPro" }, { "id": "IPR016197", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016197", "database": "InterPro" }, { "id": "IPR025995", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025995", "database": "InterPro" }, { "id": "IPR028853", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028853", "database": "InterPro" }, { "id": "IPR036431", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036431", "database": "InterPro" }, { "id": "mmu:94246", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:94246", "database": "KEGG Pathway" }, { "id": "2137512", "url": "http://www.informatics.jax.org/marker/MGI:2137512", "database": "MGI" }, { "id": "CKECENA", "url": "https://omabrowser.org/oma/group/CKECENA/", "database": "OMA" }, { "id": "329541at2759", "url": "http://www.orthodb.org/?query=329541at2759", "database": "OrthoDB" }, { "id": "PTHR13964:SF24", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13964:SF24", "database": "PANTHER" }, { "id": "PF01388", "url": "http://pfam.xfam.org/family/PF01388", "database": "Pfam" }, { "id": "PF08169", "url": "http://pfam.xfam.org/family/PF08169", "database": "Pfam" }, { "id": "PF11717", "url": "http://pfam.xfam.org/family/PF11717", "database": "Pfam" }, { "id": "PR_A2CG63", "url": "http://purl.obolibrary.org/obo/PR_A2CG63", "database": "PRO" }, { "id": "R-MMU-3214815", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-3214815", "database": "Reactome" }, { "id": "NP_919238", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919238", "database": "RefSeq" }, { "id": "A0A1Y7VIX3", "url": "https://www.uniprot.org/uniprot/A0A1Y7VIX3", "database": "UniProtKB" }, { "id": "A0A1Y7VIX3-1", "url": "https://www.uniprot.org/uniprot/A0A1Y7VIX3-1", "database": "UniProtKB" }, { "id": "A0A1Y7VKA9", "url": "https://www.uniprot.org/uniprot/A0A1Y7VKA9", "database": "UniProtKB" }, { "id": "A0A1Y7VKA9-1", "url": "https://www.uniprot.org/uniprot/A0A1Y7VKA9-1", "database": "UniProtKB" }, { "id": "A2CG63", "url": "https://www.uniprot.org/uniprot/A2CG63", "database": "UniProtKB" }, { "id": "A2CG63-1", "url": "https://www.uniprot.org/uniprot/A2CG63-1", "database": "UniProtKB" }, { "id": "A2CG63-2", "url": "https://www.uniprot.org/uniprot/A2CG63-2", "database": "UniProtKB" }, { "id": "Z4YL44", "url": "https://www.uniprot.org/uniprot/Z4YL44", "database": "UniProtKB" }, { "id": "Z4YL44-1", "url": "https://www.uniprot.org/uniprot/Z4YL44-1", "database": "UniProtKB" }, { "id": "Z4YMH1", "url": "https://www.uniprot.org/uniprot/Z4YMH1", "database": "UniProtKB" }, { "id": "Z4YMH1-1", "url": "https://www.uniprot.org/uniprot/Z4YMH1-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGPLKVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETLDQLPLTNPEHFGTPVIGKKTNRGRRSNHIPEEESSSSSSDDDEEERKQTDELLGKVVCVDYVSLEKKKAMWFPALVVCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDTVPKPDAVLKQAFDQALEFHKSRAIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIDFQMALPEKVLNKPCKDCENKEVKVKEESETEIKEVNVEDSKNVMPKEETPAEDESERKENIKPSLGSKKSLLECIPAQSDEEKEAHITKLEENENLEDKDGGRARTEEAFSTEVDGEEEQARSGDETNKEEDEDDEEIEEEEEEDEEEDEDEDDDDNNEEEEFECYPPGMKVQVRYGRGKNQKMYEASIKDSDVEGGEALYLVHYCGWNVRYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDRDEKYSPKNCKLRRLSKSPFQSNPSPEMVSKLDLADAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERCTQDVDNIGKDESKVEHSTHSRNELISKEEQSSPSLLEENKVHTDLVIAKTVSKSPERLRKDMEAISEDTDFEEEDEITKKRKDVKKDTTDKALKPQTKRGKRRYCSADECLQTGSPGKKEDRTKSKEPLCTENSSNSSSDEDEEEKSKAKMTPTKKYNGLEEKRKSLRTTSFYSGFSEVAEKRIKLLNNSDERLQNNRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPDEGAVEESLQTVAEEESCSPIMELEKPLPASVDNKPIEEKPLEVSDRKTEFPSSGSNSVLNTPPTTPESPSSVTITEASQQQSSVTVSVPLPPNQEEVRSIKSETDSTIEVDSVVGELQDLQSEGNSSPAGFDASVSSSSSNQPEPDNPEKACTGQKRVKDTQGVGSSSKKQKRSHKATVVNNKKKGKGTNSSDSEELSAGESVTKTQTIKSVPTGMKTHNSKSPARVQSPGKGGRNGDKDPDLKEPSNRLPKVYKWSFQTSDLENMTSAERISILQEKLQEIRKHYLSLKSEVASIDRRRKRLKKKERESAATSSSSSSPSSSSITAAVMLTLAEPSMSSASQNGMSVECR", "length": 1314, "header": "sp|A2CG63-1|ARI4B_MOUSE Isoform 1 of AT-rich interactive domain-containing protein 4B OS=Mus musculus OX=10090 GN=Arid4b PE=1 SV=1 CANONICAL=A2CG63-1" }, "isoforms": [ { "isoform_ac": "A0A1Y7VIX3-1", "url": "https://www.uniprot.org/uniprot/A2CG63#A0A1Y7VIX3-1", "sequence": { "sequence": "MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGPLKVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETRGGVFLLIQ", "length": 128, "header": "tr|A0A1Y7VIX3-1|ARI4B_MOUSE Computationally mapped isoform of AT-rich interactive domain-containing protein 4B OS=Mus musculus OX=10090 GN=Arid4b PE=1 SV=1 CANONICAL=A2CG63-1" }, "locus": { "chromosome": "13", "start_pos": 14317594, "end_pos": 14239459, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000222928", "url": "https://www.ensembl.org/id/ENSMUST00000222928" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000152177", "url": "https://www.ensembl.org/id/ENSMUSP00000152177" } ] } }, { "isoform_ac": "A0A1Y7VKA9-1", "url": "https://www.uniprot.org/uniprot/A2CG63#A0A1Y7VKA9-1", "sequence": { "sequence": "XGVGSSSKKQKRSHKATVVNNKKKGKGSAPH", "length": 31, "header": "tr|A0A1Y7VKA9-1|ARI4B_MOUSE Computationally mapped isoform of AT-rich interactive domain-containing protein 4B OS=Mus musculus OX=10090 GN=Arid4b PE=1 SV=1 CANONICAL=A2CG63-1" }, "locus": { "chromosome": "13", "start_pos": 14366546, "end_pos": 14365762, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000151151", "url": "https://www.ensembl.org/id/ENSMUST00000151151" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000152798", "url": "https://www.ensembl.org/id/ENSMUSP00000152798" } ] } }, { "isoform_ac": "A2CG63-1", "url": "https://www.uniprot.org/uniprot/A2CG63#A2CG63-1", "sequence": { "sequence": "MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGPLKVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETLDQLPLTNPEHFGTPVIGKKTNRGRRSNHIPEEESSSSSSDDDEEERKQTDELLGKVVCVDYVSLEKKKAMWFPALVVCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDTVPKPDAVLKQAFDQALEFHKSRAIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIDFQMALPEKVLNKPCKDCENKEVKVKEESETEIKEVNVEDSKNVMPKEETPAEDESERKENIKPSLGSKKSLLECIPAQSDEEKEAHITKLEENENLEDKDGGRARTEEAFSTEVDGEEEQARSGDETNKEEDEDDEEIEEEEEEDEEEDEDEDDDDNNEEEEFECYPPGMKVQVRYGRGKNQKMYEASIKDSDVEGGEALYLVHYCGWNVRYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDRDEKYSPKNCKLRRLSKSPFQSNPSPEMVSKLDLADAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERCTQDVDNIGKDESKVEHSTHSRNELISKEEQSSPSLLEENKVHTDLVIAKTVSKSPERLRKDMEAISEDTDFEEEDEITKKRKDVKKDTTDKALKPQTKRGKRRYCSADECLQTGSPGKKEDRTKSKEPLCTENSSNSSSDEDEEEKSKAKMTPTKKYNGLEEKRKSLRTTSFYSGFSEVAEKRIKLLNNSDERLQNNRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPDEGAVEESLQTVAEEESCSPIMELEKPLPASVDNKPIEEKPLEVSDRKTEFPSSGSNSVLNTPPTTPESPSSVTITEASQQQSSVTVSVPLPPNQEEVRSIKSETDSTIEVDSVVGELQDLQSEGNSSPAGFDASVSSSSSNQPEPDNPEKACTGQKRVKDTQGVGSSSKKQKRSHKATVVNNKKKGKGTNSSDSEELSAGESVTKTQTIKSVPTGMKTHNSKSPARVQSPGKGGRNGDKDPDLKEPSNRLPKVYKWSFQTSDLENMTSAERISILQEKLQEIRKHYLSLKSEVASIDRRRKRLKKKERESAATSSSSSSPSSSSITAAVMLTLAEPSMSSASQNGMSVECR", "length": 1314, "header": "sp|A2CG63-1|ARI4B_MOUSE Isoform 1 of AT-rich interactive domain-containing protein 4B OS=Mus musculus OX=10090 GN=Arid4b PE=1 SV=1 CANONICAL=A2CG63-1" }, "locus": { "chromosome": "13", "start_pos": 14372315, "end_pos": 14239459, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000110534", "url": "https://www.ensembl.org/id/ENSMUST00000110534" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000106163", "url": "https://www.ensembl.org/id/ENSMUSP00000106163" } ] } }, { "isoform_ac": "A2CG63-2", "url": "https://www.uniprot.org/uniprot/A2CG63#A2CG63-2", "sequence": { "sequence": "MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGPLKVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETLDQLPLTNPEHFGTPVIGKKTNRGRRSNHIPEEESSSSSSDDDEEERKQTDELLGKVVCVDYVSLEKKKAMWFPALVVCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDTVPKPDAVLKQAFDQALEFHKSRAIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIDFQMALPEKVLNKPCKDCENKEVKVKEESETEIKEVNVEDSKNVMPKEETPAEDESERKENIKPSLGSKKSLLECIPAQSDEEKEAHITKLEENENLEDKDGGRARTEEAFSTEVDGEEEQARSGYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDRDEKYSPKNCKLRRLSKSPFQSNPSPEMVSKLDLADAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERCTQDVDNIGKDESKVEHSTHSRNELISKEEQSSPSLLEENKVHTDLVIAKTVSKSPERLRKDMEAISEDTDFEEEDEITKKRKDVKKDTTDKALKPQTKRGKRRYCSADECLQTGSPGKKEDRTKSKEPLCTENSSNSSSDEDEEEKSKAKMTPTKKYNGLEEKRKSLRTTSFYSGFSEVAEKRIKLLNNSDERLQNNRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPDEGAVEESLQTVAEEESCSPIMELEKPLPASVDNKPIEEKPLEVSDRKTEFPSSGSNSVLNTPPTTPESPSSVTITEASQQQSSVTVSVPLPPNQEEVRSIKSETDSTIEVDSVVGELQDLQSEGNSSPAGFDASVSSSSSNQPEPDNPEKACTGQKRVKDTQGVGSSSKKQKRSHKATVVNNKKKGKGTNSSDSEELSAGESVTKTQTIKSVPTGMKTHNSKSPARVQSPGKGGRNGDKDPDLKEPSNRLPKVYKWSFQTSDLENMTSAERISILQEKLQEIRKHYLSLKSEVASIDRRRKRLKKKERESAATSSSSSSPSSSSITAAVMLTLAEPSMSSASQNGMSVECR", "length": 1227, "header": "sp|A2CG63-2|ARI4B_MOUSE Isoform 2 of AT-rich interactive domain-containing protein 4B OS=Mus musculus OX=10090 GN=Arid4b PE=1 SV=1 CANONICAL=A2CG63-1" }, "locus": { "chromosome": "13", "start_pos": 14372315, "end_pos": 14239459, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000110536", "url": "https://www.ensembl.org/id/ENSMUST00000110536" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000106165", "url": "https://www.ensembl.org/id/ENSMUSP00000106165" } ] } }, { "isoform_ac": "Z4YL44-1", "url": "https://www.uniprot.org/uniprot/A2CG63#Z4YL44-1", "sequence": { "sequence": "MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGPLKVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETLDQLPLTNPEHFGTPVIGKKTNRGRRSNHIPEEESSSSSSDDDEEERKQTDELLGKVVCVDYVSLEKKKAMWFPALVVCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDTVPKPDAVLKQAFDQALEFHKSRAIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIDFQMALPEKVLNKPCKDCENKEVKVKEESETEIKEVNVEDSKNVMPKEETPAEDESERKENIKPSLVTSYC", "length": 473, "header": "tr|Z4YL44-1|ARI4B_MOUSE Computationally mapped isoform of AT-rich interactive domain-containing protein 4B OS=Mus musculus OX=10090 GN=Arid4b PE=1 SV=1 CANONICAL=A2CG63-1" }, "locus": { "chromosome": "13", "start_pos": 14338949, "end_pos": 14239459, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000110533", "url": "https://www.ensembl.org/id/ENSMUST00000110533" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000106162", "url": "https://www.ensembl.org/id/ENSMUSP00000106162" } ] } }, { "isoform_ac": "Z4YMH1-1", "url": "https://www.uniprot.org/uniprot/A2CG63#Z4YMH1-1", "sequence": { "sequence": "MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGPLKVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETLDQLPLTNPEHFGTPVIGKKTNRGRRSNHIPEEESSSSSSDDDEEERKQTDELLGKVVCVDYVSLEKKKAMWFPALVVCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDTVPKPDAVLKQAFDQALEFHKSRAIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIDFQMALPEKVLNKPCKDCENKEVKVKEESETEIKEVNVEDSKNVMPKEETPAEDESERKENIKPSLGSKKSLLECIPAQSDEEKEAHITKLEENENLEDKDGGRARTEEAFSTEVDGEEEQARSGDETNKEEDEDDEE", "length": 540, "header": "tr|Z4YMH1-1|Z4YMH1_MOUSE Computationally mapped isoform of AT-rich interactive domain-containing protein 4B OS=Mus musculus OX=10090 GN=Arid4b PE=1 SV=1 CANONICAL=A2CG63-1" }, "locus": { "chromosome": "13", "start_pos": 14344543, "end_pos": 14239459, "strand": 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"UniProtKB", "id": "A2CG63", "url": "https://www.uniprot.org/uniprot/A2CG63" } ] }, { "start_pos": 1152, "end_pos": 1152, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "A2CG63", "url": "https://www.uniprot.org/uniprot/A2CG63" } ] }, { "start_pos": 1154, "end_pos": 1154, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2CG63", "url": "https://www.uniprot.org/uniprot/A2CG63" } ] }, { "start_pos": 1155, "end_pos": 1155, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2CG63", "url": "https://www.uniprot.org/uniprot/A2CG63" } ] }, { "start_pos": 1157, "end_pos": 1157, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2CG63", "url": "https://www.uniprot.org/uniprot/A2CG63" } ] }, { "start_pos": 1161, "end_pos": 1161, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2CG63", "url": "https://www.uniprot.org/uniprot/A2CG63" } ] }, { "start_pos": 276, "end_pos": 276, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2CG63", "url": "https://www.uniprot.org/uniprot/A2CG63" } ] }, { "start_pos": 295, "end_pos": 295, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2CG63", "url": "https://www.uniprot.org/uniprot/A2CG63" } ] }, { "start_pos": 296, "end_pos": 296, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2CG63", "url": "https://www.uniprot.org/uniprot/A2CG63" } ] }, { "start_pos": 482, "end_pos": 482, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2CG63", "url": "https://www.uniprot.org/uniprot/A2CG63" } ] }, { "start_pos": 666, "end_pos": 666, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2CG63", "url": "https://www.uniprot.org/uniprot/A2CG63" } ] }, { "start_pos": 668, "end_pos": 668, "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b", "residue": "Ser", "comment": "", "evidence": [ { "database": "UniProtKB", "id": "A2CG63", "url": "https://www.uniprot.org/uniprot/A2CG63" }, { "database": "iPTMnet", "id": "A2CG63", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2CG63" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 668, "end_pos": 668, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2CG63", "url": "https://www.uniprot.org/uniprot/A2CG63" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 675, "end_pos": 675, "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b", "residue": "Ser", "comment": "", "evidence": [ { "database": "UniProtKB", "id": "A2CG63", "url": "https://www.uniprot.org/uniprot/A2CG63" }, { "database": "iPTMnet", "id": "A2CG63", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2CG63" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 675, "end_pos": 675, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2CG63", "url": "https://www.uniprot.org/uniprot/A2CG63" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 717, "end_pos": 717, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2CG63", "url": "https://www.uniprot.org/uniprot/A2CG63" } ] }, { "start_pos": 778, "end_pos": 778, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2CG63", "url": "https://www.uniprot.org/uniprot/A2CG63" } ] }, { "start_pos": 790, "end_pos": 790, "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b", "residue": "Ser", "comment": "", "evidence": [ { "database": "UniProtKB", "id": "A2CG63", "url": "https://www.uniprot.org/uniprot/A2CG63" }, { "database": "iPTMnet", "id": "A2CG63", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2CG63" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 790, "end_pos": 790, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2CG63", "url": "https://www.uniprot.org/uniprot/A2CG63" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 793, "end_pos": 793, "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b", "residue": "Thr", "comment": "", "evidence": [ { "database": "UniProtKB", "id": "A2CG63", "url": "https://www.uniprot.org/uniprot/A2CG63" }, { "database": "iPTMnet", "id": "A2CG63", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2CG63" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 793, "end_pos": 793, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "A2CG63", "url": "https://www.uniprot.org/uniprot/A2CG63" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] } ], "glycation": [], "keywords": [], "publication": [ { "title": "Deficiency of Rbbp1/Arid4a and Rbbp1l1/Arid4b alters epigenetic modifications and suppresses an imprinting defect in the PWS/AS domain.", "journal": "Genes Dev.", "date": "2006", "authors": "Beaudet A.L., Wu M.Y., Tsai T.F.", "evidence": [ { "database": "UniProtKB", "id": "A2CG63", "url": "https://www.uniprot.org/uniprot/A2CG63" } ], "reference": [ { "type": "PubMed", "id": "17043311", "url": "https://glygen.org/publication/PubMed/17043311" } ] }, { "title": "Identification of chromatin remodeling genes Arid4a and Arid4b as leukemia suppressor genes.", "journal": "J. Natl. Cancer Inst.", "date": "2008", "authors": "Beaudet A.L., Wu M.Y., Eldin K.W.", "evidence": [ { "database": "UniProtKB", "id": "A2CG63", "url": "https://www.uniprot.org/uniprot/A2CG63" }, { "database": "RefSeq", "id": "NP_919238", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919238" } ], "reference": [ { "type": "PubMed", "id": "18728284", "url": "https://glygen.org/publication/PubMed/18728284" } ] }, { "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.", "journal": "Cell", "date": "2010", "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "A2CG63", "url": "https://www.uniprot.org/uniprot/A2CG63" }, { "database": "iPTMnet", "id": "A2CG63", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2CG63" } ], "reference": [ { "type": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "title": "ARID4A and ARID4B regulate male fertility, a functional link to the AR and RB pathways.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2013", "authors": "Beaudet A.L., Jiang M., Wu M.Y., Wu R.C.", "evidence": [ { "database": "UniProtKB", "id": "A2CG63", "url": "https://www.uniprot.org/uniprot/A2CG63" } ], "reference": [ { "type": "PubMed", "id": "23487765", "url": "https://glygen.org/publication/PubMed/23487765" } ] }, { "title": "Androgen Receptor Coactivator ARID4B Is Required for the Function of Sertoli Cells in Spermatogenesis.", "journal": "Molecular endocrinology (Baltimore, Md.)", "date": "2015", "authors": "Wu RC, Zeng Y, Pan IW, Wu MY", "evidence": [ { "database": "RefSeq", "id": "NP_919238", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919238" } ], "reference": [ { "type": "PubMed", "id": "26258622", "url": "https://glygen.org/publication/PubMed/26258622" } ] }, { "title": "Temporal-Spatial Establishment of Initial Niche for the Primary Spermatogonial Stem Cell Formation Is Determined by an ARID4B Regulatory Network.", "journal": "Stem cells (Dayton, Ohio)", "date": "2017", "authors": "Wu RC, Zeng Y, Chen YF, Lanz RB, Wu MY", "evidence": [ { "database": "RefSeq", "id": "NP_919238", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919238" } ], "reference": [ { "type": "PubMed", "id": "28207192", "url": "https://glygen.org/publication/PubMed/28207192" } ] }, { "title": "ARID4B is critical for mouse embryonic stem cell differentiation towards mesoderm and endoderm, linking epigenetics to pluripotency exit.", "journal": "The Journal of biological chemistry", "date": "2020", "authors": "Terzi Cizmecioglu N, Huang J, Keskin EG, Wang X, Esen I, Chen F, Orkin SH", "evidence": [ { "database": "RefSeq", "id": "NP_919238", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919238" } ], "reference": [ { "type": "PubMed", "id": "33454011", "url": "https://glygen.org/publication/PubMed/33454011" } ] }, { "title": "Differentiation of fetal hematopoietic stem cells requires ARID4B to restrict autocrine KITLG/KIT-Src signaling.", "journal": "Cell reports", "date": "2021", "authors": "Young IC, Wu B, Andricovich J, Chuang ST, Li R, Tzatsos A, Wu RC, Wu MY", "evidence": [ { "database": "RefSeq", "id": "NP_919238", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919238" } ], "reference": [ { "type": "PubMed", "id": "34818550", "url": "https://glygen.org/publication/PubMed/34818550" } ] } ], "pathway": [ { "id": "mmu:94246", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:94246", "resource": "KEGG Pathway" }, { "id": "R-MMU-3214815", "name": "HDACs deacetylate histones", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-3214815", "resource": "Reactome", "description": "HDACs deacetylate histones" } ], "orthologs": [ { "uniprot_canonical_ac": "Q4LE39-1", "protein_name": "AT-rich interactive domain-containing protein 4B", "gene_name": "ARID4B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGPLKVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETLDQLPLTNPEHFGTPVIGKKTNRGRRSNHIPEEESSSSSSDEDEDDRKQIDELLGKVVCVDYISLDKKKALWFPALVVCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDTAPKPDAVLKQAFEQALEFHKSRTIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIEFQMALPEKVVNKQCKECENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKPSLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGDETNKEEDEDDEEAEEEEEEEEEEEDEDDDDNNEEEEFECYPPGMKVQVRYGRGKNQKMYEASIKDSDVEGGEVLYLVHYCGWNVRYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDEDEEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSVELEKPPPVNVDSKPIEEKTVEVNDRKAEFPSSGSNSVLNTPPTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQEEVRSIKSETDSTIEVDSVAGELQDLQSEGNSSPAGFDASVSSSSSNQPEPEHPEKACTGQKRVKDAQGGGSSSKKQKRSHKATVVNNKKKGKGTNSSDSEELSAGESITKSQPVKSVSTGMKSHSTKSPARTQSPGKCGKNGDKDPDLKEPSNRLPKVYKWSFQMSDLENMTSAERITILQEKLQEIRKHYLSLKSEVASIDRRRKRLKKKERESAATSSSSSSPSSSSITAAVMLTLAEPSMSSASQNGMSVECR", "length": 1312 }, "evidence": [ { "id": "12847", "url": "http://www.informatics.jax.org/homology/12847", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A2CG63", "url": "https://www.uniprot.org/uniprot/A2CG63" } ], "pmid": "21873635" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A2CG63", "url": "https://www.uniprot.org/uniprot/A2CG63" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A2CG63", "url": "https://www.uniprot.org/uniprot/A2CG63" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A2CG63", "url": "https://www.uniprot.org/uniprot/A2CG63" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A2CG63", "url": "https://www.uniprot.org/uniprot/A2CG63" } ], "pmid": "21873635" }, { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "A2CG63", "url": "https://www.uniprot.org/uniprot/A2CG63" } ], "pmid": "23487765" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A2CG63", "url": "https://www.uniprot.org/uniprot/A2CG63" } ], "pmid": "23487765" }, { "name": "regulation of gene expression by genetic imprinting", "id": "GO:0006349", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006349", "evidence": [ { "database": "UniProtKB", "id": "A2CG63", "url": "https://www.uniprot.org/uniprot/A2CG63" } ], "pmid": "17043311" }, { "name": "histone H4-K20 trimethylation", "id": "GO:0034773", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034773", "evidence": [ { "database": "UniProtKB", "id": "A2CG63", "url": "https://www.uniprot.org/uniprot/A2CG63" } ], "pmid": "17043311" }, { "name": "histone H3-K9 trimethylation", "id": "GO:0036124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036124", "evidence": [ { "database": "UniProtKB", "id": "A2CG63", "url": "https://www.uniprot.org/uniprot/A2CG63" } ], "pmid": "17043311" }, { "name": "establishment of Sertoli cell barrier", "id": "GO:0097368", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097368", "evidence": [ { "database": "UniProtKB", "id": "A2CG63", "url": "https://www.uniprot.org/uniprot/A2CG63" } ], "pmid": "23487765" }, { "name": "regulation of transcription, DNA-templated", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A2CG63", "url": "https://www.uniprot.org/uniprot/A2CG63" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "transcription cis-regulatory region binding", "id": "GO:0000976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000976", "evidence": [ { "database": "UniProtKB", "id": "A2CG63", "url": "https://www.uniprot.org/uniprot/A2CG63" } ], "pmid": "21873635" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A2CG63", "url": "https://www.uniprot.org/uniprot/A2CG63" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1088, "end_pos": 1090, "annotation": 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