{
    "uniprot_canonical_ac": "A2CG22-1",
    "uniprot_ac": "A2CG22",
    "uniprot_id": "A2CG22_MOUSE",
    "mass": {
        "chemical_mass": 61019.0,
        "monoisotopic_mass": 61019.0
    },
    "refseq": {
        "ac": "NP_109672",
        "name": "butyrophilin-like 6 precursor",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_109672"
    },
    "gene_names": [
        {
            "name": "Btnl6",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2CG22",
            "id": "A2CG22"
        },
        {
            "name": "Btnl6",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_109672",
            "id": "NP_109672"
        },
        {
            "name": "EG624681; Gm6519; NG13",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_109672",
            "id": "NP_109672"
        },
        {
            "name": "EG624681",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2CG22",
            "id": "A2CG22"
        },
        {
            "name": "RP23-24A13.7-001",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2CG22",
            "id": "A2CG22"
        }
    ],
    "protein_names": [
        {
            "name": "Butyrophilin-like 6",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2CG22#names_and_taxonomy",
            "id": "A2CG22"
        },
        {
            "name": "butyrophilin-like 6 precursor",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_109672",
            "id": "NP_109672"
        }
    ],
    "function": [
        {
            "annotation": "Data show that the expression of Btnl1 and Btnl6 is delayed in the murine neonatal gut and that the appearance of the Btnl1 and Btnl6 proteins in the intestinal mucosa associates with the expansion of Vgamma7Vdelta4 TCR IELs Publication Status: Online-Only",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_109672",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_109672"
                },
                {
                    "database": "PubMed",
                    "id": "27528202",
                    "url": "https://glygen.org/publication/PubMed/27528202"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2CG22",
                    "url": "https://www.uniprot.org/uniprot/A2CG22"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Btnl6",
            "url": "https://www.uniprot.org/uniprot/A2CG22",
            "locus": {
                "chromosome": "17",
                "start_pos": 34517352,
                "end_pos": 34507804,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000092618",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000092618"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000092618",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000092618",
            "database": "Bgee"
        },
        {
            "id": "624681",
            "url": "https://www.ncbi.nlm.nih.gov/gene/624681",
            "database": "GeneID"
        },
        {
            "id": "IPR001870",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001870",
            "database": "InterPro"
        },
        {
            "id": "IPR003599",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599",
            "database": "InterPro"
        },
        {
            "id": "IPR003877",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR003877",
            "database": "InterPro"
        },
        {
            "id": "IPR003879",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR003879",
            "database": "InterPro"
        },
        {
            "id": "IPR007110",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110",
            "database": "InterPro"
        },
        {
            "id": "IPR013106",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106",
            "database": "InterPro"
        },
        {
            "id": "IPR013320",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320",
            "database": "InterPro"
        },
        {
            "id": "IPR013783",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783",
            "database": "InterPro"
        },
        {
            "id": "IPR036179",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179",
            "database": "InterPro"
        },
        {
            "id": "IPR043136",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR043136",
            "database": "InterPro"
        },
        {
            "id": "mmu:624681",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:624681",
            "database": "KEGG Pathway"
        },
        {
            "id": "1932038",
            "url": "http://www.informatics.jax.org/marker/MGI:1932038",
            "database": "MGI"
        },
        {
            "id": "VRIHKVQ",
            "url": "https://omabrowser.org/oma/group/VRIHKVQ/",
            "database": "OMA"
        },
        {
            "id": "522383at2759",
            "url": "http://www.orthodb.org/?query=522383at2759",
            "database": "OrthoDB"
        },
        {
            "id": "PF00622",
            "url": "http://pfam.xfam.org/family/PF00622",
            "database": "Pfam"
        },
        {
            "id": "PF07686",
            "url": "http://pfam.xfam.org/family/PF07686",
            "database": "Pfam"
        },
        {
            "id": "NP_109672",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_109672",
            "database": "RefSeq"
        },
        {
            "id": "A2CG22",
            "url": "https://www.uniprot.org/uniprot/A2CG22",
            "database": "UniProtKB"
        },
        {
            "id": "A2CG22-1",
            "url": "https://www.uniprot.org/uniprot/A2CG22-1",
            "database": "UniProtKB"
        }
    ],
    "sequence": {
        "sequence": "MENHRKPSLLFHVSCLFVLIQLLSWVTTKEFQVFGPSDPIVAAPGGEAILPCSVIPAMNVENMEELRWFRSRFSAAVLVYRDQEEQKREQLPEYSQRTSLVKEQFHQGTAAVRILNVQAPDSGIYICHFKQGVFYEEAILELKVAAMGSVPEVYIKGPEDGGVCVVCITSGWYPEPQVHWKDSRGEKLTASLEIHSEDAQGLFRTETSLVVRDSSVRNVTCSTFNPILGQEKAMAMFLPEPFFPKVSPWKPAFFVTLTMMGLLVLGTSYLFRRERSARLIVQELTGNLQRVEDNKAEEDTVRTIDALMVELAQRKAAYRAAWRKAQLYADWRKEQFQAWTFTLDPASAHTNLAISQDRLTVTRKDFTRCLEDLSCVLGIRGISSGRYYWEVKLTNIEGSKWILGVCREGVVRKNFYFETPRKGFWTVGQSSKGHWAYIDSGRTSLSVRQAPKSVGVFVDYTEGDISFYNMSDMSHMFSFPKASFSGTLFPYFRLRSGNVSMIINSMECASESSEGEEGRRGRKRSRRGGRGGGGRMGRS",
        "length": 539,
        "header": "tr|A2CG22-1|A2CG22_MOUSE Isoform 1 of Butyrophilin-like 6  OS=Mus musculus OX=10090 GN=Btnl6 PE=1 SV=1 CANONICAL=A2CG22-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A2CG22-1",
            "url": "https://www.uniprot.org/uniprot/A2CG22#A2CG22-1",
            "sequence": {
                "sequence": "MENHRKPSLLFHVSCLFVLIQLLSWVTTKEFQVFGPSDPIVAAPGGEAILPCSVIPAMNVENMEELRWFRSRFSAAVLVYRDQEEQKREQLPEYSQRTSLVKEQFHQGTAAVRILNVQAPDSGIYICHFKQGVFYEEAILELKVAAMGSVPEVYIKGPEDGGVCVVCITSGWYPEPQVHWKDSRGEKLTASLEIHSEDAQGLFRTETSLVVRDSSVRNVTCSTFNPILGQEKAMAMFLPEPFFPKVSPWKPAFFVTLTMMGLLVLGTSYLFRRERSARLIVQELTGNLQRVEDNKAEEDTVRTIDALMVELAQRKAAYRAAWRKAQLYADWRKEQFQAWTFTLDPASAHTNLAISQDRLTVTRKDFTRCLEDLSCVLGIRGISSGRYYWEVKLTNIEGSKWILGVCREGVVRKNFYFETPRKGFWTVGQSSKGHWAYIDSGRTSLSVRQAPKSVGVFVDYTEGDISFYNMSDMSHMFSFPKASFSGTLFPYFRLRSGNVSMIINSMECASESSEGEEGRRGRKRSRRGGRGGGGRMGRS",
                "length": 539,
                "header": "tr|A2CG22-1|A2CG22_MOUSE Isoform 1 of Butyrophilin-like 6  OS=Mus musculus OX=10090 GN=Btnl6 PE=1 SV=1 CANONICAL=A2CG22-1"
            },
            "locus": {
                "chromosome": "17",
                "start_pos": 34736326,
                "end_pos": 34726912,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000075483",
                        "url": "https://www.ensembl.org/id/ENSMUST00000075483"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000074927",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000074927"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "The ontogeny of Butyrophilin-like (Btnl) 1 and Btnl6 in murine small intestine.",
            "journal": "Scientific reports",
            "date": "2016",
            "authors": "Lebrero-Fernandez C, Bas-Forsberg A",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_109672",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_109672"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "27528202",
                    "url": "https://glygen.org/publication/PubMed/27528202"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:624681",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:624681",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "A2CG29-1",
            "protein_name": "Butyrophilin, subfamily 3, member A3",
            "gene_name": "Btnl4",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MENHRKPSLLFHVPCLFVLTQLLSWVTTQEFRVFGPSDPIVAAPGGEAILPCSVFPAMNVENMEELRWFRSRFSEAVLFYRDQEEQKEGQMPGYSQRTLLVKDQFHQGTAAVRILNVQASDSGIYICHFQQGVFYDEAILELKVAAMGSVPEVHIKGPEDGGVCVVCMTSGWYPEPQVHWKDSRGENLTAFSSETHTKDAEGLFSTETLLVVRDSSVRNVTCSIFNPILGQEKATAMFIPEPFFPQASPWKPAFLVTLTMMGLLVLGTSYLLRREHSARLKVQQETVNFQREKDESLKTRDDALRTAGALMVERDRRKAAYRAAWKKAQLYADWRKEHFEAWTFTLDPASAHPILAISPDRLSVSRKDSTLCLDDLFCVLGIRGISSGRHYWEVKLRNGDSSKWTLGVCREGVDRKGCFSECPHKGFWTVGRSSSGYLAYIDTGTALLSLRQAPQSVGVFVDYTEGDISFYNMSDMSPMFSFHEASFSGTLFPYFRLKSGNVSMIIQSMACASEGREGEDRRRGRKRSRKGRKGKRTKRGKKLVLLPLEESLSPAGEGLVPGSCVVDSFPEEVSPFLQHARNSLFP",
                "length": 586
            },
            "evidence": [
                {
                    "id": "106849",
                    "url": "http://www.informatics.jax.org/homology/106849",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "F1M8A0-1",
            "protein_name": "Butyrophilin-like 5",
            "gene_name": "Btnl5",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MGIYCKPSVLFQDSYLLVLTQLLCWVTTMARMCQELCSSDVQETHKPGTKHFAIFPFVPLTATSVSTEGFRVFGPSDPVVVAPGREAILPCSVSPAMSVENMEELRWFRTRFSEAVFVYRDQEEQKEEQMIEYSLRTSLVKDQFHEGKAAVRIQNVQESDSGIHVCHFKQGVLYEEAILELKVAAMGSTPEVYIKGPEDGGVCVVCMTSGWYPEPQVHWRDSTGEDLPASSETLHEDAEGLFSTETSLVLRDSSVRNVACSIFNPVLGQEKAIAIVIPEPFFPQASPWKAAFIVILTMMGLLVSGTSYLLIREHSGRLKLQQEWSHFQLEKDELQTIKEDALRTASALREELDRRKATYNRAWRKAQLYADWRREHFQAWTFTLDPASAHPTLVISQDRMRVTRKDTNELFRVLSIDLFSVLGTKGISSGRYYWEVKLANGEGSKWSLGVCREVVERKDFYFESPEKGFWTVGQSSCGYFAYVERGRASLSIRQAPQSVGVFVDYDEGEISFYNMSDMSHIFSYEASFSGTLLPYFRLKSGNVSMTVSTMACVSEGQEGEEGEKGEEQEEGKEGEECQLLSHARDTLFP",
                "length": 589
            },
            "evidence": [
                {
                    "id": "106849",
                    "url": "http://www.informatics.jax.org/homology/106849",
                    "database": "MGI"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "F7F1D5-1",
            "protein_name": "Similar to butyrophilin-like 7",
            "gene_name": "RGD1624210",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MENCCKPSLLFHILCLLVLTQMTSLVTAKDFLVFGPSDPIVATLGGEAILPCSVFPVMSVENMEELRWFRTRFSEAVFVYRDQEEQKEGQLPGYSQRTSLVKDQFHEGKAAVRIQNVQESDSGIYVCHFKQGHFHEEAILELKVAAMGSVPEVYIKGPEEGGVCVVCMTSGWYPEPQVHWRDSRGEDLPASSETLHEDAEGLFSTETSLVLRDSSVRNVTCSTFNPILGQEKAMAMVIPEPFFPQASPWKADISEILKMILILISGTIYLLRREHSGRLKVQQKRKHLQCEKDELQTTKEDALLFTRLFEWGYFDWVLTRVCSFTAWRKAQLYADWRKEHFQACNFTLDPASAHPILNVSQDRMRVTRKDTTMCLDDLFCVLGTNGISSGRYYWEVKLRNRDSSTWTLGVCREGVERKGCFSECPEKGFWTVGQSSSGYWAYVDSGRDSLSIRQAPQSVGVFVDYDERNISFYNMSDKSHLFSFHEASFSGTLLPYFRLKSGNISMTVSSMACVSEGQQGEEGRRGRKRSRKGRKGRRPKKGKGLALLPLKESLSPTGEEGLVPGSCVVVSPSGEESPFLQDARDTLFP",
                "length": 589
            },
            "evidence": [
                {
                    "id": "106849",
                    "url": "http://www.informatics.jax.org/homology/106849",
                    "database": "MGI"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "Q6MG92-1",
            "protein_name": "Butyrophilin-like 8",
            "gene_name": "Btnl8",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MGIYCKPSVLFQDSYLLVLTQLLCWVTTKGFRVFGPSDPVVAAPGREAILPCSVSPAMSVENMEELRWFRTRFSQAVFVYRDQEEQKEEQMIEYSWRTSLVKDKFHEGKAAVRIQNVQESDSGIYVCHFKQGHFHEEAILELKVAAMGSVPEVYIKGPEDGGVCVVCMTSGWYPEPQVHWRDSRGEILPASSETLHEDAEGLITTETSLVLRDSSVRNVTCSTFNPVLGQEKAMAMVIPEPFFPQASPWKTAFLVILTMMGLLVLGTISLFGWERFVRLKLQKEQIHIHCEKDELQTEKEDALRTAKWGYCEWVLTRVCSFTAWRKAQLYADWRKEHFQTWTFTLDPASAHPTLVISQDRMRVTRKDTTVCLDDLFSVLGTKGISSGRYYWEVKLENREGSKWILGVCREGVERKGFYFESPEKGFWTVGQSSSGYWAYVDSGRDSLSIRQAPESVGVFVDYDKRNISFYNMSDMSHLFSFHEASFSGTLLPYFQLKCGNVSMTVNSMACVSEGQEGEEGRKGRKRSRKGRKRRKGRRPKKGKGLALLPLKESLSPTGEGLVPGSCVVVSPSGEESPFLQDARDTLFP",
                "length": 588
            },
            "evidence": [
                {
                    "id": "106849",
                    "url": "http://www.informatics.jax.org/homology/106849",
                    "database": "MGI"
                },
                {
                    "id": "A2CG22",
                    "url": "https://omabrowser.org/oma/group/A2CG22/",
                    "database": "OMA"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "Q6MG93-1",
            "protein_name": "Butyrophilin-like 7",
            "gene_name": "Btnl7",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MGIYCKPSVLFQDSYLLVLTQLLCWVTTKGFWVFGPSDPVVAAPGREAILPCSVFPAMSVENMEELRWFRNRFSQAVFVYRDQEEQKEEQMIEYSWRTSLVKDQFHEGKAAVRIQNVQESDSGIYVCHFKHGHFREEAILELKVAAMGSVPEVYIKGPEDGGVCVVCMTSGWYPEPQVHWRDSRGEDLPASSETLHEDAEGLFSTENSLVVRDSSVRNVTCSTFNPILGQEKAMAIVIPEPFFPQASPWKTAFVVILTMMGLLVLGTISLFGWERFVRLKLQKEQIHIHCEKDKAQTEKEDALRTAKWGYCEWVLTRVCSFTAWRKAQLYADWRKEHFQTWTFTLDPASAHPTLVISQDRMRVTRKDTTVCLDDLFSVLGTKGISSGRYYWEVKLANGEGSKWILGVCREGVERKGFYFESPEKGFWTVGQSSSGYWAYVDSGRDSLSIRQAPQSVGVFVDYDERNISFYNMSDKSHLFSFHEASFSGTLLPYFQLKSGNVSMTVSSMACVSEGQEGEEGEKGEEQEEGKEEEESQFLQRVRDTLFP",
                "length": 547
            },
            "evidence": [
                {
                    "id": "106849",
                    "url": "http://www.informatics.jax.org/homology/106849",
                    "database": "MGI"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 3,
                "go_terms": [
                    {
                        "name": "extrathymic T cell selection",
                        "id": "GO:0045062",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045062",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2CG22",
                                "url": "https://www.uniprot.org/uniprot/A2CG22"
                            }
                        ],
                        "pmid": "27641500"
                    },
                    {
                        "name": "T cell receptor signaling pathway",
                        "id": "GO:0050852",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050852",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2CG22",
                                "url": "https://www.uniprot.org/uniprot/A2CG22"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "regulation of cytokine production",
                        "id": "GO:0001817",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001817",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2CG22",
                                "url": "https://www.uniprot.org/uniprot/A2CG22"
                            }
                        ],
                        "pmid": "21873635"
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 1,
                "go_terms": [
                    {
                        "name": "signaling receptor binding",
                        "id": "GO:0005102",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005102",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2CG22",
                                "url": "https://www.uniprot.org/uniprot/A2CG22"
                            }
                        ],
                        "pmid": "21873635"
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 2,
                "go_terms": [
                    {
                        "name": "integral component of membrane",
                        "id": "GO:0016021",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2CG22",
                                "url": "https://www.uniprot.org/uniprot/A2CG22"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "external side of plasma membrane",
                        "id": "GO:0009897",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2CG22",
                                "url": "https://www.uniprot.org/uniprot/A2CG22"
                            }
                        ],
                        "pmid": "21873635"
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 218,
            "end_pos": 220,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 469,
            "end_pos": 471,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 498,
            "end_pos": 500,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        },
        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
        }
    ]
}