{
    "uniprot_canonical_ac": "A2CE44-1",
    "uniprot_ac": "A2CE44",
    "uniprot_id": "ZXDB_MOUSE",
    "mass": {
        "chemical_mass": 90376.0,
        "monoisotopic_mass": 90376.0
    },
    "refseq": {
        "ac": "NP_001074942",
        "name": "zinc finger X-linked protein ZXDB",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074942"
    },
    "gene_names": [
        {
            "name": "Zxdb",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2CE44",
            "id": "A2CE44"
        },
        {
            "name": "Zxda",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074942",
            "id": "NP_001074942"
        },
        {
            "name": "Zxdb",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074942",
            "id": "NP_001074942"
        }
    ],
    "protein_names": [
        {
            "name": "Zinc finger X-linked protein ZXDB",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2CE44#names_and_taxonomy",
            "id": "A2CE44"
        },
        {
            "name": "zinc finger X-linked protein ZXDA/ZXDB",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074942",
            "id": "NP_001074942"
        },
        {
            "name": "zinc finger X-linked protein ZXDB",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074942",
            "id": "NP_001074942"
        }
    ],
    "function": [
        {
            "annotation": "Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2CE44",
                    "url": "https://www.uniprot.org/uniprot/A2CE44#function"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2CE44",
                    "url": "https://www.uniprot.org/uniprot/A2CE44"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Zxdb",
            "url": "https://www.uniprot.org/uniprot/A2CE44",
            "locus": {
                "chromosome": "X",
                "start_pos": 94724569,
                "end_pos": 94730187,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000073062",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000073062"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000073062",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000073062",
            "database": "Bgee"
        },
        {
            "id": "668166",
            "url": "https://www.ncbi.nlm.nih.gov/gene/668166",
            "database": "GeneID"
        },
        {
            "id": "IPR013087",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087",
            "database": "InterPro"
        },
        {
            "id": "IPR036236",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236",
            "database": "InterPro"
        },
        {
            "id": "mmu:668166",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:668166",
            "database": "KEGG Pathway"
        },
        {
            "id": "3694898",
            "url": "http://www.informatics.jax.org/marker/MGI:3694898",
            "database": "MGI"
        },
        {
            "id": "DWNVHPD",
            "url": "https://omabrowser.org/oma/group/DWNVHPD/",
            "database": "OMA"
        },
        {
            "id": "1318335at2759",
            "url": "http://www.orthodb.org/?query=1318335at2759",
            "database": "OrthoDB"
        },
        {
            "id": "PF00096",
            "url": "http://pfam.xfam.org/family/PF00096",
            "database": "Pfam"
        },
        {
            "id": "PR_A2CE44",
            "url": "http://purl.obolibrary.org/obo/PR_A2CE44",
            "database": "PRO"
        },
        {
            "id": "NP_001074942",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074942",
            "database": "RefSeq"
        },
        {
            "id": "A2CE44",
            "url": "https://www.uniprot.org/uniprot/A2CE44",
            "database": "UniProtKB"
        },
        {
            "id": "A2CE44-1",
            "url": "https://www.uniprot.org/uniprot/A2CE44-1",
            "database": "UniProtKB"
        }
    ],
    "sequence": {
        "sequence": "MEIPRLLPARGTPQGAGGGGCPAGGGGVHRAPASLACQAPTRRLLLLRGAQDGGPGPRSAEAQRASRGLGPSLNRLAPRPDHRSSGGGRGGGAGGGGGGSGGGGGGGGGGGGGGGGGGSRGGSDDFFLLLLDPVGGDVETVGTEQAGAPVRREEAGAGPRPERRQSAGPPAGRPEPGPRCLSAVPAASPLPAAGPGPAAAAAAAAAAAFAGTITIHNQDLLLRFENGVLTLTTPPLPAWEPGVAPFPQPQPPPQPGALIAPQAAAAGFPPAAAAAAAAAAAGAQLGDCPELPPDLLLAEPAEPAACPAPPEEEAEAPAAAAAQSPRGPAGPGPGPGVVLYLCPEAQCGQTFAKKHQLKVHLLTHSSSQGQRPFKCPLSGCGWTFTTSYKLKRHLQSHDKLRPFGCPVQGCGKSFTTVYNLKAHMKGHEQENSFKCEVCEESFPTQAKLSTHQRSHFEPERPYQCAFSGCKKTFITVSALFSHNRAHFREQELFACSFPGCSKQYDKACRLKIHLRSHTGERPFLCDFDGCGWNFTSMSKLLRHKRKHEDDRRFTCPVEGCGKSFTRAEHLKGHSITHLGTKPFVCPVEGCCARFSARSSLYIHSKKHLQDVGAWKSRCPVPTCNKLFTSKHSMKTHMTKRHNLSQDLLAQLEAANSLTPSSELTSPGQSDLSGAELVSLFSDVPGHGSAAVLDTALVNSGILTIDVASVNSSLAGSLPADNNSNNHSLGQAAEPRALRGAPSDLPQSLDTSLFFGTSVAGYQHSPLDMDDVSAGNVGLFGSLALKNSSLEPQALTPSNKLTVDTEALTPSSTLCENSVSELLTPAKAEWNVHPESDFFGHEEETQFGFSHPTGSHGSQKDTDLITVTGTPFLV",
        "length": 873,
        "header": "sp|A2CE44-1|ZXDB_MOUSE Isoform 1 of Zinc finger X-linked protein ZXDB  OS=Mus musculus OX=10090 GN=Zxdb PE=1 SV=1 CANONICAL=A2CE44-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A2CE44-1",
            "url": "https://www.uniprot.org/uniprot/A2CE44#A2CE44-1",
            "sequence": {
                "sequence": "MEIPRLLPARGTPQGAGGGGCPAGGGGVHRAPASLACQAPTRRLLLLRGAQDGGPGPRSAEAQRASRGLGPSLNRLAPRPDHRSSGGGRGGGAGGGGGGSGGGGGGGGGGGGGGGGGGSRGGSDDFFLLLLDPVGGDVETVGTEQAGAPVRREEAGAGPRPERRQSAGPPAGRPEPGPRCLSAVPAASPLPAAGPGPAAAAAAAAAAAFAGTITIHNQDLLLRFENGVLTLTTPPLPAWEPGVAPFPQPQPPPQPGALIAPQAAAAGFPPAAAAAAAAAAAGAQLGDCPELPPDLLLAEPAEPAACPAPPEEEAEAPAAAAAQSPRGPAGPGPGPGVVLYLCPEAQCGQTFAKKHQLKVHLLTHSSSQGQRPFKCPLSGCGWTFTTSYKLKRHLQSHDKLRPFGCPVQGCGKSFTTVYNLKAHMKGHEQENSFKCEVCEESFPTQAKLSTHQRSHFEPERPYQCAFSGCKKTFITVSALFSHNRAHFREQELFACSFPGCSKQYDKACRLKIHLRSHTGERPFLCDFDGCGWNFTSMSKLLRHKRKHEDDRRFTCPVEGCGKSFTRAEHLKGHSITHLGTKPFVCPVEGCCARFSARSSLYIHSKKHLQDVGAWKSRCPVPTCNKLFTSKHSMKTHMTKRHNLSQDLLAQLEAANSLTPSSELTSPGQSDLSGAELVSLFSDVPGHGSAAVLDTALVNSGILTIDVASVNSSLAGSLPADNNSNNHSLGQAAEPRALRGAPSDLPQSLDTSLFFGTSVAGYQHSPLDMDDVSAGNVGLFGSLALKNSSLEPQALTPSNKLTVDTEALTPSSTLCENSVSELLTPAKAEWNVHPESDFFGHEEETQFGFSHPTGSHGSQKDTDLITVTGTPFLV",
                "length": 873,
                "header": "sp|A2CE44-1|ZXDB_MOUSE Isoform 1 of Zinc finger X-linked protein ZXDB  OS=Mus musculus OX=10090 GN=Zxdb PE=1 SV=1 CANONICAL=A2CE44-1"
            },
            "locus": {
                "chromosome": "X",
                "start_pos": 93770899,
                "end_pos": 93768281,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000101388",
                        "url": "https://www.ensembl.org/id/ENSMUST00000101388"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000100524",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000100524"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.",
            "journal": "Mol. Cell. Proteomics",
            "date": "2014",
            "authors": "Beausoleil S.A., Wang Y., Zhou J., Comb M.J., Guo A., Lee K.A., Aguiar M., Bedford M.T., Gu H., Jia X., Kornhauser J., Mulhern D., Ren J., Silva J.C., Vemulapalli V., Yang V.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2CE44",
                    "url": "https://www.uniprot.org/uniprot/A2CE44"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "24129315",
                    "url": "https://glygen.org/publication/PubMed/24129315"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:668166",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:668166",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "P98169-1",
            "protein_name": "Zinc finger X-linked protein ZXDB",
            "gene_name": "ZXDB",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MEIPKLLPARGTLQGGGGGGIPAGGGRVHRGPDSPAGQVPTRRLLLLRGPQDGGPGRRREEASTASRGPGPSLLAPRTDQPSGGGGGGGDDFFLVLLDPVGGDVETAGSGQAAGPVLREEAEEGPGLQGGESGANPAGPTALGPRCLSAVPTPAPISAPGPAAAFAGTVTIHNQDLLLRFENGVLTLATPPPHAWEPGAAPAQQPGCLIAPQAGFPHAAHPGDCPELPPDLLLAEPAEPAPAPAPEEEAEGPAAALGPRGPLGSGPGVVLYLCPEAQCGQTFAKKHQLKVHLLTHSSSQGQRPFKCPLGGCGWTFTTSYKLKRHLQSHDKLRPFGCPAEGCGKSFTTVYNLKAHMKGHEQENSFKCEVCEESFPTQAKLSAHQRSHFEPERPYQCAFSGCKKTFITVSALFSHNRAHFREQELFSCSFPGCSKQYDKACRLKIHLRSHTGERPFLCDFDGCGWNFTSMSKLLRHKRKHDDDRRFMCPVEGCGKSFTRAEHLKGHSITHLGTKPFVCPVAGCCARFSARSSLYIHSKKHLQDVDTWKSRCPISSCNKLFTSKHSMKTHMVKRHKVGQDLLAQLEAANSLTPSSELTSQRQNDLSDAEIVSLFSDVPDSTSAALLDTALVNSGILTIDVASVSSTLAGHLPANNNNSVGQAVDPPSLMATSDPPQSLDTSLFFGTAATGFQQSSLNMDEVSSVSVGPLGSLDSLAMKNSSPEPQALTPSSKLTVDTDALTPSSTLCENSVSELLTPTKAEWNVHPDSDFFGQEGETQFGFPNAAGNHGSQKETDLITVTGSSFLV",
                "length": 803
            },
            "evidence": [
                {
                    "id": "21401",
                    "url": "http://www.informatics.jax.org/homology/21401",
                    "database": "MGI"
                },
                {
                    "id": "A2CE44",
                    "url": "https://omabrowser.org/oma/group/A2CE44/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Molecular Function",
                "total": 4,
                "go_terms": [
                    {
                        "name": "transcription coactivator activity",
                        "id": "GO:0003713",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2CE44",
                                "url": "https://www.uniprot.org/uniprot/A2CE44"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "metal ion binding",
                        "id": "GO:0046872",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2CE44",
                                "url": "https://www.uniprot.org/uniprot/A2CE44"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "transcription coregulator activity",
                        "id": "GO:0003712",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003712",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2CE44",
                                "url": "https://www.uniprot.org/uniprot/A2CE44"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "C2H2 zinc finger domain binding",
                        "id": "GO:0070742",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070742",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2CE44",
                                "url": "https://www.uniprot.org/uniprot/A2CE44"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 1,
                "go_terms": [
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2CE44",
                                "url": "https://www.uniprot.org/uniprot/A2CE44"
                            }
                        ],
                        "pmid": "21873635"
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 2,
                "go_terms": [
                    {
                        "name": "regulation of transcription by RNA polymerase II",
                        "id": "GO:0006357",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2CE44",
                                "url": "https://www.uniprot.org/uniprot/A2CE44"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "positive regulation of transcription, DNA-templated",
                        "id": "GO:0045893",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2CE44",
                                "url": "https://www.uniprot.org/uniprot/A2CE44"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 533,
            "end_pos": 535,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 642,
            "end_pos": 644,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 710,
            "end_pos": 712,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 721,
            "end_pos": 723,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 725,
            "end_pos": 727,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 786,
            "end_pos": 788,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        },
        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
        }
    ]
}